The Experts below are selected from a list of 18597 Experts worldwide ranked by ideXlab platform
Deborah M Hodgson - One of the best experts on this subject based on the ideXlab platform.
-
abstract 1761 neonatal immune activation with lipopolysaccharide and a second hit of adulthood stress alters ovarian inflammatory mediators implications for Female subfertility
Brain Behavior and Immunity, 2016Co-Authors: E A Fuller, M C Carey, Kate A. Redgrove, Eileen A Mclaughlin, Deborah M HodgsonAbstract:Agnogentic subfertility is a clinical concern for many women of a Healthy Reproductive age. Accumulating evidence suggests developmental factors, such as immune status, are involved in the aetiology of Female subfertility. Normal immune function is crucial for the initial quality and quantity of the ovarian follicular pool, and continued Reproductive success. Our laboratory, in parallel with others, has established that early-life immune stress leads to sustained alterations in immune and neuroendocrine function, and perinatally programs vulnerability to subsequent stressors. However, investigation into the effects of early-life immune stress on Female Reproductive development is limited. This study investigates the immediate and long-term effects of immune activation during early-life on ovarian development and continued Female Reproductive Health. Using a rat model, our findings suggest that neonatal immune activation (NIA) with lipopolysaccharide on post-natal days 3 and 5 leads to significant depletion of the ovarian follicular pool, acute upregulation of ovarian proinflammatory mediators, and precocious onset of puberty ( p p
-
Abstract # 1761 Neonatal immune activation with lipopolysaccharide and a ‘second hit’ of adulthood stress alters ovarian inflammatory mediators: Implications for Female subfertility
Brain Behavior and Immunity, 2016Co-Authors: E A Fuller, M C Carey, Kate A. Redgrove, Eileen A Mclaughlin, Deborah M HodgsonAbstract:Agnogentic subfertility is a clinical concern for many women of a Healthy Reproductive age. Accumulating evidence suggests developmental factors, such as immune status, are involved in the aetiology of Female subfertility. Normal immune function is crucial for the initial quality and quantity of the ovarian follicular pool, and continued Reproductive success. Our laboratory, in parallel with others, has established that early-life immune stress leads to sustained alterations in immune and neuroendocrine function, and perinatally programs vulnerability to subsequent stressors. However, investigation into the effects of early-life immune stress on Female Reproductive development is limited. This study investigates the immediate and long-term effects of immune activation during early-life on ovarian development and continued Female Reproductive Health. Using a rat model, our findings suggest that neonatal immune activation (NIA) with lipopolysaccharide on post-natal days 3 and 5 leads to significant depletion of the ovarian follicular pool, acute upregulation of ovarian proinflammatory mediators, and precocious onset of puberty ( p p
Eileen A Mclaughlin - One of the best experts on this subject based on the ideXlab platform.
-
abstract 1761 neonatal immune activation with lipopolysaccharide and a second hit of adulthood stress alters ovarian inflammatory mediators implications for Female subfertility
Brain Behavior and Immunity, 2016Co-Authors: E A Fuller, M C Carey, Kate A. Redgrove, Eileen A Mclaughlin, Deborah M HodgsonAbstract:Agnogentic subfertility is a clinical concern for many women of a Healthy Reproductive age. Accumulating evidence suggests developmental factors, such as immune status, are involved in the aetiology of Female subfertility. Normal immune function is crucial for the initial quality and quantity of the ovarian follicular pool, and continued Reproductive success. Our laboratory, in parallel with others, has established that early-life immune stress leads to sustained alterations in immune and neuroendocrine function, and perinatally programs vulnerability to subsequent stressors. However, investigation into the effects of early-life immune stress on Female Reproductive development is limited. This study investigates the immediate and long-term effects of immune activation during early-life on ovarian development and continued Female Reproductive Health. Using a rat model, our findings suggest that neonatal immune activation (NIA) with lipopolysaccharide on post-natal days 3 and 5 leads to significant depletion of the ovarian follicular pool, acute upregulation of ovarian proinflammatory mediators, and precocious onset of puberty ( p p
-
Abstract # 1761 Neonatal immune activation with lipopolysaccharide and a ‘second hit’ of adulthood stress alters ovarian inflammatory mediators: Implications for Female subfertility
Brain Behavior and Immunity, 2016Co-Authors: E A Fuller, M C Carey, Kate A. Redgrove, Eileen A Mclaughlin, Deborah M HodgsonAbstract:Agnogentic subfertility is a clinical concern for many women of a Healthy Reproductive age. Accumulating evidence suggests developmental factors, such as immune status, are involved in the aetiology of Female subfertility. Normal immune function is crucial for the initial quality and quantity of the ovarian follicular pool, and continued Reproductive success. Our laboratory, in parallel with others, has established that early-life immune stress leads to sustained alterations in immune and neuroendocrine function, and perinatally programs vulnerability to subsequent stressors. However, investigation into the effects of early-life immune stress on Female Reproductive development is limited. This study investigates the immediate and long-term effects of immune activation during early-life on ovarian development and continued Female Reproductive Health. Using a rat model, our findings suggest that neonatal immune activation (NIA) with lipopolysaccharide on post-natal days 3 and 5 leads to significant depletion of the ovarian follicular pool, acute upregulation of ovarian proinflammatory mediators, and precocious onset of puberty ( p p
E A Fuller - One of the best experts on this subject based on the ideXlab platform.
