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Takashi Akasaka - One of the best experts on this subject based on the ideXlab platform.
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high density lipoprotein cholesterol level is associated with Fibrous Cap thickness in acute coronary syndrome
Circulation, 2013Co-Authors: Yuichi Ozaki, Kenichi Komukai, Takashi Kubo, Hironori Kitabata, Atsushi Tanaka, Takashi Tanimoto, Toshio Imanishi, Yasushi Ino, Kohei Ishibashi, Takashi AkasakaAbstract:Background: Although low high-density lipoprotein cholesterol (HDL-C) level has been reported as an independent risk factor for coronary artery disease, few studies addressed the direct relationship between the presence of thin-Cap fibroatheroma (TCFA) that is considered as vulnerable plaque in pathology and HDL-C level. The aim of this study was to investigate whether lesion vulnerability is related to HDL-C level in patients with acute coronary syndrome (ACS). Methods and Results: A total of 261 patients with ACS who underwent optical coherence tomography prior to percutaneous coronary intervention, were enrolled. Patients were divided into a TCFA group (n=124) and a non-TCFA group (n=137). TCFA was defined as a lipid plaque (lipid content in ≥1 quadrant) covered with <70m-thickness Fibrous Caps. There were no differences in patient characteristics and clinical results between the 2 groups except for HDL-C level, low-density lipoprotein cholesterol (LDL-C) level, and high-sensitive C-reactive protein (hs-CRP) level. On multivariate regression analysis, low HDL-C level (β coefficient: 0.302, P<0.001), high LDL-C level (β coefficient: −0.172, P=0.008), hs-CRP level (β coefficient: −0.145, P=0.017), and current smoking (β coefficient: −0.124, P=0.028) were identified as independent contributors to Fibrous Cap thickness. Conclusions: HDL-C is correlated with Fibrous Cap thickness of the culprit lesion in patients with ACS. HDL-C may be considered as a therapeutic target for plaque stabilization. (Circ J 2013; 77: 2982–2989)
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The impact of ethyl icosapentate therapy on coronary Fibrous-Cap thickness in acute coronary syndrome patients without hyperlipidemia: Assessment by optical coherence tomography study
European Heart Journal, 2013Co-Authors: Takashi Yamano, Takashi Kubo, Tsuyoshi Nishiguchi, Yasushi Ino, Teruaki Wada, S. Oota, Keisuke Satogami, T. Yamaguchi, T. Imanishi, Takashi AkasakaAbstract:Backround: It plays important roles to predict vulnerable plaques in patients with acute coronary syndrome (ACS) because the vulnerability of coronary plaques has been relevant to the pathogenesis of ACS. Atheroma with thin-Fibrous Cap thickness
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Effect of statin therapy on coronary Fibrous-Cap thickness in patients with acute coronary syndrome: assessment by optical coherence tomography study.
Atherosclerosis, 2008Co-Authors: Shigeho Takarada, Takashi Kubo, Hironori Kitabata, Atsushi Tanaka, Takashi Tanimoto, Toshio Imanishi, Nobuo Nakamura, Masato Mizukoshi, Takashi AkasakaAbstract:Abstract Background The thickness of coronary Fibrous Caps is a major determinant of vulnerable plaques. Several clinical trials have suggested that statin therapy could stabilize vulnerable plaques. Recently, optical coherence tomography (OCT) has been proposed as an effective histology-resolution imaging modality for assessing such micro-structural changes. Methods Forty AMI patients with hyperlipidemia were enrolled and underwent percutaneous coronary intervention (PCI). They were divided into two groups; statin treatment group (n = 23) or control group (n = 17). Serial OCT analyses were performed at baseline and 9-month follow-up for a non-PCI lipid-rich plaque lesion. Results The LDL-cholesterol level in the statin group was significantly lower than that in the control group at follow-up. Although the Fibrous-Cap thickness was significantly increased in both the statin treatment group (151 ± 110 to 280 ± 120 μm, p Conclusion The lipid-lowering therapy with statin for 9 months after the onset of acute myocardial infarction significantly increased the Fibrous-Cap thickness in patients with hyperlipidemia.
