The Experts below are selected from a list of 1071 Experts worldwide ranked by ideXlab platform
Kyung Hee Kwak - One of the best experts on this subject based on the ideXlab platform.
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efficacy of a povidone iodine Foam Dressing betaFoam on diabetic foot ulcer
International Wound Journal, 2020Co-Authors: Heui Chul Gwak, Seung Heon Han, Jinwoo Lee, Sejin Park, Ki Sun Sung, Hak Jun Kim, Dongil Chun, Kyungmin Lee, Jae Hoon Ahn, Kyung Hee KwakAbstract:This study aimed to assess the efficacy of a new povidone-iodine (PVP-I) Foam Dressing (BetaFoam) vs Foam Dressing (MediFoam) for the management of diabetic foot ulcers. This study was conducted between March 2016 and September 2017 at 10 sites in Korea. A total of 71 patients (aged ≥19 years) with type 1/2 diabetes and early-phase diabetic foot ulcers (Wagener classification grade 1/2) were randomised to treatment with PVP-I Foam Dressing or Foam Dressing for 8 weeks. Wound healing, wound infection, patient satisfaction, and adverse events (AEs) were assessed. The PVP-I Foam and Foam Dressing groups were comparable in the proportion of patients with complete wound healing within 8 weeks (44.4% vs 42.3%, P = .9191), mean (±SD) number of days to complete healing (31.00 ± 15.07 vs 33.27 ± 12.60 days; P = .6541), and infection rates (11.1% vs 11.4%; P = 1.0000). Median satisfaction score (scored from 0 to 10) at the final visit was also comparable between groups (10 vs 9, P = .2889). There was no significant difference in AE incidence (27.8% vs 17.1%, P = .2836), and none of the reported AEs had a causal relationship with the Dressings. The results of this study suggest that PVP-I Foam Dressing has wound-healing efficacy comparable with Foam Dressing, with no notable safety concerns. This study was funded by Mundipharma Korea Ltd and registered at ClinicalTrials.gov (identifier NCT02732886).
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comparison of the efficacy and safety of povidone iodine Foam Dressing betaFoam hydrocellular Foam Dressing allevyn and petrolatum gauze for split thickness skin graft donor site Dressing
International Wound Journal, 2019Co-Authors: Chang Sik Pak, Dae Hwan Park, Won Jai Lee, Young Joon Jun, Kyung Ah Lee, Kyung Hee Kwak, Jong Won RhieAbstract:We evaluated the efficacy and safety of a povidone-iodine (PVP-I) Foam Dressing (BetaFoam) for donor site Dressing versus a hydrocellular Foam Dressing (Allevyn) and petrolatum gauze. This prospective Phase 4 study was conducted between March 2016 and April 2017 at eight sites in Korea. A total of 106 consenting patients (aged ≥ 19 years, scheduled for split-thickness skin graft) were randomised 1:1:1 to PVP-I Foam, hydrocellular, or petrolatum gauze Dressings for up to 28 days after donor site collection. We assessed time to complete epithelialisation, proportion with complete epithelialisation at Day 14, and wound infection. Epithelialisation time was the shortest with PVP-I Foam Dressing (12.74 ± 3.51 days) versus hydrocellular Foam Dressing (16.61 ± 4.45 days; P = 0.0003) and petrolatum gauze (15.06 ± 4.26 days, P = 0.0205). At Day 14, 83.87% of PVP-I Foam Dressing donor sites had complete epithelialisation, versus 36.36% of hydrocellular Foam Dressing donor sites (P = 0.0001) and 55.88% of petrolatum gauze donor sites (P = 0.0146). There were no wound infections. Incidence rates of adverse events were comparable across groups (P = 0.1940). PVP-I Foam Dressing required less time to complete epithelialisation and had a good safety profile.
