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Marc Dhont - One of the best experts on this subject based on the ideXlab platform.

  • a health economic decision analytic model comparing double with single embryo transfer in ivf icsi
    Human Reproduction, 2002
    Co-Authors: Petra De Sutter, Jan Gerris, Marc Dhont
    Abstract:

    BACKGROUND Single embryo transfer (SET) is the sole strategy with which to reduce the incidence of twins following assisted reproductive technology (ART), but SET may increase the number of ART cycles needed per live-born child. Its cost-effectiveness compared with double embryo transfer (DET) is therefore unknown. METHODS A decision-analytic model comparing SET with DET was developed. Estimates were obtained from literature, national pregnancy registers and local hospital records. A sensitivity analysis was performed, using pregnancy rates from four published studies. The outcome measure was the cost per child born, calculated from IVF procedure-related, pregnancy-related and neonatal care costs. Neonatal mortality and long-term morbidity costs were not taken into account. RESULTS Independently of the pregnancy rates used, the SET cost per child born was in all instances the same as with DET, varying from EURO= 9520 (SET) versus EURO= 9511 (DET) to EURO= 12254 (SET) versus EURO= 12934 (DET). CONCLUSIONS More ART cycles are required to obtain the same numbers of children born following SET compared with DET. Because SET allows the avoidance of twins and thus diminishes pregnancy-related and neonatal care costs, there is no difference in the cost per child born between SET and DET. The real advantage of SET is the avoidance of the very high long-term costs resulting from the increased morbidity of twins after birth.

  • a health economic decision analytic model comparing double with single embryo transfer in ivf icsi
    Human Reproduction, 2002
    Co-Authors: Petra De Sutter, Jan Gerris, Marc Dhont
    Abstract:

    BACKGROUND: Single embryo transfer (SET) is the sole strategy with which to reduce the incidence of twins following assisted reproductive technology (ART), but SET may increase the number of ART cycles needed per live-born child. Its cost-effectiveness compared with double embryo transfer (DET) is therefore unknown. METHODS: A decision-analytic model comparing SET with DET was developed. Estimates were obtained from literature, national pregnancy registers and local hospital records. A sensitivity analysis was performed, using pregnancy rates from four published studies. The outcome measure was the cost per child born, calculated from IVF procedure-related, pregnancy-related and neonatal care costs. Neonatal mortality and long-term morbidity costs were not taken into account. RESULTS: Independently of the pregnancy rates used, the SET cost per child born was in all instances the same as with DET, varying from C 9 520 (SET) versus C 9 511 (DET) to C 12 254 (SET) versus C 12 934 (DET). CONCLUSIONS: More ART cycles are required to obtain the same numbers of children born following SET compared with DET. Because SET allows the avoidance of twins and thus diminishes pregnancy-related and neonatal care costs, there is no difference in the cost per child born between SET and DET. The real advantage of SET is the avoidance of the very high long-term costs resulting from the increased morbidity of twins after birth.

Markus Schwaiger - One of the best experts on this subject based on the ideXlab platform.

  • an interindividual comparison of o 2 18f fluoroethyl l tyrosine fet and l methyl 11c methionine met pet in patients with brain gliomas and metastases
    International Journal of Radiation Oncology Biology Physics, 2011
    Co-Authors: Ancaligia Grosu, Sabrina T Astner, Eva Riedel, Carsten Nieder, N Wiedenmann, Felix Heinemann, Markus Schwaiger
    Abstract:

    Purpose L-[methyl- 11 C]methionine (MET)–positron emission tomography (PET) has a high sensitivity and specificity for imaging of gliomas and metastatic brain tumors. The short half-life of 11 C (20 minutes) limits the use of MET-PET to institutions with onsite cyclotron. O-(2- [ 18 F]fluoroethyl)-L-tyrosine (FET) is labeled with 18 F (half-life, 120 minutes) and could be used much more broadly. This study compares the uptake of FET and MET in gliomas and metastases, as well as treatment-induced changes. Furthermore, it evaluates the gross tumor volume (GTV) of gliomas defined on PET and magnetic resonance imaging (MRI). Methods and Materials We examined 42 patients with pretreated gliomas (29 patients) or brain metastases (13 patients) prospectively by FET- and MET-PET on the same day. Uptake of FET and MET was quantified by standardized uptake values. Imaging contrast was assessed by calculating lesion–to–gray matter ratios. Tumor extension was quantified by contouring GTV in 17 patients with brain gliomas. Gross tumor volume on PET was compared with GTV on MRI. Sensitivity and specificity of MET- and FET-PET for differentiation of viable tumor from benign changes were evaluated by comparing the PET result with histology or clinical follow-up. Results There was a strong linear correlation between standardized uptake values calculated for both tracers in cortex and lesions: r = 0.78 ( p = 0.001) and r = 0.84 ( p Conclusions O-(2- [ 18 F]fluoroethyl)-L-tyrosine–PET and MET-PET provide comparable diagnostic information on gliomas and brain metastases. Like MET-PET, FET-PET can be used for differentiation of residual or recurrent tumor from treatment-related changes/pseudoprogression, as well as for delineation of gliomas.

