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Burak Zeynep - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected False-positive I-131 Uptake in Patients with Differentiated Thyroid Carcinoma
    'Galenos Yayinevi', 2018
    Co-Authors: Oral Aylin, Yazici Bulent, Eraslan Cenk, Burak Zeynep
    Abstract:

    WOS: 000446711000001PubMed ID: 30317832Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients' clinical outcomes and the contribution of SPECT/CT imaging. Methods: I-131 WBSs of 1507 patients with DTC were retrospectively reviewed, and anticipated I-131 uptakes (like in breasts or thymus) were excluded from the study. The unexpected false-positive I-131 uptakes with concomitant SPECT/CT imaging were included in the study. Results: Twenty-one patients had 23 unexpected I-131 uptakes on WBS and concomitant SPECT/CT imaging. The vast majority (87%) of these cases were seen on post-therapeutic I-131 WBS. Most of the false-positive I-131 uptakes could be explained by SPECT/CT and radiologic findings, and were secondary to non-thyroid conditions (bronchiectasis, lung infection, subcutaneous injection into gluteal fatty tissue, aortic calcification, benign bone Cyst, vertebral hemangioma, recent non-thyroid surgical procedure site, rotator cuff injury, mature Cystic teratoma and ovarian Follicle Cyst). However, the possible reasons of 9 false-positive I-131 uptakes could not be explained by radiologic findings. Conclusion: We suggest that false-positive I-131 uptake and its underlying mechanisms (inflammation, trapping, increased perfusion, etc.) must be kept in mind in patients with thyroid cancer and unexpected findings must be considered together with serum thyroglobulin levels, SPECT/CT and radiologic findings in order to avoid misdiagnosis and unnecessary radioiodine treatment

  • Diferansiye Tiroid Karsinomlu Hastalarda Beklenmeyen Yanlış Pozitif I-131 Tutulumu
    'Galenos Yayinevi', 2018
    Co-Authors: Oral Aylin, Yazici Bulent, Eraslan Cenk, Burak Zeynep
    Abstract:

    Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. in this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging. Methods: I-131 WBSs of 1507 patients with DTC were retrospectively reviewed, and anticipated I-131 uptakes (like in breasts or thymus) were excluded from the study. the unexpected false-positive I-131 uptakes with concomitant SPECT/CT imaging were included in the study. Results: Twenty-one patients had 23 unexpected I-131 uptakes on WBS and concomitant SPECT/CT imaging. the vast majority (87%) of these cases were seen on post-therapeutic I-131 WBS. Most of the false-positive I-131 uptakes could be explained by SPECT/CT and radiologic findings, and were secondary to non-thyroid conditions (bronchiectasis, lung infection, subcutaneous injection into gluteal fatty tissue, aortic calcification, benign bone Cyst, vertebral hemangioma, recent nonthyroid surgical procedure site, rotator cuff injury, mature Cystic teratoma and ovarian Follicle Cyst). However, the possible reasons of 9 false-positive I-131 uptakes could not be explained by radiologic findings. Conclusion: We suggest that false-positive I-131 uptake and its underlying mechanisms (inflammation, trapping, increased perfusion, etc.) must be kept in mind in patients with thyroid cancer and unexpected findings must be considered together with serum thyroglobulin levels, SPECT/CT and radiologic findings in order to avoid misdiagnosis and unnecessary radioiodine treatment.Amaç: Radyoaktif iyot diferansiye tiroid karsinomu (DTK) görüntülemesinde kullanılan en yüksek özgüllüğe sahip radyonükliddir. Duyarlılık ve özgüllüğü yüksek olmakla birlikte I-131 tüm vücut tarama sintigrafisinde (TVTS) yanlış pozitif I-131 tutulumu görülebilmekte ve bu durum tanısal güçlüklere ve gereksiz tedavi uygulanmasına neden olabilmektedir. Bu çalışmada I-131 TVTS’de izlenen beklenmedik yanlış pozitif I-131 tutulumlarına ait TVTS ve tek foton emisyon bilgisayarlı tomografisi/ bilgisayarlı tomografi (SPECT/BT) görüntüleme bulguları ile hastaların klinik sonuçlarının ve SPECT/BT görüntülemenin katkısının sunulması amaçlanmıştır. Yöntem: Kliniğimizde takipli 1507 DTK tanılı hastaya ait I-131 TVTS’leri retrospektif olarak incelendi ve alışılagelmiş yanlış pozitif I-131 tutulumları (timüs, meme gibi) çalışma dışında bırakıldı. Eş zamanlı SPECT/BT görüntüleri olan ve beklenen alanlar dışında izlenen yanlış pozitif I-131 tutulumları çalışmaya dahil edildi. Bulgular: Yirmi bir hastada 23 adet eş zamanlı SPECT/BT ile lokalize edilen, beklenmedik yanlış pozitif I-131 tutulumu saptandı. Bulguların büyük çoğunluğu (%87) post-terapötik TVTS’de izlendi. Yanlış pozitif tutulumların çoğunun eş zamanlı SPECT/BT ve radyolojik bulgular ile tiroid dışı nedenlere (bronşektazi, akciğer enfeksiyonu, gluteal yağlı dokuya subkutan enjeksiyon, aort kalsifikasyonu, benign kemik kisti, vertebral hemanjiom, yakın zamanlı tiroid dışı cerrahi girişim, rotator kılıf yaralanması, matür kistik teratom ve overde follikül kisti) bağlı olduğu anlaşıldı. Dokuz hastada ise yanlış pozitif iyot tutulumu radyolojik görüntüleme bulguları ile açıklanamadı. Sonuç: Tiroid kanserli hastalarda yanlış pozitif I-131 tutulumunun izlenebileceği ve altta yatan mekanizmaları (enflamasyon, kanlanma artışı, kistik lezyonda tutulum vb.) akılda tutularak, beklenmeyen I-131 tutulumlarının serum tiroglobulin düzeyi, SPECT/BT ve radyolojik verilerle birlikte değerlendirilerek gereksiz tedavilerin önüne geçilmesi gerektiği sonucuna varılmıştır

