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Suzanne W Fletcher - One of the best experts on this subject based on the ideXlab platform.
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ten year risk of False Positive screening mammograms and clinical breast examinations
The New England Journal of Medicine, 1998Co-Authors: Joann G Elmore, Mary B Barton, Victoria M Moceri, Sarah Polk, Philip J Arena, Suzanne W FletcherAbstract:Background The cumulative risk of a False Positive Result of a breast-cancer screening test is unknown. Methods We performed a 10-year retrospective cohort study of breast-cancer screening and diagnostic evaluations among 2400 women who were 40 to 69 years old at study entry. Mammograms or clinical breast examinations that were interpreted as indeterminate, aroused a suspicion of cancer, or prompted recommendations for additional workup in women in whom breast cancer was not diagnosed within the next year were considered to be False Positive tests. Results A total of 9762 screening mammograms and 10,905 screening clinical breast examinations were performed, for a median of 4 mammograms and 5 clinical breast examinations per woman over the 10-year period. Of the women who were screened, 23.8 percent had at least one False Positive mammogram, 13.4 percent had at least one False Positive breast examination, and 31.7 percent had at least one False Positive Result for either test. The estimated cumulative risk...
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ten year risk of False Positive screening mammograms and clinical breast examinations
The New England Journal of Medicine, 1998Co-Authors: Joann G Elmore, Mary B Barton, Victoria M Moceri, Sarah Polk, Philip J Arena, Suzanne W FletcherAbstract:BACKGROUND: The cumulative risk of a False Positive Result from a breast-cancer screening test is unknown. METHODS: We performed a 10-year retrospective cohort study of breast-cancer screening and diagnostic evaluations among 2400 women who were 40 to 69 years old at study entry. Mammograms or clinical breast examinations that were interpreted as indeterminate, aroused a suspicion of cancer, or prompted recommendations for additional workup in women in whom breast cancer was not diagnosed within the next year were considered to be False Positive tests. ResultS: A total of 9762 screening mammograms and 10,905 screening clinical breast examinations were performed, for a median of 4 mammograms and 5 clinical breast examinations per woman over the 10-year period. Of the women who were screened, 23.8 percent had at least one False Positive mammogram, 13.4 percent had at least one False Positive breast examination, and 31.7 percent had at least one False Positive Result for either test. The estimated cumulative risk of a False Positive Result was 49.1 percent (95 percent confidence interval, 40.3 to 64.1 percent) after 10 mammograms and 22.3 percent (95 percent confidence interval, 19.2 to 27.5 percent) after 10 clinical breast examinations. The False Positive tests led to 870 outpatient appointments, 539 diagnostic mammograms, 186 ultrasound examinations, 188 biopsies, and 1 hospitalization. We estimate that among women who do not have breast cancer, 18.6 percent (95 percent confidence interval, 9.8 to 41.2 percent) will undergo a biopsy after 10 mammograms, and 6.2 percent (95 percent confidence interval, 3.7 to 11.2 percent) after 10 clinical breast examinations. For every 100 dollars spent for screening, an additional 33 dollars was spent to evaluate the False Positive Results. CONCLUSIONS: Over 10 years, one third of women screened had an abnormal test Result that required additional evaluation, even though no breast cancer was present. Techniques are needed to decrease False Positive Results while maintaining high sensitivity. Physicians should educate women about the risk of a False Positive Result from a screening test for breast cancer.
Ichiro Kita - One of the best experts on this subject based on the ideXlab platform.
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xanthogranulomatous cholecystitis mimicking gallbladder carcinoma with a False Positive Result on fluorodeoxyglucose pet
World Journal of Gastroenterology, 2009Co-Authors: Isamu Makino, Takahiro Yamaguchi, Nariatsu Sato, Toshiaki Yasui, Ichiro KitaAbstract:Recently, several reports have demonstrated that fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in differentiating between benign and malignant lesions in the gallbladder. However, there is a limitation in the ability of FDG-PET to differentiate between inflammatory and malignant lesions. We herein present a case of xanthogranulomatous cholecystitis misdiagnosed as gallbladder carcinoma by ultrasonography and computed tomography. FDG-PET also showed increased activity. In this case, FDG-PET findings Resulted in a False-Positive for the diagnosis of gallbladder carcinoma.
Sundeept Bhalara - One of the best experts on this subject based on the ideXlab platform.
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False-Positive Result provided by rapid heterophile antibody test in a case of acute infection with hepatitis E virus.