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Abstract 3063: Assessment of Fibrous Cap Thickness of the Coronary Plaque by Optical Coherence Tomography: Comparison with Coronary Angioscopic Image
Circulation, 2006Co-Authors: Takashi Kubo, Shigeho Takarada, Takashi Masyo, Takashi Yamano, Toshio Imanishi, Yoshiaki Tomobuchi, Takashi AkasakaAbstract:[Background] Coronary angioscopy (CAS) can provide detailed information of the luminal surface characteristics of the coronary artery, such as plaque color, presence or absence of thrombus, or Fibrous Cap disruption. It has been suggested that plaque color might be associated with plaque vulnerability, although CAS is limited to obtain structural and pathohistological information of the plaque. Optical coherence tomography (OCT) has recently been proposed as a histology-grade imaging modality (resolution, 10 μm; wavelength, 1300 nm; probe size, 0.018 inch; Lightlab Imaging). Previously, we reported the ability to detect lipid-core and to measure intima-media thickness accurately in postmortem histological examination. In the present study, we assessed structural differences by OCT between yellow and white plaques identified by CAS. [Methods and Results] Thirty-three coronary artery lesions in patients with acute coronary syndrome were observed by CAS, and the results were compared with OCT findings. The incidences of yellow and white plaque evaluated by CAS were 73% and 28%, respectively. In all plaques, Lipid core was observed clearly and Fibrous Cap thickness was measured accurately by OCT. The lipid core arches estimated by OCT were not different between yellow and white plaques (172 +/− 113 vs. 161 +/− 101 degrees, p=0.80). Fibrous Cap thickness of yellow plaque was significantly thinner than that of white plaque (59 +/− 13 vs. 246 +/− 112 micrometer, p [Conclusions] Yellow color of coronary plaques observed by CAS was a useful predictor for identification of TCFA. The plaque color might be determined not by the amount of lipid core but by the thickness of the Fibrous Cap, which was able to be measured by OCT in vivo.
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measurement of the thickness of the Fibrous Cap by optical coherence tomography
American Heart Journal, 2006Co-Authors: Teruyoshi Kume, Hiroyuki Okura, Takashi Akasaka, Takahiro Kawamoto, Nozomi Watanabe, Eiji Toyota, Yoji Neishi, Rena Sukmawa, Yoshito Sadahira, Kiyoshi YoshidaAbstract:Background Identification of the Fibrous Cap is important because its thickness is a major determinant of plaque vulnerability in lipid-rich plaque. Thus, a high-resolution imaging technique may be a promising method for the identification of the Fibrous Cap within lipid-rich plaque. The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to measure the thickness of the Fibrous Cap within lipid-rich plaque. Methods and Results We examined 35 lipid-rich plaques from 102 coronary arterial segments of 38 human cadavers (22 men and 16 women; mean ages, 74 ± 7 years). Optical coherence tomography and corresponding histological images were digitized for measurement of the thickness of Fibrous Cap, and the results between OCT and histological examination were compared. There was good correlation of the thickness of the Fibrous Cap between OCT and histological examination ( y = 0.97 x + 28.49; r = 0.90; P Conclusions Optical coherence tomography provides an accurate representation of the thickness of the Fibrous Cap and may prove useful in assessing plaque vulnerability in lipid-rich plaque.
Takashi Kubo - One of the best experts on this subject based on the ideXlab platform.
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Effect of Early Pitavastatin Therapy on Coronary Fibrous-Cap Thickness Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome: The ESCORT Study
JACC. Cardiovascular imaging, 2017Co-Authors: Tsuyoshi Nishiguchi, Takashi Kubo, Yoshiki Matsuo, Takashi Tanimoto, Takashi Yamano, Yasushi Ino, Kosei Terada, Hiroki Emori, Yosuke Katayama, Akira TaruyaAbstract:Abstract Objectives The aim of the present study was to assess the effect of early statin therapy on Fibrous-Cap thickness in coronary plaques of patients with acute coronary syndrome (ACS) by using optical coherence tomography. Background Statins can contribute to the stabilization of coronary plaques. Methods This is a prospective, randomized, active-controlled, single-center study. Patients with ACS and untreated dyslipidemia were enrolled and randomly allocated (ratio 1:1) to either the early statin group (received pitavastatin 4 mg/day from baseline) or the late statin group (received pitavastatin 4 mg/day from 3 weeks after the baseline). Optical coherence tomography was performed at baseline, 3-week, and 36-week follow-up to assess nonculprit coronary plaques in 53 patients. Results Between baseline and 3-week follow-up, Fibrous-Cap thickness increased in the early statin group (140 μm [interquartile range (IQR):120 to 170 μm] to 160 μm [IQR: 130 to 190 μm]; p = 0.017), but decreased in the late statin group (135 μm [IQR: 110 to 183 μm] to 130 μm [IQR: 108 to 160 μm]; p = 0.020). The percentage of increase in Fibrous-Cap thickness between baseline and 3-week follow-up was significantly greater in the early statin group compared with the late statin group (8.3% [IQR: 0.0% to 21.4%] vs. −5.8% [IQR: −16.0% to 0.0%]; p Conclusions Early therapy with pitavastatin 4 mg/day for patients with ACS provided an increase in Fibrous-Cap thickness in coronary plaques during the first 3 weeks of follow-up and a further increase during 36 weeks of follow-up. The study was registered with UMIN Clinical Trial Registry (Effect of PitavaStatin on Coronary Fibrous-Cap Thickness - Assessment by Fourier-Domain Optical CoheRence Tomography (ESCORT): UMIN000002678).