  • o 2 18f fluoroethyl l tyrosine and l methyl 11c methionine uptake in brain tumours initial results of a comparative study
    European Journal of Nuclear Medicine and Molecular Imaging, 2000
    Co-Authors: Wolfgang A Weber, Hansjurgen Wester, Anca L Grosu, Michael Herz, Brigitte Dzewas, H J Feldmann, Michael Molls, Gerhard Stocklin, Markus Schwaiger
    Abstract:

    O-(2-[18F]Fluoroethyl)-l-tyrosine (FET) is a recently described amino acid analogue that has shown high accumulation in animal tumours. The aim of this study was to compare the uptake of FET with that of l-[methyl-11C]methionine (MET) in patients with suspected primary or recurrent intracerebral tumours. Sixteen consecutive patients with intracerebral lesions were studied on the same day by positron emission tomography (PET) using MET and FET. Uptake of FET and MET was quantified by standardized uptake values. Tracer kinetics for normal brain and intracerebral lesions were compared. On the basis of the MET-PET studies, viable tumour tissue was found in 13 patients. All tumours showed rapid uptake of FET and were visualized with high contrast. Mean uptake of FET for normal grey matter, white matter and tumour tissue was 1.1±0.2, 0.8±0.2 and 2.7±0.8 SUV, respectively. In all three tissues, uptake of MET was slightly higher (1.4±0.2, 0.9±0.1 and 3.3±1.0 SUV; P<0.01). However, contrast between tumour and normal tissues was not significantly different between MET and FET. Uptake of FET in non-neoplastic lesions (1.0±0.1 SUV) was significantly lower than in tumour tissue (P=0.007). For all lesions there was a close correlation (r=0.98) between MET and FET uptake. In conclusion, in PET studies of human brain tumours, the uptake and image contrast of FET appear to be very similar to those of MET. The specificity of FET for tumour tissue is promising but has to be addressed in a larger series of patients with non-neoplastic lesions.

Petra De Sutter - One of the best experts on this subject based on the ideXlab platform.

  • a health economic decision analytic model comparing double with single embryo transfer in ivf icsi
    Human Reproduction, 2002
    Co-Authors: Petra De Sutter, Jan Gerris, Marc Dhont
    Abstract:

    BACKGROUND Single embryo transfer (SET) is the sole strategy with which to reduce the incidence of twins following assisted reproductive technology (ART), but SET may increase the number of ART cycles needed per live-born child. Its cost-effectiveness compared with double embryo transfer (DET) is therefore unknown. METHODS A decision-analytic model comparing SET with DET was developed. Estimates were obtained from literature, national pregnancy registers and local hospital records. A sensitivity analysis was performed, using pregnancy rates from four published studies. The outcome measure was the cost per child born, calculated from IVF procedure-related, pregnancy-related and neonatal care costs. Neonatal mortality and long-term morbidity costs were not taken into account. RESULTS Independently of the pregnancy rates used, the SET cost per child born was in all instances the same as with DET, varying from EURO= 9520 (SET) versus EURO= 9511 (DET) to EURO= 12254 (SET) versus EURO= 12934 (DET). CONCLUSIONS More ART cycles are required to obtain the same numbers of children born following SET compared with DET. Because SET allows the avoidance of twins and thus diminishes pregnancy-related and neonatal care costs, there is no difference in the cost per child born between SET and DET. The real advantage of SET is the avoidance of the very high long-term costs resulting from the increased morbidity of twins after birth.

  • a health economic decision analytic model comparing double with single embryo transfer in ivf icsi
    Human Reproduction, 2002
    Co-Authors: Petra De Sutter, Jan Gerris, Marc Dhont
    Abstract:

    BACKGROUND: Single embryo transfer (SET) is the sole strategy with which to reduce the incidence of twins following assisted reproductive technology (ART), but SET may increase the number of ART cycles needed per live-born child. Its cost-effectiveness compared with double embryo transfer (DET) is therefore unknown. METHODS: A decision-analytic model comparing SET with DET was developed. Estimates were obtained from literature, national pregnancy registers and local hospital records. A sensitivity analysis was performed, using pregnancy rates from four published studies. The outcome measure was the cost per child born, calculated from IVF procedure-related, pregnancy-related and neonatal care costs. Neonatal mortality and long-term morbidity costs were not taken into account. RESULTS: Independently of the pregnancy rates used, the SET cost per child born was in all instances the same as with DET, varying from C 9 520 (SET) versus C 9 511 (DET) to C 12 254 (SET) versus C 12 934 (DET). CONCLUSIONS: More ART cycles are required to obtain the same numbers of children born following SET compared with DET. Because SET allows the avoidance of twins and thus diminishes pregnancy-related and neonatal care costs, there is no difference in the cost per child born between SET and DET. The real advantage of SET is the avoidance of the very high long-term costs resulting from the increased morbidity of twins after birth.

