The Experts below are selected from a list of 4911 Experts worldwide ranked by ideXlab platform
Changren Zhou - One of the best experts on this subject based on the ideXlab platform.
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immobilization of bovine serum albumin via mussel inspired polydopamine coating on electrospun polyethersulfone pes Fiber Mat for effective bilirubin adsorption
Applied Surface Science, 2018Co-Authors: Xi Song, Yanpeng Jiao, Siyuan Cui, Changren ZhouAbstract:Abstract Hyperbilirubinemia could be treated effectively by hemoperfusion. Electrospinning Fiber Mat had been reported to be applied in the hemoperfusion field owing to its higher surface area. BSA, as one of the natural carrier proteins for bilirubin, can not only selectively adsorb bilirubin but also improve the hemocompatibility of bioMaterials. In this work, functionalized polyethersulfone (PES) electrospun Fiber Mat was prepared by immobilizing BSA on the surface to remove bilirubin efficiently, in which polydopamine (PDA) acted as an active coating for further modification. The physicochemical characteristics of the PES Fiber Mat surface were analyzed in detail, indicating that the PDA layer was coated successfully; furthermore, BSA immobilization was also studied. The adsorption experiments demonstrated that PES/PDA-BSA had an excellent adsorption capacity (192.38 mg/g), a short adsorption equilibrium time (1.5 h), and a good selectivity. The adsorption mechanism was analyzed by adsorption kinetics and isotherm models. In addition, dynamic adsorption revealed that PES/PDA-BSA had a shorter equilibrium time for bilirubin, i.e., about 30 min. The selective adsorption of PES/PDA-BSA demonstrated a preferable selectivity toward bilirubin, whether in a single or a multicomponent system, even in a serum system. Further, hemolysis and coagulation assays, as well as protein adsorption, exhibited good blood compatibility. Therefore, this study provided a promising strategy to fabricate a selective adsorbent for bilirubin.
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a surface molecularly imprinted electrospun polyethersulfone pes Fiber Mat for selective removal of bilirubin
Journal of Materials Chemistry B, 2017Co-Authors: Wufeng Yang, Yanpeng Jiao, Changren ZhouAbstract:Electrospinning has been widely recognized as a facile and scalable method for fabricating fibrous Materials, which could be used as adsorption Materials because of their high surface area. Surface molecular imprinting based on adsorption Materials has shown excellent adsorption performance, including large binding capacity, a fast adsorption rate and selective adsorption. In this study, electrospinning and surface molecular imprinting were used together to prepare a surface molecularly imprinted electrospun polyethersulfone (PES) Fiber Mat (PES@MIP). The Mat was prepared by self-polymerization of dopamine (as a functional monomer) on the electrospun PES Fiber Mat surface in weak alkaline aqueous solution in the presence of a template, bilirubin. The results indicated that a polydopamine coating was formed on the PES Fiber Mat surface successfully, and the template bilirubin could be removed. The adsorption performance of PES@MIP was investigated in detail, showing a higher adsorption capacity (184.24 mg g−1), faster adsorption kinetics and a short adsorption equilibrium time of 2 h, as well as a good selectivity toward bilirubin with an imprinting factor (IF) of 1.4. In addition, the selectivity coefficient (α) of PES@MIP toward cholesterol and testosterone could be calculated to be 1.11 and 1.43. Also, both adsorption kinetic and isotherm models were used to analyze the adsorption process. Besides, the dynamic adsorption indicated that PES@MIP adsorbed much more bilirubin, and had a shorter equilibrium time of about 40 minutes for bilirubin removal. In addition, PES@MIP had a much lower hemolysis ratio and exhibited a little anticoagulant property compared to the original PES Fiber Mat. Therefore, this work provided a new strategy to build practical PES@MIP for bilirubin adsorption.
Wiley J Youngs - One of the best experts on this subject based on the ideXlab platform.
