Ventriculomegaly

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L Guibaud - One of the best experts on this subject based on the ideXlab platform.

  • dilatation of the supra pineal recess on prenatal imaging early clue for obstructive Ventriculomegaly downstream of the third ventricle
    Prenatal Diagnosis, 2014
    Co-Authors: Caroline Azzi, Mariebrune Giaconia, Audrey Lacalm, Mona Massoud, P Gaucherand, L Guibaud
    Abstract:

    Objective The objective of this article is to describe the diagnostic significance of prenatal identification of dilated supra-pineal recess (SPR) in cases of Ventriculomegaly. Method A retrospective study, based on neurosonography and magnetic resonance imaging, of a series of five prenatal cases referred to our institution because of Ventriculomegaly associated with dilatation of the SPR. Results Ventriculomegaly of obstructive origin was diagnosed in all cases and related to obstruction downstream of the third ventricle. The diagnosis in the five prenatal cases, confirmed on early post-natal imaging, included the following: malformative aqueductal stenosis, ischemic–haemorrhagic parenchymal supra-tentorial insult complicated by aqueductal stenosis, Blake's pouch cyst, cystic lesion of the posterior fossa and sub-ependymal haemorrhage and Dandy–Walker malformation. In all cases, the third ventricle was prominent and associated with a dilated SPR. In two cases, the dilatation of the SPR was an early clue to e obstructive Ventriculomegaly, which was initially minor and became severe on follow-up imaging. Conclusion The presence of a dilated SPR prenatally in the presence of even mild Ventriculomegaly should prompt evaluation and follow-up for the presence of obstructive Ventriculomegaly with obstruction located downstream of the third ventricle. © 2014 John Wiley & Sons, Ltd.

  • Dilatation of the supra‐pineal recess on prenatal imaging: early clue for obstructive Ventriculomegaly downstream of the third ventricle
    Prenatal Diagnosis, 2014
    Co-Authors: Caroline Azzi, Mariebrune Giaconia, Audrey Lacalm, Mona Massoud, P Gaucherand, L Guibaud
    Abstract:

    Objective The objective of this article is to describe the diagnostic significance of prenatal identification of dilated supra-pineal recess (SPR) in cases of Ventriculomegaly. Method A retrospective study, based on neurosonography and magnetic resonance imaging, of a series of five prenatal cases referred to our institution because of Ventriculomegaly associated with dilatation of the SPR. Results Ventriculomegaly of obstructive origin was diagnosed in all cases and related to obstruction downstream of the third ventricle. The diagnosis in the five prenatal cases, confirmed on early post-natal imaging, included the following: malformative aqueductal stenosis, ischemic–haemorrhagic parenchymal supra-tentorial insult complicated by aqueductal stenosis, Blake's pouch cyst, cystic lesion of the posterior fossa and sub-ependymal haemorrhage and Dandy–Walker malformation. In all cases, the third ventricle was prominent and associated with a dilated SPR. In two cases, the dilatation of the SPR was an early clue to e obstructive Ventriculomegaly, which was initially minor and became severe on follow-up imaging. Conclusion The presence of a dilated SPR prenatally in the presence of even mild Ventriculomegaly should prompt evaluation and follow-up for the presence of obstructive Ventriculomegaly with obstruction located downstream of the third ventricle. © 2014 John Wiley & Sons, Ltd.

Mona Massoud - One of the best experts on this subject based on the ideXlab platform.

  • dilatation of the supra pineal recess on prenatal imaging early clue for obstructive Ventriculomegaly downstream of the third ventricle
    Prenatal Diagnosis, 2014
    Co-Authors: Caroline Azzi, Mariebrune Giaconia, Audrey Lacalm, Mona Massoud, P Gaucherand, L Guibaud
    Abstract:

    Objective The objective of this article is to describe the diagnostic significance of prenatal identification of dilated supra-pineal recess (SPR) in cases of Ventriculomegaly. Method A retrospective study, based on neurosonography and magnetic resonance imaging, of a series of five prenatal cases referred to our institution because of Ventriculomegaly associated with dilatation of the SPR. Results Ventriculomegaly of obstructive origin was diagnosed in all cases and related to obstruction downstream of the third ventricle. The diagnosis in the five prenatal cases, confirmed on early post-natal imaging, included the following: malformative aqueductal stenosis, ischemic–haemorrhagic parenchymal supra-tentorial insult complicated by aqueductal stenosis, Blake's pouch cyst, cystic lesion of the posterior fossa and sub-ependymal haemorrhage and Dandy–Walker malformation. In all cases, the third ventricle was prominent and associated with a dilated SPR. In two cases, the dilatation of the SPR was an early clue to e obstructive Ventriculomegaly, which was initially minor and became severe on follow-up imaging. Conclusion The presence of a dilated SPR prenatally in the presence of even mild Ventriculomegaly should prompt evaluation and follow-up for the presence of obstructive Ventriculomegaly with obstruction located downstream of the third ventricle. © 2014 John Wiley & Sons, Ltd.

  • Dilatation of the supra‐pineal recess on prenatal imaging: early clue for obstructive Ventriculomegaly downstream of the third ventricle
    Prenatal Diagnosis, 2014
    Co-Authors: Caroline Azzi, Mariebrune Giaconia, Audrey Lacalm, Mona Massoud, P Gaucherand, L Guibaud
    Abstract:

    Objective The objective of this article is to describe the diagnostic significance of prenatal identification of dilated supra-pineal recess (SPR) in cases of Ventriculomegaly. Method A retrospective study, based on neurosonography and magnetic resonance imaging, of a series of five prenatal cases referred to our institution because of Ventriculomegaly associated with dilatation of the SPR. Results Ventriculomegaly of obstructive origin was diagnosed in all cases and related to obstruction downstream of the third ventricle. The diagnosis in the five prenatal cases, confirmed on early post-natal imaging, included the following: malformative aqueductal stenosis, ischemic–haemorrhagic parenchymal supra-tentorial insult complicated by aqueductal stenosis, Blake's pouch cyst, cystic lesion of the posterior fossa and sub-ependymal haemorrhage and Dandy–Walker malformation. In all cases, the third ventricle was prominent and associated with a dilated SPR. In two cases, the dilatation of the SPR was an early clue to e obstructive Ventriculomegaly, which was initially minor and became severe on follow-up imaging. Conclusion The presence of a dilated SPR prenatally in the presence of even mild Ventriculomegaly should prompt evaluation and follow-up for the presence of obstructive Ventriculomegaly with obstruction located downstream of the third ventricle. © 2014 John Wiley & Sons, Ltd.

  • severe second trimester obstructive Ventriculomegaly related to disorders of diencephalic mesencephalic and rhombencephalic differentiation
    Ultrasound in Obstetrics & Gynecology, 2013
    Co-Authors: M Cagneaux, Mona Massoud, P Gaucherand, Alexandre Vasiljevic, F Allias, J Massardier, Laurent Guibaud
    Abstract:

    By review of a series of cases, we set out to identify sonographic features suggestive of an obstructive mechanism in second-trimester fetuses with Ventriculomegaly and describe developmental disorders related to pathological differentiation of the diencephalon, mesencephalon and rhombencephalon that lead to obstruction of cerebrospinal fluid flow. We studied retrospectively 11 fetuses referred for severe second-trimester Ventriculomegaly of undetermined origin. Neurosonography was performed with detailed analysis of the third ventricle, thalami, cerebral aqueduct and cerebellum. The cerebral imaging data were compared with neuropathological data in eight patients, with a focus on the level and etiology of the obstruction. Parenchymal thinning and reduction of the pericerebral spaces were highly suggestive of Ventriculomegaly due to an obstructive mechanism. The Ventriculomegaly was related to diencephalosynapsis (thalamic fusion and third ventricle atresia) in five cases and partial/complete aqueduct stenosis in six; it was associated with cerebellar hypoplasia in six cases, including rhombencephalosynapsis in two cases. In nine patients, disorders of the diencephalon, mesencephalon and rhombencephalon were present. In cases of severe isolated Ventriculomegaly in which sonographic features are suggestive of an obstructive mechanism, close examination of the third ventricle, thalami, aqueduct of Sylvius and cerebellum may reveal pathological differentiation of the diencephalon, mesencephalon or rhombencephalon, often in combination. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.