Journal of clinical microbiology, 2004Co-Authors: Benjamin A. C. Fisher, Sundeept BhalaraAbstract:The presence of heterophile antibodies has a high specificity for infectious mononucleosis. These antibodies can be detected by rapid agglutination assays, but False-Positive Results have occasionally been reported for several conditions, including leukemia, rubella, malaria, systemic lupus erythematosus, pancreatic carcinoma, viral hepatitis, and human immunodeficiency virus infection (1-3). A 31-year-old female of Pakistani ethnicity presented with a 1-week history of nausea, vomiting, diarrhea, and jaundice. Three weeks previously, she had returned from a 7-week holiday in Pakistan. None of her contacts were unwell. She had no past medical history, and her only medication was an oral contraceptive. Her examination was normal apart from jaundice and right-upper-quadrant abdominal tenderness. In particular, there was no pharyngitis, lymphadenopathy, or splenomegaly. Results of initial investigations included an alanine transaminase level of 3,308 U/liter, an alkaline phosphatase level of 240 U/liter, a bilirubin level of 104 μmol/liter, an erythrocyte sedimentation rate of 20 mm/h, a C-reactive protein level of 12 mg/liter, and a Positive Monolatex test. The patient made a spontaneous recovery, and liver function test Results at 6 weeks were normal. Tests of antibodies to Epstein-Barr virus (EBV) capsid antigen were immunoglobulin G (IgG) Positive and IgM negative, indicating past infection. Serological Results for hepatitis E were IgG and IgM Positive, indicative of acute infection. A False-Positive rapid agglutination assay for heterophile antibodies in the presence of acute hepatitis E has not previously been reported. It is conceivable, however, that this Result may have been due to liver inflammation rather than the hepatitis E itself. It is also possible that the EBV infection may have been acquired in the recent past, with a coincidental persistence of the heterophile antibody at presentation. The Monolatex test utilizes purified bovine heterophile antigens bound to latex. By using EBV-specific immunofluorescence as the standard, specificity approaches 100% for adults (4). This case emphasizes the need, however, to confirm rapid tests with EBV-specific serology whenever the clinical picture is not clearly that of infectious mononucleosis.
Kvamme, Bjørn Olav - One of the best experts on this subject based on the ideXlab platform.
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Annual report on health monitoring of wild anadromous salmonids in Norway 2020 - Screening of wild Atlantic salmon (Salmo salar) postsmolts for viral infections
Havforskningsinstituttet, 2021Co-Authors: Madhun, Abdullah Sami, Karlsen Ørjan, Nilsen Rune, Kvamme, Bjørn OlavAbstract:The Institute of Marine Research has investigated the prevalence of infectious salmon anaemia virus (ISAV) and salmonid alphavirus (SAV, PD-virus) infections in migrating wild Atlantic salmon postsmolts captured in 2019 in three fjord systems located in three aquaculture production areas (PO2-4). These areas have had a sporadic case of ISA and a stable high incidence rate of PD, as well as a very high aquaculture intensity. The fish were collected as part of the national salmon lice monitoring program in the outer parts of the Bokna (N=132), Hardanger (N=110) and Sogne (N=110) fjords by trawling during the period May-June. ISAV was detected in two postsmolts from Hardanger fjord and SAV in one smolt from Sogne fjord. The Ct-value of SAV-Positive fish was very high (38.9) which may suggest a False Positive Result. The findings from the current report indicate a very low prevalence of these viruses in wild migrating postsmolts. These findings complement and corroborate our previously reported data and may suggest that prevalence of ISAV or SAV infections in wild salmon postsmolts are not significantly influenced by the occurrence of these infections in fish farming.publishedVersio
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Annual report on health monitoring of wild anadromous salmonids in Norway 2020 - Screening of wild Atlantic salmon (Salmo salar) postsmolts for viral infections
Havforskningsinstituttet, 2021Co-Authors: Madhun, Abdullah Sami, Karlsen Ørjan, Nilsen Rune, Kvamme, Bjørn OlavAbstract:The Institute of Marine Research has investigated the prevalence of infectious salmon anaemia virus (ISAV) and salmonid alphavirus (SAV, PD-virus) infections in migrating wild Atlantic salmon postsmolts captured in 2019 in three fjord systems located in three aquaculture production areas (PO2-4). These areas have had a sporadic case of ISA and a stable high incidence rate of PD, as well as a very high aquaculture intensity. The fish were collected as part of the national salmon lice monitoring program in the outer parts of the Bokna (N=132), Hardanger (N=110) and Sogne (N=110) fjords by trawling during the period May-June. ISAV was detected in two postsmolts from Hardanger fjord and SAV in one smolt from Sogne fjord. The Ct-value of SAV-Positive fish was very high (38.9) which may suggest a False Positive Result. The findings from the current report indicate a very low prevalence of these viruses in wild migrating postsmolts. These findings complement and corroborate our previously reported data and may suggest that prevalence of ISAV or SAV infections in wild salmon postsmolts are not significantly influenced by the occurrence of these infections in fish farming
T C Yen - One of the best experts on this subject based on the ideXlab platform.
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False Positive fluorine 18 fluorodeoxy d glucose positron emission tomography finding caused by osteoradionecrosis in a nasopharyngeal carcinoma patient
British Journal of Radiology, 2004Co-Authors: Shiauchin Liu, J T Chang, Siucheung Chan, T C YenAbstract:Nasopharyngeal carcinoma (NPC) is treated by radiotherapy with or without chemotherapy. It is not uncommon to find the residual/recurrent lesion in the skull base area. For patients who had received radiotherapy, it is difficult to differentiate the skull base tumour from post-treatment change in the CT or MRI. 18F-2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) provides an alternative diagnostic choice in this situation for head and neck cancer including NPC especially when there is inconclusive CT/MRI finding. This report of an NPC patient who received radiotherapy 18 months previously, describes the misdiagnosis of tumour recurrence at the skull base found in both MRI and FDG PET scan. Histopathological studies showed osteoradionecrosis of the debrided tissue and follow-up PET showed complete regression of the skull base lesion. Therefore, a False Positive Result in FDG PET caused by osteoradionecrosis was confirmed. To the best of our knowledge, this is the first case report in the li...