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silver i imidazole cyclophane gem diol complexes encapsulated by electrospun tecophilic nanoFibers forMation of nanosilver particles and antimicrobial activity
Journal of the American Chemical Society, 2005Co-Authors: Abdulkareem Melaiye, Zhaohui Sun, Khadijah M Hindi, Amy Milsted, Daniel Ely, Darrell H Reneker, Claire A Tessier, Wiley J YoungsAbstract:Silver(I)−imidazole cyclophane gem-diol complex, 3 [Ag2C36 N10O4]2+2(x)-, where x = OH- or CO32-, was synthesized and well characterized. The minimum inhibition concentration tests showed that the aqueous form of 3 is 2 times less effective as an antibiotic than 0.5% AgNO3, with about the same amount of silver. The antimicrobial activity of 3 was enhanced when encapsulated into Tecophilic polymer by electrospinning to obtain Mats made of nano-Fibers. The Fiber Mats released nanosilver particles, which in turn sustained the antimicrobial activity of the Mats over a long period of time. The rate of bactericidal activity of 3 was greatly improved by encapsulation, and the amount of silver used was much reduced. The amount of silver contained in the Fiber Mat of 3, with 75% of 3 and 25% Tecophilic, was 8 times less than that in 0.5% AgNO3 and 5 times lower than that in silver sulfadiazine cream 1%. The Fiber Mat was found to kill S. aureus at the same rate as 0.5% AgNO3, with zero colonies on an agar plate, a...
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silver i imidazole cyclophane gem diol complexes encapsulated by electrospun tecophilic nanoFibers forMation of nanosilver particles and antimicrobial activity
Journal of the American Chemical Society, 2005Co-Authors: Abdulkareem Melaiye, Zhaohui Sun, Khadijah M Hindi, Amy Milsted, Daniel Ely, Darrell H Reneker, Claire A Tessier, Wiley J YoungsAbstract:Silver(I)-imidazole cyclophane gem-diol complex, 3 [Ag2C36 N10(O)4](2+)2(x)-, where x = OH- or CO3(2-), was synthesized and well characterized. The minimum inhibition concentration tests showed that the aqueous form of 3 is 2 times less effective as an antibiotic than 0.5% AgNO3, with about the same amount of silver. The antimicrobial activity of 3 was enhanced when encapsulated into Tecophilic polymer by electrospinning to obtain Mats made of nano-Fibers. The Fiber Mats released nanosilver particles, which in turn sustained the antimicrobial activity of the Mats over a long period of time. The rate of bactericidal activity of 3 was greatly improved by encapsulation, and the amount of silver used was much reduced. The amount of silver contained in the Fiber Mat of 3, with 75% of 3 and 25% Tecophilic, was 8 times less than that in 0.5% AgNO3 and 5 times lower than that in silver sulfadiazine cream 1%. The Fiber Mat was found to kill S. aureus at the same rate as 0.5% AgNO3, with zero colonies on an agar plate, and about 6 times faster than silver sulfadiazine cream. The silver Mats were found effective against E. coli, P. aeruginosa, S. aureus, C. albicans, A. niger, and S. cerevisiae. Transmission electron microscopy and scanning electron microscopy were used to characterize the Fiber Mats. The acute toxicity of the ligand (imidazolium cyclophane gem-diol dichloride) was assessed by intravenous administration to rats, with an LD 50 of 100 mg/kg of rat.
Yanpeng Jiao - One of the best experts on this subject based on the ideXlab platform.
