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Iqbal M Choudhary - One of the best experts on this subject based on the ideXlab platform.
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biotransformation of perfumery terpenoids ambrox by a Fungal Culture macrophomina phaseolina and a plant Cell suspension Culture of peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, Iqbal M ChoudharyAbstract:Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Biotransformation of (−)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Nine oxygenated metabolites of (−)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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biotransformation of perfumery terpenoids ambrox w by a Fungal Culture macrophomina phaseolina and a plant Cell suspension Culture of
2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, Iqbal M ChoudharyAbstract:Background: Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Results: Biotransformation of (�)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Conclusion: Nine oxygenated metabolites of (�)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
Syed Ghulam Musharraf - One of the best experts on this subject based on the ideXlab platform.
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biotransformation of perfumery terpenoids ambrox by a Fungal Culture macrophomina phaseolina and a plant Cell suspension Culture of peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, Iqbal M ChoudharyAbstract:Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Biotransformation of (−)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Nine oxygenated metabolites of (−)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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Biotransformation of perfumery terpenoids, (−)-ambrox® by a Fungal Culture Macrophomina phaseolina and a plant Cell suspension Culture of Peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, M. Iqbal ChoudharyAbstract:Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Biotransformation of (−)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Nine oxygenated metabolites of (−)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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Biotransformation of perfumery terpenoids, (−)-ambrox® by a Fungal Culture Macrophomina phaseolina and a plant Cell suspension Culture of Peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, M. Iqbal ChoudharyAbstract:Background Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Results Biotransformation of (−)-ambrox ( 1 ) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3 β -hydroxyambrox ( 2 ), 6 β -hydroxyambrox ( 3 ), 1 α -hydroxy-3oxoambrox ( 4 ), 1 α ,3 β -dihydroxyambrox ( 5 ), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol ( 6 ), 3-oxoambrox ( 7 ), 2 α -hydroxyambrox ( 8 ), 3 β -hydroxysclareolide ( 9 ), and 2 α ,3 β -dihydroxyambrox ( 10 ). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Conclusion Nine oxygenated metabolites of (−)-ambrox ( 1 ) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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biotransformation of perfumery terpenoids ambrox w by a Fungal Culture macrophomina phaseolina and a plant Cell suspension Culture of
2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, Iqbal M ChoudharyAbstract:Background: Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Results: Biotransformation of (�)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Conclusion: Nine oxygenated metabolites of (�)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
M. Iqbal Choudhary - One of the best experts on this subject based on the ideXlab platform.
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Biotransformation of perfumery terpenoids, (−)-ambrox® by a Fungal Culture Macrophomina phaseolina and a plant Cell suspension Culture of Peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, M. Iqbal ChoudharyAbstract:Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Biotransformation of (−)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Nine oxygenated metabolites of (−)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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Biotransformation of perfumery terpenoids, (−)-ambrox® by a Fungal Culture Macrophomina phaseolina and a plant Cell suspension Culture of Peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, M. Iqbal ChoudharyAbstract:Background Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Results Biotransformation of (−)-ambrox ( 1 ) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3 β -hydroxyambrox ( 2 ), 6 β -hydroxyambrox ( 3 ), 1 α -hydroxy-3oxoambrox ( 4 ), 1 α ,3 β -dihydroxyambrox ( 5 ), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol ( 6 ), 3-oxoambrox ( 7 ), 2 α -hydroxyambrox ( 8 ), 3 β -hydroxysclareolide ( 9 ), and 2 α ,3 β -dihydroxyambrox ( 10 ). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Conclusion Nine oxygenated metabolites of (−)-ambrox ( 1 ) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
Asma Najeeb - One of the best experts on this subject based on the ideXlab platform.
