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O Kato - One of the best experts on this subject based on the ideXlab platform.
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minimal ovarian stimulation combined with elective Single Embryo Transfer policy age specific results of a large Single centre japanese cohort
Reproductive Biology and Endocrinology, 2012Co-Authors: Keiichi Kato, Y Takehara, Tomoya Segawa, Satoshi Kawachiya, Takashi Okuno, Tamotsu Kobayashi, Daniel Bodri, O KatoAbstract:The two main complications associated with the use of assisted reproduction techniques, ovarian hyperstimulation syndrome and multiple pregnancies, could be eliminated by milder ovarian stimulation protocols and the increased use of a Single Embryo Transfer (SET) policy. A retrospective, cohort study was performed in private infertility centre to evaluate the Embryological and clinical results of a large exclusively SET program according to patient age (lower or equal 29, 30–34, 35–39, 40–44 and equal or higher 45 years). A total of 7,244 infertile patients have undergone 20,244 cycles with a clomiphene-based minimal stimulation or natural cycle IVF protocol during 2008. Following oocyte retrieval, fertilization and Embryo culture a total of 10,401 fresh or frozen Single Embryo Transfer procedures were performed involving cleavage-stage Embryos or blastocysts. Successful oocyte retrieval rate (78.0 %) showed no age-dependent decrease until 45 years. Fertilization (80.3 %) and cleavage (91.1 %) rates were not significantly different between age groups. Blastocyst formation (70.1 % to 22.8 %) and overall live birth rates (35.9 % to 2 %) showed an age-dependent decrease. Frozen-thawed blastocyst Transfer cycles gave the highest chance of live birth per Embryo Transfer (41.3 % to 6.1 %). High fertilization and cleavage rates were obtained regardless of age whereas blastocyst formation and live birth rates showed an age-dependent decrease. An elective Single Embryo Transfer program based on a minimal ovarian stimulation protocol yields acceptable live birth rates per Embryo Transfer in infertile patients up until their mid-forties. However in very advanced age patients (equal or higher 45 years old) success rates fall below 1 %.
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minimal ovarian stimulation combined with elective Single Embryo Transfer policy age specific results of a large Single centre japanese cohort
Reproductive Biology and Endocrinology, 2012Co-Authors: Keiichi Kato, Y Takehara, Tomoya Segawa, Satoshi Kawachiya, Takashi Okuno, Tamotsu Kobayashi, Daniel Bodri, O KatoAbstract:Background: The two main complications associated with the use of assisted reproduction techniques, ovarian hyperstimulation syndrome and multiple pregnancies, could be eliminated by milder ovarian stimulation protocols and the increased use of a Single Embryo Transfer (SET) policy. A retrospective, cohort study was performed in private infertility centre to evaluate the Embryological and clinical results of a large exclusively SET program according to patient age (lower or equal 29, 30–34, 35–39, 40–44 and equal or higher 45 years). Materials: A total of 7,244 infertile patients have undergone 20,244 cycles with a clomiphene-based minimal stimulation or natural cycle IVF protocol during 2008. Following oocyte retrieval, fertilization and Embryo culture a total of 10,401 fresh or frozen Single Embryo Transfer procedures were performed involving cleavage-stage Embryos or blastocysts. Results: Successful oocyte retrieval rate (78.0 %) showed no age-dependent decrease until 45 years. Fertilization (80.3 %) and cleavage (91.1 %) rates were not significantly different between age groups. Blastocyst formation (70.1 % to 22.8 %) and overall live birth rates (35.9 % to 2 %) showed an age-dependent decrease. Frozen-thawed blastocyst Transfer cycles gave the highest chance of live birth per Embryo Transfer (41.3 % to 6.1 %). Conclusions: High fertilization and cleavage rates were obtained regardless of age whereas blastocyst formation and live birth rates showed an age-dependent decrease. An elective Single Embryo Transfer program based on a minimal ovarian stimulation protocol yields acceptable live birth rates per Embryo Transfer in infertile patients up until their mid-forties. However in very advanced age patients (equal or higher 45 years old) success rates fall below 1 %.