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immobilization of bovine serum albumin via mussel inspired polydopamine coating on electrospun polyethersulfone pes Fiber Mat for effective bilirubin adsorption
Applied Surface Science, 2018Co-Authors: Xi Song, Yanpeng Jiao, Siyuan Cui, Changren ZhouAbstract:Abstract Hyperbilirubinemia could be treated effectively by hemoperfusion. Electrospinning Fiber Mat had been reported to be applied in the hemoperfusion field owing to its higher surface area. BSA, as one of the natural carrier proteins for bilirubin, can not only selectively adsorb bilirubin but also improve the hemocompatibility of bioMaterials. In this work, functionalized polyethersulfone (PES) electrospun Fiber Mat was prepared by immobilizing BSA on the surface to remove bilirubin efficiently, in which polydopamine (PDA) acted as an active coating for further modification. The physicochemical characteristics of the PES Fiber Mat surface were analyzed in detail, indicating that the PDA layer was coated successfully; furthermore, BSA immobilization was also studied. The adsorption experiments demonstrated that PES/PDA-BSA had an excellent adsorption capacity (192.38 mg/g), a short adsorption equilibrium time (1.5 h), and a good selectivity. The adsorption mechanism was analyzed by adsorption kinetics and isotherm models. In addition, dynamic adsorption revealed that PES/PDA-BSA had a shorter equilibrium time for bilirubin, i.e., about 30 min. The selective adsorption of PES/PDA-BSA demonstrated a preferable selectivity toward bilirubin, whether in a single or a multicomponent system, even in a serum system. Further, hemolysis and coagulation assays, as well as protein adsorption, exhibited good blood compatibility. Therefore, this study provided a promising strategy to fabricate a selective adsorbent for bilirubin.
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a surface molecularly imprinted electrospun polyethersulfone pes Fiber Mat for selective removal of bilirubin
Journal of Materials Chemistry B, 2017Co-Authors: Wufeng Yang, Yanpeng Jiao, Changren ZhouAbstract:Electrospinning has been widely recognized as a facile and scalable method for fabricating fibrous Materials, which could be used as adsorption Materials because of their high surface area. Surface molecular imprinting based on adsorption Materials has shown excellent adsorption performance, including large binding capacity, a fast adsorption rate and selective adsorption. In this study, electrospinning and surface molecular imprinting were used together to prepare a surface molecularly imprinted electrospun polyethersulfone (PES) Fiber Mat (PES@MIP). The Mat was prepared by self-polymerization of dopamine (as a functional monomer) on the electrospun PES Fiber Mat surface in weak alkaline aqueous solution in the presence of a template, bilirubin. The results indicated that a polydopamine coating was formed on the PES Fiber Mat surface successfully, and the template bilirubin could be removed. The adsorption performance of PES@MIP was investigated in detail, showing a higher adsorption capacity (184.24 mg g−1), faster adsorption kinetics and a short adsorption equilibrium time of 2 h, as well as a good selectivity toward bilirubin with an imprinting factor (IF) of 1.4. In addition, the selectivity coefficient (α) of PES@MIP toward cholesterol and testosterone could be calculated to be 1.11 and 1.43. Also, both adsorption kinetic and isotherm models were used to analyze the adsorption process. Besides, the dynamic adsorption indicated that PES@MIP adsorbed much more bilirubin, and had a shorter equilibrium time of about 40 minutes for bilirubin removal. In addition, PES@MIP had a much lower hemolysis ratio and exhibited a little anticoagulant property compared to the original PES Fiber Mat. Therefore, this work provided a new strategy to build practical PES@MIP for bilirubin adsorption.
Darrell H Reneker - One of the best experts on this subject based on the ideXlab platform.
