The Experts below are selected from a list of 22881 Experts worldwide ranked by ideXlab platform
Walid I Dagher - One of the best experts on this subject based on the ideXlab platform.
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cervical lymphatic Filariasis in a pediatric patient case report and database analysis of lymphatic Filariasis in the united states
American Journal of Tropical Medicine and Hygiene, 2018Co-Authors: Jonathan C Simmonds, Michael K Mansour, Walid I DagherAbstract:Lymphatic Filariasis is a mosquito-borne parasitic infection caused by Wuchereria bancrofti and Brugia spp. Commonly seen in tropical developing countries, lymphatic Filariasis occurs when adult worms deposit in and obstruct lymphatics. Although not endemic to the United States, a few cases of lymphatic Filariasis caused by zoonotic Brugia spp. have been reported. Here we present a case of an 11-year-old female with no travel history who was seen in our clinic for a 1-year history of painless left cervical lymphadenopathy secondary to lymphatic Filariasis. We review the literature of this infection and discuss the management of our patient. Using the National Inpatient Sample (NIS), the largest publicly available all-payer inpatient care database in the United States, we also examine the demographics of this infection. Our results show that chronic lymphadenopathy in the head and neck is the most common presenting symptoms of domestic lymphatic Filariasis. Diagnosis is often made after surgical lymph node excision. Examination of the NIS from 2000 to 2014 revealed 865 patients admitted with a diagnosis of lymphatic Filariasis. Most patients are in the mid to late sixties and are located on the eastern seaboard. Eight hundred and twenty six cases (95.5%) were likely due to zoonotic Brugia spp. and 39 (4.5%) due to W. bancrofti. Despite being rare, these data highlight the need to consider Filariasis in patients presenting with chronic lymphadenopathy in the United States.
Achim Hoerauf - One of the best experts on this subject based on the ideXlab platform.
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mansonella perstans the importance of an endosymbiont
The New England Journal of Medicine, 2009Co-Authors: Achim HoeraufAbstract:The prevalence of filarial infections in the tropics is second only to that of geohelminth (soil-transmitted helminth) infections. Filarial infections in humans include the various forms of lymphatic Filariasis (Wuchereria bancrofti, Brugia malayi, and B. timori), onchocerciasis (Onchocerca volvulus), loiasis (Loa loa), and mansonellosis (Mansonella streptocerca, M. perstans, and M. ozzardi). About 120 million people currently have lymphatic Filariasis, and about 1 billion people are considered to be at risk for infection. Lymphatic Filariasis remains endemic in 81 countries and is prevalent on all continents except Australia. Approximately 37 million people have . . .
Eisaku Kimura - One of the best experts on this subject based on the ideXlab platform.
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confirmation of elimination of lymphatic Filariasis by an igg4 enzyme linked immunosorbent assay with urine samples in yongjia zhejiang province and gaoan jiangxi province people s republic of china
American Journal of Tropical Medicine and Hygiene, 2007Co-Authors: Makoto Itoh, Renyu Chen, Kunzhao Zhang, Weiping Wu, Mohammad Zahidul Islam, Fengfei Wang, Zhihong Li, Eisaku KimuraAbstract:A sensitive and specific IgG4 enzyme-linked immunosorbent assay (ELISA) with urine samples has been reported. To confirm elimination of bancroftian Filariasis, the ELISA was used in a study conducted in Yongjia County and Gaoan City, People's Republic of China, where Filariasis elimination was declared, with 10,409 students 5-16 years of age. The antibody positive rates were 0.08% in Yongjia and 0.34% in Gaoan. All positive samples were re-examined and found to be negative. Our results show that this ELISA is practical and useful for confirmation of the elimination of Filariasis. If similar results are obtained in different Filariasis-endemic countries, this method may be useful in global Filariasis elimination programs.
Peter U. Fischer - One of the best experts on this subject based on the ideXlab platform.
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laboratory and field evaluation of a new rapid test for detecting wuchereria bancrofti antigen in human blood
American Journal of Tropical Medicine and Hygiene, 2013Co-Authors: Gary J. Weil, Kurt C Curtis, Lawrence Fakoli, Kerstin Fischer, Lincoln Gankpala, Patrick J Lammie, A C Majewski, Sonia Pelletreau, Fatorma K Bolay, Peter U. FischerAbstract:Global Program to Eliminate Lymphatic Filariasis (GPELF) guidelines call for using filarial antigen testing to identify endemic areas that require mass drug administration (MDA) and for post-MDA surveillance. We compared a new filarial antigen test (the Alere Filariasis Test Strip) with the reference BinaxNOW Filariasis card test that has been used by the GPELF for more than 10 years. Laboratory testing of 227 archived serum or plasma samples showed that the two tests had similar high rates of sensitivity and specificity and > 99% agreement. However, the test strip detected 26.5% more people with filarial antigenemia (124/503 versus 98/503) and had better test result stability than the card test in a field study conducted in a Filariasis-endemic area in Liberia. Based on its increased sensitivity and other practical advantages, we believe that the test strip represents a major step forward that will be welcomed by the GPELF and the Filariasis research community.