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effect of atorvastatin therapy on Fibrous Cap thickness in coronary atherosclerotic plaque as assessed by optical coherence tomography the easy fit study
Journal of the American College of Cardiology, 2014Co-Authors: Kenichi Komukai, Takashi Kubo, Hironori Kitabata, Yoshiki Matsuo, Yuichi Ozaki, Shigeho Takarada, Yasushi Okumoto, Yasutsugu Shiono, Makoto Orii, Kunihiro ShimamuraAbstract:Abstract Background The detailed mechanism of plaque stabilization by statin therapy is not fully understood. Objectives The aim of this study was to assess the effect of lipid-lowering therapy with 20 mg/day of atorvastatin versus 5 mg/day of atorvastatin on Fibrous Cap thickness in coronary atherosclerotic plaques by using optical coherence tomography (OCT). Methods Seventy patients with unstable angina pectoris and untreated dyslipidemia were randomized to either 20 mg/day or 5 mg/day of atorvastatin therapy. OCT was performed to assess intermediate nonculprit lesions at baseline and 12-month follow-up. Results Serum low-density lipoprotein cholesterol level was significantly lower during therapy with 20 mg/day compared with 5 mg/day of atorvastatin (69 mg/dl vs. 78 mg/dl; p = 0.039). The increase in Fibrous Cap thickness was significantly greater with 20 mg/day compared with 5 mg/day of atorvastatin (69% vs. 17%; p Conclusions Atorvastatin therapy at 20 mg/day provided a greater increase in Fibrous Cap thickness in coronary plaques compared with 5 mg/day of atorvastatin. The increase of Fibrous Cap was associated with the decrease in serum atherogenic lipoproteins and inflammatory biomarkers during atorvastatin therapy. (Effect of Atorvastatin Therapy on Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography: The EASY-FIT Study; NCT00700037 )
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Impact of eicosapentaenoic acid treatment on the Fibrous Cap thickness in patients with coronary atherosclerotic plaque: an optical coherence tomography study.
Journal of atherosclerosis and thrombosis, 2014Co-Authors: Takashi Yamano, Takashi Kubo, Hironori Kitabata, Yoshiki Matsuo, Yasutsugu Shiono, Makoto Orii, Kunihiro Shimamura, Takashi Tanimoto, Yasushi Ino, Tomoyuki YamaguchiAbstract:AIM Previous clinical trials have demonstrated the effectiveness of eicosapentaenoic acid (EPA) in preventing cardiovascular events. The aim of the present study was to investigate the effects of EPA treatment on the accumulation of coronary atherosclerotic plaque using optical coherence tomography (OCT). METHODS A total of 46 acute coronary syndrome (ACS) patients without dyslipidemia were divided into two groups: those who received 1,800 mg/day of EPA (n = 15) or the control group (n = 31). Serial OCT examinations were performed at baseline and after eight months of follow-up. The target for the OCT analysis was non-culprit plaque with a percent diameter of stenosis of 30% to 70% in non-culprit vessels of ACS. RESULTS Between the baseline and follow-up visits, the serum EPA levels increased (50 ± 26 mg/dL to 200 ± 41 mg/dL, p ＜ 0.001) in the EPA group, although they did not change in the control group. According to the OCT analysis, the lipid arc did not change in the EPA group (131 ± 52 degrees to 126 ± 54 degrees, p = 0.106) or the control group (137 ± 50 degrees to 138 ± 50 degrees, p=0.603). In contrast, the Fibrous Cap thickness significantly increased in both the EPA group (169 ± 70 μm to 201 ± 49 μm, p ＜ 0.001) and the control group (164 ± 63 μm to 174 ± 72 μm, p=0.018); however, the relative change in the Fibrous Cap thickness was significantly greater in the EPA group than in the control group (131 ± 35% vs. 106 ± 15%, p = 0.001). CONCLUSIONS In the present study, the administration of EPA for eight months significantly increased the Fibrous Cap thickness in patients with coronary atherosclerotic plaque.