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neonatal outcome and birth defects in 6623 Singletons born following minimal ovarian stimulation and vitrified versus fresh Single Embryo Transfer
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2012Co-Authors: O Kato, Keiichi Kato, Satoshi Kawachiya, Daniel Bodri, Nami Kawasaki, Tomoko Kuroda, Y TakeharaAbstract:Abstract Objective To compare neonatal outcome between children born after vitrified versus fresh Single-Embryo Transfer (SET). Study design Retrospective, Single-centre cohort study of 6623 delivered Singletons following 29,944 Single-Embryo Transfers. Patients underwent minimal ovarian stimulation/natural cycle IVF followed by SET of fresh or vitrified-warmed (using Cryotop, Kitazato) cleavage-stage Embryos or blastocysts. Outcome measures were gestational age at delivery, birth weight, birth length, low birth weight (LBW), small for gestational age (SGA) and large for gestational age (LGA) infants, perinatal mortality and minor/major birth defects (evaluated by parent questionnaire). Results Gestational age (38.6±2 versus 38.7±1.9 weeks) and preterm delivery rate (6.9% versus 6.9%, aOR: 0.96 95%CI: 0.76–1.22) in Singletons born after the Transfer of vitrified Embryos were comparable to those born after the Transfer of fresh Embryos. Children born after the Transfer of vitrified Embryos had a higher birth weight (3028±465 versus 2943±470g, p Conclusions Vitrification of Embryos/blastocysts did not increase the incidence of adverse neonatal outcomes or birth defects following Single Embryo Transfer.
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noninvasive metabolomic profiling as an adjunct to morphology for noninvasive Embryo assessment in women undergoing Single Embryo Transfer
Fertility and Sterility, 2010Co-Authors: Emre Seli, O Kato, C G Vergouw, Hiroshi Morita, Lucy Botros, P Roos, C B Lambalk, Naoki Yamashita, Denny SakkasAbstract:Objective To determine whether metabolomic profiling of spent Embryo culture media correlates with reproductive potential of human Embryos. Design Retrospective study. Setting Academic and a private assisted reproductive technology (ART) programs. Patient(s) Women undergoing Single Embryo Transfer after IVF. Intervention(s) Spent Embryo culture media were collected after Single Embryo Transfer on day 3 (n = 304) or day 2 (n = 181) and analyzed by near infrared spectroscopy. Near infrared spectral regions were correlated to reproductive potential using a genetic algorithm optimization. Models of these spectral regions were used to calculate viability indices, and were validated by blinded analysis of a subset (n = 60) of samples. Implantation rates were also compared between Embryos of higher (≥0.3) and lower ( Main Outcome Measure(s) Viability index and Embryo viability. Result(s) Mean viability indices of Embryos that resulted in positive fetal cardiac activity were significantly higher compared with Embryos that did not for both day 2 and day 3 Embryos. Blinded validation of the day 2 model proved to be significant. Increasing viability index values correlated with an increase in pregnancy. Viability indices were found to be independent of morphology for both day 2 and day 3 Embryos. Implantation rates were significantly higher among Embryos with viability indices ≥0.3. Conclusion(s) Metabolomic profiling of human Embryo culture media using near infrared spectroscopy is independent of morphology and correlates with reproductive potential of Embryos.
Aila Tiitinen - One of the best experts on this subject based on the ideXlab platform.
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Single Embryo Transfer: Why and how to identify the Embryo with the best developmental potential
Best practice & research. Clinical endocrinology & metabolism, 2019Co-Authors: Aila TiitinenAbstract:Multiple pregnancies with higher risk of preterm birth and the associated higher morbidity have been a major obstacle from the early days of in vitro fertilization. A good strategy to avoid multiple pregnancies is elective Single Embryo Transfer and cryopreservation of spare Embryos. Important factors in adopting this strategy are good counselling of the patients and the selection of Embryos with high implantation potential. Technical advances in Embryo selection have been described during recent years, time lapse monitoring and genetic assessment of the Embryos being the most important achievements. With these studies we have gained new information on early Embryos. However, at present, there is insufficient evidence to recommend the routine use of these new techniques. The ultimate goal of infertility treatment is a healthy baby.
