The Experts below are selected from a list of 1842 Experts worldwide ranked by ideXlab platform
Xiaoxi Zhuang - One of the best experts on this subject based on the ideXlab platform.
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sequential super stereotypy of an instinctive Fixed Action Pattern in hyper dopaminergic mutant mice a model of obsessive compulsive disorder and tourette s
BMC Biology, 2005Co-Authors: Kent C Berridge, Wayne J Aldridge, Kimberly R Houchard, Xiaoxi ZhuangAbstract:Excessive sequential stereotypy of behavioral Patterns (sequential super-stereotypy) in Tourette's syndrome and obsessive compulsive disorder (OCD) is thought to involve dysfunction in nigrostriatal dopamine systems. In sequential super-stereotypy, patients become trapped in overly rigid sequential Patterns of Action, language, or thought. Some instinctive behavioral Patterns of animals, such as the syntactic grooming chain Pattern of rodents, have sufficiently complex and stereotyped serial structure to detect potential production of overly-rigid sequential Patterns. A syntactic grooming chain is a Fixed Action Pattern that serially links up to 25 grooming movements into 4 predictable phases that follow 1 syntactic rule. New mutant mouse models allow gene-based manipulation of brain function relevant to sequential Patterns, but no current animal model of spontaneous OCD-like behaviors has so far been reported to exhibit sequential super-stereotypy in the sense of a whole complex serial Pattern that becomes stronger and excessively rigid. Here we used a hyper-dopaminergic mutant mouse to examine whether an OCD-like behavioral sequence in animals shows sequential super-stereotypy. Knockdown mutation of the dopamine transporter gene (DAT) causes extracellular dopamine levels in the neostriatum of these adult mutant mice to rise to 170% of wild-type control levels. We found that the serial Pattern of this instinctive behavioral sequence becomes strengthened as an entire entity in hyper-dopaminergic mutants, and more resistant to interruption. Hyper-dopaminergic mutant mice have stronger and more rigid syntactic grooming chain Patterns than wild-type control mice. Mutants showed sequential super-stereotypy in the sense of having more stereotyped and predictable syntactic grooming sequences, and were also more likely to resist disruption of the Pattern en route, by returning after a disruption to complete the Pattern from the appropriate point in the sequence. By contrast, wild-type mice exhibited weaker forms of the Fixed Action Pattern, and often failed to complete the full sequence. Sequential super-stereotypy occurs in the complex Fixed Action Patterns of hyper-dopaminergic mutant mice. Elucidation of the basis for sequential super-stereotypy of instinctive behavior in DAT knockdown mutant mice may offer insights into neural mechanisms of overly-rigid sequences of Action or thought in human patients with disorders such as Tourette's or OCD.
Kimberly R Houchard - One of the best experts on this subject based on the ideXlab platform.
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sequential super stereotypy of an instinctive Fixed Action Pattern in hyper dopaminergic mutant mice a model of obsessive compulsive disorder and tourette s
BMC Biology, 2005Co-Authors: Kent C Berridge, Wayne J Aldridge, Kimberly R Houchard, Xiaoxi ZhuangAbstract:Excessive sequential stereotypy of behavioral Patterns (sequential super-stereotypy) in Tourette's syndrome and obsessive compulsive disorder (OCD) is thought to involve dysfunction in nigrostriatal dopamine systems. In sequential super-stereotypy, patients become trapped in overly rigid sequential Patterns of Action, language, or thought. Some instinctive behavioral Patterns of animals, such as the syntactic grooming chain Pattern of rodents, have sufficiently complex and stereotyped serial structure to detect potential production of overly-rigid sequential Patterns. A syntactic grooming chain is a Fixed Action Pattern that serially links up to 25 grooming movements into 4 predictable phases that follow 1 syntactic rule. New mutant mouse models allow gene-based manipulation of brain function relevant to sequential Patterns, but no current animal model of spontaneous OCD-like behaviors has so far been reported to exhibit sequential super-stereotypy in the sense of a whole complex serial Pattern that becomes stronger and excessively rigid. Here we used a hyper-dopaminergic mutant mouse to examine whether an OCD-like behavioral sequence in animals shows sequential super-stereotypy. Knockdown mutation of the dopamine transporter gene (DAT) causes extracellular dopamine levels in the neostriatum of these adult mutant mice to rise to 170% of wild-type control levels. We found that the serial Pattern of this instinctive behavioral sequence becomes strengthened as an entire entity in hyper-dopaminergic mutants, and more resistant to interruption. Hyper-dopaminergic mutant mice have stronger and more rigid syntactic grooming chain Patterns than wild-type control mice. Mutants showed sequential super-stereotypy in the sense of having more stereotyped and predictable syntactic grooming sequences, and were also more likely to resist disruption of the Pattern en route, by returning after a disruption to complete the Pattern from the appropriate point in the sequence. By contrast, wild-type mice exhibited weaker forms of the Fixed Action Pattern, and often failed to complete the full sequence. Sequential super-stereotypy occurs in the complex Fixed Action Patterns of hyper-dopaminergic mutant mice. Elucidation of the basis for sequential super-stereotypy of instinctive behavior in DAT knockdown mutant mice may offer insights into neural mechanisms of overly-rigid sequences of Action or thought in human patients with disorders such as Tourette's or OCD.
