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Christopher R M Asquith - One of the best experts on this subject based on the ideXlab platform.
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novel epidithiodiketopiperazines as anti viral zinc ejectors of the Feline Immunodeficiency Virus fiv nucleocapsid protein as a model for hiv infection
Bioorganic & Medicinal Chemistry, 2019Co-Authors: Regina Hofmannlehmann, Christopher R M Asquith, Tuomo Laitinen, Antti Poso, Graham J Tizzard, Simon J Coles, Stephen T HiltonAbstract:Abstract Focused libraries of multi-substituted epidithiodiketopiperazines (ETP) were prepared and evaluated for efficacy of inhibiting the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV. This activity was compared and contrasted to observed toxicity utilising an in-vitro cell culture approach. This resulted in the identification of several promising lead compounds with nanomolar potency in cells with low toxicity and a favorable therapeutic index.
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investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus fiv via a potential zinc ejection mechanism as a model for hiv infection
ChemMedChem, 2019Co-Authors: Christopher R M Asquith, Lidia S Konstantinova, Tuomo Laitinen, Antti Poso, Oleg A Rakitin, Graham J TizzardAbstract:A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
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evaluation of substituted 1 2 3 dithiazoles as inhibitors of the Feline Immunodeficiency Virus fiv nucleocapsid protein via a proposed zinc ejection mechanism
ChemMedChem, 2016Co-Authors: Christopher R M Asquith, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, Regina HofmannlehmannAbstract:A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the Feline Immunodeficiency Virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
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novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the Feline Immunodeficiency Virus fiv as a model of hiv infection
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Stephen T HiltonAbstract:A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.
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evaluation of the antiviral efficacy of bis 1 2 dithiolo 1 4 thiazines and bis 1 2 dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus fiv as a model for hiv infection
Bioorganic & Medicinal Chemistry Letters, 2014Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Mikael Perakyla, Stephen T HiltonAbstract:A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
Oleg A Rakitin - One of the best experts on this subject based on the ideXlab platform.
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investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus fiv via a potential zinc ejection mechanism as a model for hiv infection
ChemMedChem, 2019Co-Authors: Christopher R M Asquith, Lidia S Konstantinova, Tuomo Laitinen, Antti Poso, Oleg A Rakitin, Graham J TizzardAbstract:A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
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evaluation of substituted 1 2 3 dithiazoles as inhibitors of the Feline Immunodeficiency Virus fiv nucleocapsid protein via a proposed zinc ejection mechanism
ChemMedChem, 2016Co-Authors: Christopher R M Asquith, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, Regina HofmannlehmannAbstract:A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the Feline Immunodeficiency Virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
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novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the Feline Immunodeficiency Virus fiv as a model of hiv infection
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Stephen T HiltonAbstract:A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.
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evaluation of the antiviral efficacy of bis 1 2 dithiolo 1 4 thiazines and bis 1 2 dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus fiv as a model for hiv infection
Bioorganic & Medicinal Chemistry Letters, 2014Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Mikael Perakyla, Stephen T HiltonAbstract:A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
Stephen T Hilton - One of the best experts on this subject based on the ideXlab platform.
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novel epidithiodiketopiperazines as anti viral zinc ejectors of the Feline Immunodeficiency Virus fiv nucleocapsid protein as a model for hiv infection
Bioorganic & Medicinal Chemistry, 2019Co-Authors: Regina Hofmannlehmann, Christopher R M Asquith, Tuomo Laitinen, Antti Poso, Graham J Tizzard, Simon J Coles, Stephen T HiltonAbstract:Abstract Focused libraries of multi-substituted epidithiodiketopiperazines (ETP) were prepared and evaluated for efficacy of inhibiting the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV. This activity was compared and contrasted to observed toxicity utilising an in-vitro cell culture approach. This resulted in the identification of several promising lead compounds with nanomolar potency in cells with low toxicity and a favorable therapeutic index.
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novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the Feline Immunodeficiency Virus fiv as a model of hiv infection
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Stephen T HiltonAbstract:A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.
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evaluation of the antiviral efficacy of bis 1 2 dithiolo 1 4 thiazines and bis 1 2 dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus fiv as a model for hiv infection
Bioorganic & Medicinal Chemistry Letters, 2014Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Mikael Perakyla, Stephen T HiltonAbstract:A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
Lidia S Konstantinova - One of the best experts on this subject based on the ideXlab platform.
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investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus fiv via a potential zinc ejection mechanism as a model for hiv infection
ChemMedChem, 2019Co-Authors: Christopher R M Asquith, Lidia S Konstantinova, Tuomo Laitinen, Antti Poso, Oleg A Rakitin, Graham J TizzardAbstract:A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
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evaluation of substituted 1 2 3 dithiazoles as inhibitors of the Feline Immunodeficiency Virus fiv nucleocapsid protein via a proposed zinc ejection mechanism
ChemMedChem, 2016Co-Authors: Christopher R M Asquith, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, Regina HofmannlehmannAbstract:A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the Feline Immunodeficiency Virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
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novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the Feline Immunodeficiency Virus fiv as a model of hiv infection
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Stephen T HiltonAbstract:A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.
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evaluation of the antiviral efficacy of bis 1 2 dithiolo 1 4 thiazines and bis 1 2 dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus fiv as a model for hiv infection
Bioorganic & Medicinal Chemistry Letters, 2014Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Mikael Perakyla, Stephen T HiltonAbstract:A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
Antti Poso - One of the best experts on this subject based on the ideXlab platform.
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novel epidithiodiketopiperazines as anti viral zinc ejectors of the Feline Immunodeficiency Virus fiv nucleocapsid protein as a model for hiv infection
Bioorganic & Medicinal Chemistry, 2019Co-Authors: Regina Hofmannlehmann, Christopher R M Asquith, Tuomo Laitinen, Antti Poso, Graham J Tizzard, Simon J Coles, Stephen T HiltonAbstract:Abstract Focused libraries of multi-substituted epidithiodiketopiperazines (ETP) were prepared and evaluated for efficacy of inhibiting the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV. This activity was compared and contrasted to observed toxicity utilising an in-vitro cell culture approach. This resulted in the identification of several promising lead compounds with nanomolar potency in cells with low toxicity and a favorable therapeutic index.
-
investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus fiv via a potential zinc ejection mechanism as a model for hiv infection
ChemMedChem, 2019Co-Authors: Christopher R M Asquith, Lidia S Konstantinova, Tuomo Laitinen, Antti Poso, Oleg A Rakitin, Graham J TizzardAbstract:A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
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evaluation of substituted 1 2 3 dithiazoles as inhibitors of the Feline Immunodeficiency Virus fiv nucleocapsid protein via a proposed zinc ejection mechanism
ChemMedChem, 2016Co-Authors: Christopher R M Asquith, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, Regina HofmannlehmannAbstract:A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the Feline Immunodeficiency Virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
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novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the Feline Immunodeficiency Virus fiv as a model of hiv infection
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Stephen T HiltonAbstract:A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.
-
evaluation of the antiviral efficacy of bis 1 2 dithiolo 1 4 thiazines and bis 1 2 dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus fiv as a model for hiv infection
Bioorganic & Medicinal Chemistry Letters, 2014Co-Authors: Christopher R M Asquith, Regina Hofmannlehmann, Lidia S Konstantinova, Tuomo Laitinen, Marina L Meli, Antti Poso, Oleg A Rakitin, K Allenspach, Mikael Perakyla, Stephen T HiltonAbstract:A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
