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Tsungshune Chin - One of the best experts on this subject based on the ideXlab platform.
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electrodeposition of zn fe alloys using electrolytes of the system zno Ferrous Gluconate koh
Journal of The Electrochemical Society, 2007Co-Authors: C J Lan, W Y Liu, Tsungshune ChinAbstract:ZnO-(Ferrous Gluconate)-KOH electrolytes were developed as novel alkaline baths for electrodeposition of Zn-Fe alloys. Ferrous Gluconate is chosen due to its uniquely high solubility in concentrated KOH solution without an additional complexing agent. The electrical conductivity of the proposed baths is 510-560 mS cm -1 , 2.5-2.7 times that of a known formula. The cathodic current efficiency of the proposed baths is higher than that of the known formula (16-31% vs 10-17%). Fe content in the Zn-Fe deposits increases with increasing ion ratio Fe/Zn in the baths and current density of deposition. The anticorrosion property of the deposits depends on their iron content. Zn-27.5 atom % Fe is the best due to its lowest corrosion current (15.6 μA cm -2 ) , being 60% lower than that of Zn-only coating and the noblest corrosion voltage (-0.872 V SCE ). Therefore, the ZnO-(Ferrous Gluconate)-KOH system is promising because it is very simple, highly conductive, nontoxic, and efficient.
Lan C. J. - One of the best experts on this subject based on the ideXlab platform.
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Electrodeposition of Zn-Fe alloys using electrolytes of the system ZnO-(Ferrous Gluconate)-KOH
Electrochemical Society, 2011Co-Authors: Lan C. J.Abstract:[[abstract]]ZnO-(Ferrous Gluconate)-KOH electrolytes were developed as novel alkaline baths for electrodeposition of Zn-Fe alloys. Ferrous Gluconate is chosen due to its uniquely high solubility in concentrated KOH solution without an additional complexing agent. The electrical conductivity of the proposed baths is 510-560 mS cm(-1), 2.5-2.7 times that of a known formula. The cathodic current efficiency of the proposed baths is higher than that of the known formula (16-31% vs 10-17%). Fe content in the Zn-Fe deposits increases with increasing ion ratio Fe/Zn in the baths and current density of deposition. The anticorrosion property of the deposits depends on their iron content. Zn-27.5 atom% Fe is the best due to its lowest corrosion current (15.6 mu A cm(-2)) , being 60% lower than that of Zn-only coating and the noblest corrosion voltage (-0.872 V-SCE). Therefore, the ZnO-(Ferrous Gluconate)-KOH system is promising because it is very simple, highly conductive, nontoxic, and efficient. (c) 2006 The Electrochemical Society.[[fileno]]2020336010074[[department]]材料
C J Lan - One of the best experts on this subject based on the ideXlab platform.
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electrodeposition of zn fe alloys using electrolytes of the system zno Ferrous Gluconate koh
Journal of The Electrochemical Society, 2007Co-Authors: C J Lan, W Y Liu, Tsungshune ChinAbstract:ZnO-(Ferrous Gluconate)-KOH electrolytes were developed as novel alkaline baths for electrodeposition of Zn-Fe alloys. Ferrous Gluconate is chosen due to its uniquely high solubility in concentrated KOH solution without an additional complexing agent. The electrical conductivity of the proposed baths is 510-560 mS cm -1 , 2.5-2.7 times that of a known formula. The cathodic current efficiency of the proposed baths is higher than that of the known formula (16-31% vs 10-17%). Fe content in the Zn-Fe deposits increases with increasing ion ratio Fe/Zn in the baths and current density of deposition. The anticorrosion property of the deposits depends on their iron content. Zn-27.5 atom % Fe is the best due to its lowest corrosion current (15.6 μA cm -2 ) , being 60% lower than that of Zn-only coating and the noblest corrosion voltage (-0.872 V SCE ). Therefore, the ZnO-(Ferrous Gluconate)-KOH system is promising because it is very simple, highly conductive, nontoxic, and efficient.
Gianfranco Raimondi - One of the best experts on this subject based on the ideXlab platform.
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A pilot study on secondary anemia in "frailty" patients treated with Ferric Sodium EDTA in combination with vitamin C, folic acid, copper Gluconate, zinc Gluconate and selenomethionine: safety of treatment explored by HRV non-linear analysis as predi
European review for medical and pharmacological sciences, 2020Co-Authors: Nicola Marchitto, Adriana Romano, Michele Pironti, Annalisa Curcio, Alessia Petrucci, N Iannarelli, P T Paparello, Gianfranco RaimondiAbstract:Objective Iron deficiency anemia (IDA) in patients with heart disease is correlated with decreased exercise capacity and poor health-related quality of life, and predicts worse cardiovascular outcomes, especially for elderly patients. IDA can worsen cardiac function that can be monitored with Heart Rate Variability (HRV) analysis, providing important information about cardiac health. In a recent study we explored the effect and the tolerability of the administration of Ferric Sodium EDTA in combination with vitamin C, folic acid, copper Gluconate, zinc Gluconate and selenomethionine (Ferachel Forte®) in "frailty" patients with secondary anemia and low kidney failure, by analysing the HRV frequency domain. The aim of the present study is the further confirmation of the safety of the already evaluated intervention, by analysing non-linear domain of HRV. Patients and methods In this pilot study we enrolled 52 "frailty" elderly patients, with a recent diagnosis of secondary anemia due to iron deficiency, with Class II New York Heart Association (NYHA) hypertensive heart disease, low kidney failure, and atherosclerosis. The patients were divided in 2 groups: Group A (N=23 patients) received oral administration of Ferric Sodium EDTA in combination with vitamin C, folic acid, copper Gluconate, zinc Gluconate and selenomethionine (Ferachel Forte®) 2 tabs/day, containing 60 mg of Fe3+, for 24 days; Group B (N=29 patients) received intravenous administration of Ferrous Gluconate 63 mg/day added to saline solution, while they were hospitalized (15±5 days). We evaluated laboratory values of hemoglobin (Hb) and sideremia levels. Furthermore, we measured ECG signals before and after treatment, using non-linear analysis techniques. Results Both intravenous and oral treatments evaluated in this study, were effective and safe about the cardiovascular risk in "frailty" elderly patients, as resulted from non-linear HRV analysis. Efficacy results showed that hemoglobin and sideremia levels after treatments are significantly increased. The HRV non-linear analysis showed that all parameters evaluated, except for the SD1 values in the Group A, were not affected by treatments, confirming the absence of cardiovascular risk of the therapy. Conclusions Non-linear HRV evaluation confirmed that oral administration of Ferric Sodium EDTA, in combination with vitamin C, folic acid, copper Gluconate, zinc Gluconate and selenomethionine (Ferachel forte®) did not impact the cardiovascular risk, without causing adverse events typically reported with other iron supplementation therapies, both oral and intravenous.
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effect of ferric sodium edta administration in combination with vitamin c folic acid copper Gluconate zinc Gluconate and selenomethionine on cardiovascular risk evaluation exploration of the hrv frequency domain
Clinical Practice (Therapy), 2019Co-Authors: Nicola Marchitto, Liuba Fusco, Adriana Romano, Michele Pironti, Annalisa Curcio, Alessia Petrucci, Gianfranco RaimondiAbstract:Background: Anaemia is a frequent co-morbidity in old patients affected by chronic heart failure and/or respiratory diseases. Using the Heart Rate Variability (HRV) analysis is possible to provide an evaluation of the safety and the effectiveness of intervention. Objective: To evaluate the efficacy and safety of Ferric Sodium EDTA in combination with vitamin C, folic acid, copper Gluconate, zinc Gluconate and selenomethionine (Ferachel forte®) 2 tabs/day for 24 days in elderly patients with secondary anaemia, by exploring the HRV frequency domain. Methods: In 45 elderly patients with secondary anaemia and/or low-moderate kidney failure, laboratory values after administration of Ferric Sodium EDTA, 2 tabs a day, in combination with vitamin C, folic acid, copper Gluconate, zinc Gluconate and selenomethionine (Ferachel forte®) for 24 days (N=16 patients) or Ferrous Gluconate 63 mg/day added to saline solution administered using intravenous access during the hospitalization period of 15+5 days (N=29 patients) were evaluated. Also, ECG signals and bioelectrical impedance (BIA) were measured. Results: Oral iron supplementation with Ferric Sodium EDTA, in combination with vitamin C, folic acid, copper Gluconate, zinc Gluconate and selenomethionine (Ferachel forte®) confirmed to be effective and safe about the cardiovascular risk in old patients. This study showed the real superiority of the oral administration about the cardiovascular risk in elderly patients in comparison with intravenous administration of Ferrous Gluconate. Conclusion: This study confirms that Ferric Sodium EDTA combination (Ferachel forte®) can be a valid alternative to Ferrous Gluconate intravenous therapy (gold standard) in the treatment of secondary anaemia in elderly patients. In fact, during the treatment, efficacy results have been maintained without statistically significant variations about cardiovascular risk, evaluated by exploring the HRV frequency domain.
Susan J Fairweathertait - One of the best experts on this subject based on the ideXlab platform.
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alginate inhibits iron absorption from Ferrous Gluconate in a randomized controlled trial and reduces iron uptake into caco 2 cells
PLOS ONE, 2014Co-Authors: Anna A Wawer, Linda J Harvey, Jack R Dainty, Natalia Perezmoral, Phillip A Sharp, Susan J FairweathertaitAbstract:Previous in vitro results indicated that alginate beads might be a useful vehicle for food iron fortification. A human study was undertaken to test the hypothesis that alginate enhances iron absorption. A randomised, single blinded, cross-over trial was carried out in which iron absorption was measured from serum iron appearance after a test meal. Overnight-fasted volunteers (n=15) were given a test meal of 200 g cola-flavoured jelly plus 21 mg iron as Ferrous Gluconate, either in alginate beads mixed into the jelly or in a capsule. Iron absorption was lower from the alginate beads than from Ferrous Gluconate (8.5% and 12.6% respectively, p=0.003). Sub-group B (n=9) consumed the test meals together with 600 mg calcium to determine whether alginate modified the inhibitory effect of calcium. Calcium reduced iron absorption from Ferrous Gluconate by 51%, from 11.5% to 5.6% (p=0.014), and from alginate beads by 37%, from 8.3% to 5.2% (p=0.009). In vitro studies using Caco-2 cells were designed to explore the reasons for the difference between the previous in vitro findings and the human study; confirmed the inhibitory effect of alginate. Beads similar to those used in the human study were subjected to simulated gastrointestinal digestion, with and without cola jelly, and the digestate applied to Caco-2 cells. Both alginate and cola jelly significantly reduced iron uptake into the cells, by 34% (p=0.009) and 35% (p=0.003) respectively. The combination of cola jelly and calcium produced a very low ferritin response, 16.5% (p,0.001) of that observed with Ferrous Gluconate alone. The results of these studies demonstrate that alginate beads are not a useful delivery system for soluble salts of iron for the purpose of food fortification. Trial Registration: ClinicalTrials.gov NCT01528644