-
abstract 1761 neonatal immune activation with lipopolysaccharide and a second hit of adulthood stress alters ovarian inflammatory mediators implications for Female subfertility
Brain Behavior and Immunity, 2016Co-Authors: E A Fuller, M C Carey, Kate A. Redgrove, Eileen A Mclaughlin, Deborah M HodgsonAbstract:Agnogentic subfertility is a clinical concern for many women of a Healthy Reproductive age. Accumulating evidence suggests developmental factors, such as immune status, are involved in the aetiology of Female subfertility. Normal immune function is crucial for the initial quality and quantity of the ovarian follicular pool, and continued Reproductive success. Our laboratory, in parallel with others, has established that early-life immune stress leads to sustained alterations in immune and neuroendocrine function, and perinatally programs vulnerability to subsequent stressors. However, investigation into the effects of early-life immune stress on Female Reproductive development is limited. This study investigates the immediate and long-term effects of immune activation during early-life on ovarian development and continued Female Reproductive Health. Using a rat model, our findings suggest that neonatal immune activation (NIA) with lipopolysaccharide on post-natal days 3 and 5 leads to significant depletion of the ovarian follicular pool, acute upregulation of ovarian proinflammatory mediators, and precocious onset of puberty ( p p
-
Abstract # 1761 Neonatal immune activation with lipopolysaccharide and a ‘second hit’ of adulthood stress alters ovarian inflammatory mediators: Implications for Female subfertility
Brain Behavior and Immunity, 2016Co-Authors: E A Fuller, M C Carey, Kate A. Redgrove, Eileen A Mclaughlin, Deborah M HodgsonAbstract:Agnogentic subfertility is a clinical concern for many women of a Healthy Reproductive age. Accumulating evidence suggests developmental factors, such as immune status, are involved in the aetiology of Female subfertility. Normal immune function is crucial for the initial quality and quantity of the ovarian follicular pool, and continued Reproductive success. Our laboratory, in parallel with others, has established that early-life immune stress leads to sustained alterations in immune and neuroendocrine function, and perinatally programs vulnerability to subsequent stressors. However, investigation into the effects of early-life immune stress on Female Reproductive development is limited. This study investigates the immediate and long-term effects of immune activation during early-life on ovarian development and continued Female Reproductive Health. Using a rat model, our findings suggest that neonatal immune activation (NIA) with lipopolysaccharide on post-natal days 3 and 5 leads to significant depletion of the ovarian follicular pool, acute upregulation of ovarian proinflammatory mediators, and precocious onset of puberty ( p p
Kersti Jääger - One of the best experts on this subject based on the ideXlab platform.
