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Omar Cauli - One of the best experts on this subject based on the ideXlab platform.
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The Association between Peripheral Blood Cells and the Frailty Syndrome in Patients with Cardiovascular Diseases.
Endocrine metabolic & immune disorders drug targets, 2020Co-Authors: Constantin Bodolea, Elisabeta Ioana Hiriscau, Elena-cristina Buzdugan, Alin I. Grosu, Laurențiu Stoicescu, Ștefan Vesa, Omar CauliAbstract:BACKGROUND Frailty Syndrome is characterized by multisystem dysregulation frequently found in older individuals or even in younger patients with chronic disabling diseases such as cardiovascular diseases. OBJECTIVE To determine whether peripheral blood cell count, and its subpopulations, red blood cell and platelets, morphology and different ratios (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and red blood distribution width-to-platelet ratio) are associated with cardiac frail patients, and through this to improve the prediction of Frailty status in patients with cardiovascular diseases. METHODS An observational, retrospective, cohort study enrolling 179 patients with cardiovascular disease divided into two groups: non-frail group (100 pts) and frail group (79 pts), a cohort detached from the Frail.RO study. The Frailty was evaluated based on the Fried criteria; haematological markers, sociodemographic data, and variables related to cardiovascular diseases and comorbidities were also recorded. RESULTS Lower lymphocytes, platelet count, and neutrophil-to-lymphocyte ratio were significantly associated with a more severe Frailty Syndrome. Regarding red blood cells, haemoglobin concentration and red cell distribution width significantly correlated with the severity of the Frailty Syndrome. Receiver operating characteristic curve analysis for these markers associated with the Frailty Syndrome revealed an acceptable sensitivity of 66 % and specificity of 65% to identify frail individuals. Malnutrition and hypercholesterolemia are relevant predictors for identifying Frailty in hospitalized cardiovascular patients. CONCLUSION The evaluation of peripheral blood cell composition routinely measured in clinical practice can represent a valuable, but limited indicator, to diagnose Frailty Syndrome and eventually, the effects of interventions in frail patients with cardiovascular diseases.
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Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy.
Cancers, 2020Co-Authors: Cristina Buigues, Rut Navarro-martínez, Vanessa Sánchez-martínez, María Serrano-carrascosa, José Rubio-briones, Omar CauliAbstract:Frailty Syndrome is a functional state that includes a loss of ability to react to stressors, and is associated with poor outcomes, morbidity and premature mortality. The first line treatment in many men with prostate cancer (PCa) consists of an androgen-deprivation therapy (ADT) which can promote or favor Frailty Syndrome and ADT may therefore favor the progression of Frailty over time. Among the pathophysiological bases of Frailty, the presence of chronic low-grade inflammation has been associated with its adverse outcomes, but longitudinal studies are needed to validate these biomarkers. In this study, we prospectively evaluate Frailty Syndrome and blood inflammatory markers (IL1-beta, IL-6, IL-8, TNF alpha, C reactive protein) and leukocytes were measured at baseline and an average of 1 year later in PCa under ADT. Frailty was defined as having three or more of the following components: low lean mass, weakness, self-reported exhaustion, low activity level, and slow walking speed; preFrailty was defined as having one or two of those components. Multinomial regression analysis showed that among the inflammatory biomarkers, those significantly and repeatedly (baseline and follow-up time points) (p < 0.05) associated with Frailty Syndrome were high IL-6 levels and low lymphocyte counts in blood. Other biomarkers such as IL-8, monocyte counts and C reactive protein were significantly associated with Frailty Syndrome (p < 0.05) in cross-sectional analyses, but they do not predict Frailty progression at 1 year-follow-up. Receiver operating characteristic curve analysis showed that both lymphocyte counts and IL-6 concentration significantly (p < 0.05) (although moderately) discriminate PCa patients that progressed in the severity of Frailty Syndrome. IL-6 and lymphocytes count are possible biomarkers, useful for identifying frail patients and predicting the progression of Frailty in PCa under ADT. Our study suggests the use of these biomarkers to guide clinical decisions on prostate cancer treatment based on a multidisciplinary approach.
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Frailty Syndrome is associated with changes in peripheral inflammatory markers in prostate cancer patients undergoing androgen deprivation therapy.
Urologic oncology, 2019Co-Authors: Rut Navarro-martínez, Cristina Buigues, Julio Fernández-garrido, Vanessa Sánchez-martínez, María Serrano-carrascosa, José Rubio-briones, Ana Belen Castello-domenech, Laura García-villodre, Augusto Wong-gutiérrez, Omar CauliAbstract:Abstract Objective To evaluate the role of peripheral inflammation (leukocyte differential count, the proinflammatory cytokines IL-beta, TNF-α, IL-6, IL-8, and the inflammatory markers fibrinogen and C-reactive protein [CRP]) in Frailty Syndrome in patients with prostate cancer (CaP) undergoing antiandrogen therapy (ADT). Methods A total of 46 men between 51 and 92 years of age with CaP and receiving ADT were classified as frail, prefrail or robust according to the Fried scale. A geriatric assessment was performed, based on the Minimental State Examination for cognitive function, the Barthel index for basic activities of daily living, the Yesavage scale for geriatric depression, and the Athens insomnia scale. In addition, blood samples were collected to assess peripheral inflammation biomarkers including proinflammatory cytokines, fibrinogen, CRP and leukocyte differential count, as well as other biochemical and hematological parameters. Results A significant negative correlation between the severity of Frailty Syndrome and lymphocyte count was observed (P Conclusions Further research into the role of leukocyte subtypes and peripheral inflammation and the associated adverse outcomes in patients with CaP under ADT is warranted in order to tailor interventions aimed at reducing symptoms of Frailty Syndrome, such as loss of muscle strength and low physical activity.
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Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial.
International journal of molecular sciences, 2016Co-Authors: Cristina Buigues, Julio Fernández-garrido, Rut Navarro-martínez, Leo Pruimboom, Aldert J. Hoogland, Mary Martinez-martinez, Yolanda Verdejo, Mari Carmen Mascaros, Carlos Peris, Omar CauliAbstract:Aging can result in major changes in the composition and metabolic activities of bacterial populations in the gastrointestinal system and result in impaired function of the immune system. We assessed the efficacy of prebiotic Darmocare Pre® (Bonusan Besloten Vennootschap (BV), Numansdorp, The Netherlands) to evaluate whether the regular intake of this product can improve Frailty criteria, functional status and response of the immune system in elderly people affected by the Frailty Syndrome. The study was a placebo-controlled, randomized, double blind design in sixty older participants aged 65 and over. The prebiotic product was composed of a mixture of inulin plus fructooligosaccharides and was compared with placebo (maltodextrin). Participants were randomized to a parallel group intervention of 13 weeks’ duration with a daily intake of Darmocare Pre® or placebo. Either prebiotic or placebo were administered after breakfast (between 9–10 a.m.) dissolved in a glass of water carefully stirred just before drinking. The primary outcome was to study the effect on Frailty Syndrome. The secondary outcomes were effect on functional and cognitive behavior and sleep quality. Moreover, we evaluated whether prebiotic administration alters blood parameters (haemogram and biochemical analysis). The overall rate of Frailty was not significantly modified by Darmocare Pre® administration. Nevertheless, prebiotic administration compared with placebo significantly improved two Frailty criteria, e.g., exhaustion and handgrip strength (p < 0.01 and p < 0.05, respectively). No significant effects were observed in functional and cognitive behavior or sleep quality. The use of novel therapeutic approaches influencing the gut microbiota–muscle–brain axis could be considered for treatment of the Frailty Syndrome.
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Frailty Syndrome and pre-operative risk evaluation: A systematic review
Archives of gerontology and geriatrics, 2015Co-Authors: Cristina Buigues, Pilar Juarros-folgado, Julio Fernández-garrido, Rut Navarro-martínez, Omar CauliAbstract:Abstract Background Frailty is a geriatric Syndrome characterized by the clinical presentation of identifiable physical alterations and decreased physiological reserve. The assessment of Frailty Syndrome has been recently related with post-surgical outcomes and overall mortality in older individuals. Design and data sources We performed searches in Pubmed, Embase, Scopus, SCIELO and IME (Spanish medical index) databases from their start dates to February 2014 for original papers about the identification of the relationship between Frailty and pre-operative risk evaluation in people aged 65 and over. Review methods We followed criteria of systematic PRISMA guidelines. Two independent reviewers extracted descriptive information on Frailty criteria and outcomes from the selected papers: of the 77 articles retrieved from the searches, 32 met the study inclusion criteria. Results Severity of Frailty Syndrome significantly correlated with post-surgical mortality rates and with many although not all post-surgical complications. These relationships emerge in different type of surgical procedures and patients' features. The comparison of diagnostic tools to assess Frailty in pre-operative risk evaluation are very few and to date, no recommendation can be made about the best scale to measure it. Conclusion Assessment of Frailty Syndrome should be added in the pre-operative risk assessment in older individuals.
Cristina Buigues - One of the best experts on this subject based on the ideXlab platform.
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Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy.
Cancers, 2020Co-Authors: Cristina Buigues, Rut Navarro-martínez, Vanessa Sánchez-martínez, María Serrano-carrascosa, José Rubio-briones, Omar CauliAbstract:Frailty Syndrome is a functional state that includes a loss of ability to react to stressors, and is associated with poor outcomes, morbidity and premature mortality. The first line treatment in many men with prostate cancer (PCa) consists of an androgen-deprivation therapy (ADT) which can promote or favor Frailty Syndrome and ADT may therefore favor the progression of Frailty over time. Among the pathophysiological bases of Frailty, the presence of chronic low-grade inflammation has been associated with its adverse outcomes, but longitudinal studies are needed to validate these biomarkers. In this study, we prospectively evaluate Frailty Syndrome and blood inflammatory markers (IL1-beta, IL-6, IL-8, TNF alpha, C reactive protein) and leukocytes were measured at baseline and an average of 1 year later in PCa under ADT. Frailty was defined as having three or more of the following components: low lean mass, weakness, self-reported exhaustion, low activity level, and slow walking speed; preFrailty was defined as having one or two of those components. Multinomial regression analysis showed that among the inflammatory biomarkers, those significantly and repeatedly (baseline and follow-up time points) (p < 0.05) associated with Frailty Syndrome were high IL-6 levels and low lymphocyte counts in blood. Other biomarkers such as IL-8, monocyte counts and C reactive protein were significantly associated with Frailty Syndrome (p < 0.05) in cross-sectional analyses, but they do not predict Frailty progression at 1 year-follow-up. Receiver operating characteristic curve analysis showed that both lymphocyte counts and IL-6 concentration significantly (p < 0.05) (although moderately) discriminate PCa patients that progressed in the severity of Frailty Syndrome. IL-6 and lymphocytes count are possible biomarkers, useful for identifying frail patients and predicting the progression of Frailty in PCa under ADT. Our study suggests the use of these biomarkers to guide clinical decisions on prostate cancer treatment based on a multidisciplinary approach.
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Frailty Syndrome is associated with changes in peripheral inflammatory markers in prostate cancer patients undergoing androgen deprivation therapy.
Urologic oncology, 2019Co-Authors: Rut Navarro-martínez, Cristina Buigues, Julio Fernández-garrido, Vanessa Sánchez-martínez, María Serrano-carrascosa, José Rubio-briones, Ana Belen Castello-domenech, Laura García-villodre, Augusto Wong-gutiérrez, Omar CauliAbstract:Abstract Objective To evaluate the role of peripheral inflammation (leukocyte differential count, the proinflammatory cytokines IL-beta, TNF-α, IL-6, IL-8, and the inflammatory markers fibrinogen and C-reactive protein [CRP]) in Frailty Syndrome in patients with prostate cancer (CaP) undergoing antiandrogen therapy (ADT). Methods A total of 46 men between 51 and 92 years of age with CaP and receiving ADT were classified as frail, prefrail or robust according to the Fried scale. A geriatric assessment was performed, based on the Minimental State Examination for cognitive function, the Barthel index for basic activities of daily living, the Yesavage scale for geriatric depression, and the Athens insomnia scale. In addition, blood samples were collected to assess peripheral inflammation biomarkers including proinflammatory cytokines, fibrinogen, CRP and leukocyte differential count, as well as other biochemical and hematological parameters. Results A significant negative correlation between the severity of Frailty Syndrome and lymphocyte count was observed (P Conclusions Further research into the role of leukocyte subtypes and peripheral inflammation and the associated adverse outcomes in patients with CaP under ADT is warranted in order to tailor interventions aimed at reducing symptoms of Frailty Syndrome, such as loss of muscle strength and low physical activity.
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Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial.
International journal of molecular sciences, 2016Co-Authors: Cristina Buigues, Julio Fernández-garrido, Rut Navarro-martínez, Leo Pruimboom, Aldert J. Hoogland, Mary Martinez-martinez, Yolanda Verdejo, Mari Carmen Mascaros, Carlos Peris, Omar CauliAbstract:Aging can result in major changes in the composition and metabolic activities of bacterial populations in the gastrointestinal system and result in impaired function of the immune system. We assessed the efficacy of prebiotic Darmocare Pre® (Bonusan Besloten Vennootschap (BV), Numansdorp, The Netherlands) to evaluate whether the regular intake of this product can improve Frailty criteria, functional status and response of the immune system in elderly people affected by the Frailty Syndrome. The study was a placebo-controlled, randomized, double blind design in sixty older participants aged 65 and over. The prebiotic product was composed of a mixture of inulin plus fructooligosaccharides and was compared with placebo (maltodextrin). Participants were randomized to a parallel group intervention of 13 weeks’ duration with a daily intake of Darmocare Pre® or placebo. Either prebiotic or placebo were administered after breakfast (between 9–10 a.m.) dissolved in a glass of water carefully stirred just before drinking. The primary outcome was to study the effect on Frailty Syndrome. The secondary outcomes were effect on functional and cognitive behavior and sleep quality. Moreover, we evaluated whether prebiotic administration alters blood parameters (haemogram and biochemical analysis). The overall rate of Frailty was not significantly modified by Darmocare Pre® administration. Nevertheless, prebiotic administration compared with placebo significantly improved two Frailty criteria, e.g., exhaustion and handgrip strength (p < 0.01 and p < 0.05, respectively). No significant effects were observed in functional and cognitive behavior or sleep quality. The use of novel therapeutic approaches influencing the gut microbiota–muscle–brain axis could be considered for treatment of the Frailty Syndrome.
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Frailty Syndrome and pre-operative risk evaluation: A systematic review
Archives of gerontology and geriatrics, 2015Co-Authors: Cristina Buigues, Pilar Juarros-folgado, Julio Fernández-garrido, Rut Navarro-martínez, Omar CauliAbstract:Abstract Background Frailty is a geriatric Syndrome characterized by the clinical presentation of identifiable physical alterations and decreased physiological reserve. The assessment of Frailty Syndrome has been recently related with post-surgical outcomes and overall mortality in older individuals. Design and data sources We performed searches in Pubmed, Embase, Scopus, SCIELO and IME (Spanish medical index) databases from their start dates to February 2014 for original papers about the identification of the relationship between Frailty and pre-operative risk evaluation in people aged 65 and over. Review methods We followed criteria of systematic PRISMA guidelines. Two independent reviewers extracted descriptive information on Frailty criteria and outcomes from the selected papers: of the 77 articles retrieved from the searches, 32 met the study inclusion criteria. Results Severity of Frailty Syndrome significantly correlated with post-surgical mortality rates and with many although not all post-surgical complications. These relationships emerge in different type of surgical procedures and patients' features. The comparison of diagnostic tools to assess Frailty in pre-operative risk evaluation are very few and to date, no recommendation can be made about the best scale to measure it. Conclusion Assessment of Frailty Syndrome should be added in the pre-operative risk assessment in older individuals.
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The relationship between depression and Frailty Syndrome: a systematic review
Aging & mental health, 2014Co-Authors: Cristina Buigues, Rut Navarro-martínez, Celia Padilla-sánchez, Julio Fernández Garrido, Vicente Ruiz-ros, Omar CauliAbstract:Objectives: Frailty is a geriatric Syndrome characterised by the clinical presentation of identifiable physical alterations such as loss of muscle mass and strength, energy and exercise tolerance, and decreased physiological reserve. Frailty and depressive symptoms are common issues facing older adults and may be associated. It is not clear if the depression facilitates the appearance of Frailty Syndrome or vice versa or these two coexist independently in the same individuals.Method: We performed searches in several databases (Embase, PubMed, CINAHL, Scopus, and PsycINFO) papers published between November 2003 to February 2014 about Frailty Syndrome and depression in people aged 65 and older published and the reference lists of from the articles retrieved were pearled in order to identify any which may have been missed in the initial search. Two independent reviewers extracted descriptive information on the prevalence and co-occurrence of Frailty and depression in older individuals and of Frailty criteria...
Rut Navarro-martínez - One of the best experts on this subject based on the ideXlab platform.
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Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy.
Cancers, 2020Co-Authors: Cristina Buigues, Rut Navarro-martínez, Vanessa Sánchez-martínez, María Serrano-carrascosa, José Rubio-briones, Omar CauliAbstract:Frailty Syndrome is a functional state that includes a loss of ability to react to stressors, and is associated with poor outcomes, morbidity and premature mortality. The first line treatment in many men with prostate cancer (PCa) consists of an androgen-deprivation therapy (ADT) which can promote or favor Frailty Syndrome and ADT may therefore favor the progression of Frailty over time. Among the pathophysiological bases of Frailty, the presence of chronic low-grade inflammation has been associated with its adverse outcomes, but longitudinal studies are needed to validate these biomarkers. In this study, we prospectively evaluate Frailty Syndrome and blood inflammatory markers (IL1-beta, IL-6, IL-8, TNF alpha, C reactive protein) and leukocytes were measured at baseline and an average of 1 year later in PCa under ADT. Frailty was defined as having three or more of the following components: low lean mass, weakness, self-reported exhaustion, low activity level, and slow walking speed; preFrailty was defined as having one or two of those components. Multinomial regression analysis showed that among the inflammatory biomarkers, those significantly and repeatedly (baseline and follow-up time points) (p < 0.05) associated with Frailty Syndrome were high IL-6 levels and low lymphocyte counts in blood. Other biomarkers such as IL-8, monocyte counts and C reactive protein were significantly associated with Frailty Syndrome (p < 0.05) in cross-sectional analyses, but they do not predict Frailty progression at 1 year-follow-up. Receiver operating characteristic curve analysis showed that both lymphocyte counts and IL-6 concentration significantly (p < 0.05) (although moderately) discriminate PCa patients that progressed in the severity of Frailty Syndrome. IL-6 and lymphocytes count are possible biomarkers, useful for identifying frail patients and predicting the progression of Frailty in PCa under ADT. Our study suggests the use of these biomarkers to guide clinical decisions on prostate cancer treatment based on a multidisciplinary approach.
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Frailty Syndrome is associated with changes in peripheral inflammatory markers in prostate cancer patients undergoing androgen deprivation therapy.
Urologic oncology, 2019Co-Authors: Rut Navarro-martínez, Cristina Buigues, Julio Fernández-garrido, Vanessa Sánchez-martínez, María Serrano-carrascosa, José Rubio-briones, Ana Belen Castello-domenech, Laura García-villodre, Augusto Wong-gutiérrez, Omar CauliAbstract:Abstract Objective To evaluate the role of peripheral inflammation (leukocyte differential count, the proinflammatory cytokines IL-beta, TNF-α, IL-6, IL-8, and the inflammatory markers fibrinogen and C-reactive protein [CRP]) in Frailty Syndrome in patients with prostate cancer (CaP) undergoing antiandrogen therapy (ADT). Methods A total of 46 men between 51 and 92 years of age with CaP and receiving ADT were classified as frail, prefrail or robust according to the Fried scale. A geriatric assessment was performed, based on the Minimental State Examination for cognitive function, the Barthel index for basic activities of daily living, the Yesavage scale for geriatric depression, and the Athens insomnia scale. In addition, blood samples were collected to assess peripheral inflammation biomarkers including proinflammatory cytokines, fibrinogen, CRP and leukocyte differential count, as well as other biochemical and hematological parameters. Results A significant negative correlation between the severity of Frailty Syndrome and lymphocyte count was observed (P Conclusions Further research into the role of leukocyte subtypes and peripheral inflammation and the associated adverse outcomes in patients with CaP under ADT is warranted in order to tailor interventions aimed at reducing symptoms of Frailty Syndrome, such as loss of muscle strength and low physical activity.
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Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial.
International journal of molecular sciences, 2016Co-Authors: Cristina Buigues, Julio Fernández-garrido, Rut Navarro-martínez, Leo Pruimboom, Aldert J. Hoogland, Mary Martinez-martinez, Yolanda Verdejo, Mari Carmen Mascaros, Carlos Peris, Omar CauliAbstract:Aging can result in major changes in the composition and metabolic activities of bacterial populations in the gastrointestinal system and result in impaired function of the immune system. We assessed the efficacy of prebiotic Darmocare Pre® (Bonusan Besloten Vennootschap (BV), Numansdorp, The Netherlands) to evaluate whether the regular intake of this product can improve Frailty criteria, functional status and response of the immune system in elderly people affected by the Frailty Syndrome. The study was a placebo-controlled, randomized, double blind design in sixty older participants aged 65 and over. The prebiotic product was composed of a mixture of inulin plus fructooligosaccharides and was compared with placebo (maltodextrin). Participants were randomized to a parallel group intervention of 13 weeks’ duration with a daily intake of Darmocare Pre® or placebo. Either prebiotic or placebo were administered after breakfast (between 9–10 a.m.) dissolved in a glass of water carefully stirred just before drinking. The primary outcome was to study the effect on Frailty Syndrome. The secondary outcomes were effect on functional and cognitive behavior and sleep quality. Moreover, we evaluated whether prebiotic administration alters blood parameters (haemogram and biochemical analysis). The overall rate of Frailty was not significantly modified by Darmocare Pre® administration. Nevertheless, prebiotic administration compared with placebo significantly improved two Frailty criteria, e.g., exhaustion and handgrip strength (p < 0.01 and p < 0.05, respectively). No significant effects were observed in functional and cognitive behavior or sleep quality. The use of novel therapeutic approaches influencing the gut microbiota–muscle–brain axis could be considered for treatment of the Frailty Syndrome.
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Frailty Syndrome and pre-operative risk evaluation: A systematic review
Archives of gerontology and geriatrics, 2015Co-Authors: Cristina Buigues, Pilar Juarros-folgado, Julio Fernández-garrido, Rut Navarro-martínez, Omar CauliAbstract:Abstract Background Frailty is a geriatric Syndrome characterized by the clinical presentation of identifiable physical alterations and decreased physiological reserve. The assessment of Frailty Syndrome has been recently related with post-surgical outcomes and overall mortality in older individuals. Design and data sources We performed searches in Pubmed, Embase, Scopus, SCIELO and IME (Spanish medical index) databases from their start dates to February 2014 for original papers about the identification of the relationship between Frailty and pre-operative risk evaluation in people aged 65 and over. Review methods We followed criteria of systematic PRISMA guidelines. Two independent reviewers extracted descriptive information on Frailty criteria and outcomes from the selected papers: of the 77 articles retrieved from the searches, 32 met the study inclusion criteria. Results Severity of Frailty Syndrome significantly correlated with post-surgical mortality rates and with many although not all post-surgical complications. These relationships emerge in different type of surgical procedures and patients' features. The comparison of diagnostic tools to assess Frailty in pre-operative risk evaluation are very few and to date, no recommendation can be made about the best scale to measure it. Conclusion Assessment of Frailty Syndrome should be added in the pre-operative risk assessment in older individuals.
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The relationship between depression and Frailty Syndrome: a systematic review
Aging & mental health, 2014Co-Authors: Cristina Buigues, Rut Navarro-martínez, Celia Padilla-sánchez, Julio Fernández Garrido, Vicente Ruiz-ros, Omar CauliAbstract:Objectives: Frailty is a geriatric Syndrome characterised by the clinical presentation of identifiable physical alterations such as loss of muscle mass and strength, energy and exercise tolerance, and decreased physiological reserve. Frailty and depressive symptoms are common issues facing older adults and may be associated. It is not clear if the depression facilitates the appearance of Frailty Syndrome or vice versa or these two coexist independently in the same individuals.Method: We performed searches in several databases (Embase, PubMed, CINAHL, Scopus, and PsycINFO) papers published between November 2003 to February 2014 about Frailty Syndrome and depression in people aged 65 and older published and the reference lists of from the articles retrieved were pearled in order to identify any which may have been missed in the initial search. Two independent reviewers extracted descriptive information on the prevalence and co-occurrence of Frailty and depression in older individuals and of Frailty criteria...
Андреева Светлана Игоревна - One of the best experts on this subject based on the ideXlab platform.
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Relationship between metformin and Frailty Syndrome in elderly people with type 2 diabetes
Obesity and metabolism, 2015Co-Authors: Svetlana Igorevna Andreeva, Андреева Светлана ИгоревнаAbstract:Relationship between metformin and Frailty Syndrome in elderly people with type 2 diabetes
Rafal Mlynarski - One of the best experts on this subject based on the ideXlab platform.
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Factors that affect the assessment of the quality of life of rheumatoid arthritis patients depending on the prevalence of Frailty Syndrome.
Health and quality of life outcomes, 2020Co-Authors: Ewelina Bąk, Agnieszka Mlynarska, Czesław Marcisz, Rafał Bobiński, Danuta Sternal, Rafal MlynarskiAbstract:Rheumatoid arthritis (RA) has a large and varied impact on the quality of life as associated with patient health including both physical and mental well-being. The aim of the study was to assess the factors that affect the assessment of the quality of life of RA patients depending on the prevalence of Frailty Syndrome. MATERIAL AND METHODS The study involved 106 patients with RA (82 women; mean age 65.83 ± 5.01), who had been hospitalized in the Silesian Centre for Rheumatology, Rehabilitation and Disability Prevention in Ustron, Poland. The patients that were included in the study were divided into two groups depending on the incidence of Frailty Syndrome: Group 1 - robust patients and Group 2 - patients with Frailty Syndrome. RESULTS Frailty Syndrome was identified in 34.9% of the patients with recognized/diagnosed RA; in women, it was 36.14% and in men, it was 25.92%. The average TFI value was 4.11 ± 2.05; in the physical domain, it was 3.39 ± 1.66; in the mental domain, it was 0.41 ± 0.55 and in the social domain, it was 0.31 ± 0.48. The robust patients assessed their quality of life associated with sleep as being worse compared to patients with recognized Frailty Syndrome. CONCLUSION Frailty Syndrome has no significant impact on the assessment of the quality of life of patients with diagnosed RA. The factors that determine quality of life are different in robust patients and in patients with Frailty Syndrome. The assessment of the quality of life is affected by the degree of an individual's fitness regardless of the occurrence of Frailty Syndrome.
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The Relationship between Frailty Syndrome and Concerns about an Implantable Cardioverter Defibrillator.
International journal of environmental research and public health, 2020Co-Authors: Agnieszka Mlynarska, Rafal Mlynarski, Izabella Uchmanowicz, Czesław Marcisz, Krzysztof S. GolbaAbstract:Frailty Syndrome may cause cognitive decline and increased sensitivity to stressors. This can result in an increased incidence of anxiety and depression, and thus, concerns about life with an implantable cardioverter defibrillator (ICD). The aim of the study was to assess the impact of Frailty Syndrome on the increase in the number of device-related concerns after the implantation of an ICD. Material and methods: The study sample was a group of 103 consecutive patients (85 M; aged 71.6 ± 8.2) with an implanted ICD. The ICD Concerns Questionnaire (ICDC) was used to analyze their concerns about life with an ICD, and the Tilburg Frailty Indicator scale (TFI) was used to diagnose Frailty. Results: In the group of patients with an ICD implanted, 73% had recognized Frailty (83.3% women, 74.1% men); the average point value was 6.55 ± 2.67. The total ICDC questionnaire score for the patients with an implanted cardioverter defibrillator was 34.06 ± 18.15. Patients with Frailty Syndrome had statistically (p = 0.039) higher scores (36.14 ± 17.08) compared to robust patients (27.56 ± 20.13). In the logistic regression analysis, the presence of Frailty was strongly associated with the total questionnaire score (OR = 1.0265, p = 0.00426), the severity of the concerns (OR = 1.0417, p = 0.00451), and device-specific concerns (OR = 1.0982, p = 0.00424). Conclusion: Frailty Syndrome occurs in about 80% of patients after ICD implantation. The presence of Frailty Syndrome was strongly associated with concerns about an implantable cardioverter defibrillator.
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Older age and a higher EHRA score allow higher levels of Frailty Syndrome to be predicted in patients with atrial fibrillation.
The aging male : the official journal of the International Society for the Study of the Aging Male, 2016Co-Authors: Agnieszka Mlynarska, Rafal Mlynarski, Krzysztof S. GolbaAbstract:Background: There is no research that evaluates the relationship between the severity of the symptoms of atrial fibrillation (AF), the presence of Frailty Syndrome and acceptance of the illness.Met...
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Frailty Syndrome in patients with heart rhythm disorders
Geriatrics & gerontology international, 2016Co-Authors: Agnieszka Mlynarska, Rafal Mlynarski, Krzysztof S. GolbaAbstract:Aim To assess the prevalence of Frailty Syndrome in patients with heart rhythm disorders that qualified for pacemaker implantation. Methods The study included 171 patients (83 women, aged 73.9 ± 6.7 years) who qualified for pacemaker implantation as a result of sinus node dysfunction (81 patients) or atrio-ventricular blocks (AVB; 90 patients). A total of 60 patients (25 women, aged 72.40 ± 7.09 years) without heart rhythm disorders were included in the control group. Frailty Syndrome was diagnosed using the Canadian Study of Health and Aging Clinical Frailty Scale test. Results Frailty Syndrome was diagnosed in 25.15% of the patients, and pre-Frailty in 36.84% of the patients. Frailty Syndrome was diagnosed in 10% of the control group, and the average value of Frailty was 3.35 ± 0.92. Frailty occurred significantly more often among patients with AVB (33.34%) compared with patients who were diagnosed with sinus node dysfunction (16.05%); P = 0.0081. The average score of Frailty for sinus node dysfunction was 3.71 ± 0.89, and for AVB it was 4.14 ± 0.93; P = 0.0152. In the case of AVB, the women had a statistically more intense level of Frailty of 4.54 ± 0.90 as compared with the men 3.87 ± 0.85; P = 0.0294. In the multiple logistic analysis, the presence of any arrhythmia was strongly associated with Frailty Syndrome (OR 2.1286, 95% CI 1.4594 - 3.1049; P = 0.0001). Conclusions Frailty Syndrome was diagnosed in one-quarter of patients with cardiac arrhythmias, whereas a further 40% were at a higher risk of Frailty Syndrome, and its occurrence was significantly higher if compared with the control group. Frailty occurred significantly more often among patients with atrio-ventricular blocks, especially in women. The results of the present research showed that there is a statistical association between Frailty and arrhythmias. Geriatr Gerontol Int 2017; 17: 1313-1318.
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Frailty Syndrome in Heart Failure Patients who are Receiving Cardiac Resynchronization.
Pacing and clinical electrophysiology : PACE, 2016Co-Authors: Agnieszka Mlynarska, Rafal Mlynarski, Jolanta Biernat, Maciej Sosnowski, Krzysztof S. GołbaAbstract:BACKGROUND We hypothesized that patients with de novo cardiac resynchronization therapy (CRT) implantation had a more intense Frailty Syndrome when compared to the patients who qualified for a system upgrade. METHODS One hundred and six patients aged ≥65 years were included. They were divided into two groups: de novo CRT implantation--74 patients and upgrade from standard right heart pacing--32 patients. A CRT was finally implanted in all of the patients. Frailty was evaluated using the Canadian Study of Health and Aging Clinical Frailty Scale (CSHA-CFS). RESULTS The average results in CSHA-CFS were statistically higher (5.3 ± 0.8) in the de novo patients when compared to the patients who qualified for a system upgrade (4.9 ± 0.8); P = 0.027. Frailty Syndrome was recognized in 81.1% of the patients in the de novo group and in 68.7% of the patients in the upgrade group; P = 0.164. Only one patient of the 106 had no attributes of Frailty (or exposed ones) Syndrome. CONCLUSIONS Frailty Syndrome is a common phenomenon in patients with heart failure and over 65 years of age. The Syndrome is most often recognized in patients who are de novo qualified for cardiac resynchronization.
