The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Francesco Violi - One of the best experts on this subject based on the ideXlab platform.
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Enhanced TNFα and oxidative stress in patients with heart Failure: Effect of TNFα on platelet O2 - production
Thrombosis and haemostasis, 2003Co-Authors: Luciano De Biase, Pasquale Pignatelli, Luisa Lenti, Giuliano Tocci, Fabiana Piccioni, Silvia Riondino, Fabio M. Pulcinelli, Speranza Rubattu, Massimo Volpe, Francesco VioliAbstract:Experimental studies have suggested that TNF alpha, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNF alpha has prooxidant activity in patients with heart Failure, and what the mechanism eventually resulting in this Effect are. We analyzed 42 patients (38 men and 4 women, aged 26 to 74 years) with heart Failure, secondary to idiopathic dilated cardiomyopathy (n=21), coronary artery disease (n=15), and valve disease (n=6), and 20 controls (18 men and 2 women, aged 49 to 67 years). Ten patients were in class I, 9 in class II, 15 in class III and 8 in class IV according to NYHA Classification. Blood samples were obtained from each patient to evaluate basal and collagen-induced platelet O(2)(-) production, and plasma TNF alpha. In vivo results showed increased platelet O(2)(-) production and plasma TNF alpha levels in NYHA class III-IV compared with that in controls or in NYHA I-II (p
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Enhanced TNFα and oxidative stress in patients with heart Failure: Effect of TNFα on platelet O2 - production
Thrombosis and Haemostasis, 2003Co-Authors: Luciano De Biase, Pasquale Pignatelli, Luisa Lenti, Giuliano Tocci, Fabiana Piccioni, Silvia Riondino, Fabio M. Pulcinelli, Speranza Rubattu, Massimo Volpe, Francesco VioliAbstract:SummaryExperimental studies have suggested that TNFα, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNFα has prooxidant activity in patients with heart Failure, and what the mechanism eventually resulting in this Effect are.We analyzed 42 patients (38 men and 4 women, aged 26 to 74 years) with heart Failure, secondary to idiopathic dilated car-diomyopathy (n=21), coronary artery disease (n=15), and valve disease (n=6), and 20 controls (18 men and 2 women, aged 49 to 67 years). Ten patients were in class I,9 in class II,15 in class III and 8 in class IV according to NYHA Classification. Blood samples were obtained from each patient to evaluate basal and collagen-induced platelet O2 - production, and plasma TNFα. In vivo results showed increased platelet O2 - production and plasma TNFα levels in NYHA class III-IV compared with that in controls or in NYHA I-II (p<0,001); platelet O2 - production correlated significantly (R=0,6; p<0,01) with TNFα plasma levels. In vitro studies showed TNFα dose-dependently (5-40 pg/ml) induced platelet O2 - production, and that this Effect was significantly inhibited by its specific inhibitor, WP9QY (1 μM); aspirin (100 μM), AACOCF3, a specific PLA2 inhibitor (14 μM), and DPI, an inhibitor of NADPH oxidase, significantly inhibited TNFα-mediated platelet O2 - production.This study suggests that in patients with heart Failure, enhanced platelet O2 - production is mediated by TNFα via activation of arachidonic acid and NADPH oxidase pathways.
Luciano De Biase - One of the best experts on this subject based on the ideXlab platform.
