The Experts below are selected from a list of 270 Experts worldwide ranked by ideXlab platform
János Rigó - One of the best experts on this subject based on the ideXlab platform.
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Isolated and ventriculomegaly-associated cases of spina bifida in genetic counseling: focus on Fetal Pathology.
Pathology research and practice, 2013Co-Authors: József Gábor Joó, Ákos Csaba, Zsanett Szigeti, János RigóAbstract:Abstract Cases of spina bifida alone and in association with ventriculomegaly represent important but different malformations according to clinical characteristics. In our study, we analyzed the data on pregancies terminated because of isolated cases ( n = 307) and ventriculomegaly-associated cases ( n = 372) of spina bifida. In spina bifida cases in association with hydrocephalus, positive obstetric history was found approximately 1.5 times more frequently than in the isolated ones. The incidence of positive genetic history was nearly two-fold in the latter cases. In isolated cases of spina bifida, associated malformations were more common than in cases of spina bifida and ventriculomegaly together. The most frequent associated malformations were those of the urogenital system (in cases of spina bifida: 11.1%; in cases of SB + V: 9.14%). The risk of recurrence of SB + V is significantly higher than that of isolated SB (8.9% vs. 2.1%). It can be concluded that positive genetic history is more common in cases of isolated spina bifida. Malformations out of the nervous system are more commonly observed in cases of isolated spina bifida. During the prenatal diagnostics of spina bifida, sonography must focus on malformations of the urogenital system.
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Spontaneous abortion in multiple pregnancy: Focus on Fetal Pathology
Pathology research and practice, 2012Co-Authors: József Gábor Joó, Ákos Csaba, Zsanett Szigeti, János RigóAbstract:Multiple pregnancy with its wide array of medical consequences poses an important condition during pregnancy. We performed perinatal autopsy in 49 cases of spontaneous abortion resulting from multiple pregnancies during the study period. Twenty-seven of the 44 twin pregnancies ending in miscarriage were conceived naturally, whereas 17 were conceived through assisted reproductive techniques. Each of the 5 triplet pregnancies ending in miscarriage was conceived through assisted reproductive techniques. There was a positive history of miscarriage in 22.4% of the cases. Monochorial placentation occurred more commonly in multiple pregnancies terminating with miscarriage than in multiple pregnancies without miscarriage. A Fetal congenital malformation was found in 8 cases. Three of these cases were conceived through assisted reproductive techniques, and 5 were conceived naturally. Miscarriage was due to intrauterine infection in 36% of the cases. Our study confirms that spontaneous abortion is more common in multiple than in singleton pregnancies. Monochorial placentation predicted a higher Fetal morbidity and mortality. In pregnancies where all fetuses were of male gender, miscarriage was more common than in pregnancies where all fetuses were female. Assisted reproductive techniques do not predispose to the development of Fetal malformations.
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Fetal Pathology in second-trimester miscarriages.
Fetal diagnosis and therapy, 2009Co-Authors: József Gábor Joó, Artúr Beke, Enikő Berkes, Zoltán Papp, János Rigó, Csaba PappAbstract:Objective: We aimed to analyze, based upon autopsy, the main characteristics of miscarriages in the second trimester. Methods: We have processed the results of fe
József Gábor Joó - One of the best experts on this subject based on the ideXlab platform.
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Isolated and ventriculomegaly-associated cases of spina bifida in genetic counseling: focus on Fetal Pathology.
Pathology research and practice, 2013Co-Authors: József Gábor Joó, Ákos Csaba, Zsanett Szigeti, János RigóAbstract:Abstract Cases of spina bifida alone and in association with ventriculomegaly represent important but different malformations according to clinical characteristics. In our study, we analyzed the data on pregancies terminated because of isolated cases ( n = 307) and ventriculomegaly-associated cases ( n = 372) of spina bifida. In spina bifida cases in association with hydrocephalus, positive obstetric history was found approximately 1.5 times more frequently than in the isolated ones. The incidence of positive genetic history was nearly two-fold in the latter cases. In isolated cases of spina bifida, associated malformations were more common than in cases of spina bifida and ventriculomegaly together. The most frequent associated malformations were those of the urogenital system (in cases of spina bifida: 11.1%; in cases of SB + V: 9.14%). The risk of recurrence of SB + V is significantly higher than that of isolated SB (8.9% vs. 2.1%). It can be concluded that positive genetic history is more common in cases of isolated spina bifida. Malformations out of the nervous system are more commonly observed in cases of isolated spina bifida. During the prenatal diagnostics of spina bifida, sonography must focus on malformations of the urogenital system.