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elective Single Embryo Transfer in women aged 36 39 years
Human Reproduction, 2006Co-Authors: Zdravka Veleva, Sirpa Vilska, Aila Tiitinen, Christel Hydengranskog, Juha S Tapanainen, Hannu MartikainenAbstract:BACKGROUND: The elective Single Embryo Transfer policy is the only effective strategy known to minimize the risk of multiple pregnancy. However, little is known about its applicability to women older than 35 years. METHODS: Analysis was carried out on 1224 fresh IVF/ICSI cycles with Embryo Transfer and 828 frozen Embryo Transfer (FET) cycles of women aged 36-39 years. In the fresh cycles, 335 elective Single top quality Embryo (eSET), 110 elective Single non top quality Embryo (nt-eSET), 194 compulsory Single Embryo (cSET) and 585 double Embryo Transfers (DET) were carried out. RESULTS: Pregnancy rate/Embryo Transfer (33.1 versus 29.9%) and live birth rate (26.0 versus 21.9%) in fresh cycles did not differ significantly between the eSET and the DET groups. However, women in the eSET group had a higher cumulative pregnancy rate (54.0% versus 35.0%) and a higher cumulative live birth rate (41.8% versus 26.7%, P < 0.0001) compared with those in the DET group. The cumulative multiple birth rate in the eSET group was 1.7%, whereas in the DET group it was 16.6% (P < 0.0001). CONCLUSIONS: The eSET policy can be applied also to patients aged 36-39 years, reducing the risk of multiple birth and increasing the safety of assisted reproduction technique (ART) in this age group.
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Single Embryo Transfer is an option in frozen Embryo Transfer
Human reproduction (Oxford England), 2005Co-Authors: Christel Hydén-granskog, Leila Unkila-kallio, Mervi Halttunen, Aila TiitinenAbstract:BACKGROUND: A good strategy to decrease multiple pregnancy rate in assisted reproduction technology (ART) is the use of Single Embryo Transfer (SET). METHODS: This retrospective study analysed 1647 frozen Embryo Transfers carried out during 1998-2003 in Helsinki University Central Hospital; of these, 872 were double Embryo Transfers (DETs) and 775 SETs. The SET group included 140 (18.1%) elective SETs (eSETs). RESULTS: The yearly rate of SETs in frozen cycles increased from 28 to 66%. Overall, the clinical pregnancy rate per frozen Embryo Transfer was 30.7% and the delivery rate 22.6%. The delivery rate was significantly higher in DET cryocycles than in SET cryocycles (25.7 versus 19.2%, respectively; P < 0.01). In DET cryocycles, the multiple delivery rate was 21.9%, 10 times higher than that observed in cryocycles with SET (2.0%) (P < 0.0001). When eSET was applied, no difference in delivery rate was observed when compared with cryocycles with DET (28.6 and 25.7%, respectively). CONCLUSIONS: SET can be used in frozen cycles to reduce multiple delivery rates.
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Single Embryo Transfer in clinical practice.
Human fertility (Cambridge England), 2004Co-Authors: Christel Hydén-granskog, Aila TiitinenAbstract:The high incidence of multiple pregnancies is the main reason for adverse treatment outcome in assisted reproduction. A good strategy to avoid multiple pregnancies is elective Single Embryo Transfer and cryopreservation of spare Embryos. Important factors in an elective Single Embryo Transfer programme are good counselling of the patients and the selection of Embryos with high implantation potential. In the infertility clinic at Helsinki University Central Hospital the elective Single Embryo Transfer programme was started in 1997 and in 2000 the Transfer policy turned to Single Embryo Transfer as primary option. In 2003 60% of fresh Transfers were elective Single Embryo Transfers and 66% of frozen Transfers were Single Embryo Transfers. It has been shown that an elective Single Embryo Transfer programme can be adopted in daily practice and that it decreases the multiple pregnancy rate, in our programme to around 7% with acceptable overall pregnancy and delivery rates. In Finland the increased use of singl...
