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Gabor Hollo - One of the best experts on this subject based on the ideXlab platform.
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comparison of structure Function Relationship between corresponding retinal nerve fibre layer thickness and octopus visual field cluster defect values determined by normal and tendency oriented strategies
British Journal of Ophthalmology, 2017Co-Authors: Gabor HolloAbstract:Background/aims Previously, we found a strong structure–Function Relationship between Octopus visual field cluster sensitivity and corresponding sector retinal nerve fibre layer thickness (RNFLT) values, using normal strategy and 16 custom-made cluster–sector pairs. However, Octopus commercially offers 10 clusters, correction for diffuse defect (corrected clusters) and tendency-oriented perimetry (TOP) strategy. In the current investigation, we evaluated structure–Function Relationship for these conditions, respectively. Methods Twenty-four healthy, 45 ocular hypertensive and 63 glaucoma eyes underwent Octopus perimetry (normal and TOP strategies) and RNFLT measurements on the same day. Pearson9s correlation between corresponding cluster defect and sector RNFLT values was investigated. Results Correlation between the corresponding cluster defect and sector RNFLT values was significant (p Conclusions Octopus normal and TOP strategies provide similar, moderate-to-strong negative correlation between the corresponding cluster defect and sector RNFLT values for all 10 manufacturer-provided clusters. For corrected clusters the Relationship is poor, which suggests that by correcting for diffuse sensitivity loss some local glaucomatous defect is removed. For structure-Function based clinical decisions, use of TOP is possible but use of corrected clusters is not recommended.
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structure Function Relationship between the octopus perimeter cluster mean sensitivity and sector retinal nerve fiber layer thickness measured with the rtvue optical coherence tomography and scanning laser polarimetry
Journal of Glaucoma, 2014Co-Authors: Farzaneh Naghizadeh, Anita Garas, Peter Vargha, Gabor HolloAbstract:Purpose:To determine structure-Function Relationship between each of 16 Octopus perimeter G2 program clusters and the corresponding 16 peripapillary sector retinal nerve fiber layer thickness (RNFLT) values measured with the RTVue-100 Fourier-domain optical coherence tomography (RTVue OCT) and scann
E. M. Hoffmann - One of the best experts on this subject based on the ideXlab platform.
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Structure-Function Relationship between FDF, FDT, SAP, and scanning laser ophthalmoscopy in glaucoma patients.
Investigative Ophthalmology & Visual Science, 2012Co-Authors: Julia Lamparter, Ann-christin Schuff, A. Schulze, Norbert Pfeiffer, Richard A Russell, E. M. HoffmannAbstract:Flicker defined form perimetry (FDF) and frequency doubling technology perimetry (FDT) are alleged to detect glaucoma at an earlier stage than standard automated perimetry (SAP). It is the purpose of this study to investigate the structure-Function Relationship between FDF, FDT, SAP, and confocal scanning laser ophthalmoscopy (cSLO) in patients with glaucoma. Seventy-six patients with glaucoma were included in the study. Patients were tested with SAP, Matrix-FDT, FDF perimetry, and cSLO. Structure-Function Relationships between global and sectoral cSLO parameters and global and sectoral mean sensitivity (MS) of SAP, Matrix-FDT, and FDF were calculated using Spearman's rank correlation and linear regression. Overall, FDF perimetry showed the strongest structure-Function Relationship (GLOBAL correlation with rim area: 0.44; range of significant sectoral FDF values: 0.23-0.69), followed by FDT (global correlation with rim area: 0.35; range of significant sectoral FDT values: 0.25-0.60). SAP presented with the weakest structure-Function Relationship and fewer statistically significant results (global correlation with rim volume: 0.32; range of significant sectoral SAP values: 0.23-0.58). Sector-by-sector, the structure-Function Relationship was greatest in the superotemporal and inferotemporal regions. Weakest correlations were found in the inferonasal and nasal sectors. The correlation between structure and Function is stronger in FDF and FDT compared with SAP. Correlations are strongest in temporal areas where glaucomatous damage tends to occur first. A better understanding of the structure-Function Relationship should allow for improved detection and management of glaucoma patients.