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high density lipoprotein cholesterol level is associated with Fibrous Cap thickness in acute coronary syndrome
Circulation, 2013Co-Authors: Yuichi Ozaki, Kenichi Komukai, Takashi Kubo, Hironori Kitabata, Atsushi Tanaka, Takashi Tanimoto, Toshio Imanishi, Yasushi Ino, Kohei Ishibashi, Takashi AkasakaAbstract:Background: Although low high-density lipoprotein cholesterol (HDL-C) level has been reported as an independent risk factor for coronary artery disease, few studies addressed the direct relationship between the presence of thin-Cap fibroatheroma (TCFA) that is considered as vulnerable plaque in pathology and HDL-C level. The aim of this study was to investigate whether lesion vulnerability is related to HDL-C level in patients with acute coronary syndrome (ACS). Methods and Results: A total of 261 patients with ACS who underwent optical coherence tomography prior to percutaneous coronary intervention, were enrolled. Patients were divided into a TCFA group (n=124) and a non-TCFA group (n=137). TCFA was defined as a lipid plaque (lipid content in ≥1 quadrant) covered with <70m-thickness Fibrous Caps. There were no differences in patient characteristics and clinical results between the 2 groups except for HDL-C level, low-density lipoprotein cholesterol (LDL-C) level, and high-sensitive C-reactive protein (hs-CRP) level. On multivariate regression analysis, low HDL-C level (β coefficient: 0.302, P<0.001), high LDL-C level (β coefficient: −0.172, P=0.008), hs-CRP level (β coefficient: −0.145, P=0.017), and current smoking (β coefficient: −0.124, P=0.028) were identified as independent contributors to Fibrous Cap thickness. Conclusions: HDL-C is correlated with Fibrous Cap thickness of the culprit lesion in patients with ACS. HDL-C may be considered as a therapeutic target for plaque stabilization. (Circ J 2013; 77: 2982–2989)
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The impact of ethyl icosapentate therapy on coronary Fibrous-Cap thickness in acute coronary syndrome patients without hyperlipidemia: Assessment by optical coherence tomography study
European Heart Journal, 2013Co-Authors: Takashi Yamano, Takashi Kubo, Tsuyoshi Nishiguchi, Yasushi Ino, Teruaki Wada, S. Oota, Keisuke Satogami, T. Yamaguchi, T. Imanishi, Takashi AkasakaAbstract:Backround: It plays important roles to predict vulnerable plaques in patients with acute coronary syndrome (ACS) because the vulnerability of coronary plaques has been relevant to the pathogenesis of ACS. Atheroma with thin-Fibrous Cap thickness
Kikuko Obase - One of the best experts on this subject based on the ideXlab platform.
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relationship between arterial and Fibrous Cap remodelingclinical perspective
Circulation-cardiovascular Interventions, 2010Co-Authors: Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Ken Saito, Yoshinori Miyamoto, Koichiro Imai, Tetsuo Tsuchiya, Tomoko Maehama, Noriko Okahashi, Kikuko ObaseAbstract:Background— Positive arterial remodeling and thin Fibrous Cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the Fibrous Cap thickness and the relationship between serial arterial remodeling and changes in Fibrous Cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in Fibrous Cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results— Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 nonsignificant, nonculprit lesions (angiographic diameter stenosis, 25% to 75%; plaque burden, >40% by IVUS). Fibroatheroma was defined by OCT as lipid-rich plaque in >1 quadrant that has lipid. Thickness of the Fibrous Cap was measured by OCT. IVUS and OCT examinations were repeated at 6-month follow-up. Serial changes and relationships between IVUS indices and Fibrous Cap thickness were investigated. Overall, Fibrous Cap thickness (98.1±38.9 to 96.9±44.5 μm) as well as IVUS indices did not change significantly within 6 months. The percent changes in Fibrous Cap thickness correlated negatively and significantly ( r =−0.54; P <0.0001; generalized estimating equation adjusted, r =−0.42; P =0.001) with the percent changes in external elastic membrane cross-sectional area. Conclusions— Arterial remodeling is related to changes in Fibrous Cap thickness. Positive arterial remodeling is not only an adaptive process, but also related to thinning of the Fibrous Cap.
