The Experts below are selected from a list of 258 Experts worldwide ranked by ideXlab platform

Leslie H. Blumgart - One of the best experts on this subject based on the ideXlab platform.

  • Diagnosis and treatment of Focal Nodular Hyperplasia
    Journal of Hepato-Biliary-Pancreatic Surgery, 1996
    Co-Authors: David L. Bartlett, Lawrence H. Schwartz, David Klimstra, Leslie H. Blumgart
    Abstract:

    Focal Nodular Hyperplasia is an uncommon, benign lesion of the liver of minimal clinical significance. Its importance lies in differentiating it from clinically significant lesions such as liver cell adenoma and hepatocellular carcinoma. The purpose of this review is to provide a background on the pathogenesis of Focal Nodular Hyperplasia, discuss current imaging modalities which provide the most specificity in diagnosis, and provide an update on the accepted management of these lesions. While debate still exists, most current authors believe that Focal Nodular Hyperplasia represents a local response of the liver to injury. The source of that injury seems to be vascular malformations. Magnetic resonance imaging (MRI) provides the most specificity in diagnosis, although the characteristics are still being described. Classically, the lesions will be isointense on T2-weighted images with rapid homogenous contrast enhancement and delayed enhancing central stellate scar. Surgical resection is limited to symptomatic lesions or lesions with atypical imaging characteristics suggesting the possibility of a malignant diagnosis. Percutaneous biopsy can be helpful in those lesions where there is an overall high suspicion of Focal Nodular Hyperplasia, but some of the clinical aspects or imaging characteristics are atypical for the diagnosis. The use of embolization as first line therapy for symptomatic lesions deserves further investigation.

Christian Côté - One of the best experts on this subject based on the ideXlab platform.

  • Regression of Focal Nodular Hyperplasia of the liver after oral contraceptive discontinuation
    Clinical nuclear medicine, 1997
    Co-Authors: Christian Côté
    Abstract:

    There is uncertainty regarding the role, if any, of oral contraceptive steroids in the development of Focal Nodular Hyperplasia of the liver. A case of Focal Nodular Hyperplasia of the liver diagnosed by scintigraphy in a 33-year-old woman is presented. The lesion regressed in a dramatic way after oral contraceptive discontinuation. This case report suggests that oral contraceptives may influence the natural history of Focal Nodular Hyperplasia of the liver, and that a trophic effect on the liver lesion is quite possible.

Ian R. Wanless - One of the best experts on this subject based on the ideXlab platform.

Brian A West - One of the best experts on this subject based on the ideXlab platform.

  • multiple Focal Nodular Hyperplasia of the liver associated with hemihypertrophy and vascular malformations
    Gastroenterology, 1995
    Co-Authors: Marian Haber, Adrian Reuben, Morton I Burrell, Patrick Oliverio, Ronald R Salem, Brian A West
    Abstract:

    Abstract A case of multiple Focal Nodular Hyperplasia of the liver occurring in a 22-year-old woman with musculoskeletal hemihypertrophy and anomalous vascular supply to the liver is described. The patient had Klippel-TrenaunayWeber syndrome and abdominal pain and tender massive hepatomegaly. Visceral angiography showed marked dilatation of the celiac axis and both the main trunk and peripheral branches of the hepatic artery. Large abdominal veins drained from the dome of the liver into the hepatic veins. The vascular anomalies were evident on contrast-enhanced computed tomography and magnetic resonance imaging. Multiple Focal Nodular Hyperplasia was confirmed by laparoscopic liver biopsy. The findings in this patient support the concept that multiple Focal Nodular Hyperplasia characteristically occurs in a syndromic form and is induced by an irregular arterial supply in the liver, with localized hyperfusion that leads to Nodular areas of hepatocyte hyperproliferation.

Pilch-kowalczyk J - One of the best experts on this subject based on the ideXlab platform.

  • Focal Nodular Hyperplasia of the liver in doppler sonography--case report
    Polskie Archiwum Medycyny Wewnetrznej, 1993
    Co-Authors: Górka Z, Maciej Kajor, Marek Hartleb, Pilch-kowalczyk J
    Abstract:

    Current diagnostic capabilities of Doppler sonography in solid Focal lesions were presented. Diagnostic difficulties were discussed in the case of Focal liver lesion, wherein the diagnosis was not reached by sonography backed up by pulsed and color Doppler. The patient was submitted to surgical treatment. A histological specimen disclosed Focal Nodular Hyperplasia. The analysis of the case in question proved that sonography even combined with Doppler method cannot differentiate between hepatocellular carcinoma and Focal Nodular Hyperplasia.