Heinz H. Coenen - One of the best experts on this subject based on the ideXlab platform.

  • comparison of 18f fet pet and perfusion weighted mr imaging a pet mr imaging hybrid study in patients with brain tumors
    The Journal of Nuclear Medicine, 2014
    Co-Authors: Christian Filss, Gabriele Stoffels, Michael Sabel, Norbert Galldiks, Hans Jorg Wittsack, Bernd Turowski, Gerald Antoch, Ke Zhang, Gereon R Fink, Heinz H. Coenen
    Abstract:

    PET using O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) provides important diagnostic information in addition to that from conventional MR imaging on tumor extent and activity of cerebral gliomas. Recent studies suggest that perfusion-weighted MR imaging (PWI), especially maps of regional cerebral blood volume (rCBV), may provide similar diagnostic information. In this study, we directly compared 18F-FET PET and PWI in patients with brain tumors. Methods: Fifty-six patients with gliomas were investigated using static 18F-FET PET and PWI. For comparison, 8 patients with meningiomas were included. We generated a set of tumor and reference volumes of interest (VOIs) based on morphologic MR imaging and transferred these VOIs to the corresponding 18F-FET PET scans and PWI maps. From these VOIs, tumor-to-brain ratios (TBR) were calculated, and normalized histograms were generated for 18F-FET PET and rCBV maps. Furthermore, in rCBV maps and in 18F-FET PET scans, tumor volumes, their spatial congruence, and the distance between the local hot spots were assessed. Results: For patients with glioma, TBR was significantly higher in 18F-FET PET than in rCBV maps (TBR, 2.28 ± 0.99 vs. 1.62 ± 1.13; P

  • comparison of 18 f fet pet and 5 ala fluorescence in cerebral gliomas
    European Journal of Nuclear Medicine and Molecular Imaging, 2011
    Co-Authors: Frank W Floeth, Christian Ewelt, Gabriele Stoffels, Jorg Felsberg, Michael Sabel, Heinz H. Coenen, Hans-jakob Steiger, Walter Stummer, Guido Reifenberger, Karl-josef Langen
    Abstract:

    Purpose The aim of the study was to compare presurgical 18F-fluoroethyl-L-tyrosine (18F-FET) uptake and Gd-diethylenetriaminepentaacetic acid (DTPA) enhancement on MRI (Gd) with intraoperative 5-aminolevulinic acid (5-ALA) fluorescence in cerebral gliomas.

Ancaligia Grosu - One of the best experts on this subject based on the ideXlab platform.

  • an interindividual comparison of o 2 18f fluoroethyl l tyrosine fet and l methyl 11c methionine met pet in patients with brain gliomas and metastases
    International Journal of Radiation Oncology Biology Physics, 2011
    Co-Authors: Ancaligia Grosu, Sabrina T Astner, Eva Riedel, Carsten Nieder, N Wiedenmann, Felix Heinemann, Markus Schwaiger
    Abstract:

    Purpose L-[methyl- 11 C]methionine (MET)–positron emission tomography (PET) has a high sensitivity and specificity for imaging of gliomas and metastatic brain tumors. The short half-life of 11 C (20 minutes) limits the use of MET-PET to institutions with onsite cyclotron. O-(2- [ 18 F]fluoroethyl)-L-tyrosine (FET) is labeled with 18 F (half-life, 120 minutes) and could be used much more broadly. This study compares the uptake of FET and MET in gliomas and metastases, as well as treatment-induced changes. Furthermore, it evaluates the gross tumor volume (GTV) of gliomas defined on PET and magnetic resonance imaging (MRI). Methods and Materials We examined 42 patients with pretreated gliomas (29 patients) or brain metastases (13 patients) prospectively by FET- and MET-PET on the same day. Uptake of FET and MET was quantified by standardized uptake values. Imaging contrast was assessed by calculating lesion–to–gray matter ratios. Tumor extension was quantified by contouring GTV in 17 patients with brain gliomas. Gross tumor volume on PET was compared with GTV on MRI. Sensitivity and specificity of MET- and FET-PET for differentiation of viable tumor from benign changes were evaluated by comparing the PET result with histology or clinical follow-up. Results There was a strong linear correlation between standardized uptake values calculated for both tracers in cortex and lesions: r = 0.78 ( p = 0.001) and r = 0.84 ( p Conclusions O-(2- [ 18 F]fluoroethyl)-L-tyrosine–PET and MET-PET provide comparable diagnostic information on gliomas and brain metastases. Like MET-PET, FET-PET can be used for differentiation of residual or recurrent tumor from treatment-related changes/pseudoprogression, as well as for delineation of gliomas.