The Experts below are selected from a list of 3687 Experts worldwide ranked by ideXlab platform
J M Dixon - One of the best experts on this subject based on the ideXlab platform.
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Fibroadenoma of the breast.
The Medical journal of Australia, 2001Co-Authors: N Houssami, M N Cheung, J M DixonAbstract:Fibroadenoma of the breast is a common cause of a benign breast lump in premenopausal women. The consensus view is that women with Fibroadenomas are not at significant increased risk of developing breast cancer. Diagnosis is based on the combination of clinical examination, imaging and non-surgical tissue biopsy (the triple test). A clinical diagnosis of Fibroadenoma alone is unreliable and does not exclude malignancy even in younger women. The choice of imaging is mammography, combined with ultrasound in older women, and ultrasound alone in younger women. Tissue biopsy, by either fine-needle aspiration or core biopsy, is the most accurate means of establishing the diagnosis. Traditionally, symptomatic Fibroadenomas were treated by surgical excision, and this option should always be offered. There is increasing evidence that a conservative approach is safe and acceptable, provided the result of an adequate triple test is both negative for cancer and consistent with a Fibroadenoma. Patients who choose conservative management need to be informed of the limitation of the tests, and must be assessed promptly if there is symptomatic or clinical change.
Eun-kyung Kim - One of the best experts on this subject based on the ideXlab platform.
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radiomics of us texture features in differential diagnosis between triple negative breast cancer and Fibroadenoma
Scientific Reports, 2018Co-Authors: Si Eun Lee, Kyunghwa Han, Jin Young Kwak, Eunjung Lee, Eun-kyung KimAbstract:Triple-negative breast cancer (TNBC) is sometimes mistaken for Fibroadenoma due to its tendency to show benign morphology on breast ultrasound (US) albeit its aggressive nature. This study aims to develop a radiomics score based on US texture analysis for differential diagnosis between TNBC and Fibroadenoma, and to evaluate its diagnostic performance compared with pathologic results. We retrospectively included 715 pathology-proven Fibroadenomas and 186 pathology-proven TNBCs which were examined by three different US machines. We developed the radiomics score by using penalized logistic regression with a least absolute shrinkage and selection operator (LASSO) analysis from 730 extracted features consisting of 14 intensity-based features, 132 textural features and 584 wavelet-based features. The constructed radiomics score showed significant difference between Fibroadenoma and TNBC for all three US machines (p < 0.001). Although the radiomics score showed dependency on the type of US machine, we developed more elaborate radiomics score for a subgroup in which US examinations were performed with iU22. This subsequent radiomics score also showed good diagnostic performance, even for BI-RADS category 3 or 4a lesions (AUC 0.782) which were presumed as probably benign or low suspicious of malignancy by radiologists. It was expected to assist radiologist’s diagnosis and reduce the number of invasive biopsies, although US standardization should be overcome before clinical application.
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Radiomics of US texture features in differential diagnosis between triple-negative breast cancer and Fibroadenoma
Nature Publishing Group, 2018Co-Authors: Si Eun Lee, Kyunghwa Han, Jin Young Kwak, Eunjung Lee, Eun-kyung KimAbstract:Abstract Triple-negative breast cancer (TNBC) is sometimes mistaken for Fibroadenoma due to its tendency to show benign morphology on breast ultrasound (US) albeit its aggressive nature. This study aims to develop a radiomics score based on US texture analysis for differential diagnosis between TNBC and Fibroadenoma, and to evaluate its diagnostic performance compared with pathologic results. We retrospectively included 715 pathology-proven Fibroadenomas and 186 pathology-proven TNBCs which were examined by three different US machines. We developed the radiomics score by using penalized logistic regression with a least absolute shrinkage and selection operator (LASSO) analysis from 730 extracted features consisting of 14 intensity-based features, 132 textural features and 584 wavelet-based features. The constructed radiomics score showed significant difference between Fibroadenoma and TNBC for all three US machines (p
Gaby N Moawad - One of the best experts on this subject based on the ideXlab platform.
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ectopic breast Fibroadenoma of the vulva
Obstetrics & Gynecology, 2009Co-Authors: Elliott W Lucas, Philip Branton, Fred Mecklenburg, Gaby N MoawadAbstract:BACKGROUND: Ectopic breast (extramammary) Fibroadenomas of the vulva are rare, cosmetically disfiguring, and very difficult to distinguish from other labial masses on physical examination. Extramammary tissue is susceptible to similar benign and malignant changes seen in the breast. Some patients with ectopic breast lesions may harbor an underlying urinary tract anomaly. CASE: We report a case of a young woman who presented with an unknown progressively enlarging mass in the vulva. The mass was excised completely in a cosmetic manner and histology demonstrated an ectopic breast Fibroadenoma. CONCLUSION: Clinicians should include extramammary lesions in their preoperative differential diagnosis of vulvar masses since some may become neoplastic. Treatment is complete excision and renal imaging should be considered after a confirmed histopathologic diagnosis.
Knut Engedal - One of the best experts on this subject based on the ideXlab platform.
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analysis of sonographic features in the differentiation of Fibroadenoma and invasive ductal carcinoma
American Journal of Roentgenology, 1998Co-Authors: Per Skaane, Knut EngedalAbstract:The purpose of this study was to determine the predictive power of sonographic tumor descriptors in the differentiation of Fibroadenoma from invasive ductal carcinoma of the breast.Three hundred thirty-six tumors (142 Fibroadenomas and 194 invasive ductal carcinomas) of the breast diagnosed using sonography were prospectively recorded with respect to the shape, contour, echo texture, echogenicity, sound transmission, and surrounding tissue of the tumors. Evaluation included odds and odds ratios of single sonographic features as well as sensitivity, specificity, and positive and negative predictive values of combinations of features. Tumor descriptors were also evaluated using multiple logistic regression analysis after adjustment for age and clinical examination.Irregular shape and contour, extensive hypoechogenicity, shadowing, echogenic halo, and distortion of surrounding tissue were the findings with the highest predictive value of malignancy. A thin echogenic pseudocapsule was the most important sonog...
N Houssami - One of the best experts on this subject based on the ideXlab platform.
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Fibroadenoma of the breast.
The Medical journal of Australia, 2001Co-Authors: N Houssami, M N Cheung, J M DixonAbstract:Fibroadenoma of the breast is a common cause of a benign breast lump in premenopausal women. The consensus view is that women with Fibroadenomas are not at significant increased risk of developing breast cancer. Diagnosis is based on the combination of clinical examination, imaging and non-surgical tissue biopsy (the triple test). A clinical diagnosis of Fibroadenoma alone is unreliable and does not exclude malignancy even in younger women. The choice of imaging is mammography, combined with ultrasound in older women, and ultrasound alone in younger women. Tissue biopsy, by either fine-needle aspiration or core biopsy, is the most accurate means of establishing the diagnosis. Traditionally, symptomatic Fibroadenomas were treated by surgical excision, and this option should always be offered. There is increasing evidence that a conservative approach is safe and acceptable, provided the result of an adequate triple test is both negative for cancer and consistent with a Fibroadenoma. Patients who choose conservative management need to be informed of the limitation of the tests, and must be assessed promptly if there is symptomatic or clinical change.