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relationship between arterial and Fibrous Cap remodeling a serial three vessel intravascular ultrasound and optical coherence tomography study
Circulation-cardiovascular Interventions, 2010Co-Authors: Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Ken Saito, Yoshinori Miyamoto, Koichiro Imai, Tetsuo Tsuchiya, Tomoko Maehama, Noriko Okahashi, Kikuko ObaseAbstract:Background —Positive arterial remodeling and thin Fibrous Cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the Fibrous Cap thickness and the relationship between serial arterial remodeling and changes in Fibrous Cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in Fibrous Cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results —Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 nonsignificant, nonculprit lesions (angiographic diameter stenosis, 25% to 75%; plaque burden, >40% by IVUS). Fibroatheroma was defined by OCT as lipid-rich plaque in >1 quadrant that has lipid. Thickness of the Fibrous Cap was measured by OCT. IVUS and OCT examinations were repeated at 6-month follow-up. Serial changes and relationships between IVUS indices and Fibrous Cap thickness were investigated. Overall, Fibrous Cap thickness (98.1±38.9 to 96.9±44.5 μ m) as well as IVUS indices did not change significantly within 6 months. The percent changes in Fibrous Cap thickness correlated negatively and significantly ( r =−0.54; P r =−0.42; P =0.001) with the percent changes in external elastic membrane cross-sectional area. Conclusions —Arterial remodeling is related to changes in Fibrous Cap thickness. Positive arterial remodeling is not only an adaptive process, but also related to thinning of the Fibrous Cap.
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Relationship Between Arterial and Fibrous Cap RemodelingClinical Perspective: A Serial Three-Vessel Intravascular Ultrasound and Optical Coherence Tomography Study
Circulation. Cardiovascular interventions, 2010Co-Authors: Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Ken Saito, Yoshinori Miyamoto, Koichiro Imai, Tetsuo Tsuchiya, Tomoko Maehama, Noriko Okahashi, Kikuko ObaseAbstract:Background— Positive arterial remodeling and thin Fibrous Cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the Fibrous Cap thickness and the relationship between serial arterial remodeling and changes in Fibrous Cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in Fibrous Cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results— Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 nonsignificant, nonculprit lesions (angiographic diameter stenosis, 25% to 75%; plaque burden, >40% by IVUS). Fibroatheroma was defined by OCT as lipid-rich plaque in >1 quadrant that has lipid. Thickness of the Fibrous Cap was measured by OCT. IVUS and OCT examinations were repeated at 6-month follow-up. Serial changes and relationships between IVUS indices and Fibrous Cap thickness were investigated. Overall, Fibrous Cap thickness (98.1±38.9 to 96.9±44.5 μm) as well as IVUS indices did not change significantly within 6 months. The percent changes in Fibrous Cap thickness correlated negatively and significantly ( r =−0.54; P r =−0.42; P =0.001) with the percent changes in external elastic membrane cross-sectional area. Conclusions— Arterial remodeling is related to changes in Fibrous Cap thickness. Positive arterial remodeling is not only an adaptive process, but also related to thinning of the Fibrous Cap.