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Spontaneous abortion in multiple pregnancy: Focus on Fetal Pathology
Pathology research and practice, 2012Co-Authors: József Gábor Joó, Ákos Csaba, Zsanett Szigeti, János RigóAbstract:Multiple pregnancy with its wide array of medical consequences poses an important condition during pregnancy. We performed perinatal autopsy in 49 cases of spontaneous abortion resulting from multiple pregnancies during the study period. Twenty-seven of the 44 twin pregnancies ending in miscarriage were conceived naturally, whereas 17 were conceived through assisted reproductive techniques. Each of the 5 triplet pregnancies ending in miscarriage was conceived through assisted reproductive techniques. There was a positive history of miscarriage in 22.4% of the cases. Monochorial placentation occurred more commonly in multiple pregnancies terminating with miscarriage than in multiple pregnancies without miscarriage. A Fetal congenital malformation was found in 8 cases. Three of these cases were conceived through assisted reproductive techniques, and 5 were conceived naturally. Miscarriage was due to intrauterine infection in 36% of the cases. Our study confirms that spontaneous abortion is more common in multiple than in singleton pregnancies. Monochorial placentation predicted a higher Fetal morbidity and mortality. In pregnancies where all fetuses were of male gender, miscarriage was more common than in pregnancies where all fetuses were female. Assisted reproductive techniques do not predispose to the development of Fetal malformations.
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Fetal Pathology in second-trimester miscarriages.
Fetal diagnosis and therapy, 2009Co-Authors: József Gábor Joó, Artúr Beke, Enikő Berkes, Zoltán Papp, János Rigó, Csaba PappAbstract:Objective: We aimed to analyze, based upon autopsy, the main characteristics of miscarriages in the second trimester. Methods: We have processed the results of fe
Jose Antonio Sainz Bueno - One of the best experts on this subject based on the ideXlab platform.
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evaluation of levator ani muscle throughout the different stages of labor by transperineal 3d ultrasound
Neurourology and Urodynamics, 2017Co-Authors: Jose Antonio Garcia Mejido, Carmen Suarez Serrano, Ana Fernendez Palacin, Adriana Aquise Pino, Maria Jose Bonomi Barby, Jose Antonio Sainz BuenoAbstract:OBJECTIVE Description and assessment by 3-D transperineal ultrasound of modifications suffered by pelvic floor muscles during the passage of the Fetal head through the birth canal during the second stage of labor, as well as the identification of the precise moment in which levator ani muscle avulsion takes place. MATERIALS AND METHODS Patients included were 35 primigravidae, recruited during the first stage of labor, with at term pregnancy (37-42 weeks), without serious maternal-Fetal Pathology and cephalic presentation. A prospective observational study of 35 primigravidae, recruited during the first stage of labor, with at term pregnancy (37-42 weeks), with fetus in cephalic presentation and without serious maternal-Fetal Pathology. Sonographic evaluation was carried out by 3-D transperineal ultrasound during the first and second stages of labor (with Fetal head in 1st, 2nd-3rd and 4th planes of Hodge), immediately postpartum and 6 months postpartum. Ultrasound parameters studied were antero-posterior and transverse diameters, as well as levator hiatus area and levator ani muscle thickness and area. RESULTS Twenty-one patients were studied (15 spontaneous deliveries; 6 instrumental deliveries). When measured with Fetal head in the 4th plane of Hodge, a significant increase both in the levator hiatus area (15.39 cm2/15.68 cm2/20.96 cm2/42.55 cm2/22.92 cm2/18.18 cm2; P < 0.0005) and in the levator ani muscle area (8.78 cm2/9.18 cm2/9.69 cm2/15.07 cm2/11.33 cm2/12.36 cm2; P < 0.0005) was identified. Four cases of unilateral right avulsion (two vacuum and two forceps deliveries) were identified. CONCLUSIONS We conclude that the phase of delivery that causes a major increase in the area of the levator hiatus area and in the levator ani muscle area is when the Fetal head reaches the 4th plane of Hodge. Furthermore, data in our paper indicates that the exact moment in which the avulsion of the levator ani muscle is produced is when the bulging of the Fetal head on the maternal perineum occurs.
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Evaluation of levator ani muscle throughout the different stages of labor by transperineal 3D ultrasound.
