The Experts below are selected from a list of 3171 Experts worldwide ranked by ideXlab platform
Satoru Watano - One of the best experts on this subject based on the ideXlab platform.
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simple and rapid synthesis of magnetite hydroxyapatite composites for hyperthermia treatments via a mechanochemical route
International Journal of Molecular Sciences, 2013Co-Authors: Tomohiro Iwasaki, Ryo Nakatsuka, Hiroshige Takata, Hideya Nakamura, Kenya Murase, Satoru WatanoAbstract:This paper presents a simple method for the rapid synthesis of magnetite/hydroxyapatite composite particles. In this method, superparamagnetic magnetite nanoparticles are first synthesized by coprecipitation using Ferrous Chloride and ferric Chloride. Immediately following the synthesis, carbonate-substituted (B-type) hydroxyapatite particles are mechanochemically synthesized by wet milling dicalcium phosphate dihydrate and calcium carbonate in a dispersed suspension of magnetite nanoparticles, during which the magnetite nanoparticles are incorporated into the hydroxyapatite matrix. We observed that the resultant magnetite/hydroxyapatite composites possessed a homogeneous dispersion of magnetite nanoparticles, characterized by an absence of large aggregates. When this material was subjected to an alternating magnetic field, the heat generated increased with increasing magnetite concentration. For a magnetite concentration of 30 mass%, a temperature increase greater than 20 K was achieved in less than 50 s. These results suggest that our composites exhibit good hyperthermia properties and are promising candidates for hyperthermia treatments.
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Simple and Rapid Synthesis of Magnetite/Hydroxyapatite Composites for Hyperthermia Treatments via a Mechanochemical Route
2013Co-Authors: Tomohiro Iwasaki, Ryo Nakatsuka, Hiroshige Takata, Hideya Nakamura, Kenya Murase, Satoru WatanoAbstract:Abstract: This paper presents a simple method for the rapid synthesis of magnetite/hydroxyapatite composite particles. In this method, superparamagnetic magnetite nanoparticles are first synthesized by coprecipitation using Ferrous Chloride and ferric Chloride. Immediately following the synthesis, carbonate-substituted (B-type) hydroxyapatite particles are mechanochemically synthesized by wet milling dicalcium phosphate dihydrate and calcium carbonate in a dispersed suspension of magnetite nanoparticles, during which the magnetite nanoparticles are incorporated into the hydroxyapatite matrix. We observed that the resultant magnetite/hydroxyapatite composites possessed a homogeneous dispersion of magnetite nanoparticles, characterized by an absence of large aggregates. When this material was subjected to an alternating magnetic field, the heat generated increased with increasing magnetite concentration. For a magnetite concentration of 30 mass%, a temperature increase greater than 20 K was achieved in less than 50 s. These results suggest that our composites exhibit goo
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Simple and Rapid Synthesis of Magnetite/Hydroxyapatite Composites for Hyperthermia Treatments via a Mechanochemical Route
MDPI AG, 2013Co-Authors: Tomohiro Iwasaki, Ryo Nakatsuka, Hiroshige Takata, Hideya Nakamura, Kenya Murase, Satoru WatanoAbstract:This paper presents a simple method for the rapid synthesis of magnetite/hydroxyapatite composite particles. In this method, superparamagnetic magnetite nanoparticles are first synthesized by coprecipitation using Ferrous Chloride and ferric Chloride. Immediately following the synthesis, carbonate-substituted (B-type) hydroxyapatite particles are mechanochemically synthesized by wet milling dicalcium phosphate dihydrate and calcium carbonate in a dispersed suspension of magnetite nanoparticles, during which the magnetite nanoparticles are incorporated into the hydroxyapatite matrix. We observed that the resultant magnetite/hydroxyapatite composites possessed a homogeneous dispersion of magnetite nanoparticles, characterized by an absence of large aggregates. When this material was subjected to an alternating magnetic field, the heat generated increased with increasing magnetite concentration. For a magnetite concentration of 30 mass%, a temperature increase greater than 20 K was achieved in less than 50 s. These results suggest that our composites exhibit good hyperthermia properties and are promising candidates for hyperthermia treatments
Huan Wang - One of the best experts on this subject based on the ideXlab platform.
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fecl2 catalyzed hydroboration of aryl alkenes with bis pinacolato diboron
ChemInform, 2016Co-Authors: Yang Liu, Yuhan Zhou, Huan WangAbstract:A novel protocol is presented for a ligand-free Ferrous Chloride-catalyzed hydroboration of non-activated aryl alkenes.