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impact of elective Single Embryo Transfer on the twin pregnancy rate
Human Reproduction, 2003Co-Authors: Aila Tiitinen, Mervi Halttunen, Leila Unkilakallio, Christel HydengranskogAbstract:BACKGROUND: It is unclear how the implementation of elective Single Embryo Transfer in clinical practice would affect clinical pregnancy and delivery rates and multiple birth rates. METHODS: This retrospective study analysed 1871 IVF/ICSI cycles carried out from 1997 to 2001 in the IVF programme of a Single university infertility clinic. RESULTS: The number of elective Single Embryo Transfers increased from 11 to 56%. At the same time the clinical pregnancy rate was relatively stable; mean 34.0% (range 28‐42). The number of Embryos per Embryo Transfer decreased from 1.8 to 1.3. The multiple pregnancy and delivery rates dropped markedly from 25 to 7.5% and from 25 to 5% respectively. CONCLUSIONS: An elective Single Embryo Transfer programme can be adopted in daily practice that decreases the twinning rate to <10% and does not affect the overall pregnancy rate.
Jan Gerris - One of the best experts on this subject based on the ideXlab platform.
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Single Embryo Transfer - Single Embryo Transfer
Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 2010Co-Authors: Jan Gerris, G. David Adamson, Petra De Sutter, Catherine RacowskyAbstract:Preface Jan Gerris Part I. Preliminaries: 1. The risks associated with multiple pregnancies Ulla-Britt Wennerholm 2. An overview of determinants of oocyte and Embryo developmental competence: specificity, accuracy and applicability in clinical IVF Jonathan Van Blerkom Part II. Clinical Aspects: 3. Single Embryo Transfer - concepts and definitions Jan Gerris and Petra De Sutter 4. Patient selection for Single Embryo Transfer Ofer Fainaru and Mark D. Hornstein 5. Perinatal outcome after Single Embryo Transfer Petra De Sutter and Jan Gerris 6. Single Embryo Transfer as a model for early conception and implantation Anja Pinborg and Anne Loft 7. Ovarian stimulation, blastocyst culture and preimplantation genetic screening for elective Single Embryo Transfer Steven J. McArthur and Robert Jansen 8. Sequential Embryo selection for Single Embryo Transfer Lynette Scott 9A. Cryo-augmentation after Single Embryo Transfer: the European experience Aila Tiitinen 9B. Cryo-augmentation after Single Embryo Transfer: the American experience Marius Meintjes 10A. Single Embryo Transfer in recipients of donated oocytes Viveca Soderstrom-Anttilla 10B. The impact of Single Embryo Transfer on Embryo donation Jeffrey A. Keenan and Reginald Finger 10C. Single Embryo Transfer in unique clinical situations: Single women, lesbians Karen Purcell 10D. Preimplantation genetic diagnosis and Single Embryo Transfer Willem Verpoest 11. Counselling patients for Single Embryo Transfer Sharon N. Covington 12. Stress-reduction techniques to reduce patient dropout rates during elective Single Embryo Transfer Janetti Marotta 13. Barriers for elective Single Embryo Transfer implementation A. M. van Peperstraten, J. A. M. Kremer and D. D. M. Braat 14. Single Embryo Transfer - the Swedish experience Christina Bergh, P. O. Karlstrom and Ann Thurin-Kjellberg 15. Single Embryo Transfer - the Dutch experience Aafke P. A. van Montfoort 16. Philosophical and ethical considerations on Single Embryo Transfer Guido Pennings Part III. Controversies: 17. What is the optimum day of Transfer for Single Embryo Transfer? Success rates, monozygotic twinning and epigenetic issues Christine C. Skiadas and Catherine Racowsky 18. Cost-effectiveness of Single Embryo Transfer in assisted reproduction cycles John Collins 19. Defining success in assisted reproduction Siladitya Bhattacharya 20. Should sperm parameters be considered in patient selection for Single Embryo Transfer? Denny Sakkas, Hasan M. El-Fakahany and Emre Seli 21. Does self-regulation work for implementation of Single Embryo Transfer? G. David Adamson 22. How should we proceed? The American experience John M. Norian, Eric D. Levens, Alan H. DeCherney and G. David Adamson 23. How should we proceed? The European experience Andre Van Steirteghem Index.