P Gaucherand - One of the best experts on this subject based on the ideXlab platform.

  • dilatation of the supra pineal recess on prenatal imaging early clue for obstructive Ventriculomegaly downstream of the third ventricle
    Prenatal Diagnosis, 2014
    Co-Authors: Caroline Azzi, Mariebrune Giaconia, Audrey Lacalm, Mona Massoud, P Gaucherand, L Guibaud
    Abstract:

    Objective The objective of this article is to describe the diagnostic significance of prenatal identification of dilated supra-pineal recess (SPR) in cases of Ventriculomegaly. Method A retrospective study, based on neurosonography and magnetic resonance imaging, of a series of five prenatal cases referred to our institution because of Ventriculomegaly associated with dilatation of the SPR. Results Ventriculomegaly of obstructive origin was diagnosed in all cases and related to obstruction downstream of the third ventricle. The diagnosis in the five prenatal cases, confirmed on early post-natal imaging, included the following: malformative aqueductal stenosis, ischemic–haemorrhagic parenchymal supra-tentorial insult complicated by aqueductal stenosis, Blake's pouch cyst, cystic lesion of the posterior fossa and sub-ependymal haemorrhage and Dandy–Walker malformation. In all cases, the third ventricle was prominent and associated with a dilated SPR. In two cases, the dilatation of the SPR was an early clue to e obstructive Ventriculomegaly, which was initially minor and became severe on follow-up imaging. Conclusion The presence of a dilated SPR prenatally in the presence of even mild Ventriculomegaly should prompt evaluation and follow-up for the presence of obstructive Ventriculomegaly with obstruction located downstream of the third ventricle. © 2014 John Wiley & Sons, Ltd.

  • Dilatation of the supra‐pineal recess on prenatal imaging: early clue for obstructive Ventriculomegaly downstream of the third ventricle
    Prenatal Diagnosis, 2014
    Co-Authors: Caroline Azzi, Mariebrune Giaconia, Audrey Lacalm, Mona Massoud, P Gaucherand, L Guibaud
    Abstract:

    Objective The objective of this article is to describe the diagnostic significance of prenatal identification of dilated supra-pineal recess (SPR) in cases of Ventriculomegaly. Method A retrospective study, based on neurosonography and magnetic resonance imaging, of a series of five prenatal cases referred to our institution because of Ventriculomegaly associated with dilatation of the SPR. Results Ventriculomegaly of obstructive origin was diagnosed in all cases and related to obstruction downstream of the third ventricle. The diagnosis in the five prenatal cases, confirmed on early post-natal imaging, included the following: malformative aqueductal stenosis, ischemic–haemorrhagic parenchymal supra-tentorial insult complicated by aqueductal stenosis, Blake's pouch cyst, cystic lesion of the posterior fossa and sub-ependymal haemorrhage and Dandy–Walker malformation. In all cases, the third ventricle was prominent and associated with a dilated SPR. In two cases, the dilatation of the SPR was an early clue to e obstructive Ventriculomegaly, which was initially minor and became severe on follow-up imaging. Conclusion The presence of a dilated SPR prenatally in the presence of even mild Ventriculomegaly should prompt evaluation and follow-up for the presence of obstructive Ventriculomegaly with obstruction located downstream of the third ventricle. © 2014 John Wiley & Sons, Ltd.

  • severe second trimester obstructive Ventriculomegaly related to disorders of diencephalic mesencephalic and rhombencephalic differentiation
    Ultrasound in Obstetrics & Gynecology, 2013
    Co-Authors: M Cagneaux, Mona Massoud, P Gaucherand, Alexandre Vasiljevic, F Allias, J Massardier, Laurent Guibaud
    Abstract:

    By review of a series of cases, we set out to identify sonographic features suggestive of an obstructive mechanism in second-trimester fetuses with Ventriculomegaly and describe developmental disorders related to pathological differentiation of the diencephalon, mesencephalon and rhombencephalon that lead to obstruction of cerebrospinal fluid flow. We studied retrospectively 11 fetuses referred for severe second-trimester Ventriculomegaly of undetermined origin. Neurosonography was performed with detailed analysis of the third ventricle, thalami, cerebral aqueduct and cerebellum. The cerebral imaging data were compared with neuropathological data in eight patients, with a focus on the level and etiology of the obstruction. Parenchymal thinning and reduction of the pericerebral spaces were highly suggestive of Ventriculomegaly due to an obstructive mechanism. The Ventriculomegaly was related to diencephalosynapsis (thalamic fusion and third ventricle atresia) in five cases and partial/complete aqueduct stenosis in six; it was associated with cerebellar hypoplasia in six cases, including rhombencephalosynapsis in two cases. In nine patients, disorders of the diencephalon, mesencephalon and rhombencephalon were present. In cases of severe isolated Ventriculomegaly in which sonographic features are suggestive of an obstructive mechanism, close examination of the third ventricle, thalami, aqueduct of Sylvius and cerebellum may reveal pathological differentiation of the diencephalon, mesencephalon or rhombencephalon, often in combination. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.

G Pagani - One of the best experts on this subject based on the ideXlab platform.

  • neurodevelopmental outcome in isolated mild fetal Ventriculomegaly systematic review and meta analysis
    Ultrasound in Obstetrics & Gynecology, 2014
    Co-Authors: B Thilaganathan, G Pagani, F Prefumo
    Abstract:

    Objectives The finding of fetal Ventriculomegaly is variably associated with other fetal abnormalities and, even when isolated, is thought to be linked to abnormal neurodevelopmental outcome. The aim of this study was to undertake a systematic review and meta-analysis of the current literature to assess the prevalence of neurodevelopmental delay in cases of isolated mild fetal Ventriculomegaly, as well as the false-negative rate of prenatal imaging for the diagnosis of associated abnormalities in patients referred for isolated mild Ventriculomegaly. Methods Studies that assessed neurodevelopmental outcome in isolated Ventriculomegaly were identified from a search of scientific databases. Studies that did not check for karyotype or that excluded cases of bilateral Ventriculomegaly were not included in the analysis. Ventriculomegaly was defined as mild when the width of the ventricular atrium was between 10 and 15 mm. Cases in which an associated abnormality (abnormal karyotype, structural abnormality or fetal infection) was observed either before or after birth were not considered as part of the isolated group. Neurodevelopmental delay was defined as an abnormal quotient score, according to the test used. Results The search yielded 961 possible citations; of these, 904 were excluded by review of the title or abstract as they did not meet the selection criteria. Full manuscripts were retrieved for 57 studies, and 20 were included in the review with a total of 699 cases of isolated mild Ventriculomegaly. The overall prevalence of neurodevelopmental delay was 7.9% (95% CI, 4.7–11.1%). Of the 20 studies included in the systematic review, nine reported data on postnatal imaging, showing a prevalence of previously undiagnosed findings of 7.4% (95% CI, 3.1–11.8%). Conclusions The false-negative rate of prenatal imaging is 7.4% in apparently isolated fetal Ventriculomegaly of ≤ 15 mm. The incidence of neurodevelopmental delay in truly isolated Ventriculomegaly of ≤ 15 mm is 7.9%. As the latter rate is similar to that noted in the general population, large prospective cohort studies assessing the prevalence of childhood disability, rather than subtle neurodevelopmental delay, are required. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd

B Thilaganathan - One of the best experts on this subject based on the ideXlab platform.

  • perinatal and long term outcomes in fetuses diagnosed with isolated unilateral Ventriculomegaly systematic review and meta analysis
    Ultrasound in Obstetrics & Gynecology, 2017
    Co-Authors: Carolina Scala, A Familiari, A Pinas, A T Papageorghiou, A Bhide, B Thilaganathan, A Khalil
    Abstract:

    Objectives The majority of studies on fetal Ventriculomegaly have focused on the perinatal and long-term outcomes in fetuses with an antenatal diagnosis of bilateral Ventriculomegaly. The aim of this study was to undertake a systematic review and meta-analysis to quantify the perinatal and long-term outcomes in fetuses diagnosed in the second or third trimester of pregnancy with isolated unilateral Ventriculomegaly. Methods MEDLINE, EMBASE and The Cochrane Library were searched electronically. Outcomes investigated included incidence of aneuploidy, congenital infection, progression of Ventriculomegaly, associated brain and extracerebral abnormalities in the apparently isolated cases and neurodevelopmental delay in both apparently and truly isolated cases. Sensitivity analysis was performed according to whether the Ventriculomegaly was mild/moderate (atrial width < 15 mm) or severe (atrial width ≥ 15 mm). Reference lists within relevant articles and reviews were hand-searched for additional reports. Cohort and case–control studies were included. Meta-analysis of proportions was used, and between-study heterogeneity was assessed using the I2 test. Results The search yielded 2053 citations. The full text was retrieved for 202, and 11 studies were included in the systematic review. In fetuses with apparently isolated unilateral Ventriculomegaly, no chromosomal abnormalities were identified and the pooled prevalence of congenital infection was 8.2% (95% CI, 3.6–14.5%). The pooled prevalence of additional brain abnormalities detected prenatally and postnatally by magnetic resonance imaging was 5.1% (95% CI, 0.2–16.1%) and 6.4% (95% CI, 0.3–19.4%), respectively. The pooled prevalence of abnormal neurodevelopment was 5.9% (95% CI, 2.2–11.2%) in apparently isolated cases with an atrial width of < 15 mm, and it was 7.0% (95% CI, 3.2–12.2%) in fetuses with truly isolated unilateral Ventriculomegaly. Most cases with apparently isolated Ventriculomegaly were classified as mild/moderate (93.5%) and therefore the outcomes in this group were similar to those in the whole cohort of apparently isolated Ventriculomegaly. Conclusions The prevalence of aneuploidy, congenital infection and neurodevelopmental delay in fetuses with a prenatal diagnosis of isolated unilateral Ventriculomegaly is likely to be low. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.

  • neurodevelopmental outcome in isolated mild fetal Ventriculomegaly systematic review and meta analysis
    Ultrasound in Obstetrics & Gynecology, 2014
    Co-Authors: B Thilaganathan, G Pagani, F Prefumo
    Abstract:

    Objectives The finding of fetal Ventriculomegaly is variably associated with other fetal abnormalities and, even when isolated, is thought to be linked to abnormal neurodevelopmental outcome. The aim of this study was to undertake a systematic review and meta-analysis of the current literature to assess the prevalence of neurodevelopmental delay in cases of isolated mild fetal Ventriculomegaly, as well as the false-negative rate of prenatal imaging for the diagnosis of associated abnormalities in patients referred for isolated mild Ventriculomegaly. Methods Studies that assessed neurodevelopmental outcome in isolated Ventriculomegaly were identified from a search of scientific databases. Studies that did not check for karyotype or that excluded cases of bilateral Ventriculomegaly were not included in the analysis. Ventriculomegaly was defined as mild when the width of the ventricular atrium was between 10 and 15 mm. Cases in which an associated abnormality (abnormal karyotype, structural abnormality or fetal infection) was observed either before or after birth were not considered as part of the isolated group. Neurodevelopmental delay was defined as an abnormal quotient score, according to the test used. Results The search yielded 961 possible citations; of these, 904 were excluded by review of the title or abstract as they did not meet the selection criteria. Full manuscripts were retrieved for 57 studies, and 20 were included in the review with a total of 699 cases of isolated mild Ventriculomegaly. The overall prevalence of neurodevelopmental delay was 7.9% (95% CI, 4.7–11.1%). Of the 20 studies included in the systematic review, nine reported data on postnatal imaging, showing a prevalence of previously undiagnosed findings of 7.4% (95% CI, 3.1–11.8%). Conclusions The false-negative rate of prenatal imaging is 7.4% in apparently isolated fetal Ventriculomegaly of ≤ 15 mm. The incidence of neurodevelopmental delay in truly isolated Ventriculomegaly of ≤ 15 mm is 7.9%. As the latter rate is similar to that noted in the general population, large prospective cohort studies assessing the prevalence of childhood disability, rather than subtle neurodevelopmental delay, are required. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd