The Experts below are selected from a list of 138 Experts worldwide ranked by ideXlab platform
Blandine Courbiere - One of the best experts on this subject based on the ideXlab platform.
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Fertility preservation in Turner syndrome: Karyotype does not predict ovarian response to stimulation
Clinical Endocrinology, 2019Co-Authors: Julia Vergier, Pauline Bottin, Jacqueline Saias, Rachel Reynaud, Catherine Guillemain, Blandine CourbiereAbstract:Objective Turner syndrome (TS) is responsible for gonadal dysgenesis with high risk of premature ovarian insufficiency. Little is known about Fertility preservation (FP) strategies is this population. Design Data from women with TS consulting with a Fertility Specialist in our FP centre from 2014 to 2018 were retrospectively collected. Measurement Total number of mature oocytes cryopreserved using vitrification. Patients Nine women with TS were referred. Three women with different karyotypes underwent controlled ovarian stimulation (COS) for oocyte vitrification. Mean age at TS diagnosis was 13.7 years [9‐20]. Mean referral delay between TS diagnosis and Fertility consultation was 9.7 years [7‐14]. First counselling for FP was provided at 23.7 years [18‐28]. Mean AMH serum level prior to COS was 53.8 pmol/L [3.6‐95]. Results All three women succeeded in obtaining cryopreserved oocytes with a mean number of 15.3 per woman [9‐20] and 9.2 per COS cycle [2‐20]. Ovarian response to COS was unexpectedly remarkable for the woman with a complete 45,X monosomy. Procedure was well tolerated for all women. None of them have used oocytes for in vitro fertilization yet. Conclusions Independently of karyotype, antral follicular count, AMH and FSH levels seemed to be reliable predictive markers of oocyte cryopreservation success. In a monosomic TS woman, cryptic ovarian mosaicism could explain a successful ovarian response to stimulation with a high number of retrieved oocytes. In case of spontaneous menarche, TS adolescents should be referred during transition to adulthood for FP counselling to avoid referral delay and limit time‐related diminished ovarian reserve.
Julia Vergier - One of the best experts on this subject based on the ideXlab platform.
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Fertility preservation in Turner syndrome: Karyotype does not predict ovarian response to stimulation
Clinical Endocrinology, 2019Co-Authors: Julia Vergier, Pauline Bottin, Jacqueline Saias, Rachel Reynaud, Catherine Guillemain, Blandine CourbiereAbstract:Objective Turner syndrome (TS) is responsible for gonadal dysgenesis with high risk of premature ovarian insufficiency. Little is known about Fertility preservation (FP) strategies is this population. Design Data from women with TS consulting with a Fertility Specialist in our FP centre from 2014 to 2018 were retrospectively collected. Measurement Total number of mature oocytes cryopreserved using vitrification. Patients Nine women with TS were referred. Three women with different karyotypes underwent controlled ovarian stimulation (COS) for oocyte vitrification. Mean age at TS diagnosis was 13.7 years [9‐20]. Mean referral delay between TS diagnosis and Fertility consultation was 9.7 years [7‐14]. First counselling for FP was provided at 23.7 years [18‐28]. Mean AMH serum level prior to COS was 53.8 pmol/L [3.6‐95]. Results All three women succeeded in obtaining cryopreserved oocytes with a mean number of 15.3 per woman [9‐20] and 9.2 per COS cycle [2‐20]. Ovarian response to COS was unexpectedly remarkable for the woman with a complete 45,X monosomy. Procedure was well tolerated for all women. None of them have used oocytes for in vitro fertilization yet. Conclusions Independently of karyotype, antral follicular count, AMH and FSH levels seemed to be reliable predictive markers of oocyte cryopreservation success. In a monosomic TS woman, cryptic ovarian mosaicism could explain a successful ovarian response to stimulation with a high number of retrieved oocytes. In case of spontaneous menarche, TS adolescents should be referred during transition to adulthood for FP counselling to avoid referral delay and limit time‐related diminished ovarian reserve.
Mary L. Gemignani - One of the best experts on this subject based on the ideXlab platform.
