The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

Rob A. Voskuyl - One of the best experts on this subject based on the ideXlab platform.

  • Population pharmaCokinetiC analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABAA-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABAA-reCeptor properties, CharaCterized by Bmax and KD.

  • Population PharmaCokinetiC Analysis for Simultaneous Determination of B _max and K _D In Vivo by Positron Emission Tomography
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABA_A-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABA_A-reCeptor properties, CharaCterized by B _max and K _D. ProCedures Following an injeCtion of [C-11]FMZ (dose range: 1–2,000 μg) to 21 rats, ConCentration time Curves of FMZ in brain (using PET) and blood (using HPLC-UV) were analyzed simultaneously using a population pharmaCokinetiC (PK) model, Containing expressions to desCribe the time Course of the plasma ConCentration (inCluding distribution to the body), the brain distribution, and the speCifiC binding within the brain. Results AppliCation of this method in Control rats resulted in estimates of B _max and K _D (14.5 ± 3.7 ng/ml and 4.68 ± 1.5 ng/ml, respeCtively). ConClusions The proposed population PK model allowed for simultaneous estimation of B _max and K _D for a group of animals using single injeCtion PET experiments per animal.

Lia C. Liefaard - One of the best experts on this subject based on the ideXlab platform.

  • Population pharmaCokinetiC analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABAA-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABAA-reCeptor properties, CharaCterized by Bmax and KD.

  • Population PharmaCokinetiC Analysis for Simultaneous Determination of B _max and K _D In Vivo by Positron Emission Tomography
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABA_A-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABA_A-reCeptor properties, CharaCterized by B _max and K _D. ProCedures Following an injeCtion of [C-11]FMZ (dose range: 1–2,000 μg) to 21 rats, ConCentration time Curves of FMZ in brain (using PET) and blood (using HPLC-UV) were analyzed simultaneously using a population pharmaCokinetiC (PK) model, Containing expressions to desCribe the time Course of the plasma ConCentration (inCluding distribution to the body), the brain distribution, and the speCifiC binding within the brain. Results AppliCation of this method in Control rats resulted in estimates of B _max and K _D (14.5 ± 3.7 ng/ml and 4.68 ± 1.5 ng/ml, respeCtively). ConClusions The proposed population PK model allowed for simultaneous estimation of B _max and K _D for a group of animals using single injeCtion PET experiments per animal.

Bart A. Ploeger - One of the best experts on this subject based on the ideXlab platform.

  • Population pharmaCokinetiC analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABAA-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABAA-reCeptor properties, CharaCterized by Bmax and KD.

  • Population PharmaCokinetiC Analysis for Simultaneous Determination of B _max and K _D In Vivo by Positron Emission Tomography
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABA_A-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABA_A-reCeptor properties, CharaCterized by B _max and K _D. ProCedures Following an injeCtion of [C-11]FMZ (dose range: 1–2,000 μg) to 21 rats, ConCentration time Curves of FMZ in brain (using PET) and blood (using HPLC-UV) were analyzed simultaneously using a population pharmaCokinetiC (PK) model, Containing expressions to desCribe the time Course of the plasma ConCentration (inCluding distribution to the body), the brain distribution, and the speCifiC binding within the brain. Results AppliCation of this method in Control rats resulted in estimates of B _max and K _D (14.5 ± 3.7 ng/ml and 4.68 ± 1.5 ng/ml, respeCtively). ConClusions The proposed population PK model allowed for simultaneous estimation of B _max and K _D for a group of animals using single injeCtion PET experiments per animal.

Carla F. M. Molthoff - One of the best experts on this subject based on the ideXlab platform.

  • Population pharmaCokinetiC analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABAA-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABAA-reCeptor properties, CharaCterized by Bmax and KD.

  • Population PharmaCokinetiC Analysis for Simultaneous Determination of B _max and K _D In Vivo by Positron Emission Tomography
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABA_A-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABA_A-reCeptor properties, CharaCterized by B _max and K _D. ProCedures Following an injeCtion of [C-11]FMZ (dose range: 1–2,000 μg) to 21 rats, ConCentration time Curves of FMZ in brain (using PET) and blood (using HPLC-UV) were analyzed simultaneously using a population pharmaCokinetiC (PK) model, Containing expressions to desCribe the time Course of the plasma ConCentration (inCluding distribution to the body), the brain distribution, and the speCifiC binding within the brain. Results AppliCation of this method in Control rats resulted in estimates of B _max and K _D (14.5 ± 3.7 ng/ml and 4.68 ± 1.5 ng/ml, respeCtively). ConClusions The proposed population PK model allowed for simultaneous estimation of B _max and K _D for a group of animals using single injeCtion PET experiments per animal.

Ronald Boellaard - One of the best experts on this subject based on the ideXlab platform.

  • Population pharmaCokinetiC analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography.
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABAA-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABAA-reCeptor properties, CharaCterized by Bmax and KD.

  • Population PharmaCokinetiC Analysis for Simultaneous Determination of B _max and K _D In Vivo by Positron Emission Tomography
    Molecular Imaging and Biology, 2005
    Co-Authors: Lia C. Liefaard, Bart A. Ploeger, Carla F. M. Molthoff, Ronald Boellaard, Adriaan A. Lammertsma, Meindert Danhof, Rob A. Voskuyl
    Abstract:

    Purpose Changes in GABA_A-reCeptor density and affinity play an important role in many forms of epilepsy. A novel approaCh, using positron emission tomography (PET) and [C-11]Flumazenil ([C-11]FMZ), was developed for simultaneous estimation of GABA_A-reCeptor properties, CharaCterized by B _max and K _D. ProCedures Following an injeCtion of [C-11]FMZ (dose range: 1–2,000 μg) to 21 rats, ConCentration time Curves of FMZ in brain (using PET) and blood (using HPLC-UV) were analyzed simultaneously using a population pharmaCokinetiC (PK) model, Containing expressions to desCribe the time Course of the plasma ConCentration (inCluding distribution to the body), the brain distribution, and the speCifiC binding within the brain. Results AppliCation of this method in Control rats resulted in estimates of B _max and K _D (14.5 ± 3.7 ng/ml and 4.68 ± 1.5 ng/ml, respeCtively). ConClusions The proposed population PK model allowed for simultaneous estimation of B _max and K _D for a group of animals using single injeCtion PET experiments per animal.