The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Geoffrey A Cordell - One of the best experts on this subject based on the ideXlab platform.
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lc esi ms study of the Flavonoid Glycoside malonates of red clover trifolium pratense
Journal of Agricultural and Food Chemistry, 2000Co-Authors: Longze Lin, Michael Lindenmaier, Jie Yang, Michael Cleary, Shengxiang Qiu, Geoffrey A CordellAbstract:High-performance liquid chromatography−electrospray ionization−mass spectrometry (LC-ESI-MS) was applied to the analysis of the Flavonoids and their Glycoside malonates of the flowers and leaves of red clover (Trifolium pratense). Through LC-MS comparative studies on the plant extracts and their malonate-free extracts, ∼20 Flavonoid Glycoside malonates were detected in the flower extract. Eight were identified as genistin 6‘ ‘-O-malonate (39), formononetin 7-O-β-d-glucoside 6‘ ‘-O-malonate (40), biochanin A 7-O-β-d-glucoside 6‘ ‘-O-malonate (41), trifoside 6‘ ‘-O-malonate (42), irilone 4‘-O-β-d-glucoside 6‘ ‘-O-malonate (43), pratensein 7-O-β-d-glucoside 6‘ ‘-O-malonate (44), isoquercitrin 6‘ ‘-O-malonate (45), and 3-methylquercetin 7-O-β-d-glucoside 6‘ ‘-O-malonate (46). About 15 other Flavonoids and clovamides were proved to be present in this extract. The study also found that the flowers contained flavones as the major Flavonoids, whereas the leaves had isoflavones as the major Flavonoids. This is the...
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lc esi ms study of the Flavonoid Glycoside malonates of red clover trifolium pratense
Journal of Agricultural and Food Chemistry, 2000Co-Authors: Longze Lin, Michael Lindenmaier, Jie Yang, Michael Cleary, Shengxiang Qiu, Geoffrey A CordellAbstract:High-performance liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) was applied to the analysis of the Flavonoids and their Glycoside malonates of the flowers and leaves of red clover (Trifolium pratense). Through LC-MS comparative studies on the plant extracts and their malonate-free extracts, approximately 20 Flavonoid Glycoside malonates were detected in the flower extract. Eight were identified as genistin 6' '-O-malonate (39), formononetin 7-O-beta-D-glucoside 6' '-O-malonate (40), biochanin A 7-O-beta-D-glucoside 6' '-O-malonate (41), trifoside 6' '-O-malonate (42), irilone 4'-O-beta-D-glucoside 6' '-O-malonate (43), pratensein 7-O-beta-D-glucoside 6' '-O-malonate (44), isoquercitrin 6' '-O-malonate (45), and 3-methylquercetin 7-O-beta-D-glucoside 6' '-O-malonate (46). About 15 other Flavonoids and clovamides were proved to be present in this extract. The study also found that the flowers contained flavones as the major Flavonoids, whereas the leaves had isoflavones as the major Flavonoids. This is the first detection of the six malonates (39 and 42-46) in the extracts of red clover, and among them, 42, 43, and 46 are new compounds.
Lee Jia - One of the best experts on this subject based on the ideXlab platform.
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A Flavonoid Glycoside Compound from Murraya paniculata (L.) Interrupts Metastatic Characteristics of A549 Cells by Regulating STAT3/NF-κB/COX-2 and EGFR Signaling Pathways
The AAPS Journal, 2017Co-Authors: Qing Shi, Yunlong Cheng, Yaqiong Pang, Jiahang Chen, Zhou Jiang, Ning Zheng, Jingyi Yang, Wenge Chen, Lee JiaAbstract:Metastasis remains the leading cause of death from lung carcinoma. It is urgent to find safe and efficient pre-metastasis preventive agents for cancer survivors. We isolated a Flavonoid Glycoside, hexamethoxy flavanone-o-[rhamnopyranosyl-(1 → 4)-rhamnopyranoside (HMFRR), from the traditional Chinese medicine (TCM) Murraya paniculata (L.) that can effectively inhibit the adhesion, migration, and invasion of lung adenocarcinoma A549 cells in vitro. Molecular and cellular studies demonstrated that HMFRR significantly downregulated the expressions of cell adhesion-related and invasion-related molecules such as integrin β1, EGFR, COX-2, MMP-2, and MMP-9 proteins. Additionally, HMFRR effectively downregulated the expressions of epithelial–mesenchymal transition (EMT) markers (N-cadherin and vimentin) and upregulated that of E-cadherin. Moreover, these inhibitions were mediated by interrupting STAT3/NF-κB/COX-2 and EGFR/PI3K/AKT signaling pathways. Furthermore, HMFRR counteracted the expressions of cell adhesion molecules (ICAM-1, VCAM-1, and E-selectin) stimulated by interleukin-1β in human pulmonary microvascular endothelial cells (HPMECs). As a result, HMFRR interrupted the adhesion of A549 cells to HPMECs. Collectively, these results indicate that HMFRR may become a good candidate for cancer metastatic chemopreventive agents by interrupting the STAT3/NF-κB/COX-2 and EGFR signaling pathways.
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a Flavonoid Glycoside compound from murraya paniculata l interrupts metastatic characteristics of a549 cells by regulating stat3 nf κb cox 2 and egfr signaling pathways
Aaps Journal, 2017Co-Authors: Qing Shi, Yunlong Cheng, Yaqiong Pang, Jiahang Chen, Zhou Jiang, Ning Zheng, Jingyi Yang, Wenge Chen, Lee JiaAbstract:Metastasis remains the leading cause of death from lung carcinoma. It is urgent to find safe and efficient pre-metastasis preventive agents for cancer survivors. We isolated a Flavonoid Glycoside, hexamethoxy flavanone-o-[rhamnopyranosyl-(1 → 4)-rhamnopyranoside (HMFRR), from the traditional Chinese medicine (TCM) Murraya paniculata (L.) that can effectively inhibit the adhesion, migration, and invasion of lung adenocarcinoma A549 cells in vitro. Molecular and cellular studies demonstrated that HMFRR significantly downregulated the expressions of cell adhesion-related and invasion-related molecules such as integrin β1, EGFR, COX-2, MMP-2, and MMP-9 proteins. Additionally, HMFRR effectively downregulated the expressions of epithelial–mesenchymal transition (EMT) markers (N-cadherin and vimentin) and upregulated that of E-cadherin. Moreover, these inhibitions were mediated by interrupting STAT3/NF-κB/COX-2 and EGFR/PI3K/AKT signaling pathways. Furthermore, HMFRR counteracted the expressions of cell adhesion molecules (ICAM-1, VCAM-1, and E-selectin) stimulated by interleukin-1β in human pulmonary microvascular endothelial cells (HPMECs). As a result, HMFRR interrupted the adhesion of A549 cells to HPMECs. Collectively, these results indicate that HMFRR may become a good candidate for cancer metastatic chemopreventive agents by interrupting the STAT3/NF-κB/COX-2 and EGFR signaling pathways.
Longze Lin - One of the best experts on this subject based on the ideXlab platform.
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lc esi ms study of the Flavonoid Glycoside malonates of red clover trifolium pratense
Journal of Agricultural and Food Chemistry, 2000Co-Authors: Longze Lin, Michael Lindenmaier, Jie Yang, Michael Cleary, Shengxiang Qiu, Geoffrey A CordellAbstract:High-performance liquid chromatography−electrospray ionization−mass spectrometry (LC-ESI-MS) was applied to the analysis of the Flavonoids and their Glycoside malonates of the flowers and leaves of red clover (Trifolium pratense). Through LC-MS comparative studies on the plant extracts and their malonate-free extracts, ∼20 Flavonoid Glycoside malonates were detected in the flower extract. Eight were identified as genistin 6‘ ‘-O-malonate (39), formononetin 7-O-β-d-glucoside 6‘ ‘-O-malonate (40), biochanin A 7-O-β-d-glucoside 6‘ ‘-O-malonate (41), trifoside 6‘ ‘-O-malonate (42), irilone 4‘-O-β-d-glucoside 6‘ ‘-O-malonate (43), pratensein 7-O-β-d-glucoside 6‘ ‘-O-malonate (44), isoquercitrin 6‘ ‘-O-malonate (45), and 3-methylquercetin 7-O-β-d-glucoside 6‘ ‘-O-malonate (46). About 15 other Flavonoids and clovamides were proved to be present in this extract. The study also found that the flowers contained flavones as the major Flavonoids, whereas the leaves had isoflavones as the major Flavonoids. This is the...
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lc esi ms study of the Flavonoid Glycoside malonates of red clover trifolium pratense
Journal of Agricultural and Food Chemistry, 2000Co-Authors: Longze Lin, Michael Lindenmaier, Jie Yang, Michael Cleary, Shengxiang Qiu, Geoffrey A CordellAbstract:High-performance liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) was applied to the analysis of the Flavonoids and their Glycoside malonates of the flowers and leaves of red clover (Trifolium pratense). Through LC-MS comparative studies on the plant extracts and their malonate-free extracts, approximately 20 Flavonoid Glycoside malonates were detected in the flower extract. Eight were identified as genistin 6' '-O-malonate (39), formononetin 7-O-beta-D-glucoside 6' '-O-malonate (40), biochanin A 7-O-beta-D-glucoside 6' '-O-malonate (41), trifoside 6' '-O-malonate (42), irilone 4'-O-beta-D-glucoside 6' '-O-malonate (43), pratensein 7-O-beta-D-glucoside 6' '-O-malonate (44), isoquercitrin 6' '-O-malonate (45), and 3-methylquercetin 7-O-beta-D-glucoside 6' '-O-malonate (46). About 15 other Flavonoids and clovamides were proved to be present in this extract. The study also found that the flowers contained flavones as the major Flavonoids, whereas the leaves had isoflavones as the major Flavonoids. This is the first detection of the six malonates (39 and 42-46) in the extracts of red clover, and among them, 42, 43, and 46 are new compounds.
Qing Shi - One of the best experts on this subject based on the ideXlab platform.
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A Flavonoid Glycoside Compound from Murraya paniculata (L.) Interrupts Metastatic Characteristics of A549 Cells by Regulating STAT3/NF-κB/COX-2 and EGFR Signaling Pathways
The AAPS Journal, 2017Co-Authors: Qing Shi, Yunlong Cheng, Yaqiong Pang, Jiahang Chen, Zhou Jiang, Ning Zheng, Jingyi Yang, Wenge Chen, Lee JiaAbstract:Metastasis remains the leading cause of death from lung carcinoma. It is urgent to find safe and efficient pre-metastasis preventive agents for cancer survivors. We isolated a Flavonoid Glycoside, hexamethoxy flavanone-o-[rhamnopyranosyl-(1 → 4)-rhamnopyranoside (HMFRR), from the traditional Chinese medicine (TCM) Murraya paniculata (L.) that can effectively inhibit the adhesion, migration, and invasion of lung adenocarcinoma A549 cells in vitro. Molecular and cellular studies demonstrated that HMFRR significantly downregulated the expressions of cell adhesion-related and invasion-related molecules such as integrin β1, EGFR, COX-2, MMP-2, and MMP-9 proteins. Additionally, HMFRR effectively downregulated the expressions of epithelial–mesenchymal transition (EMT) markers (N-cadherin and vimentin) and upregulated that of E-cadherin. Moreover, these inhibitions were mediated by interrupting STAT3/NF-κB/COX-2 and EGFR/PI3K/AKT signaling pathways. Furthermore, HMFRR counteracted the expressions of cell adhesion molecules (ICAM-1, VCAM-1, and E-selectin) stimulated by interleukin-1β in human pulmonary microvascular endothelial cells (HPMECs). As a result, HMFRR interrupted the adhesion of A549 cells to HPMECs. Collectively, these results indicate that HMFRR may become a good candidate for cancer metastatic chemopreventive agents by interrupting the STAT3/NF-κB/COX-2 and EGFR signaling pathways.
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a Flavonoid Glycoside compound from murraya paniculata l interrupts metastatic characteristics of a549 cells by regulating stat3 nf κb cox 2 and egfr signaling pathways
Aaps Journal, 2017Co-Authors: Qing Shi, Yunlong Cheng, Yaqiong Pang, Jiahang Chen, Zhou Jiang, Ning Zheng, Jingyi Yang, Wenge Chen, Lee JiaAbstract:Metastasis remains the leading cause of death from lung carcinoma. It is urgent to find safe and efficient pre-metastasis preventive agents for cancer survivors. We isolated a Flavonoid Glycoside, hexamethoxy flavanone-o-[rhamnopyranosyl-(1 → 4)-rhamnopyranoside (HMFRR), from the traditional Chinese medicine (TCM) Murraya paniculata (L.) that can effectively inhibit the adhesion, migration, and invasion of lung adenocarcinoma A549 cells in vitro. Molecular and cellular studies demonstrated that HMFRR significantly downregulated the expressions of cell adhesion-related and invasion-related molecules such as integrin β1, EGFR, COX-2, MMP-2, and MMP-9 proteins. Additionally, HMFRR effectively downregulated the expressions of epithelial–mesenchymal transition (EMT) markers (N-cadherin and vimentin) and upregulated that of E-cadherin. Moreover, these inhibitions were mediated by interrupting STAT3/NF-κB/COX-2 and EGFR/PI3K/AKT signaling pathways. Furthermore, HMFRR counteracted the expressions of cell adhesion molecules (ICAM-1, VCAM-1, and E-selectin) stimulated by interleukin-1β in human pulmonary microvascular endothelial cells (HPMECs). As a result, HMFRR interrupted the adhesion of A549 cells to HPMECs. Collectively, these results indicate that HMFRR may become a good candidate for cancer metastatic chemopreventive agents by interrupting the STAT3/NF-κB/COX-2 and EGFR signaling pathways.
Michael Lindenmaier - One of the best experts on this subject based on the ideXlab platform.
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lc esi ms study of the Flavonoid Glycoside malonates of red clover trifolium pratense
Journal of Agricultural and Food Chemistry, 2000Co-Authors: Longze Lin, Michael Lindenmaier, Jie Yang, Michael Cleary, Shengxiang Qiu, Geoffrey A CordellAbstract:High-performance liquid chromatography−electrospray ionization−mass spectrometry (LC-ESI-MS) was applied to the analysis of the Flavonoids and their Glycoside malonates of the flowers and leaves of red clover (Trifolium pratense). Through LC-MS comparative studies on the plant extracts and their malonate-free extracts, ∼20 Flavonoid Glycoside malonates were detected in the flower extract. Eight were identified as genistin 6‘ ‘-O-malonate (39), formononetin 7-O-β-d-glucoside 6‘ ‘-O-malonate (40), biochanin A 7-O-β-d-glucoside 6‘ ‘-O-malonate (41), trifoside 6‘ ‘-O-malonate (42), irilone 4‘-O-β-d-glucoside 6‘ ‘-O-malonate (43), pratensein 7-O-β-d-glucoside 6‘ ‘-O-malonate (44), isoquercitrin 6‘ ‘-O-malonate (45), and 3-methylquercetin 7-O-β-d-glucoside 6‘ ‘-O-malonate (46). About 15 other Flavonoids and clovamides were proved to be present in this extract. The study also found that the flowers contained flavones as the major Flavonoids, whereas the leaves had isoflavones as the major Flavonoids. This is the...
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lc esi ms study of the Flavonoid Glycoside malonates of red clover trifolium pratense
Journal of Agricultural and Food Chemistry, 2000Co-Authors: Longze Lin, Michael Lindenmaier, Jie Yang, Michael Cleary, Shengxiang Qiu, Geoffrey A CordellAbstract:High-performance liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) was applied to the analysis of the Flavonoids and their Glycoside malonates of the flowers and leaves of red clover (Trifolium pratense). Through LC-MS comparative studies on the plant extracts and their malonate-free extracts, approximately 20 Flavonoid Glycoside malonates were detected in the flower extract. Eight were identified as genistin 6' '-O-malonate (39), formononetin 7-O-beta-D-glucoside 6' '-O-malonate (40), biochanin A 7-O-beta-D-glucoside 6' '-O-malonate (41), trifoside 6' '-O-malonate (42), irilone 4'-O-beta-D-glucoside 6' '-O-malonate (43), pratensein 7-O-beta-D-glucoside 6' '-O-malonate (44), isoquercitrin 6' '-O-malonate (45), and 3-methylquercetin 7-O-beta-D-glucoside 6' '-O-malonate (46). About 15 other Flavonoids and clovamides were proved to be present in this extract. The study also found that the flowers contained flavones as the major Flavonoids, whereas the leaves had isoflavones as the major Flavonoids. This is the first detection of the six malonates (39 and 42-46) in the extracts of red clover, and among them, 42, 43, and 46 are new compounds.