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relationship between arterial and Fibrous Cap remodeling a serial three vessel intravascular ultrasound and optical coherence tomography study
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Ken Saito, Yoshinori Miyamoto, Koichiro Imai, Tetsuo Tsuchiya, Tomoko Maehama, Noriko Okahashi, Kikuko ObaseAbstract:Background-Positive arterial remodeling and thin Fibrous Cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the Fibrous Cap thickness and the relationship between serial arterial remodeling and changes in Fibrous Cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in Fibrous Cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results-Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 nonsignificant, nonculprit lesions (angiographic diameter stenosis, 25% to 75%; plaque burden, >40% by IVUS). Fibroatheroma was defined by OCT as lipid-rich plaque in > 1 quadrant that has lipid. Thickness of the Fibrous Cap was measured by OCT. IVUS and OCT examinations were repeated at 6-month follow-up. Serial changes and relationships between IVUS indices and Fibrous Cap thickness were investigated. Overall, Fibrous Cap thickness (98.1 ±38.9 to 96.9±44.5 μm) as well as IVUS indices did not change significantly within 6 months. The percent changes in Fibrous Cap thickness correlated negatively and significantly (r=—0.54; P<0.0001; generalized estimating equation adjusted, r=—0.42; P=0.001) with the percent changes in external elastic membrane cross-sectional area. Conclusions—Arterial remodeling is related to changes in Fibrous Cap thickness. Positive arterial remodeling is not only an adaptive process, but also related to thinning of the Fibrous Cap.
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Relationship Between Arterial and Fibrous Cap Remodeling A Serial Three-Vessel Intravascular Ultrasound and Optical Coherence Tomography Study
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Ken Saito, Yoshinori Miyamoto, Koichiro Imai, Tetsuo Tsuchiya, Tomoko Maehama, Noriko Okahashi, Kikuko ObaseAbstract:Background-Positive arterial remodeling and thin Fibrous Cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the Fibrous Cap thickness and the relationship between serial arterial remodeling and changes in Fibrous Cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in Fibrous Cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results-Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 nonsignificant, nonculprit lesions (angiographic diameter stenosis, 25% to 75%; plaque burden, >40% by IVUS). Fibroatheroma was defined by OCT as lipid-rich plaque in > 1 quadrant that has lipid. Thickness of the Fibrous Cap was measured by OCT. IVUS and OCT examinations were repeated at 6-month follow-up. Serial changes and relationships between IVUS indices and Fibrous Cap thickness were investigated. Overall, Fibrous Cap thickness (98.1 ±38.9 to 96.9±44.5 μm) as well as IVUS indices did not change significantly within 6 months. The percent changes in Fibrous Cap thickness correlated negatively and significantly (r=—0.54; P
Teruyoshi Kume - One of the best experts on this subject based on the ideXlab platform.
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TCT-274 Relationship Between Arterial Remodeling, Fibrous Cap Thinning and Lipid Accumulation: A Serial Integrated Backscatter Intravascular Ultrasound and Optical Coherence Tomography Study
Journal of the American College of Cardiology, 2012Co-Authors: Teruyoshi Kume, Hiroyuki Okura, Yoshinori Miyamoto, Takahiro Kawamoto, Yoji Neishi, Kenzo Fukuhara, Shintaro Nezuo, Akihiro Hayashida, Kiyoshi YoshidaAbstract:A serial intravascular ultrasound (IVUS) and optical coherence tomography (OCT) study has shown that positive arterial remodeling was related to thinning of Fibrous Cap. Serial changes in tissue components associated with Fibrous Cap and/or arterial remodeling is unknown Therefore, the purpose of
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relationship between arterial and Fibrous Cap remodelingclinical perspective
Circulation-cardiovascular Interventions, 2010Co-Authors: Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Ken Saito, Yoshinori Miyamoto, Koichiro Imai, Tetsuo Tsuchiya, Tomoko Maehama, Noriko Okahashi, Kikuko ObaseAbstract:Background— Positive arterial remodeling and thin Fibrous Cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the Fibrous Cap thickness and the relationship between serial arterial remodeling and changes in Fibrous Cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in Fibrous Cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results— Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 nonsignificant, nonculprit lesions (angiographic diameter stenosis, 25% to 75%; plaque burden, >40% by IVUS). Fibroatheroma was defined by OCT as lipid-rich plaque in >1 quadrant that has lipid. Thickness of the Fibrous Cap was measured by OCT. IVUS and OCT examinations were repeated at 6-month follow-up. Serial changes and relationships between IVUS indices and Fibrous Cap thickness were investigated. Overall, Fibrous Cap thickness (98.1±38.9 to 96.9±44.5 μm) as well as IVUS indices did not change significantly within 6 months. The percent changes in Fibrous Cap thickness correlated negatively and significantly ( r =−0.54; P <0.0001; generalized estimating equation adjusted, r =−0.42; P =0.001) with the percent changes in external elastic membrane cross-sectional area. Conclusions— Arterial remodeling is related to changes in Fibrous Cap thickness. Positive arterial remodeling is not only an adaptive process, but also related to thinning of the Fibrous Cap.
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relationship between arterial and Fibrous Cap remodeling a serial three vessel intravascular ultrasound and optical coherence tomography study
Circulation-cardiovascular Interventions, 2010Co-Authors: Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Ken Saito, Yoshinori Miyamoto, Koichiro Imai, Tetsuo Tsuchiya, Tomoko Maehama, Noriko Okahashi, Kikuko ObaseAbstract:Background —Positive arterial remodeling and thin Fibrous Cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the Fibrous Cap thickness and the relationship between serial arterial remodeling and changes in Fibrous Cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in Fibrous Cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results —Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 nonsignificant, nonculprit lesions (angiographic diameter stenosis, 25% to 75%; plaque burden, >40% by IVUS). Fibroatheroma was defined by OCT as lipid-rich plaque in >1 quadrant that has lipid. Thickness of the Fibrous Cap was measured by OCT. IVUS and OCT examinations were repeated at 6-month follow-up. Serial changes and relationships between IVUS indices and Fibrous Cap thickness were investigated. Overall, Fibrous Cap thickness (98.1±38.9 to 96.9±44.5 μ m) as well as IVUS indices did not change significantly within 6 months. The percent changes in Fibrous Cap thickness correlated negatively and significantly ( r =−0.54; P r =−0.42; P =0.001) with the percent changes in external elastic membrane cross-sectional area. Conclusions —Arterial remodeling is related to changes in Fibrous Cap thickness. Positive arterial remodeling is not only an adaptive process, but also related to thinning of the Fibrous Cap.
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Relationship Between Arterial and Fibrous Cap RemodelingClinical Perspective: A Serial Three-Vessel Intravascular Ultrasound and Optical Coherence Tomography Study
Circulation. Cardiovascular interventions, 2010Co-Authors: Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Ken Saito, Yoshinori Miyamoto, Koichiro Imai, Tetsuo Tsuchiya, Tomoko Maehama, Noriko Okahashi, Kikuko ObaseAbstract:Background— Positive arterial remodeling and thin Fibrous Cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the Fibrous Cap thickness and the relationship between serial arterial remodeling and changes in Fibrous Cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in Fibrous Cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results— Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 nonsignificant, nonculprit lesions (angiographic diameter stenosis, 25% to 75%; plaque burden, >40% by IVUS). Fibroatheroma was defined by OCT as lipid-rich plaque in >1 quadrant that has lipid. Thickness of the Fibrous Cap was measured by OCT. IVUS and OCT examinations were repeated at 6-month follow-up. Serial changes and relationships between IVUS indices and Fibrous Cap thickness were investigated. Overall, Fibrous Cap thickness (98.1±38.9 to 96.9±44.5 μm) as well as IVUS indices did not change significantly within 6 months. The percent changes in Fibrous Cap thickness correlated negatively and significantly ( r =−0.54; P r =−0.42; P =0.001) with the percent changes in external elastic membrane cross-sectional area. Conclusions— Arterial remodeling is related to changes in Fibrous Cap thickness. Positive arterial remodeling is not only an adaptive process, but also related to thinning of the Fibrous Cap.
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relationship between arterial and Fibrous Cap remodeling a serial three vessel intravascular ultrasound and optical coherence tomography study
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Ken Saito, Yoshinori Miyamoto, Koichiro Imai, Tetsuo Tsuchiya, Tomoko Maehama, Noriko Okahashi, Kikuko ObaseAbstract:Background-Positive arterial remodeling and thin Fibrous Cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the Fibrous Cap thickness and the relationship between serial arterial remodeling and changes in Fibrous Cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in Fibrous Cap thickness and arterial remodeling by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) during 6-month follow-up. Methods and Results-Both IVUS and OCT examinations were performed on 108 vessels from 36 patients with ischemic heart disease who underwent percutaneous coronary intervention. Fifty-eight fibroatheromas were selected from 82 nonsignificant, nonculprit lesions (angiographic diameter stenosis, 25% to 75%; plaque burden, >40% by IVUS). Fibroatheroma was defined by OCT as lipid-rich plaque in > 1 quadrant that has lipid. Thickness of the Fibrous Cap was measured by OCT. IVUS and OCT examinations were repeated at 6-month follow-up. Serial changes and relationships between IVUS indices and Fibrous Cap thickness were investigated. Overall, Fibrous Cap thickness (98.1 ±38.9 to 96.9±44.5 μm) as well as IVUS indices did not change significantly within 6 months. The percent changes in Fibrous Cap thickness correlated negatively and significantly (r=—0.54; P<0.0001; generalized estimating equation adjusted, r=—0.42; P=0.001) with the percent changes in external elastic membrane cross-sectional area. Conclusions—Arterial remodeling is related to changes in Fibrous Cap thickness. Positive arterial remodeling is not only an adaptive process, but also related to thinning of the Fibrous Cap.