Kent C Berridge - One of the best experts on this subject based on the ideXlab platform.
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sequential super stereotypy of an instinctive Fixed Action Pattern in hyper dopaminergic mutant mice a model of obsessive compulsive disorder and tourette s
BMC Biology, 2005Co-Authors: Kent C Berridge, Wayne J Aldridge, Kimberly R Houchard, Xiaoxi ZhuangAbstract:Excessive sequential stereotypy of behavioral Patterns (sequential super-stereotypy) in Tourette's syndrome and obsessive compulsive disorder (OCD) is thought to involve dysfunction in nigrostriatal dopamine systems. In sequential super-stereotypy, patients become trapped in overly rigid sequential Patterns of Action, language, or thought. Some instinctive behavioral Patterns of animals, such as the syntactic grooming chain Pattern of rodents, have sufficiently complex and stereotyped serial structure to detect potential production of overly-rigid sequential Patterns. A syntactic grooming chain is a Fixed Action Pattern that serially links up to 25 grooming movements into 4 predictable phases that follow 1 syntactic rule. New mutant mouse models allow gene-based manipulation of brain function relevant to sequential Patterns, but no current animal model of spontaneous OCD-like behaviors has so far been reported to exhibit sequential super-stereotypy in the sense of a whole complex serial Pattern that becomes stronger and excessively rigid. Here we used a hyper-dopaminergic mutant mouse to examine whether an OCD-like behavioral sequence in animals shows sequential super-stereotypy. Knockdown mutation of the dopamine transporter gene (DAT) causes extracellular dopamine levels in the neostriatum of these adult mutant mice to rise to 170% of wild-type control levels. We found that the serial Pattern of this instinctive behavioral sequence becomes strengthened as an entire entity in hyper-dopaminergic mutants, and more resistant to interruption. Hyper-dopaminergic mutant mice have stronger and more rigid syntactic grooming chain Patterns than wild-type control mice. Mutants showed sequential super-stereotypy in the sense of having more stereotyped and predictable syntactic grooming sequences, and were also more likely to resist disruption of the Pattern en route, by returning after a disruption to complete the Pattern from the appropriate point in the sequence. By contrast, wild-type mice exhibited weaker forms of the Fixed Action Pattern, and often failed to complete the full sequence. Sequential super-stereotypy occurs in the complex Fixed Action Patterns of hyper-dopaminergic mutant mice. Elucidation of the basis for sequential super-stereotypy of instinctive behavior in DAT knockdown mutant mice may offer insights into neural mechanisms of overly-rigid sequences of Action or thought in human patients with disorders such as Tourette's or OCD.
Wayne J Aldridge - One of the best experts on this subject based on the ideXlab platform.
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sequential super stereotypy of an instinctive Fixed Action Pattern in hyper dopaminergic mutant mice a model of obsessive compulsive disorder and tourette s
BMC Biology, 2005Co-Authors: Kent C Berridge, Wayne J Aldridge, Kimberly R Houchard, Xiaoxi ZhuangAbstract:Excessive sequential stereotypy of behavioral Patterns (sequential super-stereotypy) in Tourette's syndrome and obsessive compulsive disorder (OCD) is thought to involve dysfunction in nigrostriatal dopamine systems. In sequential super-stereotypy, patients become trapped in overly rigid sequential Patterns of Action, language, or thought. Some instinctive behavioral Patterns of animals, such as the syntactic grooming chain Pattern of rodents, have sufficiently complex and stereotyped serial structure to detect potential production of overly-rigid sequential Patterns. A syntactic grooming chain is a Fixed Action Pattern that serially links up to 25 grooming movements into 4 predictable phases that follow 1 syntactic rule. New mutant mouse models allow gene-based manipulation of brain function relevant to sequential Patterns, but no current animal model of spontaneous OCD-like behaviors has so far been reported to exhibit sequential super-stereotypy in the sense of a whole complex serial Pattern that becomes stronger and excessively rigid. Here we used a hyper-dopaminergic mutant mouse to examine whether an OCD-like behavioral sequence in animals shows sequential super-stereotypy. Knockdown mutation of the dopamine transporter gene (DAT) causes extracellular dopamine levels in the neostriatum of these adult mutant mice to rise to 170% of wild-type control levels. We found that the serial Pattern of this instinctive behavioral sequence becomes strengthened as an entire entity in hyper-dopaminergic mutants, and more resistant to interruption. Hyper-dopaminergic mutant mice have stronger and more rigid syntactic grooming chain Patterns than wild-type control mice. Mutants showed sequential super-stereotypy in the sense of having more stereotyped and predictable syntactic grooming sequences, and were also more likely to resist disruption of the Pattern en route, by returning after a disruption to complete the Pattern from the appropriate point in the sequence. By contrast, wild-type mice exhibited weaker forms of the Fixed Action Pattern, and often failed to complete the full sequence. Sequential super-stereotypy occurs in the complex Fixed Action Patterns of hyper-dopaminergic mutant mice. Elucidation of the basis for sequential super-stereotypy of instinctive behavior in DAT knockdown mutant mice may offer insights into neural mechanisms of overly-rigid sequences of Action or thought in human patients with disorders such as Tourette's or OCD.