Oral Aylin - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected False-positive I-131 Uptake in Patients with Differentiated Thyroid Carcinoma
    'Galenos Yayinevi', 2018
    Co-Authors: Oral Aylin, Yazici Bulent, Eraslan Cenk, Burak Zeynep
    Abstract:

    WOS: 000446711000001PubMed ID: 30317832Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients' clinical outcomes and the contribution of SPECT/CT imaging. Methods: I-131 WBSs of 1507 patients with DTC were retrospectively reviewed, and anticipated I-131 uptakes (like in breasts or thymus) were excluded from the study. The unexpected false-positive I-131 uptakes with concomitant SPECT/CT imaging were included in the study. Results: Twenty-one patients had 23 unexpected I-131 uptakes on WBS and concomitant SPECT/CT imaging. The vast majority (87%) of these cases were seen on post-therapeutic I-131 WBS. Most of the false-positive I-131 uptakes could be explained by SPECT/CT and radiologic findings, and were secondary to non-thyroid conditions (bronchiectasis, lung infection, subcutaneous injection into gluteal fatty tissue, aortic calcification, benign bone Cyst, vertebral hemangioma, recent non-thyroid surgical procedure site, rotator cuff injury, mature Cystic teratoma and ovarian Follicle Cyst). However, the possible reasons of 9 false-positive I-131 uptakes could not be explained by radiologic findings. Conclusion: We suggest that false-positive I-131 uptake and its underlying mechanisms (inflammation, trapping, increased perfusion, etc.) must be kept in mind in patients with thyroid cancer and unexpected findings must be considered together with serum thyroglobulin levels, SPECT/CT and radiologic findings in order to avoid misdiagnosis and unnecessary radioiodine treatment

  • Diferansiye Tiroid Karsinomlu Hastalarda Beklenmeyen Yanlış Pozitif I-131 Tutulumu
    'Galenos Yayinevi', 2018
    Co-Authors: Oral Aylin, Yazici Bulent, Eraslan Cenk, Burak Zeynep
    Abstract:

    Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. in this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging. Methods: I-131 WBSs of 1507 patients with DTC were retrospectively reviewed, and anticipated I-131 uptakes (like in breasts or thymus) were excluded from the study. the unexpected false-positive I-131 uptakes with concomitant SPECT/CT imaging were included in the study. Results: Twenty-one patients had 23 unexpected I-131 uptakes on WBS and concomitant SPECT/CT imaging. the vast majority (87%) of these cases were seen on post-therapeutic I-131 WBS. Most of the false-positive I-131 uptakes could be explained by SPECT/CT and radiologic findings, and were secondary to non-thyroid conditions (bronchiectasis, lung infection, subcutaneous injection into gluteal fatty tissue, aortic calcification, benign bone Cyst, vertebral hemangioma, recent nonthyroid surgical procedure site, rotator cuff injury, mature Cystic teratoma and ovarian Follicle Cyst). However, the possible reasons of 9 false-positive I-131 uptakes could not be explained by radiologic findings. Conclusion: We suggest that false-positive I-131 uptake and its underlying mechanisms (inflammation, trapping, increased perfusion, etc.) must be kept in mind in patients with thyroid cancer and unexpected findings must be considered together with serum thyroglobulin levels, SPECT/CT and radiologic findings in order to avoid misdiagnosis and unnecessary radioiodine treatment.Amaç: Radyoaktif iyot diferansiye tiroid karsinomu (DTK) görüntülemesinde kullanılan en yüksek özgüllüğe sahip radyonükliddir. Duyarlılık ve özgüllüğü yüksek olmakla birlikte I-131 tüm vücut tarama sintigrafisinde (TVTS) yanlış pozitif I-131 tutulumu görülebilmekte ve bu durum tanısal güçlüklere ve gereksiz tedavi uygulanmasına neden olabilmektedir. Bu çalışmada I-131 TVTS’de izlenen beklenmedik yanlış pozitif I-131 tutulumlarına ait TVTS ve tek foton emisyon bilgisayarlı tomografisi/ bilgisayarlı tomografi (SPECT/BT) görüntüleme bulguları ile hastaların klinik sonuçlarının ve SPECT/BT görüntülemenin katkısının sunulması amaçlanmıştır. Yöntem: Kliniğimizde takipli 1507 DTK tanılı hastaya ait I-131 TVTS’leri retrospektif olarak incelendi ve alışılagelmiş yanlış pozitif I-131 tutulumları (timüs, meme gibi) çalışma dışında bırakıldı. Eş zamanlı SPECT/BT görüntüleri olan ve beklenen alanlar dışında izlenen yanlış pozitif I-131 tutulumları çalışmaya dahil edildi. Bulgular: Yirmi bir hastada 23 adet eş zamanlı SPECT/BT ile lokalize edilen, beklenmedik yanlış pozitif I-131 tutulumu saptandı. Bulguların büyük çoğunluğu (%87) post-terapötik TVTS’de izlendi. Yanlış pozitif tutulumların çoğunun eş zamanlı SPECT/BT ve radyolojik bulgular ile tiroid dışı nedenlere (bronşektazi, akciğer enfeksiyonu, gluteal yağlı dokuya subkutan enjeksiyon, aort kalsifikasyonu, benign kemik kisti, vertebral hemanjiom, yakın zamanlı tiroid dışı cerrahi girişim, rotator kılıf yaralanması, matür kistik teratom ve overde follikül kisti) bağlı olduğu anlaşıldı. Dokuz hastada ise yanlış pozitif iyot tutulumu radyolojik görüntüleme bulguları ile açıklanamadı. Sonuç: Tiroid kanserli hastalarda yanlış pozitif I-131 tutulumunun izlenebileceği ve altta yatan mekanizmaları (enflamasyon, kanlanma artışı, kistik lezyonda tutulum vb.) akılda tutularak, beklenmeyen I-131 tutulumlarının serum tiroglobulin düzeyi, SPECT/BT ve radyolojik verilerle birlikte değerlendirilerek gereksiz tedavilerin önüne geçilmesi gerektiği sonucuna varılmıştır

Eraslan Cenk - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected False-positive I-131 Uptake in Patients with Differentiated Thyroid Carcinoma
    'Galenos Yayinevi', 2018
    Co-Authors: Oral Aylin, Yazici Bulent, Eraslan Cenk, Burak Zeynep
    Abstract:

    WOS: 000446711000001PubMed ID: 30317832Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients' clinical outcomes and the contribution of SPECT/CT imaging. Methods: I-131 WBSs of 1507 patients with DTC were retrospectively reviewed, and anticipated I-131 uptakes (like in breasts or thymus) were excluded from the study. The unexpected false-positive I-131 uptakes with concomitant SPECT/CT imaging were included in the study. Results: Twenty-one patients had 23 unexpected I-131 uptakes on WBS and concomitant SPECT/CT imaging. The vast majority (87%) of these cases were seen on post-therapeutic I-131 WBS. Most of the false-positive I-131 uptakes could be explained by SPECT/CT and radiologic findings, and were secondary to non-thyroid conditions (bronchiectasis, lung infection, subcutaneous injection into gluteal fatty tissue, aortic calcification, benign bone Cyst, vertebral hemangioma, recent non-thyroid surgical procedure site, rotator cuff injury, mature Cystic teratoma and ovarian Follicle Cyst). However, the possible reasons of 9 false-positive I-131 uptakes could not be explained by radiologic findings. Conclusion: We suggest that false-positive I-131 uptake and its underlying mechanisms (inflammation, trapping, increased perfusion, etc.) must be kept in mind in patients with thyroid cancer and unexpected findings must be considered together with serum thyroglobulin levels, SPECT/CT and radiologic findings in order to avoid misdiagnosis and unnecessary radioiodine treatment

  • Diferansiye Tiroid Karsinomlu Hastalarda Beklenmeyen Yanlış Pozitif I-131 Tutulumu
    'Galenos Yayinevi', 2018
    Co-Authors: Oral Aylin, Yazici Bulent, Eraslan Cenk, Burak Zeynep
    Abstract:

    Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. in this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging. Methods: I-131 WBSs of 1507 patients with DTC were retrospectively reviewed, and anticipated I-131 uptakes (like in breasts or thymus) were excluded from the study. the unexpected false-positive I-131 uptakes with concomitant SPECT/CT imaging were included in the study. Results: Twenty-one patients had 23 unexpected I-131 uptakes on WBS and concomitant SPECT/CT imaging. the vast majority (87%) of these cases were seen on post-therapeutic I-131 WBS. Most of the false-positive I-131 uptakes could be explained by SPECT/CT and radiologic findings, and were secondary to non-thyroid conditions (bronchiectasis, lung infection, subcutaneous injection into gluteal fatty tissue, aortic calcification, benign bone Cyst, vertebral hemangioma, recent nonthyroid surgical procedure site, rotator cuff injury, mature Cystic teratoma and ovarian Follicle Cyst). However, the possible reasons of 9 false-positive I-131 uptakes could not be explained by radiologic findings. Conclusion: We suggest that false-positive I-131 uptake and its underlying mechanisms (inflammation, trapping, increased perfusion, etc.) must be kept in mind in patients with thyroid cancer and unexpected findings must be considered together with serum thyroglobulin levels, SPECT/CT and radiologic findings in order to avoid misdiagnosis and unnecessary radioiodine treatment.Amaç: Radyoaktif iyot diferansiye tiroid karsinomu (DTK) görüntülemesinde kullanılan en yüksek özgüllüğe sahip radyonükliddir. Duyarlılık ve özgüllüğü yüksek olmakla birlikte I-131 tüm vücut tarama sintigrafisinde (TVTS) yanlış pozitif I-131 tutulumu görülebilmekte ve bu durum tanısal güçlüklere ve gereksiz tedavi uygulanmasına neden olabilmektedir. Bu çalışmada I-131 TVTS’de izlenen beklenmedik yanlış pozitif I-131 tutulumlarına ait TVTS ve tek foton emisyon bilgisayarlı tomografisi/ bilgisayarlı tomografi (SPECT/BT) görüntüleme bulguları ile hastaların klinik sonuçlarının ve SPECT/BT görüntülemenin katkısının sunulması amaçlanmıştır. Yöntem: Kliniğimizde takipli 1507 DTK tanılı hastaya ait I-131 TVTS’leri retrospektif olarak incelendi ve alışılagelmiş yanlış pozitif I-131 tutulumları (timüs, meme gibi) çalışma dışında bırakıldı. Eş zamanlı SPECT/BT görüntüleri olan ve beklenen alanlar dışında izlenen yanlış pozitif I-131 tutulumları çalışmaya dahil edildi. Bulgular: Yirmi bir hastada 23 adet eş zamanlı SPECT/BT ile lokalize edilen, beklenmedik yanlış pozitif I-131 tutulumu saptandı. Bulguların büyük çoğunluğu (%87) post-terapötik TVTS’de izlendi. Yanlış pozitif tutulumların çoğunun eş zamanlı SPECT/BT ve radyolojik bulgular ile tiroid dışı nedenlere (bronşektazi, akciğer enfeksiyonu, gluteal yağlı dokuya subkutan enjeksiyon, aort kalsifikasyonu, benign kemik kisti, vertebral hemanjiom, yakın zamanlı tiroid dışı cerrahi girişim, rotator kılıf yaralanması, matür kistik teratom ve overde follikül kisti) bağlı olduğu anlaşıldı. Dokuz hastada ise yanlış pozitif iyot tutulumu radyolojik görüntüleme bulguları ile açıklanamadı. Sonuç: Tiroid kanserli hastalarda yanlış pozitif I-131 tutulumunun izlenebileceği ve altta yatan mekanizmaları (enflamasyon, kanlanma artışı, kistik lezyonda tutulum vb.) akılda tutularak, beklenmeyen I-131 tutulumlarının serum tiroglobulin düzeyi, SPECT/BT ve radyolojik verilerle birlikte değerlendirilerek gereksiz tedavilerin önüne geçilmesi gerektiği sonucuna varılmıştır