Anthony J Grabs - One of the best experts on this subject based on the ideXlab platform.
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matrix vesicles in the Fibrous Cap of atherosclerotic plaque possible contribution to plaque rupture
Journal of Cellular and Molecular Medicine, 2008Co-Authors: Yuri V. Bobryshev, Murray C. Killingsworth, Reginald S A Lord, Anthony J GrabsAbstract:Plaque rupture is the most common type of plaque complication and leads to acute ischaemic events such as myocardial infarction and stroke. Calcification has been suggested as a possible indicator of plaque instability. Although the role of matrix vesicles in the initial stages of arterial calcification has been recognized, no studies have yet been carried out to examine a possible role of matrix vesicles in plaque destabilization. Tissue specimens selected for the present study represented carotid specimens obtained from patients undergoing carotid endarterectomy. Serial frozen cross-sections of the tissue specimens were cut and mounted on glass slides. The thickness of the Fibrous Cap (FCT) in each advanced atherosclerotic lesion, containing a well developed lipid/necrotic core, was measured at its narrowest sites in sets of serial sections. According to established criteria, atherosclerotic plaque specimens were histologically subdivided into two groups: vulnerable plaques with thin Fibrous Caps (FCT <100 μm) and presumably stable plaques, in which Fibrous Caps were thicker than 100 μm. Twenty-four carotid plaques (12 vulnerable and 12 presumably stable plaques) were collected for the present analysis of matrix vesicles in Fibrous Caps. In order to provide a sufficient number of representative areas from each plaque, laser Capture microdissection (LCM) was carried out. The quantification of matrix vesicles in ultrathin sections of vulnerable and stable plaques revealed that the numbers of matrix vesicles were significantly higher in Fibrous Caps of vulnerable plaques than those in stable plaques (8.908±0.544 versus 6.208±0.467 matrix vesicles per 1.92 μm2 standard area; P= 0.0002). Electron microscopy combined with X-ray elemental microanalysis showed that some matrix vesicles in atherosclerotic plaques were undergoing calcification and were characterized by a high content of calcium and phosphorus. The percentage of calcified matrix vesicles/microcalcifications was significantly higher in Fibrous Caps in vulnerable plaques compared with that in stable plaques (6.705±0.436 versus 5.322±0A94; P= 0.0474). The findings reinforce a view that the texture of the extracellular matrix in the thinning Fibrous Cap of atherosclerotic plaque is altered and this might contribute to plaque destabilization.
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Matrix vesicles in the Fibrous Cap of atherosclerotic plaque: possible contribution to plaque rupture
Journal of cellular and molecular medicine, 2008Co-Authors: Yuri V. Bobryshev, Murray C. Killingsworth, Reginald S A Lord, Anthony J GrabsAbstract:Plaque rupture is the most common type of plaque complication and leads to acute ischaemic events such as myocardial infarction and stroke. Calcification has been suggested as a possible indicator of plaque instability. Although the role of matrix vesicles in the initial stages of arterial calcification has been recognized, no studies have yet been carried out to examine a possible role of matrix vesicles in plaque destabilization. Tissue specimens selected for the present study represented carotid specimens obtained from patients undergoing carotid endarterectomy. Serial frozen cross-sections of the tissue specimens were cut and mounted on glass slides. The thickness of the Fibrous Cap (FCT) in each advanced atherosclerotic lesion, containing a well developed lipid/necrotic core, was measured at its narrowest sites in sets of serial sections. According to established criteria, atherosclerotic plaque specimens were histologically subdivided into two groups: vulnerable plaques with thin Fibrous Caps (FCT