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Charlotte Suppli Ulrik - One of the best experts on this subject based on the ideXlab platform.
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Extrinsic and intrinsic Asthma from childhood to early adult age. A 10-year follow-up
Ugeskrift for laeger, 1996Co-Authors: Charlotte Suppli Ulrik, Vibeke Backer, A. Dirksen, M. Pedersen, C. KochAbstract:The purpose of this study was to describe factors of potential importance for the outcome in children with intrinsic and Extrinsic Asthma. Of 85 consecutive children, five to 15 years of age, with Asthma, 70 (82%) participated in a ten year follow up examination. At the time of referral all children underwent certain tests for Asthma (case history, total IgE, skin prick tests, radioallergosorbent tests (RAST) and specific bronchial provocations). On the basis of these tests 24 children had intrinsic Asthma and 46 Extrinsic Asthma. At the follow up examination 60 of the 70 adults (86%; 20 with intrinsic Asthma) had current symptoms; 54 of the 60 (90%; 18 with intrinsic Asthma) were receiving maintenance therapy. Both FEV1 %pred (from 73% +/- 19% to 92% +/- 17%) and FEV1/FVC (from 75% +/- 13% to 80% +/- 12%) increased significantly from childhood to early adulthood (p < 0.0002 and p < 0.001, respectively); a corresponding amelioration of symptoms was also observed (p < 0.0001). In children with intrinsic Asthma the outcome seems to be predicted by a combination of the initial frequency of symptoms (p = 0.04), initial FEV1 (p = 0.001), active smoking (p = 0.001) and age at onset of respiratory symptoms (p = 0.001), whereas the initial FEV1 (p < 0.001) seems to be a strong predictor for the outcome in children with Extrinsic Asthma. These findings suggest that the pathogenetic mechanisms underlying intrinsic and Extrinsic Asthma in children may differ.
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Extrinsic and intrinsic Asthma from childhood to adult age a 10 yr follow up
Respiratory Medicine, 1995Co-Authors: Charlotte Suppli Ulrik, Vibeke Backer, M. Pedersen, A Dirksen, C. KochAbstract:Background: Asthma constitutes one of the most common chronic diseases in childhood, yet little is known about the factors that determine the outcome in childhood Asthma. The purpose of this study was to describe various factors of potential importance for the outcome in children with intrinsic and Extrinsic Asthma. Methods: Of 85 consecutive children, 5-15 years of age with Asthma, 70 (82%) participated in a lo-yr follow-up examination. At the time of referral, all children underwent certain tests for Asthma (case history, total IgE, skin prick tests, radioallergosorbent (RAST) tests and specific bronchial provocations). On the basis of these tests, 24 children had intrinsic Asthma and 46 children had Extrinsic Asthma. Results: At the follow-up examination, 60 of the 70 adults (86%, 20 with intrinsic Asthma) had current symptoms; 54 of the 60 (900/,; 18 with intrinsic Asthma) were receiving maintenance therapy. Both FEV, %predicted and FEVJFVC increased significantly (from 73% f 19% to 92% f 17% and from 75% f 13% to 80% f 12% respectively) from childhood to early adulthood (P
wheezing. Conclusions: In children with intrinsic Asthma, the outcome seems to be predicted by a combination of the initial frequency of symptoms (P=O.O4), initial FEV, (P=O.O02), active smoking (P=O.OOl) and age at onset of respiratory symptoms (P=O.OOl), whereas the initial FEV, (P -
Extrinsic and intrinsic Asthma from childhood to adult age: a 10-yr follow-up
Respiratory medicine, 1995Co-Authors: Charlotte Suppli Ulrik, Vibeke Backer, M. Pedersen, A Dirksen, C. KochAbstract:Background: Asthma constitutes one of the most common chronic diseases in childhood, yet little is known about the factors that determine the outcome in childhood Asthma. The purpose of this study was to describe various factors of potential importance for the outcome in children with intrinsic and Extrinsic Asthma. Methods: Of 85 consecutive children, 5-15 years of age with Asthma, 70 (82%) participated in a lo-yr follow-up examination. At the time of referral, all children underwent certain tests for Asthma (case history, total IgE, skin prick tests, radioallergosorbent (RAST) tests and specific bronchial provocations). On the basis of these tests, 24 children had intrinsic Asthma and 46 children had Extrinsic Asthma. Results: At the follow-up examination, 60 of the 70 adults (86%, 20 with intrinsic Asthma) had current symptoms; 54 of the 60 (900/,; 18 with intrinsic Asthma) were receiving maintenance therapy. Both FEV, %predicted and FEVJFVC increased significantly (from 73% f 19% to 92% f 17% and from 75% f 13% to 80% f 12% respectively) from childhood to early adulthood (P
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The course of bronchial Asthma in adults. Factors of importance for the annual decline of lung function
Ugeskrift for laeger, 1993Co-Authors: Charlotte Suppli Ulrik, Backer, Dirksen AAbstract:The purpose of this study was to describe the relation of various factors of potential importance to the rate of decline in lung function in adults with intrinsic and Extrinsic Asthma. Of 180 Asthmatic patients, 143 (79%) participated in a 10 year follow up examination; 94 patients had intrinsic Asthma and 49 Extrinsic Asthma. Patients with intrinsic Asthma had an annual decline in FEV1 of 50 ml, whereas those with Extrinsic Asthma had a decline of 23 ml; the rate of decline of lung function increased with increasing age in both groups. There was no relation between rate of decline in lung function and number of cigarettes smoked. An inverse relation between initial FEV1 and decline in FEV1 was found for the patients with Extrinsic Asthma but not for the patients with intrinsic Asthma. A high degree of airway variability--that is, reversibility in FEV1--at the time of enrollment was found to be associated with a steeper decline in lung function in patients with intrinsic Asthma, whereas increasing degrees of obstruction (decreasing FEV1/VC ratio at enrollment) and need for treatment with corticosteroids were associated with a more pronounced decline in FEV1 in patients with Extrinsic Asthma. The rate of decline in lung function is greater in patients with intrinsic Asthma than in patients with Extrinsic Asthma; the prognosis for intrinsic and Extrinsic Asthma is to some extent influenced by different factors, which suggests that the pathogenetic mechanisms underlying intrinsic and Extrinsic Asthma may differ.
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Bronchial responsiveness to inhaled histamine in both adults with intrinsic and Extrinsic Asthma: The importance of prechallenge forced expiratory volume in 1 second
Journal of Allergy and Clinical Immunology, 1993Co-Authors: Charlotte Suppli UlrikAbstract:Abstract Background: Recent evidence suggests that both nonspecific bronchial hyperresponsiveness and degree of airflow obstruction may be involved in the deterioration of lung function observed in patients with bronchial Asthma. To investigate to which degree the level of bronchial hyperresponsiveness reflects the size of the airways at the time of testing, we examined the relationship of nonspecific bronchial responsiveness to prechallenge pulmonary function in adult Asthmatic patients. Methods: Bronchial responsiveness to inhaled histamine was measured in 100 patients (age range, 28 to 79 years), of whom 62 had intrinsic and 38 had Extrinsic Asthma. Histamine responsiveness was analyzed by means of the dose-response slope (DRS). Results: No significant difference in prechallenge forced expiratory volume expressed as a percentage of predicted value (FEV 1 %pred), duration of Asthma, smoking habits (pack years), or bronchial responsiveness (DRS) was found between the patients with intrinsic and those with Extrinsic Asthma. The patients had, in general, reduced pulmonary function, because 80% had a prechallenge FEV 1 less than 80%pred. The DRS displayed a significant inverse relationship to the prechallenge level of FEV 1 %pred in both patients with intrinsic Asthma and those with Extrinsic Asthma ( p 1 %pred accounted for approximately 35% of the variance in measurements of histamine responsiveness. Excluding patients with abnormal prechallenge FEV 1 ( n = 67) from the analysis did not change these findings. Conclusion: Nonspecific bronchial responsiveness is to some extent determined by the prechallenge level of pulmonary function in both adults with intrinsic and Extrinsic Asthma.
Dragan Dekaris - One of the best experts on this subject based on the ideXlab platform.
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Expression of CD23 antigen and its ligands in children with intrinsic and Extrinsic Asthma
Allergy, 1997Co-Authors: Neda Aberle, Alenka Gagro, Sabina Rabatić, Željka Reiner-banovac, Dragan DekarisAbstract:The role of the low-affinity IgE receptor CD23 in immune reactions has been further emphasized by recent discoveries of novel surface ligands for CD23: CD21, CD11b, and CD11c. We previously observed the difference between the expression of CD23 and CD21 antigens in children suffering from Extrinsic Asthma when compared to healthy controls. In the present study, we investigated the expression of CD23 and its ligand CD21 on CD20 B cells in 44 Asthmatic children (23 allergic and 21 nonallergic) using three-color immunofluorescence analysis. In addition, the expression of two other ligands for CD23, CD11b, and CD11c, on T cells (CD3+), a subpopulation of T cells (CD4+ and CD8+), natural killer cells (CD56+), and monocytes (CD14+) was tested by two-color immunofluorescence analysis in 12 allergic and 14 nonallergic children. We found that children with Extrinsic Asthma had higher levels of CD23+ B cells than those with intrinsic Asthma. No difference was observed in the percentage of either CD23+CD21+ or CD23-CD21+ B cells. The CD11b antigen was expressed on each tested population, but only on CD4+ T cells was CD11b significantly increased in children with Extrinsic Asthma. CD11c was expressed mainly on monocytes, and no difference was observed between tested groups. The increased percentage of CD11b antigen on CD4+ T cells and the increased percentage of CD23 antigen on B cells in children with Extrinsic Asthma provide further evidence of the immunologic differences between intrinsic and Extrinsic Asthma.
J. Hernández - One of the best experts on this subject based on the ideXlab platform.
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Soluble CD23 (sCD23) serum levels and lymphocyte subpopulations in peripheral blood in rhinitis and Extrinsic and intrinsic Asthma
Allergy, 1994Co-Authors: I. M. Sánchez‐guerrero, M. D. Albaladejo, Manuel Muro, J. HernándezAbstract:To determine serum levels of IgE and sCD23 and lymphocyte subpopulations, we studied 37 control subjects and 84 patients (27 with allergic rhinitis, 27 with Extrinsic Asthma, and 30 with intrinsic Asthma). A rise in surface CD23 on B and monocyte cells and sCD23 serum levels was exhibited by patients with rhinitis and Extrinsic Asthma. Unexpectedly, in intrinsic Asthmatic patients, high CD23 expression on monocytes and high sCD23 levels were seen that did not result in IgE production. It appears that CD23, in its soluble form, could be a good disease marker, especially in Asthma. Atopic patients yielded a significantly lower proportion of CD4+ T cells than intrinsic Asthmatic patients and normal persons. Otherwise, CD4+ CD29+ CD45RA - and CD4+ CD29 – CD45RA + T-cell subsets were significantly decreased in all patient groups.
Despina Papakosta - One of the best experts on this subject based on the ideXlab platform.
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IL-4 polymorphisms in intrinsic and Extrinsic Asthma in a Greek population
European Respiratory Journal, 2013Co-Authors: Eirini Kontakioti, Dionysios Spyratos, Kalliopi Domvri, Michail Daniilidis, Lazaros Sichletidis, Konstantinos Zarogoulidis, Despina PapakostaAbstract:Objective. The aim of the study was to investigate the IL-4 and IL-4Receptor polymorphisms in Asthmatic patients and their association with Asthma and Asthma severity in a Greece. Materials and methods. Thirty patients with Extrinsic Asthma, mean age 35.2±14.51 years (Group A) and 22 patients with intrinsic Asthma, mean age 47.1±16.3 years (Group B) were included in the study. All patients were recruited from the Asthma Clinic of Pulmonary Department, Aristotle University of Thessaloniki. 21 healthy control subjects, mean age 36.6±10.5 years were also included (Group C). All patients were subjected to skin prick tests, spirometry, methacholine challenge, determination of total serum IgE and exhaled FeNO. For the immunogenetic study DNA was extracted from the patients’ peripheral blood samples. Determination of IL4-1098(T/G), IL4-590(C/T), IL4-33(C/Τ), IL4RPOS-1902, polymorphisms were performed by PCR (C:cytocine, T:thymine, G:Guanine και A:Adenine). Results. Analysis of IL4 -1098 polymorphisms showed an increased frequency of guanine in Group A (p=0.036) when compared to Group C, whereas for IL4 –590, CC genotype showed an increased frequency in Group C and C/T in Group A (p=0.003), Regarding Asthma severity, severe Asthma when compared with mild Asthma, was associated with the IL-4TTT/GCC diplotype (p=0.033). Conclusions. This is the first study to investigate interleukin gene polymorphisms in a Greek Asthmatic population and one of the very few studies on intrinsic Asthma. IL-4 polymorphisms showed significant differences between patients with Extrinsic and intrinsic Asthma and also compared to controls. The above findings could be associated with risk of Asthma development and Asthma severity.
A Sabbah - One of the best experts on this subject based on the ideXlab platform.
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the pattern and genetics of pediatric Extrinsic Asthma risk factors in polluted environment
European annals of allergy and clinical immunology, 2007Co-Authors: Abdulbari Bener, Mohammed Ehlayel, A SabbahAbstract:Aim : The aim of the present study is to determine the effect of polluted environment on Extrinsic of Asthma and allergic diseases among school children. Design: This is case and control study. Setting: The study was carried out among school chidren living and attending the school in industrial and residential area during the period of October 2004 and June 2005. Subjects: The study based on age, sex, and ethnicity of 716 cases (with Asthma) and 716 controls (without Asthma) school children living in both urban and in industrial polluted with oil refinery and chemical pollutant. Methods: The International study of Asthma and allergies in childhood (ISAAC) and some additional questionnaires were used to collect the data of the school children. The questionnaire included information about: - socio-demographic characteristics; - respiratory symptoms; - associated respiratory illness; family history of allergic diseases among first-degree relatives of Asthmatic children; - behavioural factors wich could be additive to Asthma. Univariate and multivariate statistical analyses were performed. Results: The proportion of children in the Asthmatic group who reported symptoms was significantly higher than in non-Asthmatic group (<0.0001). The Asthmatic group reported that 47.5% morning time breathlessness, shortness of breath (61.4%), wheeze after exercise (65.4%), phlegm (45.3%) and chronic cough (42.2%). Male Asthmatics had a average age at onset of symptoms of 6.9% (±4.8%) years compared with female Asthmatics who had higher age at onset of symptoms, 7.6(±5.9). Male Asthmatics also had longer duration of symptoms (7.5±4.9 in males and 6.4±4.6 years in females). Significantly odds ratios were found higher in Asthmatic compared to controls for pneumonia, bronchitis, atopy (allergic rhinitis and atopic dermatitis), sinusitis, croup, parental Asthmas, parental atopy including parental allergic rhinitis, atopic dermatitis and parental smoking (p<0.0001). The logistic regression model showed that shortness of breath, bronchitis, pneumonia, sinusitis, parental Asthma, allergic rhinitis, atopic dermatitis, croup, pets ownership and parental smoking were significant risk factors for Asthma. Conclusion: The present study provides some evidence that exposure to outdoor air pollutants increases the risk of childhood Asthma and allergic diseases in school children. The results are consistent with the hypothesis that long term exposure to NOx and CO levels suggests that emissions from photochemical air pollution and oil refinery contributes to adverse health effects in Qatar.
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The pattern and genetics of pediatric Extrinsic Asthma risk factors in polluted environment.
European annals of allergy and clinical immunology, 2007Co-Authors: Abdulbari Bener, Mohammed Ehlayel, A SabbahAbstract:Aim : The aim of the present study is to determine the effect of polluted environment on Extrinsic of Asthma and allergic diseases among school children. Design: This is case and control study. Setting: The study was carried out among school chidren living and attending the school in industrial and residential area during the period of October 2004 and June 2005. Subjects: The study based on age, sex, and ethnicity of 716 cases (with Asthma) and 716 controls (without Asthma) school children living in both urban and in industrial polluted with oil refinery and chemical pollutant. Methods: The International study of Asthma and allergies in childhood (ISAAC) and some additional questionnaires were used to collect the data of the school children. The questionnaire included information about: - socio-demographic characteristics; - respiratory symptoms; - associated respiratory illness; family history of allergic diseases among first-degree relatives of Asthmatic children; - behavioural factors wich could be additive to Asthma. Univariate and multivariate statistical analyses were performed. Results: The proportion of children in the Asthmatic group who reported symptoms was significantly higher than in non-Asthmatic group (