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Elective Single-Embryo Transfer
Biennial Review of Infertility, 2009Co-Authors: Jan Gerris, Petra De SutterAbstract:In the early days of IVF, replacement of several Embryos in order to compensate for low implantation rates in the human was considered good clinical practice. Lack of funding, suboptimal Embryo culture and selection techniques and pressure from patients led to a staggering 50% of all children born after IVF/ICSI belonging to a set of multiples. The first step towards a more reasonable approach came when it was shown that Transferring two or three Embryos did not influence the pregnancy rate but only the triplet rate. Unfortunately, this step in the right direction did n ot result in a decrease of twins. Although the challenge of a triplet pregnancy is much greater than that of a twin, the epidemic size of iatrogenic twinning results in a more widespread negative effect on neonatal, perinatal and maternal outcome. The challenge is to combine excellent pregnancy rates with a reduction in twinning rate from 25–30% to 5–10%. The second step has received much attention but little following: elective Single-Embryo Transfer (eSET). Published data indicate the feasibility to perform judicious eSET. This is definitely the case in good prognosis patients (less than 36 years of age, first or second IVF/ICSI trial) and if there is a choice from several Embryos. Embryo selection, still on the basis of an optimized morphology assessment using strict criteria and time intervals, is essential. Apart from the preventive effect on the complications associated with many (but not all) twin pregnancies, both health-economic considerations and neonatal outcome considerations also underpin the value of SET. Cryopreservation is a useful tool in an optimal strategy and management of all oocyte harvests.
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Single-Embryo Transfer versus multiple-Embryo Transfer
Reproductive Biomedicine Online, 2009Co-Authors: Jan GerrisAbstract:Despite the progress made in assisted reproductive technology, live birth rates remain disappointingly low. Multiple-Embryo Transfer has been an accepted practice with which to increase the success rate. This has led to a higher incidence of multiple-order births compared with natural conception, which not only increase the risk of mortality and morbidity to both mother and children but are also associated with social and economic consequences. Elective Single-Embryo Transfer (eSET) was developed in an effort to increase Singleton pregnancies in assisted reproduction. Studies comparing eSET with multiple-Embryo Transfer highlight the benefit of this approach and suggest that, with careful patient selection and the Transfer of good-quality Embryos, the risk of a multiple-order pregnancy can be reduced without significantly decreasing live birth rates. Although the use of eSET has gradually increased in clinical practice, its acceptance has been limited by factors such as availability of funding and awareness of the procedure. An open discussion of eSET is warranted in an effort to enable a broader understanding by physicians and patients of the merits of this approach. Ultimately, eSET may provide a more cost-effective, potentially safer approach to patients undergoing assisted reproduction technology.