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biotransformation of perfumery terpenoids ambrox by a Fungal Culture macrophomina phaseolina and a plant Cell suspension Culture of peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, Iqbal M ChoudharyAbstract:Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Biotransformation of (−)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Nine oxygenated metabolites of (−)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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Biotransformation of perfumery terpenoids, (−)-ambrox® by a Fungal Culture Macrophomina phaseolina and a plant Cell suspension Culture of Peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, M. Iqbal ChoudharyAbstract:Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Biotransformation of (−)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Nine oxygenated metabolites of (−)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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Biotransformation of perfumery terpenoids, (−)-ambrox® by a Fungal Culture Macrophomina phaseolina and a plant Cell suspension Culture of Peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, M. Iqbal ChoudharyAbstract:Background Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Results Biotransformation of (−)-ambrox ( 1 ) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3 β -hydroxyambrox ( 2 ), 6 β -hydroxyambrox ( 3 ), 1 α -hydroxy-3oxoambrox ( 4 ), 1 α ,3 β -dihydroxyambrox ( 5 ), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol ( 6 ), 3-oxoambrox ( 7 ), 2 α -hydroxyambrox ( 8 ), 3 β -hydroxysclareolide ( 9 ), and 2 α ,3 β -dihydroxyambrox ( 10 ). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Conclusion Nine oxygenated metabolites of (−)-ambrox ( 1 ) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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biotransformation of perfumery terpenoids ambrox w by a Fungal Culture macrophomina phaseolina and a plant Cell suspension Culture of
2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, Iqbal M ChoudharyAbstract:Background: Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Results: Biotransformation of (�)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Conclusion: Nine oxygenated metabolites of (�)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
Saifullah Khan - One of the best experts on this subject based on the ideXlab platform.
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biotransformation of perfumery terpenoids ambrox by a Fungal Culture macrophomina phaseolina and a plant Cell suspension Culture of peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, Iqbal M ChoudharyAbstract:Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Biotransformation of (−)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Nine oxygenated metabolites of (−)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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Biotransformation of perfumery terpenoids, (−)-ambrox® by a Fungal Culture Macrophomina phaseolina and a plant Cell suspension Culture of Peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, M. Iqbal ChoudharyAbstract:Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Biotransformation of (−)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Nine oxygenated metabolites of (−)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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Biotransformation of perfumery terpenoids, (−)-ambrox® by a Fungal Culture Macrophomina phaseolina and a plant Cell suspension Culture of Peganum harmala
Chemistry Central Journal, 2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, M. Iqbal ChoudharyAbstract:Background Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Results Biotransformation of (−)-ambrox ( 1 ) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3 β -hydroxyambrox ( 2 ), 6 β -hydroxyambrox ( 3 ), 1 α -hydroxy-3oxoambrox ( 4 ), 1 α ,3 β -dihydroxyambrox ( 5 ), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol ( 6 ), 3-oxoambrox ( 7 ), 2 α -hydroxyambrox ( 8 ), 3 β -hydroxysclareolide ( 9 ), and 2 α ,3 β -dihydroxyambrox ( 10 ). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Conclusion Nine oxygenated metabolites of (−)-ambrox ( 1 ) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
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biotransformation of perfumery terpenoids ambrox w by a Fungal Culture macrophomina phaseolina and a plant Cell suspension Culture of
2012Co-Authors: Syed Ghulam Musharraf, Asma Najeeb, Saifullah Khan, Iqbal M ChoudharyAbstract:Background: Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods. This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with Fungal and plant Cell Culture. Results: Biotransformation of (�)-ambrox (1) with a Fungal Cell Culture of Macrophomina phaseolina and a plant Cell suspension Cultures of Peganum harmala yielded oxygenated products, 3β-hydroxyambrox (2), 6β-hydroxyambrox (3), 1α-hydroxy-3oxoambrox (4), 1α,3β-dihydroxyambrox (5), 13,14,15,16-tetranorlabdane-3-oxo-8,12-diol (6), 3-oxoambrox (7), 2α-hydroxyambrox (8), 3β-hydroxysclareolide (9), and 2α,3β-dihydroxyambrox (10). Metabolite 4 was found to be new compound. These metabolites were structurally characterized on the basis of spectroscopic studies. Conclusion: Nine oxygenated metabolites of (�)-ambrox (1) were obtained from Macrophomina phaseolina and Peganum harmala. Enzymatic system of screened organisms introduced hydroxyl and keto functionalities at various positions of compound 1 in a stereo- and regio-controlled manner.