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Developments in lymphatic Filariasis research
Trends in Parasitology, 2002Co-Authors: Peter U. FischerAbstract:Lymphatic Filariasisedited by T.B. Nutman, Imperial College Press, 2000. £30.00 (283 pages) ISBN 1 86094 059 5The book Lymphatic Filariasis is part of the series Tropical Medicine: Science and Practice edited by G. Pasvol and S.L. Hoffman. Lymphatic Filariasis is a comprehensive book, which consists of ten chapters written by 13 internationally well recognized scientists working in the field of lymphatic Filariasis. Emphasis is on clinical and laboratory diagnosis, immunology in addition to treatment and control. This book is particularly helpful for readers who are medically oriented, and is recommended for graduate students and scientists involved in teaching and research of parasitic diseases. Many new developments in lymphatic Filariasis research, especially recent insights in lymphatic pathology and the new strategies for treatment are summarized in this book. Hence, it is a must have for those working or involved in Filariasis control programmes. This book covers almost all aspects of lymphatic Filariasis, except for entomology and ecology of the infection. The editor mentioned in the preface that dramatic advances have been made during recent years. Therefore, frequent revisions will be needed to include the current research progress. With a lymphatic Filariasis elimination programme under way, which aims to eliminate lymphatic Filariasis as a public health problem by the year 2020, such updates will be essential to reflect the future status of lymphatic Filariasis.Minor points to be criticized include the repetitions between the chapters: for example, four chapters mention the estimated prevalence of lymphatic Filariasis (128 million cases) in their first paragraphs. Lymphatic Filariasis is caused by three different filarial species, therefore the morphological description for each developmental stage should pay more attention on the examined species. Furthermore, different strains of Brugia malayi have been described, which differ in their degree of anthropophily, their periodicity and their mosquito vectors, and only few of these strains can be maintained for several generations in laboratory rodents. Some statements appear contradictory and need clarification. For example, it is cited that, ‘in bancroftian Filariasis, recurrent attacks of fever associated with lymphadenitis are less frequently seen as in brugian Filariasis,’ whereas four pages further, it is stated that, ‘the frequency of acute attacks is generally higher in bancroftian Filariasis as compared to brugian Filariasis’. In the chapter on the diagnosis, it should be noted that microfilariae of Brugia timori are significantly longer than those of B. malayi and cannot, therefore, be summarised within one group. Although not recommended for routine treatment of Filariasis, it should be mentioned that the use of antibiotics to target the Wolbachia endobacteria in filarial parasites could be a promising new strategy for chemotherapy. The observation that worms and microorganisms can cause lymphatic disease is probably a new and noteworthy issue for some readers. However, most underlying studies have been performed on Wuchereria bancrofti and need to be confirmed for Brugia. One important tool to study is the localisation of adult worms in humans by ultrasound, which, so far, has only been reported for W. bancrofti. The authors describe, ‘fundamental differences in the pathogenesis of lymphoedema and hydroceles’. Because no hydroceles are found in brugian Filariasis, the authors should stress that also differences in the pathogenesis of bancroftian and brugian Filariasis have to be postulated.The form and the layout of the book are good, but it contains only a few colour images of low quality. Apart from a few gaps in biological aspects of the infection and some minor inaccuracies, the book gives a comprehensive overview of lymphatic Filariasis.
Jonathan C Simmonds - One of the best experts on this subject based on the ideXlab platform.
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cervical lymphatic Filariasis in a pediatric patient case report and database analysis of lymphatic Filariasis in the united states
American Journal of Tropical Medicine and Hygiene, 2018Co-Authors: Jonathan C Simmonds, Michael K Mansour, Walid I DagherAbstract:Lymphatic Filariasis is a mosquito-borne parasitic infection caused by Wuchereria bancrofti and Brugia spp. Commonly seen in tropical developing countries, lymphatic Filariasis occurs when adult worms deposit in and obstruct lymphatics. Although not endemic to the United States, a few cases of lymphatic Filariasis caused by zoonotic Brugia spp. have been reported. Here we present a case of an 11-year-old female with no travel history who was seen in our clinic for a 1-year history of painless left cervical lymphadenopathy secondary to lymphatic Filariasis. We review the literature of this infection and discuss the management of our patient. Using the National Inpatient Sample (NIS), the largest publicly available all-payer inpatient care database in the United States, we also examine the demographics of this infection. Our results show that chronic lymphadenopathy in the head and neck is the most common presenting symptoms of domestic lymphatic Filariasis. Diagnosis is often made after surgical lymph node excision. Examination of the NIS from 2000 to 2014 revealed 865 patients admitted with a diagnosis of lymphatic Filariasis. Most patients are in the mid to late sixties and are located on the eastern seaboard. Eight hundred and twenty six cases (95.5%) were likely due to zoonotic Brugia spp. and 39 (4.5%) due to W. bancrofti. Despite being rare, these data highlight the need to consider Filariasis in patients presenting with chronic lymphadenopathy in the United States.