Neurourology and Urodynamics, 2016Co-Authors: Jose Antonio Garcia Mejido, Carmen Suarez Serrano, Ana Fernendez Palacin, Adriana Aquise Pino, Maria Jose Bonomi Barby, Jose Antonio Sainz BuenoAbstract:OBJECTIVE Description and assessment by 3-D transperineal ultrasound of modifications suffered by pelvic floor muscles during the passage of the Fetal head through the birth canal during the second stage of labor, as well as the identification of the precise moment in which levator ani muscle avulsion takes place. MATERIALS AND METHODS Patients included were 35 primigravidae, recruited during the first stage of labor, with at term pregnancy (37-42 weeks), without serious maternal-Fetal Pathology and cephalic presentation. A prospective observational study of 35 primigravidae, recruited during the first stage of labor, with at term pregnancy (37-42 weeks), with fetus in cephalic presentation and without serious maternal-Fetal Pathology. Sonographic evaluation was carried out by 3-D transperineal ultrasound during the first and second stages of labor (with Fetal head in 1st, 2nd-3rd and 4th planes of Hodge), immediately postpartum and 6 months postpartum. Ultrasound parameters studied were antero-posterior and transverse diameters, as well as levator hiatus area and levator ani muscle thickness and area. RESULTS Twenty-one patients were studied (15 spontaneous deliveries; 6 instrumental deliveries). When measured with Fetal head in the 4th plane of Hodge, a significant increase both in the levator hiatus area (15.39 cm2/15.68 cm2/20.96 cm2/42.55 cm2/22.92 cm2/18.18 cm2; P
Leticia Reyes - One of the best experts on this subject based on the ideXlab platform.
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Host Genetic Background Impacts Disease Outcome During Intrauterine Infection with Ureaplasma parvum
PLOS ONE, 2012Co-Authors: Maria Von Chamier, Mary K Reinhard, Ayman B Allam, Mary B Brown, Leticia ReyesAbstract:Ureaplasma parvum, an opportunistic pathogen of the human urogenital tract, has been implicated in contributing to chorioamnionitis, Fetal morbidity, and Fetal mortality. It has been proposed that the host genetic background is a critical factor in adverse pregnancy outcome as sequela to U. parvum intra-amniotic infection. To test this hypothesis we assessed the impact of intrauterine U. parvum infection in the prototypical TH1/M1 C57BL/6 and TH2/M2 BALB/c mouse strain. Sterile medium or U. parvum was inoculated into each uterine horn and animals were evaluated for intra-amniotic infection, Fetal infection, chorioamnionitis and Fetal Pathology at 72 hours post-inoculation. Disease outcome was assessed by microbial culture, in situ detection of U. parvum in Fetal and utero-placental tissues, grading of chorioamnionitis, and placental gene expression of IL-1α, IL-1β, IL-6, TNF-α, S100A8, and S100A9. Placental infection and colonization rates were equivalent in both strains. The in situ distribution of U. parvum in placental tissues was also similar. However, a significantly greater proportion of BALB/c fetuses were infected (P
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host genetic background impacts disease outcome during intrauterine infection with ureaplasma parvum
PLOS ONE, 2012Co-Authors: Maria Von Chamier, Mary K Reinhard, Ayman B Allam, Mary B Brown, Leticia ReyesAbstract:Ureaplasma parvum, an opportunistic pathogen of the human urogenital tract, has been implicated in contributing to chorioamnionitis, Fetal morbidity, and Fetal mortality. It has been proposed that the host genetic background is a critical factor in adverse pregnancy outcome as sequela to U. parvum intra-amniotic infection. To test this hypothesis we assessed the impact of intrauterine U. parvum infection in the prototypical TH1/M1 C57BL/6 and TH2/M2 BALB/c mouse strain. Sterile medium or U. parvum was inoculated into each uterine horn and animals were evaluated for intra-amniotic infection, Fetal infection, chorioamnionitis and Fetal Pathology at 72 hours post-inoculation. Disease outcome was assessed by microbial culture, in situ detection of U. parvum in Fetal and utero-placental tissues, grading of chorioamnionitis, and placental gene expression of IL-1α, IL-1β, IL-6, TNF-α, S100A8, and S100A9. Placental infection and colonization rates were equivalent in both strains. The in situ distribution of U. parvum in placental tissues was also similar. However, a significantly greater proportion of BALB/c fetuses were infected (P<0.02). C57BL/6 infected animals predominantly exhibited mild to moderate chorioamnionitis (P<0.0001), and a significant reduction in placental expression of IL-1α, IL-1β, IL-6, TNF-α, S100A8, and S100A9 compared to sham controls (P<0.02). Conversely, severe protracted chorioamnionitis with cellular necrosis was the predominant lesion phenotype in BALB/c mice, which also exhibited a significant increase in placental expression of IL-1α, IL-1β, IL-6, TNF-α, S100A8, and S100A9 (P<0.01). Fetal Pathology in BALB/c was multi-organ and included brain, lung, heart, liver, and intestine, whereas Fetal Pathology in C57BL/6 was only detected in the liver and intestines. These results confirm that the host genetic background is a major determinant in ureaplasmal induced chorioamnionitis with Fetal infection and Fetal inflammatory response.
