The Experts below are selected from a list of 381 Experts worldwide ranked by ideXlab platform
Patricia B Hoyer - One of the best experts on this subject based on the ideXlab platform.
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4 14 Female Reproductive Toxicology
Reference Module in Biomedical Sciences#R##N#Comprehensive Toxicology (Third Edition), 2018Co-Authors: Patricia B HoyerAbstract:The mother serves a critical role in reproduction, such that fertility problems in Females within a population may have a direct impact on Reproductive capabilities in the entire species. Reproductive Toxicology involves the study of the effects of xenobiotic agents on the development and Reproductive capacity of individuals. All of the important features of Female Reproductive functions as they are or may be affected by exposure to occupational and environmental toxicants will be addressed in later chapters. The article also provides an overview of the topics that are covered in depth in the articles that follow.
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Female Reproductive Toxicology
Comprehensive Toxicology, 2010Co-Authors: Patricia B HoyerAbstract:This is an update of PB Hoyer, Female Reproductive Toxicology, Comprehensive Toxicology, Second Edition, edited by Charlene A. McQueen, Elsevier, Oxford, 2010, Volume 11, Pages 339–345.
Indrani C. Bagchi - One of the best experts on this subject based on the ideXlab platform.
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Genetic Mouse Models for Female Reproductive Toxicology Studies
Comprehensive Toxicology, 2018Co-Authors: Juanmahel Davila, Indrani C. BagchiAbstract:The incidence of Reproductive problems such as infertility and cancers in women has increased at an alarming rate, particularly in developed countries. One potential cause of the rising incidence of Reproductive problems is exposure to by-products of industrialization such as man-made chemicals and additives. These man-made chemicals could mimic or interfere with Reproductive hormones and their functions, therefore leading to Reproductive disorders. In addition, certain populations could be more susceptible to particular types of man-made chemicals due to genetic polymorphisms. The advancement of transgenic technology in mice over the past decade has brought the field of Reproductive Toxicology to a critical crossroad. These genetic models create unique opportunities for Reproductive toxicologists to explore questions that could never before be imagined. To take full advantage of the power of these genetic models, a basic understanding of both Female reproduction and the strengths and limitations of the genetic models is necessary. It is hoped that this article will trigger interest in and promote better use of transgenic mouse models in Female Reproductive Toxicology.
Andre Wolterbeek - One of the best experts on this subject based on the ideXlab platform.
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the bovine oocyte in vitro maturation model a potential tool for Reproductive Toxicology screening
Reproductive Toxicology, 2012Co-Authors: Anna Beker Van Woudenberg, Mariska Grollersmulderij, Cor Snel, Nelleke Jeurissen, Rob Stierum, Andre WolterbeekAbstract:Reproductive toxicity testing according to the present guidelines requires a high number of animals. Therefore, the development of alternative in vitro methods is urgently required. The aim of the present study was to investigate the applicability domain of the bovine oocyte in vitro maturation assay (bIVM) to study Female Reproductive Toxicology. Therefore, bovine oocytes were exposed to a broad set of chemicals of two distinct biological function groups: (a) affecting Female fertility and (b) affecting embryonic development and having a broad range of physical and chemical properties. The endpoints evaluated were the oocyte nuclear maturation (progression of meiosis) and general cytotoxicity. The oocyte nuclear maturation was negatively affected by all compounds tested and the effect was observed at concentrations lower than the cytotoxic ones. The bIVM assay correctly predicted the classification of compounds between those predefined groups. Additionally, the bIVM model contributes significantly for the 3R principle, since no test animals are used in this assay. In conclusion, the bIVM is a sensitive and valuable alternative assay to identify potential chemical hazard on Female fertility. © 2012 Elsevier Inc.
Juanmahel Davila - One of the best experts on this subject based on the ideXlab platform.
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Genetic Mouse Models for Female Reproductive Toxicology Studies
Comprehensive Toxicology, 2018Co-Authors: Juanmahel Davila, Indrani C. BagchiAbstract:The incidence of Reproductive problems such as infertility and cancers in women has increased at an alarming rate, particularly in developed countries. One potential cause of the rising incidence of Reproductive problems is exposure to by-products of industrialization such as man-made chemicals and additives. These man-made chemicals could mimic or interfere with Reproductive hormones and their functions, therefore leading to Reproductive disorders. In addition, certain populations could be more susceptible to particular types of man-made chemicals due to genetic polymorphisms. The advancement of transgenic technology in mice over the past decade has brought the field of Reproductive Toxicology to a critical crossroad. These genetic models create unique opportunities for Reproductive toxicologists to explore questions that could never before be imagined. To take full advantage of the power of these genetic models, a basic understanding of both Female reproduction and the strengths and limitations of the genetic models is necessary. It is hoped that this article will trigger interest in and promote better use of transgenic mouse models in Female Reproductive Toxicology.
Anna Beker Van Woudenberg - One of the best experts on this subject based on the ideXlab platform.
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the bovine oocyte in vitro maturation model a potential tool for Reproductive Toxicology screening
Reproductive Toxicology, 2012Co-Authors: Anna Beker Van Woudenberg, Mariska Grollersmulderij, Cor Snel, Nelleke Jeurissen, Rob Stierum, Andre WolterbeekAbstract:Reproductive toxicity testing according to the present guidelines requires a high number of animals. Therefore, the development of alternative in vitro methods is urgently required. The aim of the present study was to investigate the applicability domain of the bovine oocyte in vitro maturation assay (bIVM) to study Female Reproductive Toxicology. Therefore, bovine oocytes were exposed to a broad set of chemicals of two distinct biological function groups: (a) affecting Female fertility and (b) affecting embryonic development and having a broad range of physical and chemical properties. The endpoints evaluated were the oocyte nuclear maturation (progression of meiosis) and general cytotoxicity. The oocyte nuclear maturation was negatively affected by all compounds tested and the effect was observed at concentrations lower than the cytotoxic ones. The bIVM assay correctly predicted the classification of compounds between those predefined groups. Additionally, the bIVM model contributes significantly for the 3R principle, since no test animals are used in this assay. In conclusion, the bIVM is a sensitive and valuable alternative assay to identify potential chemical hazard on Female fertility. © 2012 Elsevier Inc.