Yazici Bulent - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected False-positive I-131 Uptake in Patients with Differentiated Thyroid Carcinoma
    'Galenos Yayinevi', 2018
    Co-Authors: Oral Aylin, Yazici Bulent, Eraslan Cenk, Burak Zeynep
    Abstract:

    WOS: 000446711000001PubMed ID: 30317832Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients' clinical outcomes and the contribution of SPECT/CT imaging. Methods: I-131 WBSs of 1507 patients with DTC were retrospectively reviewed, and anticipated I-131 uptakes (like in breasts or thymus) were excluded from the study. The unexpected false-positive I-131 uptakes with concomitant SPECT/CT imaging were included in the study. Results: Twenty-one patients had 23 unexpected I-131 uptakes on WBS and concomitant SPECT/CT imaging. The vast majority (87%) of these cases were seen on post-therapeutic I-131 WBS. Most of the false-positive I-131 uptakes could be explained by SPECT/CT and radiologic findings, and were secondary to non-thyroid conditions (bronchiectasis, lung infection, subcutaneous injection into gluteal fatty tissue, aortic calcification, benign bone Cyst, vertebral hemangioma, recent non-thyroid surgical procedure site, rotator cuff injury, mature Cystic teratoma and ovarian Follicle Cyst). However, the possible reasons of 9 false-positive I-131 uptakes could not be explained by radiologic findings. Conclusion: We suggest that false-positive I-131 uptake and its underlying mechanisms (inflammation, trapping, increased perfusion, etc.) must be kept in mind in patients with thyroid cancer and unexpected findings must be considered together with serum thyroglobulin levels, SPECT/CT and radiologic findings in order to avoid misdiagnosis and unnecessary radioiodine treatment

  • Diferansiye Tiroid Karsinomlu Hastalarda Beklenmeyen Yanlış Pozitif I-131 Tutulumu
    'Galenos Yayinevi', 2018
    Co-Authors: Oral Aylin, Yazici Bulent, Eraslan Cenk, Burak Zeynep
    Abstract:

    Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. in this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging. Methods: I-131 WBSs of 1507 patients with DTC were retrospectively reviewed, and anticipated I-131 uptakes (like in breasts or thymus) were excluded from the study. the unexpected false-positive I-131 uptakes with concomitant SPECT/CT imaging were included in the study. Results: Twenty-one patients had 23 unexpected I-131 uptakes on WBS and concomitant SPECT/CT imaging. the vast majority (87%) of these cases were seen on post-therapeutic I-131 WBS. Most of the false-positive I-131 uptakes could be explained by SPECT/CT and radiologic findings, and were secondary to non-thyroid conditions (bronchiectasis, lung infection, subcutaneous injection into gluteal fatty tissue, aortic calcification, benign bone Cyst, vertebral hemangioma, recent nonthyroid surgical procedure site, rotator cuff injury, mature Cystic teratoma and ovarian Follicle Cyst). However, the possible reasons of 9 false-positive I-131 uptakes could not be explained by radiologic findings. Conclusion: We suggest that false-positive I-131 uptake and its underlying mechanisms (inflammation, trapping, increased perfusion, etc.) must be kept in mind in patients with thyroid cancer and unexpected findings must be considered together with serum thyroglobulin levels, SPECT/CT and radiologic findings in order to avoid misdiagnosis and unnecessary radioiodine treatment.Amaç: Radyoaktif iyot diferansiye tiroid karsinomu (DTK) görüntülemesinde kullanılan en yüksek özgüllüğe sahip radyonükliddir. Duyarlılık ve özgüllüğü yüksek olmakla birlikte I-131 tüm vücut tarama sintigrafisinde (TVTS) yanlış pozitif I-131 tutulumu görülebilmekte ve bu durum tanısal güçlüklere ve gereksiz tedavi uygulanmasına neden olabilmektedir. Bu çalışmada I-131 TVTS’de izlenen beklenmedik yanlış pozitif I-131 tutulumlarına ait TVTS ve tek foton emisyon bilgisayarlı tomografisi/ bilgisayarlı tomografi (SPECT/BT) görüntüleme bulguları ile hastaların klinik sonuçlarının ve SPECT/BT görüntülemenin katkısının sunulması amaçlanmıştır. Yöntem: Kliniğimizde takipli 1507 DTK tanılı hastaya ait I-131 TVTS’leri retrospektif olarak incelendi ve alışılagelmiş yanlış pozitif I-131 tutulumları (timüs, meme gibi) çalışma dışında bırakıldı. Eş zamanlı SPECT/BT görüntüleri olan ve beklenen alanlar dışında izlenen yanlış pozitif I-131 tutulumları çalışmaya dahil edildi. Bulgular: Yirmi bir hastada 23 adet eş zamanlı SPECT/BT ile lokalize edilen, beklenmedik yanlış pozitif I-131 tutulumu saptandı. Bulguların büyük çoğunluğu (%87) post-terapötik TVTS’de izlendi. Yanlış pozitif tutulumların çoğunun eş zamanlı SPECT/BT ve radyolojik bulgular ile tiroid dışı nedenlere (bronşektazi, akciğer enfeksiyonu, gluteal yağlı dokuya subkutan enjeksiyon, aort kalsifikasyonu, benign kemik kisti, vertebral hemanjiom, yakın zamanlı tiroid dışı cerrahi girişim, rotator kılıf yaralanması, matür kistik teratom ve overde follikül kisti) bağlı olduğu anlaşıldı. Dokuz hastada ise yanlış pozitif iyot tutulumu radyolojik görüntüleme bulguları ile açıklanamadı. Sonuç: Tiroid kanserli hastalarda yanlış pozitif I-131 tutulumunun izlenebileceği ve altta yatan mekanizmaları (enflamasyon, kanlanma artışı, kistik lezyonda tutulum vb.) akılda tutularak, beklenmeyen I-131 tutulumlarının serum tiroglobulin düzeyi, SPECT/BT ve radyolojik verilerle birlikte değerlendirilerek gereksiz tedavilerin önüne geçilmesi gerektiği sonucuna varılmıştır

Burak Z. - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected false-positive i-131 uptake in patients with differentiated thyroid carcinoma [Diferansiye tiroid karsinomlu hastalarda beklenmeyen yanlış pozitif i-131 tutulumu]
    'Galenos Yayinevi', 2018
    Co-Authors: Oral A., Yazıcı B., Eraslan C., Burak Z.
    Abstract:

    Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging. Methods: I-131 WBSs of 1507 patients with DTC were retrospectively reviewed, and anticipated I-131 uptakes (like in breasts or thymus) were excluded from the study. The unexpected false-positive I-131 uptakes with concomitant SPECT/CT imaging were included in the study. Results: Twenty-one patients had 23 unexpected I-131 uptakes on WBS and concomitant SPECT/CT imaging. The vast majority (87%) of these cases were seen on post-therapeutic I-131 WBS. Most of the false-positive I-131 uptakes could be explained by SPECT/CT and radiologic findings, and were secondary to non-thyroid conditions (bronchiectasis, lung infection, subcutaneous injection into gluteal fatty tissue, aortic calcification, benign bone Cyst, vertebral hemangioma, recent non-thyroid surgical procedure site, rotator cuff injury, mature Cystic teratoma and ovarian Follicle Cyst). However, the possible reasons of 9 false-positive I-131 uptakes could not be explained by radiologic findings. Conclusion: We suggest that false-positive I-131 uptake and its underlying mechanisms (inflammation, trapping, increased perfusion, etc.) must be kept in mind in patients with thyroid cancer and unexpected findings must be considered together with serum thyroglobulin levels, SPECT/CT and radiologic findings in order to avoid misdiagnosis and unnecessary radioiodine treatment. © 2018 by Turkish Society of Nuclear Medicine Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi