The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Jeong Min Hwang - One of the best experts on this subject based on the ideXlab platform.
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efficacy and safety of loteprednol 0 5 and Fluorometholone 0 1 after strabismus surgery in children
Journal of Ocular Pharmacology and Therapeutics, 2018Co-Authors: Hee Kyung Yang, Jeong Min HwangAbstract:Abstract Purpose: To compare the effects of topical loteprednol and Fluorometholone in children who underwent strabismus surgery. Methods: This is a retrospective observational case series. A total...
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diclofenac versus Fluorometholone after strabismus surgery in children
British Journal of Ophthalmology, 2014Co-Authors: Hee Kyung Yang, Jeong Min HwangAbstract:Aims To compare the effects of topical diclofenac sodium with those of Fluorometholone on intraocular pressure (IOP) and conjunctival inflammation after strabismus surgery. Methods We retrospectively analysed 60 Korean children who underwent strabismus surgery for intermittent exotropia in an institutional referral centre. Patients received topical diclofenac 0.1% or Fluorometholone 0.1% after surgery for up to 4 weeks. IOP, patient discomfort, conjunctival inflammation and conjunctival injection were evaluated at 1, 2, 3 and 4 weeks after surgery. Results In the Fluorometholone group, 23% showed an increase of ≥10 mm Hg compared to the baseline IOP within 4 weeks of surgery. The Fluorometholone group showed a significant change in IOP compared to baseline (p Conclusions Postoperative topical diclofenac is an excellent substitute for steroids, particularly in young children under 7 years of age.
Charles N J Mcghee - One of the best experts on this subject based on the ideXlab platform.
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the metabolism of Fluorometholone by bovine cornea
Journal of Pharmaceutical and Biomedical Analysis, 1993Co-Authors: Zafar Iqbal, David G. Watson, J M Midgley, P R Dennison, Charles N J McgheeAbstract:Abstract Isolated bovine cornea was found to reduce the 20 ketone group in Fluorometholone (FML) to produce a mixture of 20α- and 20β-dihydroFluorometholone (DHFML). Incubation of FML with bovine cornea at pH 7.4 in phosphate buffer produced an increase in the amount of reduction products up to 8 h; after this time the rate of reduction decreased. The reduced products were quantified by GC—MS against [ 2 H 3 ] 20α-DHFML. Variable amounts of 20β-DHFML were detected in six samples of human aqueous humour following topical application of 50 μg of FML to the eye. The rapid metabolism of the side chain of FML may account for the unexpected low concentrations of FML which are found in human aqueous humour following its application to the surface of the eye.
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penetration of synthetic corticosteroids into human aqueous humour
Eye, 1990Co-Authors: M Noble, John M. Midgley, G. N. Dutton, David G. Watson, Charles N J Mcghee, A I FernAbstract:The penetration of prednisolone acetate (1%) and Fluorometholone alcohol (0.1%) into human aqueous humour following topical application was determined using the very sensitive and specific technique of Gas Chromatography with Mass Spectrometry (GCMS). Prednisolone acetate afforded peak mean concentrations of 669.9 ng/ml within two hours and levels of 28.6 ng/ml in aqueous humour were detected almost 24 hours post application. The peak aqueous humour level of Fluorometholone was 5.1ng/ml. The results are compared and contrasted with the absorption of dexamethasone alcohol (0.1%), betamethasone sodium phosphate (0.1%) and prednisolone sodium phosphate (0.5%) into human aqueous humour.
Theofilos Tourtas - One of the best experts on this subject based on the ideXlab platform.
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Randomized comparison of topical prednisolone acetate 1% versus Fluorometholone 0.1% in the first year after descemet membrane endothelial keratoplasty.
Cornea, 2014Co-Authors: Marianne O. Price, Francis W. Price, Friedrich E. Kruse, Bjoern O. Bachmann, Theofilos TourtasAbstract:PURPOSE: The aim of this study was to compare the efficacy and side effects of prednisolone acetate 1% versus Fluorometholone 0.1% after Descemet membrane endothelial keratoplasty (DMEK). METHODS: DMEK recipients used prednisolone acetate 1% for 1 month, and they were randomized to either prednisolone or Fluorometholone for months 2 through 12. Dosing was 4 times daily in months 1 to 3, thrice daily in month 4, twice daily in month 5, and once daily in months 6 to 12. The main outcomes were immunologic rejection episodes and intraocular pressure (IOP) elevation (defined as ≥24 mm Hg or ≥10 mm Hg increase over the preoperative baseline level), assessed by the Kaplan-Meier survival analysis. RESULTS: The study included 325 eyes (99% were white, 96% had Fuchs dystrophy, and 9% had a previous glaucoma diagnosis). No eyes (0%) assigned to prednisolone versus 2 eyes (1.4%) assigned to Fluorometholone experienced a possible (n = 1) or probable (n = 1) rejection episode (P = 0.17). Both rejection episodes resolved successfully with increased topical steroids. In the prednisolone arm, a significantly higher proportion exceeded the defined IOP elevation threshold (22% vs. 6%, P = 0.0005), and glaucoma medications were initiated or increased more often (17% vs. 5%, P = 0.0003). The most frequent reasons for discontinuing the assigned intervention were IOP management (n = 13 eyes assigned to prednisolone) or inflammation management (n = 3 eyes assigned to Fluorometholone). One-year endothelial cell loss was comparable in both arms (30% vs. 31%, P = 0.50). CONCLUSIONS: DMEK has a remarkably low rejection episode rate (