-
Putative adverse outcome pathways for Female Reproductive disorders to improve testing and regulation of chemicals
Archives of Toxicology, 2020Co-Authors: Hanna K. L. Johansson, Julie Boberg, Pauliina Damdimopoulou, Majorie B. M. Duursen, Delphine Franssen, Marijke Cock, Kersti Jääger, Magdalena Wagner, Agne Velthut-meikas, Lisa ConnollyAbstract:Modern living challenges Female Reproductive Health. We are witnessing a rise in Reproductive disorders and drop in birth rates across the world. The reasons for these manifestations are multifaceted and most likely include continuous exposure to an ever-increasing number of chemicals. The cause–effect relationships between chemical exposure and Female Reproductive disorders, however, have proven problematic to determine. This has made it difficult to assess the risks chemical exposures pose to a woman’s Reproductive development and function. To address this challenge, this review uses the adverse outcome pathway (AOP) concept to summarize current knowledge about how chemical exposure can affect Female Reproductive Health. We have a special focus on effects on the ovaries, since they are essential for lifelong Reproductive Health in women, being the source of both oocytes and several Reproductive hormones, including sex steroids. The AOP framework is widely accepted as a new tool for toxicological safety assessment that enables better use of mechanistic knowledge for regulatory purposes. AOPs equip assessors and regulators with a pragmatic network of linear cause–effect relationships, enabling the use of a wider range of test method data in chemical risk assessment and regulation. Based on current knowledge, we propose ten putative AOPs relevant for Female Reproductive disorders that can be further elaborated and potentially be included in the AOPwiki. This effort is an important step towards better safeguarding the Reproductive Health of all girls and women.
-
Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project.
International journal of molecular sciences, 2020Co-Authors: Majorie B.m. Van Duursen, Julie Boberg, Pauliina Damdimopoulou, Lisa Connolly, Sofie Christiansen, Panagiotis Filis, Paul Fowler, Bart M. Gadella, Jan Holte, Kersti JäägerAbstract:Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in Female Reproductive development and function. This renders women's Reproductive Health at increasing risk globally, which, coupled with increasing incidence rates of Reproductive disorders, is of great concern. A woman's Reproductive Health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the Female Reproductive system, thereby making appropriate hormone levels imperative for correct functioning of Reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and Female Reproductive Health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact Female Reproductive Health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the Reproductive Health of women globally.
Kate A. Redgrove - One of the best experts on this subject based on the ideXlab platform.
-
abstract 1761 neonatal immune activation with lipopolysaccharide and a second hit of adulthood stress alters ovarian inflammatory mediators implications for Female subfertility
Brain Behavior and Immunity, 2016Co-Authors: E A Fuller, M C Carey, Kate A. Redgrove, Eileen A Mclaughlin, Deborah M HodgsonAbstract:Agnogentic subfertility is a clinical concern for many women of a Healthy Reproductive age. Accumulating evidence suggests developmental factors, such as immune status, are involved in the aetiology of Female subfertility. Normal immune function is crucial for the initial quality and quantity of the ovarian follicular pool, and continued Reproductive success. Our laboratory, in parallel with others, has established that early-life immune stress leads to sustained alterations in immune and neuroendocrine function, and perinatally programs vulnerability to subsequent stressors. However, investigation into the effects of early-life immune stress on Female Reproductive development is limited. This study investigates the immediate and long-term effects of immune activation during early-life on ovarian development and continued Female Reproductive Health. Using a rat model, our findings suggest that neonatal immune activation (NIA) with lipopolysaccharide on post-natal days 3 and 5 leads to significant depletion of the ovarian follicular pool, acute upregulation of ovarian proinflammatory mediators, and precocious onset of puberty ( p p
-
Abstract # 1761 Neonatal immune activation with lipopolysaccharide and a ‘second hit’ of adulthood stress alters ovarian inflammatory mediators: Implications for Female subfertility
Brain Behavior and Immunity, 2016Co-Authors: E A Fuller, M C Carey, Kate A. Redgrove, Eileen A Mclaughlin, Deborah M HodgsonAbstract:Agnogentic subfertility is a clinical concern for many women of a Healthy Reproductive age. Accumulating evidence suggests developmental factors, such as immune status, are involved in the aetiology of Female subfertility. Normal immune function is crucial for the initial quality and quantity of the ovarian follicular pool, and continued Reproductive success. Our laboratory, in parallel with others, has established that early-life immune stress leads to sustained alterations in immune and neuroendocrine function, and perinatally programs vulnerability to subsequent stressors. However, investigation into the effects of early-life immune stress on Female Reproductive development is limited. This study investigates the immediate and long-term effects of immune activation during early-life on ovarian development and continued Female Reproductive Health. Using a rat model, our findings suggest that neonatal immune activation (NIA) with lipopolysaccharide on post-natal days 3 and 5 leads to significant depletion of the ovarian follicular pool, acute upregulation of ovarian proinflammatory mediators, and precocious onset of puberty ( p p