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fecl2 catalyzed hydroboration of aryl alkenes with bis pinacolato diboron
RSC Advances, 2015Co-Authors: Yang Liu, Yuhan Zhou, Huan WangAbstract:The first ligand-free Ferrous Chloride catalyzed anti-Markovnikov hydroboration of un-activated aryl alkenes with bis(pinacolato)diboron (B2pin2) has been reported. The reactions proceeded smoothly with high regioselectivity for a large range of aryl alkenes with wide functional-group compatibility and low catalyst loading under mild conditions.
S H Pawar - One of the best experts on this subject based on the ideXlab platform.
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magnetic chitosan nanocomposite for hyperthermia therapy application preparation characterization and in vitro experiments
Applied Surface Science, 2014Co-Authors: P B Shete, Nanasaheb D Thorat, R M Patil, R S Ningthoujam, S J Ghosh, A I Prasad, S H PawarAbstract:Abstract Nanocrystals of magnetite (Fe 3 O 4 ) were prepared by alkaline precipitation. The precursor used for synthesis was Ferrous Chloride only and the reaction was carried out in absence of any oxidant. The synthesized pure phase magnetic nanoparticles (MNPs) were coated with a biocompatible polymer, chitosan (CS). FTIR and TGA confirm coating of CS on MNPs. Both bare and coated MNPs (Fe 3 O 4 and CS-Fe 3 O 4 ) show particle size 21.8 ± 5.3 and 15.1 ± 5.0 nm respectively. The magnetization values of both the MNPs are 51.68 and 49.96 emu/g at room temperature respectively. Negligible Coercivity and Remenance values at room temperature imply superparamagnetic behavior of the MNPs. The MNPs are studied for their induction heating abilities at 167.6, 251.4 and 335.2 Oe (equivalent to 13.3, 20.0 and 26.7 kA m −1 respectively), in order to use them in magnetic fluid hyperthermia therapy. At 335.2 Oe, CS coated nanoparticles (NPs) show maximum SAR of 118.85 W/g, while bare NPs show SAR of 79.32 W/g. Low cytotoxic effects of both the MNPs on L929 cell line proved their suitability for in vivo applications. NH 2 group rendered by CS can further be used for conjugation of biomolecules to make them suitable candidates for biosensing and targeted drug delivery.
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magnetic core shell structures for magnetic fluid hyperthermia therapy application
New Journal of Chemistry, 2013Co-Authors: P B Shete, R M Patil, R S Ningthoujam, S J Ghosh, S H PawarAbstract:Nanocrystals of magnetite (Fe3O4) were prepared by alkaline precipitation. The precursor used for synthesis was Ferrous Chloride alone and the reaction was carried out in the absence of any oxidant. The synthesized pure phase magnetic nanoparticles (MNPs) were coated with a biocompatible polymer, acrypol (AP). Fourier transform infrared and thermogravimetric studies confirmed coating of AP on MNPs. Bare and coated MNPs (Fe3O4 and AP–Fe3O4) showed particle sizes of 21.8 ± 5.3 and 14.2 ± 5.0 nm respectively. The magnetization values of the MNPs were 37.77 and 32.71 emu g−1 at room temperature respectively. Negligible coercivity and remanence values at room temperature implied superparamagnetic behavior of the MNPs. The induction heating abilities of MNPs at 167.6, 251.4 and 335.2 Oe (equivalent to 13.3, 20.0 and 26.7 kA m−1 respectively) were studied, in order to use them in magnetic fluid hyperthermia therapy. At 335.2 Oe, AP coated NPs showed a maximum specific absorption rate (SAR) of 95.8 W g−1, while bare NPs showed a SAR of 74.4 W g−1. Zeta potential values of bare and coated MNPs were measured at a pH range from 2 to 10 in water. Both the colloidal suspensions were found to be very stable at extreme pH values. However, higher zeta potential values of coated MNPs were assigned to their higher colloidal stability. Low cytotoxic effects of both the MNPs on the L929 cell line proved their suitability for in vivo applications.
Tomohiro Iwasaki - One of the best experts on this subject based on the ideXlab platform.
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simple and rapid synthesis of magnetite hydroxyapatite composites for hyperthermia treatments via a mechanochemical route
International Journal of Molecular Sciences, 2013Co-Authors: Tomohiro Iwasaki, Ryo Nakatsuka, Hiroshige Takata, Hideya Nakamura, Kenya Murase, Satoru WatanoAbstract:This paper presents a simple method for the rapid synthesis of magnetite/hydroxyapatite composite particles. In this method, superparamagnetic magnetite nanoparticles are first synthesized by coprecipitation using Ferrous Chloride and ferric Chloride. Immediately following the synthesis, carbonate-substituted (B-type) hydroxyapatite particles are mechanochemically synthesized by wet milling dicalcium phosphate dihydrate and calcium carbonate in a dispersed suspension of magnetite nanoparticles, during which the magnetite nanoparticles are incorporated into the hydroxyapatite matrix. We observed that the resultant magnetite/hydroxyapatite composites possessed a homogeneous dispersion of magnetite nanoparticles, characterized by an absence of large aggregates. When this material was subjected to an alternating magnetic field, the heat generated increased with increasing magnetite concentration. For a magnetite concentration of 30 mass%, a temperature increase greater than 20 K was achieved in less than 50 s. These results suggest that our composites exhibit good hyperthermia properties and are promising candidates for hyperthermia treatments.