Michael E Adams - One of the best experts on this subject based on the ideXlab platform.
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RESEARCH ARTICLE Rescheduling Behavioral Subunits of a Fixed Action Pattern by Genetic Manipulation of Peptidergic Signaling
2016Co-Authors: Miran Han, Youngjoon Kim, Gyunghee Lee, Sang Soo Lee, Michael E AdamsAbstract:The ecdysis behavioral sequence in insects is a classic Fixed Action Pattern (FAP) initiated by hormonal signaling. Ecdysis triggering hormones (ETHs) release the FAP through direct Actions on the CNS. Here we present evidence implicating two groups of central ETH recep-tor (ETHR) neurons in scheduling the first two steps of the FAP: kinin (aka drosokinin, leuco-kinin) neurons regulate pre-ecdysis behavior and CAMB neurons (CCAP, AstCC,MIP, and Bursicon) initiate the switch to ecdysis behavior. Ablation of kinin neurons or altering levels of ETH receptor (ETHR) expression in these neurons modifies timing and intensity of pre-ecdysis behavior. Cell ablation or ETHR knockdown in CAMB neurons delays the switch to ecdysis, whereas overexpression of ETHR or expression of pertussis toxin in these neurons accelerates timing of the switch. Calcium dynamics in kinin neurons are temporally aligned with pre-ecdysis behavior, whereas activity of CAMB neurons coincides with the switch from pre-ecdysis to ecdysis behavior. Activation of CCAP or CAMB neurons through tem-perature-sensitive TRPM8 gating is sufficient to trigger ecdysis behavior. Our findings dem-onstrate that kinin and CAMB neurons are direct targets of ETH and play critical roles in scheduling successive behavioral steps in the ecdysis FAP. Moreover, temporal organiza-tion of the FAP is likely a function of ETH receptor density in target neurons
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rescheduling behavioral subunits of a Fixed Action Pattern by genetic manipulation of peptidergic signaling
PLOS Genetics, 2015Co-Authors: Dohyoung Kim, Youngjoon Kim, Miran Han, Gyunghee Lee, Sang Soo Lee, Michael E AdamsAbstract:The ecdysis behavioral sequence in insects is a classic Fixed Action Pattern (FAP) initiated by hormonal signaling. Ecdysis triggering hormones (ETHs) release the FAP through direct Actions on the CNS. Here we present evidence implicating two groups of central ETH receptor (ETHR) neurons in scheduling the first two steps of the FAP: kinin (aka drosokinin, leucokinin) neurons regulate pre-ecdysis behavior and CAMB neurons (CCAP, AstCC, MIP, and Bursicon) initiate the switch to ecdysis behavior. Ablation of kinin neurons or altering levels of ETH receptor (ETHR) expression in these neurons modifies timing and intensity of pre-ecdysis behavior. Cell ablation or ETHR knockdown in CAMB neurons delays the switch to ecdysis, whereas overexpression of ETHR or expression of pertussis toxin in these neurons accelerates timing of the switch. Calcium dynamics in kinin neurons are temporally aligned with pre-ecdysis behavior, whereas activity of CAMB neurons coincides with the switch from pre-ecdysis to ecdysis behavior. Activation of CCAP or CAMB neurons through temperature-sensitive TRPM8 gating is sufficient to trigger ecdysis behavior. Our findings demonstrate that kinin and CAMB neurons are direct targets of ETH and play critical roles in scheduling successive behavioral steps in the ecdysis FAP. Moreover, temporal organization of the FAP is likely a function of ETH receptor density in target neurons.