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fabrication polarization of electrospun polyvinylidene fluoride electret Fibers and effect on capturing nanoscale solid aerosols
Materials, 2016Co-Authors: Dinesh Lolla, Darrell H Reneker, Manideep Lolla, Ahmed Abutaleb, Hyeon U Shin, George G ChaseAbstract:Electrospun polyvinylidene fluoride (PVDF) Fiber Mats with average Fiber diameters (≈200 nm, ≈2000 nm) were fabricated by controlled electrospinning conditions. These Fiber Mats were polarized using a custom-made device to enhance the forMation of the electret β-phase ferroelectric property of the Fibers by simultaneous uniaxial stretching of the Fiber Mat and heating the Mat to the Curie temperature of the PVDF polymer in a strong electric field of 2.5 kV/cm. Scanning electron microscopy, Fourier transform infrared spectroscopy, thermal gravimetric analysis, differential scanning calorimetry and Brunauer-Emmett-Teller (BET) surface area analyses were performed to characterize both the internal and external morphologies of the Fiber Mat samples to study polarization-associated changes. MatLAB simulations revealed the changes in the paths of the electric fields and the magnetic flux inside the polarization field with inclusion of the ferroelectric Fiber Mats. Both polarized and unpolarized Fiber Mats were challenged as filters against NaCl particles with average particle diameters of about 150 nm using a TSI 8130 to study capture efficiencies and relative pressure drops. Twelve filter experiments were conducted on each sample at one month time intervals between experiments to evaluate the reduction of the polarization enhancement over time. The results showed negligible polarization loss for the 200-nm Fiber sample. The polarized Mats had the highest filter efficiencies and lowest pressure drops.
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silver i imidazole cyclophane gem diol complexes encapsulated by electrospun tecophilic nanoFibers forMation of nanosilver particles and antimicrobial activity
Journal of the American Chemical Society, 2005Co-Authors: Abdulkareem Melaiye, Zhaohui Sun, Khadijah M Hindi, Amy Milsted, Daniel Ely, Darrell H Reneker, Claire A Tessier, Wiley J YoungsAbstract:Silver(I)−imidazole cyclophane gem-diol complex, 3 [Ag2C36 N10O4]2+2(x)-, where x = OH- or CO32-, was synthesized and well characterized. The minimum inhibition concentration tests showed that the aqueous form of 3 is 2 times less effective as an antibiotic than 0.5% AgNO3, with about the same amount of silver. The antimicrobial activity of 3 was enhanced when encapsulated into Tecophilic polymer by electrospinning to obtain Mats made of nano-Fibers. The Fiber Mats released nanosilver particles, which in turn sustained the antimicrobial activity of the Mats over a long period of time. The rate of bactericidal activity of 3 was greatly improved by encapsulation, and the amount of silver used was much reduced. The amount of silver contained in the Fiber Mat of 3, with 75% of 3 and 25% Tecophilic, was 8 times less than that in 0.5% AgNO3 and 5 times lower than that in silver sulfadiazine cream 1%. The Fiber Mat was found to kill S. aureus at the same rate as 0.5% AgNO3, with zero colonies on an agar plate, a...
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silver i imidazole cyclophane gem diol complexes encapsulated by electrospun tecophilic nanoFibers forMation of nanosilver particles and antimicrobial activity
Journal of the American Chemical Society, 2005Co-Authors: Abdulkareem Melaiye, Zhaohui Sun, Khadijah M Hindi, Amy Milsted, Daniel Ely, Darrell H Reneker, Claire A Tessier, Wiley J YoungsAbstract:Silver(I)-imidazole cyclophane gem-diol complex, 3 [Ag2C36 N10(O)4](2+)2(x)-, where x = OH- or CO3(2-), was synthesized and well characterized. The minimum inhibition concentration tests showed that the aqueous form of 3 is 2 times less effective as an antibiotic than 0.5% AgNO3, with about the same amount of silver. The antimicrobial activity of 3 was enhanced when encapsulated into Tecophilic polymer by electrospinning to obtain Mats made of nano-Fibers. The Fiber Mats released nanosilver particles, which in turn sustained the antimicrobial activity of the Mats over a long period of time. The rate of bactericidal activity of 3 was greatly improved by encapsulation, and the amount of silver used was much reduced. The amount of silver contained in the Fiber Mat of 3, with 75% of 3 and 25% Tecophilic, was 8 times less than that in 0.5% AgNO3 and 5 times lower than that in silver sulfadiazine cream 1%. The Fiber Mat was found to kill S. aureus at the same rate as 0.5% AgNO3, with zero colonies on an agar plate, and about 6 times faster than silver sulfadiazine cream. The silver Mats were found effective against E. coli, P. aeruginosa, S. aureus, C. albicans, A. niger, and S. cerevisiae. Transmission electron microscopy and scanning electron microscopy were used to characterize the Fiber Mats. The acute toxicity of the ligand (imidazolium cyclophane gem-diol dichloride) was assessed by intravenous administration to rats, with an LD 50 of 100 mg/kg of rat.