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Comprar Single Embryo Transfer | Jan Gerris | 9780521888349 | Cambridge University Press
2008Co-Authors: Jan Gerris, G. David Adamson, Petra De Sutter, Catherine RacowskyAbstract:Tienda online donde Comprar Single Embryo Transfer al precio 65,31 € de Jan Gerris | G. David Adamson | Petra de Sutter | Catherine Racowsky, tienda de Libros de Medicina, Libros de Ginecologia y Obstetricia - Fertilidad y embarazo
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Single Embryo Transfer – state of the art
Reproductive biomedicine online, 2003Co-Authors: Diane De Neubourg, Jan GerrisAbstract:Abstract Every practitioner active in the field of assisted reproduction treatment is aware of the risks and complications related to twin and higher-order multiple pregnancies. Introduction of Single Embryo Transfer (SET) into IVF/intracytoplasmic sperm injection (ICSI) is one of the possible ways of reducing the rate of twin pregnancy. Careful selection of patients, in combination with elective SET, has been shown to decrease the twin pregnancy rate while maintaining a stable ongoing pregnancy rate. The combination of a woman younger than 38 years of age, in her first or second IVF/ICSI cycle and with an Embryo with a high implantation potential is the key to successful SET. This article will discuss Embryo selection and patient selection and review the data published on SET. In the Centre for Reproductive Medicine at Middelheim Hospital, 39% of all Transfers in 2002 were SET; the ongoing pregnancy rate remained stable at 30.6%. The twin (multiple) pregnancy rate declined to 11.7%. Particular attention should be drawn to the augmenting effect of the pregnancy rate of frozen–thawed cycles. Health economic data available so far subscribe the plea for SET.
Mohamed Abd El Aziz Mousta - One of the best experts on this subject based on the ideXlab platform.
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Elective Single Embryo Transfer versus double Embryo Transfer in assisted reproduction
Reproductive biomedicine online, 2008Co-Authors: Mohamed Khaled Moustafa, Sheded Ashour Sheded, Mohamed Abd El Aziz MoustaAbstract:High numbers of Embryos Transferred during assisted reproduction have become implicated as the cause of higher than normal twinning and multiple gestation rates following this form of therapy. However, reducing the number to a Single Embryo Transferred has been shown to carry unfavourable results in the first cycle, but with similar cumulative live birth rates. This study tested the theory by performing a randomized controlled trial of elective Single Embryo Transfer (SET) versus double Embryo Transfer (DET) in young women, and follow them up for 1 year to determine the result of cryo-Embryo Transfer cycles in the two cohorts. The results showed that the probability of a live birth was not significantly different between the two groups, but with a higher rate of twins in the DET group. In addition, during the 1-year follow-up period, the live birth, clinical pregnancy and multiple pregnancy rates were also similar, and in line with the results of the randomized trial. In conclusion, the results of this prospective randomized trial and 1-year follow-up show that in young women, elective SET should be the first line of choice. Even so, these results should be confirmed by larger randomized studies.
Keiichi Kato - One of the best experts on this subject based on the ideXlab platform.
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minimal ovarian stimulation combined with elective Single Embryo Transfer policy age specific results of a large Single centre japanese cohort
Reproductive Biology and Endocrinology, 2012Co-Authors: Keiichi Kato, Y Takehara, Tomoya Segawa, Satoshi Kawachiya, Takashi Okuno, Tamotsu Kobayashi, Daniel Bodri, O KatoAbstract:The two main complications associated with the use of assisted reproduction techniques, ovarian hyperstimulation syndrome and multiple pregnancies, could be eliminated by milder ovarian stimulation protocols and the increased use of a Single Embryo Transfer (SET) policy. A retrospective, cohort study was performed in private infertility centre to evaluate the Embryological and clinical results of a large exclusively SET program according to patient age (lower or equal 29, 30–34, 35–39, 40–44 and equal or higher 45 years). A total of 7,244 infertile patients have undergone 20,244 cycles with a clomiphene-based minimal stimulation or natural cycle IVF protocol during 2008. Following oocyte retrieval, fertilization and Embryo culture a total of 10,401 fresh or frozen Single Embryo Transfer procedures were performed involving cleavage-stage Embryos or blastocysts. Successful oocyte retrieval rate (78.0 %) showed no age-dependent decrease until 45 years. Fertilization (80.3 %) and cleavage (91.1 %) rates were not significantly different between age groups. Blastocyst formation (70.1 % to 22.8 %) and overall live birth rates (35.9 % to 2 %) showed an age-dependent decrease. Frozen-thawed blastocyst Transfer cycles gave the highest chance of live birth per Embryo Transfer (41.3 % to 6.1 %). High fertilization and cleavage rates were obtained regardless of age whereas blastocyst formation and live birth rates showed an age-dependent decrease. An elective Single Embryo Transfer program based on a minimal ovarian stimulation protocol yields acceptable live birth rates per Embryo Transfer in infertile patients up until their mid-forties. However in very advanced age patients (equal or higher 45 years old) success rates fall below 1 %.