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A pilot study to compare the efficacy and safety of BetaFoam® and Allevyn® Ag in the management of acute partial thickness burns
Elsevier, 2019Co-Authors: Cheol Soo Jeong, Kyung Hee Kwak, Jun Hur, Dohern KymAbstract:BetaFoam® is a new polyurethane Foam Dressing containing 3% povidone-iodine. This pilot study aimed to assess the performance of BetaFoam® for the management of acute partial thickness burn wounds, by comparing its efficacy and safety with those of a silver Foam Dressing, Allevyn® Ag Gentle. This randomized, two-arm, pilot study was conducted between June 2016 and February 2017 at 2 sites in the Republic of Korea. A total of 32 patients (aged ≥19 years) with acute partial thickness burn wounds and burn total body surface area ≤15% were randomized to treatment with BetaFoam® or Allevyn® Ag Gentle Dressings for 28 days. Endpoints included target lesion re-epithelialization, infection, pain, and adverse events. Mean time to complete re-epithelialization was similar in the BetaFoam® and Allevyn® Ag Gentle groups (12.53 ± 1.13 vs 9.88 ± 1.02 days, P = 0.1556). All patients had complete re-epithelialization by day 28, and none had a burn wound infection during the study period. Analgesic use and patient-reported pain scores during Dressing changes were not significantly different between Dressing groups. No adverse events were associated with application of the Dressings. The results of this first-in-human study suggest that BetaFoam® has comparable wound healing efficacy to Allevyn® Ag Gentle, with no notable safety concerns. Keywords: Wound healing, Partial thickness burns, BetaFoam, Allevyn, Povidone-iodine, Burns, Pilot project
Kris Kieswetter - One of the best experts on this subject based on the ideXlab platform.
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effects of negative pressure wound therapy on cellular energetics in fibroblasts grown in a provisional wound fibrin matrix
Wound Repair and Regeneration, 2009Co-Authors: Amy Mcnulty, Marisa Schmidt, Patricia A Villanueva, Teri D. Feeley, Kris KieswetterAbstract:Negative pressure wound therapy (NPWT) using reticulated open cell Foam Dressing (ROCF) is effective for treatment of recalcitrant wounds; however, the effects of this therapy on cellular metabolism remain to be elucidated. The effect of two different subatmospheric pressure applications on the cell energetics of human fibroblasts grown in a 3D fibrin matrix was studied using two different pressure-manifolding materials, an ROCF or gauze under suction (GUS). It was found that levels of cytochrome c oxidase, energy charge, and adenosine triphosphate/adenosine diphosphate were significantly increased following the application of NPWT using ROCF vs. GUS (p < 0.05). Increases in these parameters likely reflect an improved energetic status. In addition, levels of transforming growth factor-β and platelet-derived growth factor (α and isoforms) were significantly increased (80 and 53%, respectively; p < 0.05) over static control cultures following treatment with NPWT using ROCF but not following GUS. These growth factors are known to be important during wound healing. Clearly, both the material used as the Dressing to manifold the subatmospheric pressure and the pressure used have a dramatic effect on cellular response.
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effects of negative pressure wound therapy on cellular energetics in fibroblasts grown in a provisional wound fibrin matrix
Wound Repair and Regeneration, 2009Co-Authors: Amy Mcnulty, Marisa Schmidt, Patricia A Villanueva, Teri D. Feeley, Kris KieswetterAbstract:Negative pressure wound therapy (NPWT) using reticulated open cell Foam Dressing (ROCF) is effective for treatment of recalcitrant wounds; however, the effects of this therapy on cellular metabolism remain to be elucidated. The effect of two different subatmospheric pressure applications on the cell energetics of human fibroblasts grown in a 3D fibrin matrix was studied using two different pressure-manifolding materials, an ROCF or gauze under suction (GUS). It was found that levels of cytochrome c oxidase, energy charge, and adenosine triphosphate/adenosine diphosphate were significantly increased following the application of NPWT using ROCF vs. GUS (p<0.05). Increases in these parameters likely reflect an improved energetic status. In addition, levels of transforming growth factor-beta and platelet-derived growth factor (alpha and beta isoforms) were significantly increased (80 and 53%, respectively; p<0.05) over static control cultures following treatment with NPWT using ROCF but not following GUS. These growth factors are known to be important during wound healing. Clearly, both the material used as the Dressing to manifold the subatmospheric pressure and the pressure used have a dramatic effect on cellular response.