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Enhanced TNFα and oxidative stress in patients with heart Failure: Effect of TNFα on platelet O2 - production
Thrombosis and haemostasis, 2003Co-Authors: Luciano De Biase, Pasquale Pignatelli, Luisa Lenti, Giuliano Tocci, Fabiana Piccioni, Silvia Riondino, Fabio M. Pulcinelli, Speranza Rubattu, Massimo Volpe, Francesco VioliAbstract:Experimental studies have suggested that TNF alpha, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNF alpha has prooxidant activity in patients with heart Failure, and what the mechanism eventually resulting in this Effect are. We analyzed 42 patients (38 men and 4 women, aged 26 to 74 years) with heart Failure, secondary to idiopathic dilated cardiomyopathy (n=21), coronary artery disease (n=15), and valve disease (n=6), and 20 controls (18 men and 2 women, aged 49 to 67 years). Ten patients were in class I, 9 in class II, 15 in class III and 8 in class IV according to NYHA Classification. Blood samples were obtained from each patient to evaluate basal and collagen-induced platelet O(2)(-) production, and plasma TNF alpha. In vivo results showed increased platelet O(2)(-) production and plasma TNF alpha levels in NYHA class III-IV compared with that in controls or in NYHA I-II (p
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Enhanced TNFα and oxidative stress in patients with heart Failure: Effect of TNFα on platelet O2 - production
Thrombosis and Haemostasis, 2003Co-Authors: Luciano De Biase, Pasquale Pignatelli, Luisa Lenti, Giuliano Tocci, Fabiana Piccioni, Silvia Riondino, Fabio M. Pulcinelli, Speranza Rubattu, Massimo Volpe, Francesco VioliAbstract:SummaryExperimental studies have suggested that TNFα, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNFα has prooxidant activity in patients with heart Failure, and what the mechanism eventually resulting in this Effect are.We analyzed 42 patients (38 men and 4 women, aged 26 to 74 years) with heart Failure, secondary to idiopathic dilated car-diomyopathy (n=21), coronary artery disease (n=15), and valve disease (n=6), and 20 controls (18 men and 2 women, aged 49 to 67 years). Ten patients were in class I,9 in class II,15 in class III and 8 in class IV according to NYHA Classification. Blood samples were obtained from each patient to evaluate basal and collagen-induced platelet O2 - production, and plasma TNFα. In vivo results showed increased platelet O2 - production and plasma TNFα levels in NYHA class III-IV compared with that in controls or in NYHA I-II (p<0,001); platelet O2 - production correlated significantly (R=0,6; p<0,01) with TNFα plasma levels. In vitro studies showed TNFα dose-dependently (5-40 pg/ml) induced platelet O2 - production, and that this Effect was significantly inhibited by its specific inhibitor, WP9QY (1 μM); aspirin (100 μM), AACOCF3, a specific PLA2 inhibitor (14 μM), and DPI, an inhibitor of NADPH oxidase, significantly inhibited TNFα-mediated platelet O2 - production.This study suggests that in patients with heart Failure, enhanced platelet O2 - production is mediated by TNFα via activation of arachidonic acid and NADPH oxidase pathways.
Alain Pavie - One of the best experts on this subject based on the ideXlab platform.
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Mechanical circulatory support for advanced heart Failure: Effect of patient selection on outcome.
Circulation, 2001Co-Authors: Mario C. Deng, Matthias Loebe, Aly El-banayosy, Edoardo Gronda, Piet G.m. Jansen, Mario Viganò, Georg Wieselthaler, Bruno Reichart, E. Vitali, Alain PavieAbstract:Use of wearable left ventricular assist systems (LVAS) in the treatment of advanced heart Failure has steadily increased since 1993, when these devices became generally available in Europe. The aim of this study was to identify in an unselected cohort of LVAS recipients those aspects of patient selection that have an impact on postimplant survival. Data were obtained from the Novacor European Registry. Between 1993 and 1999, 464 patients were implanted with the Novacor LVAS. The majority had idiopathic (60%) or ischemic (27%) cardiomyopathy; the median age at implant was 49 (16 to 75) years. The median support time was 100 days (4.1 years maximum). Forty-nine percent of the recipients were discharged from the hospital on LVAS; they spent 75% of their time out of the hospital. For a subset of 366 recipients, for whom a complete set of data was available, multivariate analysis revealed that the following preimplant conditions were independent risk factors for survival after LVAS implantation: respiratory Failure associated with septicemia (odds ratio 11.2), right heart Failure (odds ratio 3.2), age >65 years (odds ratio 3.01), acute postcardiotomy (odds ratio 1.8), and acute infarction (odds ratio 1.7). For patients without any of these factors, the 1-year survival after LVAS implantation including the posttransplantation period was 60%; for the combined group with at least 1 risk factor, it was 24%. Careful selection, specifically implantation before patients become moribund, and improvement of management may result in improved outcomes of LVAS treatment for advanced heart Failure.