Jose Antonio Garcia Mejido - One of the best experts on this subject based on the ideXlab platform.
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evaluation of levator ani muscle throughout the different stages of labor by transperineal 3d ultrasound
Neurourology and Urodynamics, 2017Co-Authors: Jose Antonio Garcia Mejido, Carmen Suarez Serrano, Ana Fernendez Palacin, Adriana Aquise Pino, Maria Jose Bonomi Barby, Jose Antonio Sainz BuenoAbstract:OBJECTIVE Description and assessment by 3-D transperineal ultrasound of modifications suffered by pelvic floor muscles during the passage of the Fetal head through the birth canal during the second stage of labor, as well as the identification of the precise moment in which levator ani muscle avulsion takes place. MATERIALS AND METHODS Patients included were 35 primigravidae, recruited during the first stage of labor, with at term pregnancy (37-42 weeks), without serious maternal-Fetal Pathology and cephalic presentation. A prospective observational study of 35 primigravidae, recruited during the first stage of labor, with at term pregnancy (37-42 weeks), with fetus in cephalic presentation and without serious maternal-Fetal Pathology. Sonographic evaluation was carried out by 3-D transperineal ultrasound during the first and second stages of labor (with Fetal head in 1st, 2nd-3rd and 4th planes of Hodge), immediately postpartum and 6 months postpartum. Ultrasound parameters studied were antero-posterior and transverse diameters, as well as levator hiatus area and levator ani muscle thickness and area. RESULTS Twenty-one patients were studied (15 spontaneous deliveries; 6 instrumental deliveries). When measured with Fetal head in the 4th plane of Hodge, a significant increase both in the levator hiatus area (15.39 cm2/15.68 cm2/20.96 cm2/42.55 cm2/22.92 cm2/18.18 cm2; P < 0.0005) and in the levator ani muscle area (8.78 cm2/9.18 cm2/9.69 cm2/15.07 cm2/11.33 cm2/12.36 cm2; P < 0.0005) was identified. Four cases of unilateral right avulsion (two vacuum and two forceps deliveries) were identified. CONCLUSIONS We conclude that the phase of delivery that causes a major increase in the area of the levator hiatus area and in the levator ani muscle area is when the Fetal head reaches the 4th plane of Hodge. Furthermore, data in our paper indicates that the exact moment in which the avulsion of the levator ani muscle is produced is when the bulging of the Fetal head on the maternal perineum occurs.
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Evaluation of levator ani muscle throughout the different stages of labor by transperineal 3D ultrasound.
Neurourology and Urodynamics, 2016Co-Authors: Jose Antonio Garcia Mejido, Carmen Suarez Serrano, Ana Fernendez Palacin, Adriana Aquise Pino, Maria Jose Bonomi Barby, Jose Antonio Sainz BuenoAbstract:OBJECTIVE Description and assessment by 3-D transperineal ultrasound of modifications suffered by pelvic floor muscles during the passage of the Fetal head through the birth canal during the second stage of labor, as well as the identification of the precise moment in which levator ani muscle avulsion takes place. MATERIALS AND METHODS Patients included were 35 primigravidae, recruited during the first stage of labor, with at term pregnancy (37-42 weeks), without serious maternal-Fetal Pathology and cephalic presentation. A prospective observational study of 35 primigravidae, recruited during the first stage of labor, with at term pregnancy (37-42 weeks), with fetus in cephalic presentation and without serious maternal-Fetal Pathology. Sonographic evaluation was carried out by 3-D transperineal ultrasound during the first and second stages of labor (with Fetal head in 1st, 2nd-3rd and 4th planes of Hodge), immediately postpartum and 6 months postpartum. Ultrasound parameters studied were antero-posterior and transverse diameters, as well as levator hiatus area and levator ani muscle thickness and area. RESULTS Twenty-one patients were studied (15 spontaneous deliveries; 6 instrumental deliveries). When measured with Fetal head in the 4th plane of Hodge, a significant increase both in the levator hiatus area (15.39 cm2/15.68 cm2/20.96 cm2/42.55 cm2/22.92 cm2/18.18 cm2; P