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Issues with Fertility in Young Women with Breast Cancer.
Current oncology reports, 2019Co-Authors: Nicole Christian, Mary L. GemignaniAbstract:Purpose of review There are competing risks and benefits of cancer therapies and Fertility preservation in young women with breast cancer. Here we discuss the impact of therapy on Fertility, Fertility preservation options, and emerging information in Fertility issues for the breast cancer patient. Recent findings All systemic forms of breast cancer treatment can impact future Fertility. Pre-therapy Fertility preservation may offer the best opportunity for future Fertility. Shared decision making with the individual patient and clinical scenario is important. Early referral to a Fertility Specialist should be offered to young patients. We find that Fertility preservation options for young women diagnosed with breast cancer are currently available, but potentially under-utilized. We conclude that a multidisciplinary approach is necessary, with discussion of potential risks and benefits of Fertility preservation options in the context of the patient's clinical disease.
Kirsten T. Macklon - One of the best experts on this subject based on the ideXlab platform.
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Young female cancer patients’ experiences with Fertility counselling and Fertility preservation—a qualitative small-scale study within the Danish health care setting
Upsala journal of medical sciences, 2016Co-Authors: Didde Hoeg, Lone Schmidt, Kirsten T. MacklonAbstract:AbstractIntroduction: Fertility counselling for young women newly diagnosed with cancer is an important field of preconceptional counselling. This qualitative, small-scale study explored how young women newly diagnosed with cancer experienced specialized Fertility preservation counselling and treatment in the public Danish health care system.Methods: Semi-structured, in-depth interviews were conducted with five women below 40 years recently diagnosed with cancer. All women received Fertility counselling by a Fertility Specialist at the Fertility Clinic, University Hospital of Copenhagen, Denmark before initiation of cancer treatment. Participants were interviewed at a place chosen by them, and interviews were recorded and transcribed verbatim. Data were analysed using systematic text condensation developed by Malterud and inspired by Giorgi’s phenomenological analysis.Results: None of the participants were aware that chemotherapy could destroy their eggs. The participants described how specialized fertili...
Pauline Bottin - One of the best experts on this subject based on the ideXlab platform.
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Fertility preservation in Turner syndrome: Karyotype does not predict ovarian response to stimulation
Clinical Endocrinology, 2019Co-Authors: Julia Vergier, Pauline Bottin, Jacqueline Saias, Rachel Reynaud, Catherine Guillemain, Blandine CourbiereAbstract:Objective Turner syndrome (TS) is responsible for gonadal dysgenesis with high risk of premature ovarian insufficiency. Little is known about Fertility preservation (FP) strategies is this population. Design Data from women with TS consulting with a Fertility Specialist in our FP centre from 2014 to 2018 were retrospectively collected. Measurement Total number of mature oocytes cryopreserved using vitrification. Patients Nine women with TS were referred. Three women with different karyotypes underwent controlled ovarian stimulation (COS) for oocyte vitrification. Mean age at TS diagnosis was 13.7 years [9‐20]. Mean referral delay between TS diagnosis and Fertility consultation was 9.7 years [7‐14]. First counselling for FP was provided at 23.7 years [18‐28]. Mean AMH serum level prior to COS was 53.8 pmol/L [3.6‐95]. Results All three women succeeded in obtaining cryopreserved oocytes with a mean number of 15.3 per woman [9‐20] and 9.2 per COS cycle [2‐20]. Ovarian response to COS was unexpectedly remarkable for the woman with a complete 45,X monosomy. Procedure was well tolerated for all women. None of them have used oocytes for in vitro fertilization yet. Conclusions Independently of karyotype, antral follicular count, AMH and FSH levels seemed to be reliable predictive markers of oocyte cryopreservation success. In a monosomic TS woman, cryptic ovarian mosaicism could explain a successful ovarian response to stimulation with a high number of retrieved oocytes. In case of spontaneous menarche, TS adolescents should be referred during transition to adulthood for FP counselling to avoid referral delay and limit time‐related diminished ovarian reserve.