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mechanical circulatory support for advanced heart Failure Effect of patient selection on outcome
Circulation, 2001Co-Authors: Mario C. Deng, Matthias Loebe, Edoardo Gronda, Piet G.m. Jansen, Mario Viganò, Georg Wieselthaler, Bruno Reichart, E. Vitali, A Elbanayosy, Alain PavieAbstract:Background—Use of wearable left ventricular assist systems (LVAS) in the treatment of advanced heart Failure has steadily increased since 1993, when these devices became generally available in Europe. The aim of this study was to identify in an unselected cohort of LVAS recipients those aspects of patient selection that have an impact on postimplant survival. Methods and Results—Data were obtained from the Novacor European Registry. Between 1993 and 1999, 464 patients were implanted with the Novacor LVAS. The majority had idiopathic (60%) or ischemic (27%) cardiomyopathy; the median age at implant was 49 (16 to 75) years. The median support time was 100 days (4.1 years maximum). Forty-nine percent of the recipients were discharged from the hospital on LVAS; they spent 75% of their time out of the hospital. For a subset of 366 recipients, for whom a complete set of data was available, multivariate analysis revealed that the following preimplant conditions were independent risk factors for survival after LVAS implantation: respiratory Failure associated with septicemia (odds ratio 11.2), right heart Failure (odds ratio 3.2), age .65 years (odds ratio 3.01), acute postcardiotomy (odds ratio 1.8), and acute infarction (odds ratio 1.7). For patients without any of these factors, the 1-year survival after LVAS implantation including the posttransplantation period was 60%; for the combined group with at least 1 risk factor, it was 24%. Conclusions—Careful selection, specifically implantation before patients become moribund, and improvement of management may result in improved outcomes of LVAS treatment for advanced heart Failure. (Circulation. 2001;103: 231-237.)
Mauro Heleno Chagas - One of the best experts on this subject based on the ideXlab platform.
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Resistance training with different repetition duration to Failure: Effect on hypertrophy, strength and muscle activation
PeerJ, 2021Co-Authors: Lucas Túlio Lacerda, Rodrigo Otávio Marra-lopes, Marcel Bahia Lanza, Rodrigo César Ribeiro Diniz, Fernando Vitor Lima, Hugo Cesar Martins-costa, Gustavo Ferreira Pedrosa, André Gustavo Pereira Andrade, Armin Kibele, Mauro Heleno ChagasAbstract:Background This study investigated the Effects of two 14-week resistance training protocols with different repetition duration (RD) performed to muscle Failure (MF) on gains in strength and muscle hypertrophy as well as on normalized electromyographic (EMG) amplitude and force-angle relationships. Methods The left and right legs of ten untrained males were assigned to either one of the two protocols (2-s or 6-s RD) incorporating unilateral knee extension exercise. Both protocols were performed with 3–4 sets, 50–60% of the one-repetition maximum (1RM), and 3 min rest. Rectus femoris and vastus lateralis cross-sectional areas (CSA), maximal voluntary isometric contraction (MVIC) at 30o and 90o of knee flexion and 1RM performance were assessed before and after the training period. In addition, normalized EMG amplitude-angle and force-angle relationships were assessed in the 6th and 39th experimental sessions. Results The 6-s RD protocol induced larger gains in MVIC at 30o of knee angle measurement than the 2-s RD protocol. Increases in MVIC at 90o of knee angle, 1RM, rectus femoris and vastus lateralis CSA were not significant between the 2-s and 6-s RD protocols. Moreover, different normalized EMG amplitude-angle and force-angle values were detected between protocols over most of the angles analyzed. Conclusion Performing longer RD could be a more appropriate strategy to provide greater gains in isometric maximal muscle strength at shortened knee positions. However, similar maximum dynamic strength and muscle hypertrophy gains would be provided by protocols with different RD.