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Simple and Rapid Synthesis of Magnetite/Hydroxyapatite Composites for Hyperthermia Treatments via a Mechanochemical Route
2013Co-Authors: Tomohiro Iwasaki, Ryo Nakatsuka, Hiroshige Takata, Hideya Nakamura, Kenya Murase, Satoru WatanoAbstract:Abstract: This paper presents a simple method for the rapid synthesis of magnetite/hydroxyapatite composite particles. In this method, superparamagnetic magnetite nanoparticles are first synthesized by coprecipitation using Ferrous Chloride and ferric Chloride. Immediately following the synthesis, carbonate-substituted (B-type) hydroxyapatite particles are mechanochemically synthesized by wet milling dicalcium phosphate dihydrate and calcium carbonate in a dispersed suspension of magnetite nanoparticles, during which the magnetite nanoparticles are incorporated into the hydroxyapatite matrix. We observed that the resultant magnetite/hydroxyapatite composites possessed a homogeneous dispersion of magnetite nanoparticles, characterized by an absence of large aggregates. When this material was subjected to an alternating magnetic field, the heat generated increased with increasing magnetite concentration. For a magnetite concentration of 30 mass%, a temperature increase greater than 20 K was achieved in less than 50 s. These results suggest that our composites exhibit goo
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Simple and Rapid Synthesis of Magnetite/Hydroxyapatite Composites for Hyperthermia Treatments via a Mechanochemical Route
MDPI AG, 2013Co-Authors: Tomohiro Iwasaki, Ryo Nakatsuka, Hiroshige Takata, Hideya Nakamura, Kenya Murase, Satoru WatanoAbstract:This paper presents a simple method for the rapid synthesis of magnetite/hydroxyapatite composite particles. In this method, superparamagnetic magnetite nanoparticles are first synthesized by coprecipitation using Ferrous Chloride and ferric Chloride. Immediately following the synthesis, carbonate-substituted (B-type) hydroxyapatite particles are mechanochemically synthesized by wet milling dicalcium phosphate dihydrate and calcium carbonate in a dispersed suspension of magnetite nanoparticles, during which the magnetite nanoparticles are incorporated into the hydroxyapatite matrix. We observed that the resultant magnetite/hydroxyapatite composites possessed a homogeneous dispersion of magnetite nanoparticles, characterized by an absence of large aggregates. When this material was subjected to an alternating magnetic field, the heat generated increased with increasing magnetite concentration. For a magnetite concentration of 30 mass%, a temperature increase greater than 20 K was achieved in less than 50 s. These results suggest that our composites exhibit good hyperthermia properties and are promising candidates for hyperthermia treatments
Yang Liu - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of gem-Difluoroallylboronates via FeCl2‑Catalyzed Boration/β-Fluorine Elimination of Trifluoromethyl Alkenes
2017Co-Authors: Yang Liu, Yuhan Zhou, Yilong ZhaoAbstract:The first Ferrous Chloride catalyzed boration/β-fluorine elimination of trifluoromethyl alkenes is described. Thus, a full range of gem-difluoroallylboronates were obtained in high yield under mild conditions. As an important fluorinated building block, gem-difluoroallylboronate can be readily converted into diverse difluoro-substituted species
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fecl2 catalyzed hydroboration of aryl alkenes with bis pinacolato diboron
ChemInform, 2016Co-Authors: Yang Liu, Yuhan Zhou, Huan WangAbstract:A novel protocol is presented for a ligand-free Ferrous Chloride-catalyzed hydroboration of non-activated aryl alkenes.
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fecl2 catalyzed hydroboration of aryl alkenes with bis pinacolato diboron
RSC Advances, 2015Co-Authors: Yang Liu, Yuhan Zhou, Huan WangAbstract:The first ligand-free Ferrous Chloride catalyzed anti-Markovnikov hydroboration of un-activated aryl alkenes with bis(pinacolato)diboron (B2pin2) has been reported. The reactions proceeded smoothly with high regioselectivity for a large range of aryl alkenes with wide functional-group compatibility and low catalyst loading under mild conditions.