Abdulkareem Melaiye - One of the best experts on this subject based on the ideXlab platform.
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silver i imidazole cyclophane gem diol complexes encapsulated by electrospun tecophilic nanoFibers forMation of nanosilver particles and antimicrobial activity
Journal of the American Chemical Society, 2005Co-Authors: Abdulkareem Melaiye, Zhaohui Sun, Khadijah M Hindi, Amy Milsted, Daniel Ely, Darrell H Reneker, Claire A Tessier, Wiley J YoungsAbstract:Silver(I)−imidazole cyclophane gem-diol complex, 3 [Ag2C36 N10O4]2+2(x)-, where x = OH- or CO32-, was synthesized and well characterized. The minimum inhibition concentration tests showed that the aqueous form of 3 is 2 times less effective as an antibiotic than 0.5% AgNO3, with about the same amount of silver. The antimicrobial activity of 3 was enhanced when encapsulated into Tecophilic polymer by electrospinning to obtain Mats made of nano-Fibers. The Fiber Mats released nanosilver particles, which in turn sustained the antimicrobial activity of the Mats over a long period of time. The rate of bactericidal activity of 3 was greatly improved by encapsulation, and the amount of silver used was much reduced. The amount of silver contained in the Fiber Mat of 3, with 75% of 3 and 25% Tecophilic, was 8 times less than that in 0.5% AgNO3 and 5 times lower than that in silver sulfadiazine cream 1%. The Fiber Mat was found to kill S. aureus at the same rate as 0.5% AgNO3, with zero colonies on an agar plate, a...
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silver i imidazole cyclophane gem diol complexes encapsulated by electrospun tecophilic nanoFibers forMation of nanosilver particles and antimicrobial activity
Journal of the American Chemical Society, 2005Co-Authors: Abdulkareem Melaiye, Zhaohui Sun, Khadijah M Hindi, Amy Milsted, Daniel Ely, Darrell H Reneker, Claire A Tessier, Wiley J YoungsAbstract:Silver(I)-imidazole cyclophane gem-diol complex, 3 [Ag2C36 N10(O)4](2+)2(x)-, where x = OH- or CO3(2-), was synthesized and well characterized. The minimum inhibition concentration tests showed that the aqueous form of 3 is 2 times less effective as an antibiotic than 0.5% AgNO3, with about the same amount of silver. The antimicrobial activity of 3 was enhanced when encapsulated into Tecophilic polymer by electrospinning to obtain Mats made of nano-Fibers. The Fiber Mats released nanosilver particles, which in turn sustained the antimicrobial activity of the Mats over a long period of time. The rate of bactericidal activity of 3 was greatly improved by encapsulation, and the amount of silver used was much reduced. The amount of silver contained in the Fiber Mat of 3, with 75% of 3 and 25% Tecophilic, was 8 times less than that in 0.5% AgNO3 and 5 times lower than that in silver sulfadiazine cream 1%. The Fiber Mat was found to kill S. aureus at the same rate as 0.5% AgNO3, with zero colonies on an agar plate, and about 6 times faster than silver sulfadiazine cream. The silver Mats were found effective against E. coli, P. aeruginosa, S. aureus, C. albicans, A. niger, and S. cerevisiae. Transmission electron microscopy and scanning electron microscopy were used to characterize the Fiber Mats. The acute toxicity of the ligand (imidazolium cyclophane gem-diol dichloride) was assessed by intravenous administration to rats, with an LD 50 of 100 mg/kg of rat.