The Experts below are selected from a list of 1887 Experts worldwide ranked by ideXlab platform
Mitchel S Berger - One of the best experts on this subject based on the ideXlab platform.
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Frontal Operculum gliomas language outcome following resection
Journal of Neurosurgery, 2015Co-Authors: John D Rolston, Dario J Englot, Arnau Benet, Jing Li, Mitchel S BergerAbstract:OBJECT The dominant hemisphere Frontal Operculum may contain critical speech and language pathways, and due to these properties, patients with tumors of the opercular region may be at higher risk for postoperative speech dysfunction. However, the likelihood of incurring temporary or permanent language dysfunction is unknown. METHODS The authors retrospectively analyzed their cohort of patients with Frontal gliomas to identify those tumors that predominantly involved the dominant Frontal Operculum. Each tumor was classified as involving the pars orbitalis, pars triangularis, pars opercularis, or a combination of some or all of these areas. The authors then identified and compared characteristics between those patients experiencing transient or permanent speech deficits, as opposed to those with no language dysfunction. RESULTS Forty-three patients were identified for inclusion in this analysis. Transient deficits occurred in 12 patients (27.9%), while 4 patients (9.8%) had persistent deficits involving lan...
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preoperative correlation of intraoperative cortical mapping with magnetic resonance imaging landmarks to predict localization of the broca area
Journal of Neurosurgery, 2003Co-Authors: Alfredo Quinoneshinojosa, Steven G Ojemann, Nader Sanai, William P Dillon, Mitchel S BergerAbstract:Object. Broca identified the posterior third of the inferior Frontal gyrus as a locus essential for the production of fluent speech. The authors have conducted this retrospective analysis in an attempt to find readily identifiable landmarks on magnetic resonance (MR) imaging that correspond to intraoperative cortical stimulation-induced speech arrest. These landmarks demonstrate novel structural—functional relationships that can be used preoperatively to predict the location of the Broca area. Methods. Using a neuronavigation system, sites where stimulation produced speech arrest (Broca area) were recorded in a consecutive series of patients undergoing awake tumor resections in the perisylvian territory of the dominant hemisphere. The authors reviewed 33 consecutive patients by projecting the MR imaging data sets and marking the site where the Broca area was identified. Sulcus topography was analyzed with respect to this site by scrolling into neighboring planes and classifying the Frontal Operculum into ...
Sergei V Adamovich - One of the best experts on this subject based on the ideXlab platform.
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transcranial magnetic stimulation to the Frontal Operculum and supramarginal gyrus disrupts planning of outcome based hand object interactions
The Journal of Neuroscience, 2008Co-Authors: Eugene Tunik, Onyee Lo, Sergei V AdamovichAbstract:Behavioral data suggest that goals inform the selection of motor commands during planning. We investigated the neural correlates that mediate planning of goal-oriented actions by asking 10 healthy subjects to prepare either a goal-specific movement toward a common object (a cup), with the intent of grasping-to-pour (liquid into it) or grasping-to-move (to another location) the object, or performing a non-object-oriented stimulus-response task (move a finger). Single-pulse transcranial magnetic stimulation was administered on 50% of trials to the supramarginal gyrus (SMG), anterior intraparietal sulcus, inferior Frontal gyrus opercularis (IFGo), and triangularis during motor planning. Stimulation to SMG and IFGo caused a significant delay in planning goal-oriented actions but not responses to an arbitrary stimulus. Despite the delay, movement execution was not affected, suggesting that the motor plan remained intact. Our data implicate the SMG and IFGo in planning goal-oriented hand–object interactions.
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Transcranial Magnetic Stimulation to the Frontal Operculum and Supramarginal Gyrus Disrupts Planning of Outcome-Based Hand–Object Interactions
The Journal of Neuroscience, 2008Co-Authors: Eugene Tunik, Onyee Lo, Sergei V AdamovichAbstract:Behavioral data suggest that goals inform the selection of motor commands during planning. We investigated the neural correlates that mediate planning of goal-oriented actions by asking 10 healthy subjects to prepare either a goal-specific movement toward a common object (a cup), with the intent of grasping-to-pour (liquid into it) or grasping-to-move (to another location) the object, or performing a non-object-oriented stimulus-response task (move a finger). Single-pulse transcranial magnetic stimulation was administered on 50% of trials to the supramarginal gyrus (SMG), anterior intraparietal sulcus, inferior Frontal gyrus opercularis (IFGo), and triangularis during motor planning. Stimulation to SMG and IFGo caused a significant delay in planning goal-oriented actions but not responses to an arbitrary stimulus. Despite the delay, movement execution was not affected, suggesting that the motor plan remained intact. Our data implicate the SMG and IFGo in planning goal-oriented hand–object interactions.
Martin Staudt - One of the best experts on this subject based on the ideXlab platform.
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Presurgical Language fMRI in Children, Adolescents and Young Adults
Clinical Neuroradiology, 2020Co-Authors: Theresa Meinhold, Wiebke Hofer, Tom Pieper, Manfred Kudernatsch, Martin StaudtAbstract:Purpose To validate four established, child-friendly functional magnetic resonance imaging (fMRI) language tasks (word chain task [WCT], vowel identification task [VIT], synonym task [SYT] and beep story task [BST]) in a predominantly pediatric cohort. Methods Intracarotid amobarbital procedures (IAP) ( n = 17) and unchanged language after hemispherotomy ( n = 6) were used as gold standards. The fMRI activations of nine regions of interest (ROI) in the Frontal, temporal and parietal lobes as well as in the cerebellum were visually assessed in 23 fMRI examinations (in total 117 fMRI task sessions) of 23 patients (age range 10.0–23.0 years) with drug-refractory epilepsies. Results The ROIs were considered valid when they showed activation in more than 25% of all sessions for the respective task and never showed false lateralization (in comparison to gold standards). Thus, 13 valid, task-specific ROIs were identified: 5 ROIs for the WCT (Frontal Operculum, inferior Frontal gyrus, middle Frontal gyrus, intraparietal sulcus, cerebellum), 3 ROIs for the VIT (Frontal Operculum, inferior Frontal gyrus, middle Frontal gyrus), 3 ROIs for the SYT (Frontal Operculum, inferior Frontal gyrus, temporal language area) and 2 ROIs for the BST (inferior Frontal gyrus, middle Frontal gyrus). Conclusion Clinical fMRI using the battery of four tasks is a valid tool for lateralizing language in children, adolescents and young adults. Each task proved to be specifically useful, which confirms that applying different tasks increases the probability of diagnosing language dominance in presurgical candidates.
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Presurgical Language fMRI in Children, Adolescents and Young Adults: A Validation Study
Clinical Neuroradiology-klinische Neuroradiologie, 2020Co-Authors: Theresa Meinhold, Wiebke Hofer, Tom Pieper, Manfred Kudernatsch, Martin StaudtAbstract:To validate four established, child-friendly functional magnetic resonance imaging (fMRI) language tasks (word chain task [WCT], vowel identification task [VIT], synonym task [SYT] and beep story task [BST]) in a predominantly pediatric cohort. Intracarotid amobarbital procedures (IAP) (n = 17) and unchanged language after hemispherotomy (n = 6) were used as gold standards. The fMRI activations of nine regions of interest (ROI) in the Frontal, temporal and parietal lobes as well as in the cerebellum were visually assessed in 23 fMRI examinations (in total 117 fMRI task sessions) of 23 patients (age range 10.0–23.0 years) with drug-refractory epilepsies. The ROIs were considered valid when they showed activation in more than 25% of all sessions for the respective task and never showed false lateralization (in comparison to gold standards). Thus, 13 valid, task-specific ROIs were identified: 5 ROIs for the WCT (Frontal Operculum, inferior Frontal gyrus, middle Frontal gyrus, intraparietal sulcus, cerebellum), 3 ROIs for the VIT (Frontal Operculum, inferior Frontal gyrus, middle Frontal gyrus), 3 ROIs for the SYT (Frontal Operculum, inferior Frontal gyrus, temporal language area) and 2 ROIs for the BST (inferior Frontal gyrus, middle Frontal gyrus). Clinical fMRI using the battery of four tasks is a valid tool for lateralizing language in children, adolescents and young adults. Each task proved to be specifically useful, which confirms that applying different tasks increases the probability of diagnosing language dominance in presurgical candidates.
Burkhard Pleger - One of the best experts on this subject based on the ideXlab platform.
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Satiety-induced enhanced neuronal activity in the Frontal Operculum relates to the desire for food in the obese female brain
Experimental Brain Research, 2018Co-Authors: Saurabh Kumar, Felicitas Grundeis, Cristin Brand, Han-jeong Hwang, Jan Mehnert, Burkhard PlegerAbstract:In the present pilot study, we questioned how eating to satiety affects cognitive influences on the desire for food and corresponding neuronal activity in the obese female brain. During EEG recording, lean ( n = 10) and obese women ( n = 10) self-rated the ability to reappraise visually presented food. All women were measured twice, when hungry and after eating to satiety. After eating to satiety, reappraisal of food was easier than when being hungry. Comparing the EEG data of the sated to the hungry state, we found that only in obese women the Frontal Operculum was involved not only in the reappraisal of food but also in admitting the desire for the same food. The right Frontal Operculum in the obese female brain, assumed to primarily host gustatory processes, may be involved in opposing cognitive influences on the desire for food. These findings may help to find potential brain targets for non-invasive brain stimulation or neurofeedback studies that aim at modulating the desire for food.
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fat perception in the human Frontal Operculum insular and somatosensory cortex
Scientific Reports, 2018Co-Authors: Thomas Wistehube, Michael Rullmann, Claudia Wiacek, Peggy G Braun, Burkhard PlegerAbstract:Here, we combined magnetic resonance imaging with lesion-symptom mapping in patients with chronic brain lesions to investigate brain representations of sugar and fat perception. Patients and healthy controls rated chocolate milkshakes that only differed in sugar or fat content. As compared to controls, patients showed an impaired fat, but not sugar perception. Impairments in fat perception overlapped with the anterior insula and Frontal Operculum, together assumed to underpin gustatory processing. We also identified the mid-dorsal insula as well as the primary and secondary somatosensory cortex - regions previously assumed to integrate oral-sensory inputs. These findings suggest that fat perception involves a specific set of brain regions that were previously reported to underpin gustatory processing and oral-sensory integration processes.
Eugene Tunik - One of the best experts on this subject based on the ideXlab platform.
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transcranial magnetic stimulation to the Frontal Operculum and supramarginal gyrus disrupts planning of outcome based hand object interactions
The Journal of Neuroscience, 2008Co-Authors: Eugene Tunik, Onyee Lo, Sergei V AdamovichAbstract:Behavioral data suggest that goals inform the selection of motor commands during planning. We investigated the neural correlates that mediate planning of goal-oriented actions by asking 10 healthy subjects to prepare either a goal-specific movement toward a common object (a cup), with the intent of grasping-to-pour (liquid into it) or grasping-to-move (to another location) the object, or performing a non-object-oriented stimulus-response task (move a finger). Single-pulse transcranial magnetic stimulation was administered on 50% of trials to the supramarginal gyrus (SMG), anterior intraparietal sulcus, inferior Frontal gyrus opercularis (IFGo), and triangularis during motor planning. Stimulation to SMG and IFGo caused a significant delay in planning goal-oriented actions but not responses to an arbitrary stimulus. Despite the delay, movement execution was not affected, suggesting that the motor plan remained intact. Our data implicate the SMG and IFGo in planning goal-oriented hand–object interactions.
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Transcranial Magnetic Stimulation to the Frontal Operculum and Supramarginal Gyrus Disrupts Planning of Outcome-Based Hand–Object Interactions
The Journal of Neuroscience, 2008Co-Authors: Eugene Tunik, Onyee Lo, Sergei V AdamovichAbstract:Behavioral data suggest that goals inform the selection of motor commands during planning. We investigated the neural correlates that mediate planning of goal-oriented actions by asking 10 healthy subjects to prepare either a goal-specific movement toward a common object (a cup), with the intent of grasping-to-pour (liquid into it) or grasping-to-move (to another location) the object, or performing a non-object-oriented stimulus-response task (move a finger). Single-pulse transcranial magnetic stimulation was administered on 50% of trials to the supramarginal gyrus (SMG), anterior intraparietal sulcus, inferior Frontal gyrus opercularis (IFGo), and triangularis during motor planning. Stimulation to SMG and IFGo caused a significant delay in planning goal-oriented actions but not responses to an arbitrary stimulus. Despite the delay, movement execution was not affected, suggesting that the motor plan remained intact. Our data implicate the SMG and IFGo in planning goal-oriented hand–object interactions.