S. Miraj - One of the best experts on this subject based on the ideXlab platform.
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Therapeutic Effects of Rheum palmatum L. (Dahuang): A systematic review
2016Co-Authors: S. MirajAbstract:Rheum palmatum L. (Dahuang) is a wild rebus, erect, glabrous, perennial aromatic herb, which grows up to 120 to 200 cm high. The flowers are 1 to 2 mm in diameter, all hermaphrodites and Petals are yellow and produced in compound umbels. While this plant has lots of properties, the aim of this study is to overview its therapeutic Effects than its nutritive and industrial Effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases up to 2016.totally, of 94 found articles, 40 articles(42 in vitro and 5 animal studies) were included. The search terms were "Calendula.", "therapeutic", "pharmacological". Various studies have shown that Rheum palmatum L. (Dahuang). Possess Antioxidant Effect, Effect-enhancing and toxicity-reducing, Anti-viral Effect, Liver Failure Effect, Anti-metastatic Effects, Hepatitis and renal Failure Effect, Metabolic syndrome treatment Effect, Antipyretic and reducing plasma concentration Effect, Inhibitory Effect, Hepatotoxicity Effect, Anti-SARS coronavirus Effect, Anti-liver Effect, Anti-stress Effect, Anti-liver and hepatic Effect, Anti HBV Effect, Anthracene derivatives, Increasing intelligence Effect, Anti-inflammation Effect, Anthracene derivatives production Effect, Homogenate of Candida utilis Effect Rheum palmatum L. (Dahuang) is widely used for therapeutic and purposes that trigger its significant value. Various combinations and numerous medicinal properties of its extract, essential oils, its stems and leaves demand further and more studies about the other useful and unknown properties of this multipurpose plant.
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Therapeutic Effects of Rheum palmatum L. (Dahuang): A systematic reviewSepideh Miraj
2016Co-Authors: S. MirajAbstract:Rheum palmatum L. (Dahuang) is a wild rebus, erect, glabrous, perennial aromatic herb, which grows up to 120 to 200 cm high. The flowers are 1 to 2 mm in diameter, all hermaphrodites and Petals are yellow and produced in compound umbels. While this plant has lots of properties, the aim of this study is to overview its therapeutic Effects than its nutritive and industrial Effects. This review article was carried out by searching studies in PubMed, Medline, , Web of Science, and Iran Medex databases up to 2016.totally, of 94 found articles,40 articles(42 in vitro and 5 animal studies) were included. The search terms were “Calendula. ”, “therapeutic”, “pharmacological”. Various studies have shown that Rheum palmatum L. (Dahuang). Possess Antioxidant Effect, Effect-enhancing and toxicity-reducing, Anti-viral Effect, Liver Failure Effect ,Anti-metastatic Effects ,Hepatitis and renal Failure Effect ,Metabolic syndrome treatment Effect ,Antipyretic and reducing plasma concentration Effect ,Inhibitory Effect ,Hepatotoxicity Effect ,Anti-SARS coronavirus Effect ,Anti-liver Effect ,Anti-stress Effect ,Anti-liver and hepatic Effect ,Anti HBV Effect ,Anthracene derivatives ,Increasing intelligence Effect ,Anti-inflammation Effect ,Anthracene derivatives production Effect ,Homogenate of Candida utilis Effect Rheum palmatum L. (Dahuang) is widely used for therapeutic and purposes that trigger its significant value. Various combinations and numerous medicinal properties of its extract, essential oils, its stems and leaves demand further and more studies about the other useful and unknown properties of this multipurpose plant.