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effects of Dressing type on 3d tissue microdeformations during negative pressure wound therapy a computational study
Journal of Biomechanical Engineering-transactions of The Asme, 2009Co-Authors: Robert Peyton Wilkes, Kris Kieswetter, Y Zhao, Balakrishna HaridasAbstract:Vacuum-assisted closure ® (VAC ® ) therapy, also referred to as vacuum-assisted closure ® negative pressure wound therapy (VAC ® NPWT), delivered to various dermal wounds is believed to influence the formation of granulation tissue via the mechanism of microdeformational signals. In recent years, numerous experimental investigations have been initiated to study the cause-effect relationships between the mechanical signals and the transduction pathways that result in improved granulation response. To accurately quantify the tissue microdeformations during therapy, a new three-dimensional finite element model has been developed and is described in this paper. This model is used to study the effect of Dressing type and subatmospheric pressure level on the variations in the microdeformational strain fields in a model dermal wound bed. Three-dimensional geometric models representing typical control volumes of NPWT Dressings were generated using micro-CT scanning of VAC ® GranuFoam ® , a reticulated open-cell polyurethane Foam (ROCF), and a gauze Dressing (constructed from USP Class VII gauze). Using a nonlinear hyperFoam constitutive model for the wound bed, simulated tissue microdeformations were generated using the Foam and gauze Dressing models at equivalent negative pressures. The model results showed that Foam produces significantly greater strain than gauze in the tissue model at all pressures and in all metrics (p 0.0001 for all but vol at 50 mm Hg and 100 mm Hg where p 0.05). Specifically, it was demonstrated in this current work that the ROCF Dressing produces higher levels of tissue microdeformation than gauze at all levels of subatmospheric pressure. This observation is consistent across all of the strain invariants assessed, i.e., vol, dist, the minimum and maximum principal strains, and the maximum shear strain. The distribution of the microdeformations and strain appears as a repeating mosaic beneath the Foam Dressing, whereas the gauze Dressings appear to produce an irregular distribution of strains in the wound surface. Strain predictions from the developed computational model results agree well with those predicted from prior two-dimensional experimental and computational studies of Foambased NPWT (Saxena, V., et al., 2004, “Vacuum-assisted closure: Microdeformations of Wounds and Cell Proliferation,” Plast. Reconstr. Surg., 114(5), pp. 1086–1096). In conjunction with experimental in vitro and in vivo studies, the developed model can now be extended into more detailed investigations into the mechanobiological underpinnings of VAC ® NPWT and can help to further develop and optimize this treatment modality for the
Jong Won Rhie - One of the best experts on this subject based on the ideXlab platform.
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comparison of the efficacy and safety of povidone iodine Foam Dressing betaFoam hydrocellular Foam Dressing allevyn and petrolatum gauze for split thickness skin graft donor site Dressing
International Wound Journal, 2019Co-Authors: Chang Sik Pak, Dae Hwan Park, Won Jai Lee, Young Joon Jun, Kyung Ah Lee, Kyung Hee Kwak, Jong Won RhieAbstract:We evaluated the efficacy and safety of a povidone-iodine (PVP-I) Foam Dressing (BetaFoam) for donor site Dressing versus a hydrocellular Foam Dressing (Allevyn) and petrolatum gauze. This prospective Phase 4 study was conducted between March 2016 and April 2017 at eight sites in Korea. A total of 106 consenting patients (aged ≥ 19 years, scheduled for split-thickness skin graft) were randomised 1:1:1 to PVP-I Foam, hydrocellular, or petrolatum gauze Dressings for up to 28 days after donor site collection. We assessed time to complete epithelialisation, proportion with complete epithelialisation at Day 14, and wound infection. Epithelialisation time was the shortest with PVP-I Foam Dressing (12.74 ± 3.51 days) versus hydrocellular Foam Dressing (16.61 ± 4.45 days; P = 0.0003) and petrolatum gauze (15.06 ± 4.26 days, P = 0.0205). At Day 14, 83.87% of PVP-I Foam Dressing donor sites had complete epithelialisation, versus 36.36% of hydrocellular Foam Dressing donor sites (P = 0.0001) and 55.88% of petrolatum gauze donor sites (P = 0.0146). There were no wound infections. Incidence rates of adverse events were comparable across groups (P = 0.1940). PVP-I Foam Dressing required less time to complete epithelialisation and had a good safety profile.
Helmuth Goepfert - One of the best experts on this subject based on the ideXlab platform.
