The Experts below are selected from a list of 57 Experts worldwide ranked by ideXlab platform
Mariadhas Valan Arasu - One of the best experts on this subject based on the ideXlab platform.
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1,2,4-Triazolo-quinazoline-thiones: Non-conventional synthetic approach, Study of solvatochromism and antioxidant assessment.
Journal of photochemistry and photobiology. B Biology, 2016Co-Authors: Rajesh Sompalle, Selvaraj Mohana Roopan, Naif Abdullah Al-dhabi, K. Suthindhiran, Gargi Sarkar, Mariadhas Valan ArasuAbstract:A non-conventional methodology has been utilized for the synthesis of a series of 1,2,4-triazolo-quinazoline-thiones (2a-l). Here the reaction was carried out between 1,2,4-triazolo-quinazolinones (1a-l), in the presence of 1,4-dioxane. The mixture was irradiated under microwave (100W) for 7min to obtain targeted molecules (2a-l). All the synthesized molecules were confirmed by (1)H, (13)C NMR and HRMS. The solvatochromic property (absorption spectra) of compounds (2a-l) in solvents of different polarities was studied. The compounds (2a-l) were further subjected for their in vitro free radical screening using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and also screened for their in vitro anti-Fungal property against Aspergillus flavus (A. flavus) and Aspergillus niger (A. niger). The results from free radical scavenging assay showed promising activity for compounds 2a, e-i, whereas compound 2d showed significant antioxidant activity when compared to ascorbic acid. In vitro anti-Fungal Study showed that the 1,2,4-triazolo-quinazoline-thiones (2a-l) had significant activity against A. flavus and A. niger compared with widely used antiFungal agent Fluconazole.
Mohammad A. Abou-elela - One of the best experts on this subject based on the ideXlab platform.
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Sinus aspirates in chronic rhinosinusitis: Fungal colonization of paranasal sinuses, evaluation of ICAM-1 and IL-8 and Studying of immunological effect of long-term macrolide therapy.
Rhinology, 2010Co-Authors: Shawky Elmorsy, M.m. El-naggar, Sanaa M. Abdel Aal, Mohammad A. Abou-elelaAbstract:PURPOSE In patients with chronic Fungal sinusitis, concentrations of interleukin-8 (IL-8), immunoglobulin E (IgE), and soluble intercellular adhesion molecule-1 (sICAM-1) were compared in paranasal sinus aspirates and serum. Furthermore, immunological effects of macrolide treatment of our patients with chronic Fungal rhinosinusitis were also studied. MATERIAL AND METHODS In our cohort Study, 108 patients with chronic rhinosinusitis undergoing sinus surgery were selected. Sinus aspirates were collected, and used for immunological assasy and cultured for Fungal Study. All patients were examined for the presence of characteristic allergic mucin of chronic allergic Fungal rhinosinusitis and this was confirmed later by measurement of total serum IgE. RESULTS Our cases were classified into 3 groups: chronic rhinosinusitis with positive Fungal culture and negative allergic mucin, chronic rhinosinusitis with positive Fungal culture and positive allergic mucin and chronic rhinosinusitis without Fungal growth. A control group was included. We found 57.4% of the patient cultures positive for fungus and 36.4% of the control subjects. Aspergillus ssp. were the most prevalent followed by Bipolaris ssp., and Curvularia. IgE levels were increased in group II compared to group I, III and IV. ICAM-1 and IL-8 levels were increased in groups I, II and III compared to the control group. Erythromycin given in group II decreased the levels of IL-8 and ICAM-1. CONCLUSION Aspergillus species were the most common. These results confirm the role of ICAM-1 and IL-8 in all types of rhinosinusitis. Erythromycin modulated the immune status of the patients.
Rajesh Sompalle - One of the best experts on this subject based on the ideXlab platform.
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1,2,4-Triazolo-quinazoline-thiones: Non-conventional synthetic approach, Study of solvatochromism and antioxidant assessment.
Journal of photochemistry and photobiology. B Biology, 2016Co-Authors: Rajesh Sompalle, Selvaraj Mohana Roopan, Naif Abdullah Al-dhabi, K. Suthindhiran, Gargi Sarkar, Mariadhas Valan ArasuAbstract:A non-conventional methodology has been utilized for the synthesis of a series of 1,2,4-triazolo-quinazoline-thiones (2a-l). Here the reaction was carried out between 1,2,4-triazolo-quinazolinones (1a-l), in the presence of 1,4-dioxane. The mixture was irradiated under microwave (100W) for 7min to obtain targeted molecules (2a-l). All the synthesized molecules were confirmed by (1)H, (13)C NMR and HRMS. The solvatochromic property (absorption spectra) of compounds (2a-l) in solvents of different polarities was studied. The compounds (2a-l) were further subjected for their in vitro free radical screening using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and also screened for their in vitro anti-Fungal property against Aspergillus flavus (A. flavus) and Aspergillus niger (A. niger). The results from free radical scavenging assay showed promising activity for compounds 2a, e-i, whereas compound 2d showed significant antioxidant activity when compared to ascorbic acid. In vitro anti-Fungal Study showed that the 1,2,4-triazolo-quinazoline-thiones (2a-l) had significant activity against A. flavus and A. niger compared with widely used antiFungal agent Fluconazole.
Awad M. Abdel-rahim - One of the best experts on this subject based on the ideXlab platform.
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Physiochemical Characteristic and Biological Activity of the Clove (Syzygium aromaticum) Bud Oil
2015Co-Authors: Awad M. Abdel-rahim, Samahir H Osman, Mai Abdalla AliAbstract:The present Study was investigating the physiochemical and the biological activity of the Clove bud oil against the fungus ( A. niger) and two bacteria ( E. coli and Staph. aurues ). The inhibition zone plate method was used for bacterial test, while the mycelia weights and radial growth methods were used for the Fungal Study. The A.O.S. official methods were used to determine the physiochemical properties. The studies on the physiochemical characteristics of the Clove bud oil proved that the acid value was (3.86), the saponification value was (38.27),the peroxide value was (3.83), the specific gravity was (1.043), the reflective index was (1.525), the iodine value was (182.43), and the free fatty acid was (1.94). The results of the antimicrobial tests showed that the Clove bud oil gave a complete inhibition of the radial growth of the fungus ( A. niger) at its higher concentration and a high reduction percent at its lower concentrations. However, the mycelial fresh and dry weights of the fungus A. niger were completely inhibited by the Clove bud oil at its higher concentration, and clearly reduced at its lower concentrations. The inhibition zone of growth of both bacteria was larger than that of the control treatment. Clove bud oil showed clear inhibition zone when used against Staph. aurues compared to its use against E. coli. Many studies have reported that oils of different herbs and spices can yield medicinal compounds. Spices and herbs have been used for thousand of years by man in traditional medicine. However, more physiochemical characterizations need to be done and the antiFungal and the antibacterial properties should be verified in any further studies on the Clove bud oil.
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Antimicrobial Activity and Some Physiochemical Properties of Pumpkin (Cucurbita pepo L.) Seed oil
2015Co-Authors: Awad M. Abdel-rahim, Shomoos A.osman, Atif A. A. Yasin, Yasir M. AbdelraheemAbstract:Pumpkin and squash plants grow in warm, humid regions, cannot withstand frost. Most of the pumpkin consumed in Sudan was grown in Kordufan (western sudan).The use of plants and their extracts as remedies for curing many diseases have stimulate studies for investigating the presence of effective antimicrobial substances in them The present Study was investigating the physiochemical and the biological activity of the different solvent extracts of pumpkin ( Cucurbita pepo ) seed oil (hexane, ethanol, methanol, and water) against two fungi ( A. niger and P. italicum ) and two bacteria (E.coli and Staph. aureus). The inhibition zone method was used for bacterial tests and the mycelia weight method was used for the Fungal Study. The results of the physiochemical showed that the specific gravity of the oil was between 0.997–0.908. The Refractive index was between 1.46–1.470. The average iodine value was 117.97, the free fatty acids was between 0.2 and 0.55. The peroxide value was in the normal range (5.92–9 and the average saponification value was about 188. The biological Study showed that the fresh and the dry weights of mycelia were highly reduced, although the reduction was only statistically different at the higher concentrations (75-100%).The fresh weights for the higher concentrations were 1.65 and 1.0 and for the lower concentrations were 3.1 and 3.7 for both A. niger and P. italicum , respectively. The inhibition zone of growth of both bacteria was far greater than that of the control treatment. The results indicated that the pumpkin oil extracts are more effective against bacteria compared to fungi. The hexane extract was giving a large inhibition zone (about 26.5 mm diameter) while, the ethanol extract was giving a less inhibition zone (about 14.2.mm diameter). On the other hand both methanol and the aqueous extracts were giving very low inhibition zones (13.5 and 13.6 mm diameter, respectively). However, more physiochemical characterizations need to be done and the antiFungal and the antibacterial properties should verified in any further studies on the pumpkin seed oil. Key words : Pumpkin seed oil, Physiochemical properties, Antimicrobial Activity.
Manoj Kumar Mishra - One of the best experts on this subject based on the ideXlab platform.
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formulation and evaluation of herbal oral gel containing extracts of powdered psidium guajava linn leaves with curcuma longa linn rhizomes totreat mouth ulcer
International Journal of Drug Development and Research, 2020Co-Authors: Richa Sing, Sagar Bansal, Manoj Kumar MishraAbstract:The objective of this Study was to formulate and evaluate the herbal oral gel containing extracts of powdered Psidium guajava Linn leaves and Curcuma longa Linn rhizomes to treat mouth ulcer. The traditional medical Study is an integral part of the culture and the interpretation of health by indigenous populations in almost world. Guava leaves have been usually used to govern several diseases such as rheumatism, diarrhea, diabetes mellitus, wound sore throat, cough and it also gives good antimicrobial, antiFungal, anticancer activity. Guava comprises some essential phytoconstituents such as tannins, triterpenes, flavonoid: quercetin, pentacyclic triterpenoid: guajanoic acid, saponins, carotenoids, lectins, leucocyanidin, ellagic acid, amritoside, betasitosterol, uvaol, oleanolic acid and ursolic acid while turmeric has anti-inflammatory, antibacterial activity, virucidal, antimutagenic, antioxidant properties. Turmeric contains a large variety of phytochemicals such as curcumin, demethoxycurcumin, eugenol, tannins, alkaloids, saponins, terpenoids and curcumol. The herbal oral gel formulation was prepared by using guava leaf extract, turmeric rhizome extract, carbopol 934, propylene glycol, methyl paraben, propyl paraben, triethnolamine and required amount of distilled water. The triethanolamine was added drop wise to maintain the pH (6.7-7.2) of oral mucosa. The physicochemical parameters of formulations such as pH, spreadability, viscosity, extrudability, gelling strength and antiFungal activity were determined. The results showed that the optimized herbal oral formulation containing guava leaf extract and turmeric rhizomes extract shows that all physicochemical parameters were found to be compatible with the normal range. Anti-Fungal Study of formulation revealed excellent efficacy against Candida albicans. Developed herbal oral formulation was stable, safe and effective for the treatment of mouth ulcer.
