The Experts below are selected from a list of 29550 Experts worldwide ranked by ideXlab platform
A. Prabhakar - One of the best experts on this subject based on the ideXlab platform.
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effect of superficial air velocity on solid state fermentation of palm kernel cake in a lab scale fermenter using locally isolated Fungal Strain
Industrial Crops and Products, 2009Co-Authors: Chee Woh Foong, K. Krishnaiah, Jidon Janaun, A. PrabhakarAbstract:Solid state fermentation (SSF) is emerging as an attractive alternative to submerged fermentation despite the engineering problems such as removal of metabolic heat, transport of oxygen and moisture into the particles and the heterogeneity of the substrate. In the present work, a lab scale fermenter which can be operated as fluidized bed and packed bed was fabricated. Solid state fermentation of palm kernel cake (PKC) using Fungal Strain TW1 was carried out at three superficial air velocities. PKC particles of mean diameter 855 μm were used and the fluidizing medium was air. Reducing sugar concentration, biomass growth, bed moisture content, substrate pH, and hemicellulose content were measured. The maximum increase in reducing sugar concentration was at 0.17 m/s since an increase in mannose from 14.55 to 18.63 mg mannose/g dry PKC was observed. The hemicellulose content of this fermented PKC was estimated and the result was around 10% in reduction of hemicellulose content in fermented PKC. Further improvement of PKC bioconversion can likely be achieved by selection of a more robust microbe that can withstand the conditions in the fluidized bed during SSF and by creating a system which can maintain the moisture content of PKC during SSF of PKC throughout the packed bed.
Yongbo Xue - One of the best experts on this subject based on the ideXlab platform.
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atrichodermones a c three new secondary metabolites from the solid culture of an endophytic Fungal Strain trichoderma atroviride
Fitoterapia, 2017Co-Authors: Peng Zhou, Dongdong Tan, Jing Yang, Qun Zhou, Fanrong Zeng, Mi Zhang, Qiong Bie, Chunmei Chen, Yongbo Xue, Zengwei LuoAbstract:An endophytic Fungal Strain named Trichoderma atroviride was isolated from the bulb of Lycoris radiata. Following cultivation on rice medium, a novel 3-amino-5-hydroxy-5-vinyl-2-cyclopenten-1-one dimer, atrichodermone A (1), a new cyclopentenone derivative, atrichodermone B (2), and a new sesquiterpene, atrichodermone C (3), together with three known cyclopentenone derivatives (4-6) were isolated. Their structures were elucidated by extensive spectroscopic (UV, IR, ECD, HRESIMS, and NMR) data analyses, and absolute configurations of the new compounds were determined by comparing their experimental ECD spectra with structurally similar compounds and computational analyses of their electronic circular dichroism (ECD) spectra. Compounds 1-3 were evaluated for their cytotoxicity against HL60 and U937 cell lines, as well as anti-inflammatory effect against the production of the pro-inflammatory cytokines TNF-α and IL-1β.
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Atrichodermones A–C, three new secondary metabolites from the solid culture of an endophytic Fungal Strain, Trichoderma atroviride
Fitoterapia, 2017Co-Authors: Peng Zhou, Dongdong Tan, Jing Yang, Qun Zhou, Fanrong Zeng, Mi Zhang, Qiong Bie, Chunmei Chen, Yongbo XueAbstract:Abstract An endophytic Fungal Strain named Trichoderma atroviride was isolated from the bulb of Lycoris radiata . Following cultivation on rice medium, a novel 3-amino-5-hydroxy-5-vinyl-2-cyclopenten-1-one dimer, atrichodermone A ( 1 ), a new cyclopentenone derivative, atrichodermone B ( 2 ), and a new sesquiterpene, atrichodermone C ( 3 ), together with three known cyclopentenone derivatives ( 4 – 6 ) were isolated. Their structures were elucidated by extensive spectroscopic (UV, IR, ECD, HRESIMS, and NMR) data analyses, and absolute configurations of the new compounds were determined by comparing their experimental ECD spectra with structurally similar compounds and computational analyses of their electronic circular dichroism (ECD) spectra. Compounds 1 – 3 were evaluated for their cytotoxicity against HL60 and U937 cell lines, as well as anti-inflammatory effect against the production of the pro-inflammatory cytokines TNF- α and IL-1 β .
Peng Zhou - One of the best experts on this subject based on the ideXlab platform.
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atrichodermones a c three new secondary metabolites from the solid culture of an endophytic Fungal Strain trichoderma atroviride
Fitoterapia, 2017Co-Authors: Peng Zhou, Dongdong Tan, Jing Yang, Qun Zhou, Fanrong Zeng, Mi Zhang, Qiong Bie, Chunmei Chen, Yongbo Xue, Zengwei LuoAbstract:An endophytic Fungal Strain named Trichoderma atroviride was isolated from the bulb of Lycoris radiata. Following cultivation on rice medium, a novel 3-amino-5-hydroxy-5-vinyl-2-cyclopenten-1-one dimer, atrichodermone A (1), a new cyclopentenone derivative, atrichodermone B (2), and a new sesquiterpene, atrichodermone C (3), together with three known cyclopentenone derivatives (4-6) were isolated. Their structures were elucidated by extensive spectroscopic (UV, IR, ECD, HRESIMS, and NMR) data analyses, and absolute configurations of the new compounds were determined by comparing their experimental ECD spectra with structurally similar compounds and computational analyses of their electronic circular dichroism (ECD) spectra. Compounds 1-3 were evaluated for their cytotoxicity against HL60 and U937 cell lines, as well as anti-inflammatory effect against the production of the pro-inflammatory cytokines TNF-α and IL-1β.
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Atrichodermones A–C, three new secondary metabolites from the solid culture of an endophytic Fungal Strain, Trichoderma atroviride
Fitoterapia, 2017Co-Authors: Peng Zhou, Dongdong Tan, Jing Yang, Qun Zhou, Fanrong Zeng, Mi Zhang, Qiong Bie, Chunmei Chen, Yongbo XueAbstract:Abstract An endophytic Fungal Strain named Trichoderma atroviride was isolated from the bulb of Lycoris radiata . Following cultivation on rice medium, a novel 3-amino-5-hydroxy-5-vinyl-2-cyclopenten-1-one dimer, atrichodermone A ( 1 ), a new cyclopentenone derivative, atrichodermone B ( 2 ), and a new sesquiterpene, atrichodermone C ( 3 ), together with three known cyclopentenone derivatives ( 4 – 6 ) were isolated. Their structures were elucidated by extensive spectroscopic (UV, IR, ECD, HRESIMS, and NMR) data analyses, and absolute configurations of the new compounds were determined by comparing their experimental ECD spectra with structurally similar compounds and computational analyses of their electronic circular dichroism (ECD) spectra. Compounds 1 – 3 were evaluated for their cytotoxicity against HL60 and U937 cell lines, as well as anti-inflammatory effect against the production of the pro-inflammatory cytokines TNF- α and IL-1 β .
Apostolis A. Koutinas - One of the best experts on this subject based on the ideXlab platform.
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Orange processing waste valorisation for the production of bio-based pigments using the Fungal Strains Monascus purpureus and Penicillium purpurogenum
Journal of Cleaner Production, 2018Co-Authors: A. Kantifedaki, Vasiliki Kachrimanidou, Athanasios Mallouchos, Seraphim Papanikolaou, Apostolis A. KoutinasAbstract:Abstract Orange processing wastes have been evaluated for the production of pigments by the Fungal Strains Monascus purpureus ATCC 16365 and Penicillium purpurogenum CBS 113139. Solid state fermentations were initially conducted on waste orange peels with the Fungal Strain M. purpureus aiming to assess various pigment extraction methods, the effect of particle size as well as the effect of nitrogen addition and incubation time. Under the optimum conditions, solid state fermentations were also performed with the Strain P. purpuronegum to evaluate pigment production on waste orange peels. M. purpureus was more efficient than P. purpurogenum for the production of pigments during solid state fermentation, yielding 9 absorbance units (AU) per g of dry fermented substrate. Semi-solid state fermentations were subsequently conducted by suspending waste orange peels in liquid media leading to pigment production of up to 0.95 AU mL−1. Submerged fermentations were carried out with both Fungal Strains using aqueous extracts from either boiled or hydrodistilled orange peel residues as the sole fermentation medium showing that up to 0.58 AU mL−1 of pigment production could be achieved. Each fermentation feedstock and fermentation mode influenced significantly the production of pigments by each Fungal Strain used.
Youn-chul Kim - One of the best experts on this subject based on the ideXlab platform.
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Anti-inflammatory effects of secondary metabolites isolated from the marine-derived Fungal Strain Penicillium sp. SF-5629
Archives of Pharmacal Research, 2017Co-Authors: Nguyen Thi Thanh Ngan, Tran Hong Quang, Jae Hak Sohn, Kwan-woo Kim, Hye Jin Kim, Dae Gill Kang, Ho Sub Lee, Youn-chul KimAbstract:After the chemical investigation of the ethyl acetate extract of the marine-derived Fungal Strain Penicillium sp. SF-5629, the isolation and structural elucidation of eight secondary metabolites, including (3 R ,4 S )-6,8-dihydroxy-3,4,7-trimethylisocoumarin ( 1 ), (3 S ,4 S )-sclerotinin A ( 2 ), penicitrinone A ( 3 ), citrinin H1 ( 4 ), emodin ( 5 ), ω-hydroxyemodin ( 6 ), 8-hydroxy-6-methyl-9-oxo-9 H -xanthene-1-carboxylate ( 7 ), and 3,8-dihydroxy-6-methyl-9-oxo-9 H -xanthene-1-carboxylate ( 8 ) were carried out. Evaluation of the anti-inflammatory activity of these metabolites showed that 4 inhibited nitric oxide and prostaglandin E2 production in lipopolysaccharide-stimulated BV2 microglia, with IC_50 values of 8.1 ± 1.9 and 8.0 ± 2.8 μM, respectively. The inhibitory function of 4 was confirmed based on decreases in inducible nitric oxide synthesis and cyclooxygenase-2 gene expression. In addition, 4 was found to suppress the phosphorylation of inhibitor kappa B-α, interrupt the nuclear translocation of nuclear factor kappa B, and decrease the activation of p38 mitogen-activated protein kinase.