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split thickness skin graft donor site management a randomized prospective trial comparing a hydrophilic polyurethane absorbent Foam Dressing with a petrolatum gauze Dressing
Archives of Otolaryngology-head & Neck Surgery, 1995Co-Authors: Randal S Weber, Patti Hankins, Ellen Limitone, David L Callender, Robert M Frankenthaler, Pat Wolf, Helmuth GoepfertAbstract:Objective: Traditionally, skin graft donor sites have been covered with fine-mesh gauze Dressings, and a dry eschar has been allowed to form. Newer Dressings that can provide a moist wound environment may facilitate reepithelialization. We compared a hydrophilic semipermeable absorbent polyurethane Foam Dressing that provides a moist wound environment with a petrolatum gauze Dressing for donor sites. Design: Prospective randomized trial; follow-up at 14 days. Setting: Department of head and neck surgery in a tertiary care center. Patients: Sixty-eight eligible patients received one of the two Dressings. Harvested skin grafts were 0.375-mm (0.015-in) thick; donor site surface areas were recorded. At postoperative day 14, the Dressings were removed, and wound epithelialization was scored: 1, none; 2, scattered or spotty; and 3, complete. Donor site and operative site pain intensities were assessed by a visual numeric scale: none (0) to the worst (100) experienced over the preceding 24-hour period. Pain scores were available for 58 patients. Main Outcome Measures: Dressings were compared based on these criteria: healing at 14 days, infection, and donor site and operative site pain. Results: A healing score of 3 was seen in 37% (14/38) of patients with hydrophilic semipermeable absorbent polyurethane Foam Dressings and in 17% (5/30) of patients with petrolatum gauze Dressings ( P =.06) by day 14. Overall, however, mean healing scores were similar in both groups. Mean healing scores for the patients who received a hydrophilic semipermeable absorbent polyurethane Foam Dressing was 2.3 (SD=0.6) vs 2.2 (SD=0.6) for patients who received the petrolatum gauze Dressing ( P =.20). Numbers of days required for complete epithelialization in these groups were 20.6 (SD=10.1) and 19.3 (SD=5.1), respectively ( P =.49). One infection occurred in the group who received the petrolatum gauze Dressing. The mean maximum pain intensity scores were lower for those who were given the hydrophilic semipermeable absorbent polyurethane Foam Dressing on postoperative days 1 through 3 ( P =.003,.03, and.04, respectively). Pain increased with a larger donor site surface area for the patients with the petrolatum gauze Dressing but not for the patients with the hydrophilic semipermeable absorbent polyurethane Foam Dressing. Conclusions: The hydrophilic semipermeable absorbent polyurethane Foam Dressing appears to have potential advantages over the petrolatum gauze Dressing: it produces less initial patient donor site discomfort and tends to produce more complete donor site healing by postoperative day 14. (Arch Otolaryngol Head Neck Surg. 1995;121:1145-1149)
Chang Sik Pak - One of the best experts on this subject based on the ideXlab platform.
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comparison of the efficacy and safety of povidone iodine Foam Dressing betaFoam hydrocellular Foam Dressing allevyn and petrolatum gauze for split thickness skin graft donor site Dressing
International Wound Journal, 2019Co-Authors: Chang Sik Pak, Dae Hwan Park, Won Jai Lee, Young Joon Jun, Kyung Ah Lee, Kyung Hee Kwak, Jong Won RhieAbstract:We evaluated the efficacy and safety of a povidone-iodine (PVP-I) Foam Dressing (BetaFoam) for donor site Dressing versus a hydrocellular Foam Dressing (Allevyn) and petrolatum gauze. This prospective Phase 4 study was conducted between March 2016 and April 2017 at eight sites in Korea. A total of 106 consenting patients (aged ≥ 19 years, scheduled for split-thickness skin graft) were randomised 1:1:1 to PVP-I Foam, hydrocellular, or petrolatum gauze Dressings for up to 28 days after donor site collection. We assessed time to complete epithelialisation, proportion with complete epithelialisation at Day 14, and wound infection. Epithelialisation time was the shortest with PVP-I Foam Dressing (12.74 ± 3.51 days) versus hydrocellular Foam Dressing (16.61 ± 4.45 days; P = 0.0003) and petrolatum gauze (15.06 ± 4.26 days, P = 0.0205). At Day 14, 83.87% of PVP-I Foam Dressing donor sites had complete epithelialisation, versus 36.36% of hydrocellular Foam Dressing donor sites (P = 0.0001) and 55.88% of petrolatum gauze donor sites (P = 0.0146). There were no wound infections. Incidence rates of adverse events were comparable across groups (P = 0.1940). PVP-I Foam Dressing required less time to complete epithelialisation and had a good safety profile.