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minimal ovarian stimulation combined with elective Single Embryo Transfer policy age specific results of a large Single centre japanese cohort
Reproductive Biology and Endocrinology, 2012Co-Authors: Keiichi Kato, Y Takehara, Tomoya Segawa, Satoshi Kawachiya, Takashi Okuno, Tamotsu Kobayashi, Daniel Bodri, O KatoAbstract:Background: The two main complications associated with the use of assisted reproduction techniques, ovarian hyperstimulation syndrome and multiple pregnancies, could be eliminated by milder ovarian stimulation protocols and the increased use of a Single Embryo Transfer (SET) policy. A retrospective, cohort study was performed in private infertility centre to evaluate the Embryological and clinical results of a large exclusively SET program according to patient age (lower or equal 29, 30–34, 35–39, 40–44 and equal or higher 45 years). Materials: A total of 7,244 infertile patients have undergone 20,244 cycles with a clomiphene-based minimal stimulation or natural cycle IVF protocol during 2008. Following oocyte retrieval, fertilization and Embryo culture a total of 10,401 fresh or frozen Single Embryo Transfer procedures were performed involving cleavage-stage Embryos or blastocysts. Results: Successful oocyte retrieval rate (78.0 %) showed no age-dependent decrease until 45 years. Fertilization (80.3 %) and cleavage (91.1 %) rates were not significantly different between age groups. Blastocyst formation (70.1 % to 22.8 %) and overall live birth rates (35.9 % to 2 %) showed an age-dependent decrease. Frozen-thawed blastocyst Transfer cycles gave the highest chance of live birth per Embryo Transfer (41.3 % to 6.1 %). Conclusions: High fertilization and cleavage rates were obtained regardless of age whereas blastocyst formation and live birth rates showed an age-dependent decrease. An elective Single Embryo Transfer program based on a minimal ovarian stimulation protocol yields acceptable live birth rates per Embryo Transfer in infertile patients up until their mid-forties. However in very advanced age patients (equal or higher 45 years old) success rates fall below 1 %.
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neonatal outcome and birth defects in 6623 Singletons born following minimal ovarian stimulation and vitrified versus fresh Single Embryo Transfer
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2012Co-Authors: O Kato, Keiichi Kato, Satoshi Kawachiya, Daniel Bodri, Nami Kawasaki, Tomoko Kuroda, Y TakeharaAbstract:Abstract Objective To compare neonatal outcome between children born after vitrified versus fresh Single-Embryo Transfer (SET). Study design Retrospective, Single-centre cohort study of 6623 delivered Singletons following 29,944 Single-Embryo Transfers. Patients underwent minimal ovarian stimulation/natural cycle IVF followed by SET of fresh or vitrified-warmed (using Cryotop, Kitazato) cleavage-stage Embryos or blastocysts. Outcome measures were gestational age at delivery, birth weight, birth length, low birth weight (LBW), small for gestational age (SGA) and large for gestational age (LGA) infants, perinatal mortality and minor/major birth defects (evaluated by parent questionnaire). Results Gestational age (38.6±2 versus 38.7±1.9 weeks) and preterm delivery rate (6.9% versus 6.9%, aOR: 0.96 95%CI: 0.76–1.22) in Singletons born after the Transfer of vitrified Embryos were comparable to those born after the Transfer of fresh Embryos. Children born after the Transfer of vitrified Embryos had a higher birth weight (3028±465 versus 2943±470g, p Conclusions Vitrification of Embryos/blastocysts did not increase the incidence of adverse neonatal outcomes or birth defects following Single Embryo Transfer.