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Structure-Function Relationship between FDF, FDT, SAP, and scanning laser ophthalmoscopy in glaucoma patients.
Investigative Opthalmology & Visual Science, 2012Co-Authors: Julia Lamparter, Ann-christin Schuff, A. Schulze, Norbert Pfeiffer, Richard A Russell, E. M. HoffmannAbstract:PURPOSE Flicker defined form perimetry (FDF) and frequency doubling technology perimetry (FDT) are alleged to detect glaucoma at an earlier stage than standard automated perimetry (SAP). It is the purpose of this study to investigate the structure-Function Relationship between FDF, FDT, SAP, and confocal scanning laser ophthalmoscopy (cSLO) in patients with glaucoma. METHODS Seventy-six patients with glaucoma were included in the study. Patients were tested with SAP, Matrix-FDT, FDF perimetry, and cSLO. Structure-Function Relationships between global and sectoral cSLO parameters and global and sectoral mean sensitivity (MS) of SAP, Matrix-FDT, and FDF were calculated using Spearman's rank correlation and linear regression. RESULTS Overall, FDF perimetry showed the strongest structure-Function Relationship (GLOBAL correlation with rim area: 0.44; range of significant sectoral FDF values: 0.23-0.69), followed by FDT (global correlation with rim area: 0.35; range of significant sectoral FDT values: 0.25-0.60). SAP presented with the weakest structure-Function Relationship and fewer statistically significant results (global correlation with rim volume: 0.32; range of significant sectoral SAP values: 0.23-0.58). Sector-by-sector, the structure-Function Relationship was greatest in the superotemporal and inferotemporal regions. Weakest correlations were found in the inferonasal and nasal sectors. CONCLUSIONS The correlation between structure and Function is stronger in FDF and FDT compared with SAP. Correlations are strongest in temporal areas where glaucomatous damage tends to occur first. A better understanding of the structure-Function Relationship should allow for improved detection and management of glaucoma patients.
Hans G. Lemij - One of the best experts on this subject based on the ideXlab platform.
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optimizing structure Function Relationship by maximizing correspondence between glaucomatous visual fields and mathematical retinal nerve fiber models
Investigative Ophthalmology & Visual Science, 2014Co-Authors: Nicole S Erler, Hans G. Lemij, Susan R Bryan, Paul H C Eilers, Emmanuel Lesaffre, K A VermeerAbstract:Purpose. To introduce a method to optimize structural retinal nerve fiber layer (RNFL) models based on glaucomatous visual field data and to show how such an optimized model can be used to reduce noise in visual fields while probably preserving clinically important features. Methods. Correlation coefficients between age-adjusted deviation values of pairs of visual field test locations were calculated from 103 visual fields of eyes with moderate glaucomatous damage. Distances between those test locations were defined for various parameters of a mathematical RNFL model. Then, the correspondence between the structural and Functional data was defined by the spread, or variance, of the correlation coefficients for all distances. The model parameters that minimized this spread constituted the optimized model. To reduce noise in visual fields, the optimized model was used to smooth visual field data according to the RNFL's structure. The resulting fields were compared with visual fields that were smoothed based on the regular testing grid. Results. The optimal parameters for the RNFL model reduced the variance of the correlation coefficients by 78% and were well within the range of parameters previously determined from fundus photographs. Smoothing the visual fields based on the optimized RNFL model strongly reduced noise while keeping important features. Conclusions. Mathematic RNFL models can be optimized based on visual field data, resulting in a strong structure-Function Relationship. Taking the RNFL's shape, as defined by such an optimized model, into account when smoothing visual fields results in better noise reduction while preserving important details.
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Structure-Function Relationship is stronger with enhanced corneal compensation than with variable corneal compensation in scanning laser polarimetry.
Investigative Opthalmology & Visual Science, 2007Co-Authors: Nicolaas J. Reus, Hans G. LemijAbstract:PURPOSE. To compare the structure-Function Relationship between peripapillary retinal nerve fiber layer (RNFL) retardation, measured with scanning laser polarimetry (SLP) with both enhanced and variable corneal compensation (ECC [enhanced corneal compensation] and VCC [variable corneal compensation], respectively; features of the GDx Nerve Fiber Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA), and visual field (VF) sensitivity, measured with standard automated perimetry (SAP) in normal and glaucomatous eyes and the effect of marked atypical birefringence patterns (ABPs) on this Relationship. METHODS. Thirty-three healthy subjects, and 68 patients with primary open-angle glaucoma (POAG) took part in the study. ECC and VCC images were taken in one randomly selected eye of each subject. VF tests were also obtained in the same eyes. The structure-Function Relationship was assessed in six peripapillary sectors and their matching VF areas and was reassessed after eliminating eyes with marked ABPs. RESULTS. Correlations (Spearman's correlation coefficients, r s ) in the structure-Function Relationship were generally stronger in images taken with ECC than in those taken with VCC. With ECC, the Relationship was significantly more curvilinear when VF sensitivity was expressed in the standard decibel scale and more linear when VF sensitivity was expressed in an antilog scale than with VCC. When eyes with marked ABP images were removed from the analysis, the structure-Function Relationship with VCC improved, and no statistically significantly differences were found in the Relationships between VCC and ECC. CONCLUSIONS. The structure-Function Relationship between RNFL retardation and SAP VF sensitivity was stronger in images obtained with the GDx ECC than with the GDx VCC (Carl Zeiss Meditec, Inc., Dublin, CA). ABPs, which appeared more markedly with VCC than with ECC, weakened the structure-Function Relationship.
Rudi F. Vogel - One of the best experts on this subject based on the ideXlab platform.
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Structure/Function Relationship of homopolysaccharide producing glycansucrases and therapeutic potential of their synthesised glycans
Applied Microbiology and Biotechnology, 2006Co-Authors: Maher Korakli, Rudi F. VogelAbstract:The capability of lactic acid bacteria (LAB) to produce exopoly- and oligosaccharides was and is the subject of expanding research efforts. Due to their physicochemical properties and health-promoting potential, exopoly- and oligosaccharides from food-grade LAB can be used in the food and other industries and may have additional medical applications. In the last years, many LAB have been screened for their ability to produce exopoly- and oligosaccharides, and several glycosyltransferases involved in their biosynthesis have been characterised at biochemical and genetic levels. These research efforts aim to exploit the full potential of these organisms and to understand the structure/Function Relationship of glycosyltransferases. The latter knowledge is a prerequisite for the production of tailored exopoly- and oligosaccharides for the diverse applications. This review will survey the results of recent works on the structure/Function Relationship of homopolysaccharide producing glycosyltransferases and the therapeutic potential of their synthesised exopoly- and oligosaccharides.
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structure Function Relationship of homopolysaccharide producing glycansucrases and therapeutic potential of their synthesised glycans
Applied Microbiology and Biotechnology, 2006Co-Authors: Maher Korakli, Rudi F. VogelAbstract:The capability of lactic acid bacteria (LAB) to produce exopoly- and oligosaccharides was and is the subject of expanding research efforts. Due to their physicochemical properties and health-promoting potential, exopoly- and oligosaccharides from food-grade LAB can be used in the food and other industries and may have additional medical applications. In the last years, many LAB have been screened for their ability to produce exopoly- and oligosaccharides, and several glycosyltransferases involved in their biosynthesis have been characterised at biochemical and genetic levels. These research efforts aim to exploit the full potential of these organisms and to understand the structure/Function Relationship of glycosyltransferases. The latter knowledge is a prerequisite for the production of tailored exopoly- and oligosaccharides for the diverse applications. This review will survey the results of recent works on the structure/Function Relationship of homopolysaccharide producing glycosyltransferases and the therapeutic potential of their synthesised exopoly- and oligosaccharides.
Julia Lamparter - One of the best experts on this subject based on the ideXlab platform.
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Structure-Function Relationship between FDF, FDT, SAP, and scanning laser ophthalmoscopy in glaucoma patients.
Investigative Ophthalmology & Visual Science, 2012Co-Authors: Julia Lamparter, Ann-christin Schuff, A. Schulze, Norbert Pfeiffer, Richard A Russell, E. M. HoffmannAbstract:Flicker defined form perimetry (FDF) and frequency doubling technology perimetry (FDT) are alleged to detect glaucoma at an earlier stage than standard automated perimetry (SAP). It is the purpose of this study to investigate the structure-Function Relationship between FDF, FDT, SAP, and confocal scanning laser ophthalmoscopy (cSLO) in patients with glaucoma. Seventy-six patients with glaucoma were included in the study. Patients were tested with SAP, Matrix-FDT, FDF perimetry, and cSLO. Structure-Function Relationships between global and sectoral cSLO parameters and global and sectoral mean sensitivity (MS) of SAP, Matrix-FDT, and FDF were calculated using Spearman's rank correlation and linear regression. Overall, FDF perimetry showed the strongest structure-Function Relationship (GLOBAL correlation with rim area: 0.44; range of significant sectoral FDF values: 0.23-0.69), followed by FDT (global correlation with rim area: 0.35; range of significant sectoral FDT values: 0.25-0.60). SAP presented with the weakest structure-Function Relationship and fewer statistically significant results (global correlation with rim volume: 0.32; range of significant sectoral SAP values: 0.23-0.58). Sector-by-sector, the structure-Function Relationship was greatest in the superotemporal and inferotemporal regions. Weakest correlations were found in the inferonasal and nasal sectors. The correlation between structure and Function is stronger in FDF and FDT compared with SAP. Correlations are strongest in temporal areas where glaucomatous damage tends to occur first. A better understanding of the structure-Function Relationship should allow for improved detection and management of glaucoma patients.
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Structure-Function Relationship between FDF, FDT, SAP, and scanning laser ophthalmoscopy in glaucoma patients.
Investigative Opthalmology & Visual Science, 2012Co-Authors: Julia Lamparter, Ann-christin Schuff, A. Schulze, Norbert Pfeiffer, Richard A Russell, E. M. HoffmannAbstract:PURPOSE Flicker defined form perimetry (FDF) and frequency doubling technology perimetry (FDT) are alleged to detect glaucoma at an earlier stage than standard automated perimetry (SAP). It is the purpose of this study to investigate the structure-Function Relationship between FDF, FDT, SAP, and confocal scanning laser ophthalmoscopy (cSLO) in patients with glaucoma. METHODS Seventy-six patients with glaucoma were included in the study. Patients were tested with SAP, Matrix-FDT, FDF perimetry, and cSLO. Structure-Function Relationships between global and sectoral cSLO parameters and global and sectoral mean sensitivity (MS) of SAP, Matrix-FDT, and FDF were calculated using Spearman's rank correlation and linear regression. RESULTS Overall, FDF perimetry showed the strongest structure-Function Relationship (GLOBAL correlation with rim area: 0.44; range of significant sectoral FDF values: 0.23-0.69), followed by FDT (global correlation with rim area: 0.35; range of significant sectoral FDT values: 0.25-0.60). SAP presented with the weakest structure-Function Relationship and fewer statistically significant results (global correlation with rim volume: 0.32; range of significant sectoral SAP values: 0.23-0.58). Sector-by-sector, the structure-Function Relationship was greatest in the superotemporal and inferotemporal regions. Weakest correlations were found in the inferonasal and nasal sectors. CONCLUSIONS The correlation between structure and Function is stronger in FDF and FDT compared with SAP. Correlations are strongest in temporal areas where glaucomatous damage tends to occur first. A better understanding of the structure-Function Relationship should allow for improved detection and management of glaucoma patients.