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randomized comparison of topical prednisolone acetate 1 versus Fluorometholone 0 1 in the first year after descemet membrane endothelial keratoplasty
Cornea, 2014Co-Authors: Marianne O. Price, Francis W. Price, Friedrich E. Kruse, Bjoern O. Bachmann, Theofilos TourtasAbstract:PURPOSE: The aim of this study was to compare the efficacy and side effects of prednisolone acetate 1% versus Fluorometholone 0.1% after Descemet membrane endothelial keratoplasty (DMEK). METHODS: DMEK recipients used prednisolone acetate 1% for 1 month, and they were randomized to either prednisolone or Fluorometholone for months 2 through 12. Dosing was 4 times daily in months 1 to 3, thrice daily in month 4, twice daily in month 5, and once daily in months 6 to 12. The main outcomes were immunologic rejection episodes and intraocular pressure (IOP) elevation (defined as ≥24 mm Hg or ≥10 mm Hg increase over the preoperative baseline level), assessed by the Kaplan-Meier survival analysis. RESULTS: The study included 325 eyes (99% were white, 96% had Fuchs dystrophy, and 9% had a previous glaucoma diagnosis). No eyes (0%) assigned to prednisolone versus 2 eyes (1.4%) assigned to Fluorometholone experienced a possible (n = 1) or probable (n = 1) rejection episode (P = 0.17). Both rejection episodes resolved successfully with increased topical steroids. In the prednisolone arm, a significantly higher proportion exceeded the defined IOP elevation threshold (22% vs. 6%, P = 0.0005), and glaucoma medications were initiated or increased more often (17% vs. 5%, P = 0.0003). The most frequent reasons for discontinuing the assigned intervention were IOP management (n = 13 eyes assigned to prednisolone) or inflammation management (n = 3 eyes assigned to Fluorometholone). One-year endothelial cell loss was comparable in both arms (30% vs. 31%, P = 0.50). CONCLUSIONS: DMEK has a remarkably low rejection episode rate (<1% through 1 year), as confirmed in this prospective randomized study. This provides a unique opportunity to reduce postoperative topical corticosteroid strength and thereby reduce the risk of steroid-associated complications.
Soliman A Alkharashi - One of the best experts on this subject based on the ideXlab platform.
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efficacy of nedocromil 2 versus Fluorometholone 0 1 a randomised double masked trial comparing the effects on severe vernal keratoconjunctivitis
British Journal of Ophthalmology, 1999Co-Authors: Khalid F Tabbara, Soliman A AlkharashiAbstract:AIMS To compare the efficacy of topical nedocromil 2% with Fluorometholone 0.1% in vernal keratoconjunctivitis (VKC). METHODS In a double masked random design, 24 patients with severe vernal keratoconjunctivitis were placed at random on nedocromil 2% eye drops in one eye and Fluorometholone 0.1% in the fellow eye. At the end of the 2 week treatment period, the patient crossed over the eye drops (if asymptomatic in one eye), or continued with nedocromil sodium in both eyes (if asymptomatic in both eyes). All patients were examined weekly and ocular surface temperature recorded for a period of 6 weeks. RESULTS Improvement in the watering, discharge, conjunctival hyperaemia, papillary hypertrophy, and Trantas’ dots was noted in both groups, but overall Fluorometholone was significantly more effective than nedocromil. Eyes treated with Fluorometholone showed a significant decrease in ocular surface temperature compared with nedocromil treated eyes (p = 0.03). CONCLUSIONS Both nedocromil and Fluorometholone were effective in ameliorating the signs and symptoms of vernal keratoconjunctivitis. No adverse effects were noted in the nedocromil group.
Hee Kyung Yang - One of the best experts on this subject based on the ideXlab platform.
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efficacy and safety of loteprednol 0 5 and Fluorometholone 0 1 after strabismus surgery in children
Journal of Ocular Pharmacology and Therapeutics, 2018Co-Authors: Hee Kyung Yang, Jeong Min HwangAbstract:Abstract Purpose: To compare the effects of topical loteprednol and Fluorometholone in children who underwent strabismus surgery. Methods: This is a retrospective observational case series. A total...
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diclofenac versus Fluorometholone after strabismus surgery in children
British Journal of Ophthalmology, 2014Co-Authors: Hee Kyung Yang, Jeong Min HwangAbstract:Aims To compare the effects of topical diclofenac sodium with those of Fluorometholone on intraocular pressure (IOP) and conjunctival inflammation after strabismus surgery. Methods We retrospectively analysed 60 Korean children who underwent strabismus surgery for intermittent exotropia in an institutional referral centre. Patients received topical diclofenac 0.1% or Fluorometholone 0.1% after surgery for up to 4 weeks. IOP, patient discomfort, conjunctival inflammation and conjunctival injection were evaluated at 1, 2, 3 and 4 weeks after surgery. Results In the Fluorometholone group, 23% showed an increase of ≥10 mm Hg compared to the baseline IOP within 4 weeks of surgery. The Fluorometholone group showed a significant change in IOP compared to baseline (p Conclusions Postoperative topical diclofenac is an excellent substitute for steroids, particularly in young children under 7 years of age.