Fusarium tricinctum

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Joseph D. Rosen - One of the best experts on this subject based on the ideXlab platform.

  • Mechanism for sodium bicarbonate inhibition of trichothecene biosynthesis in Fusarium tricinctum
    Journal of Agricultural and Food Chemistry, 1994
    Co-Authors: Kurt S. Roinestad, Thomas J. Montville, Joseph D. Rosen
    Abstract:

    Treatment of Fusarium tricinctum NRRL 13426 cultures with dilute sodium bicarbonate resulted in dramatic reductions in the production of trichothecene mycotoxins, geraniol, and carotenoids. All of these compounds are biosynthesized from mevalonic acid (I). In addition, three apparent mevalonic acid metabolites were found in the bicarbonate-treated cultures at concentrations of several parts per million each. Two of these compounds were tentatively identified as 3-methyl-4-oxo-2-pentenoic acid (IV) and its rearrangement product, 4,5-dimethyl-5-hydroxy-2(5H)-furanone (VI). These results suggest a pH-related inhibition of mevalonate kinase or a pH-related activation of an enzyme that is responsible, at least in part, for the conversion of mevalonic acid to the pentenoic acid or its precursor

  • Inhibition of trichothecene biosynthesis in Fusarium tricinctum by sodium bicarbonate
    Journal of Agricultural and Food Chemistry, 1993
    Co-Authors: Kurt S. Roinestad, Thomas J. Montville, Joseph D. Rosen
    Abstract:

    The effect of 0.11 M sodium bicarbonate on trichothecene mycotoxin formation was determined by analyzing cultures of Fusarium tricinctum NRRL 13426 incubated in peptone- and saccharose-supplemented Czapek-Dox broth in the presence and absence of the base. Sodium bicarbonate-treated cultures exhibited a 7-51-fold decrease in the production of diacetoxyscirpenol (DAS) and T-2 toxin. The production of 15-acetoxyscirpenol, acetyl T-2 toxin, and neosolaniol was completely inhibited by the sodium bicarbonate. The analysis method (which could also detect 3-acetyl-DAS, deoxynivalenol, HT-2 toxin, scirpentriol, T-2 tetrol, T-2 tetraacetate, and T-2 triol) employed cold on-column capillary gas chromatography/isobutane chemical ionization ion trap mass spectrometry of the underivatized mycotoxins.

Kurt S. Roinestad - One of the best experts on this subject based on the ideXlab platform.

  • Mechanism for sodium bicarbonate inhibition of trichothecene biosynthesis in Fusarium tricinctum
    Journal of Agricultural and Food Chemistry, 1994
    Co-Authors: Kurt S. Roinestad, Thomas J. Montville, Joseph D. Rosen
    Abstract:

    Treatment of Fusarium tricinctum NRRL 13426 cultures with dilute sodium bicarbonate resulted in dramatic reductions in the production of trichothecene mycotoxins, geraniol, and carotenoids. All of these compounds are biosynthesized from mevalonic acid (I). In addition, three apparent mevalonic acid metabolites were found in the bicarbonate-treated cultures at concentrations of several parts per million each. Two of these compounds were tentatively identified as 3-methyl-4-oxo-2-pentenoic acid (IV) and its rearrangement product, 4,5-dimethyl-5-hydroxy-2(5H)-furanone (VI). These results suggest a pH-related inhibition of mevalonate kinase or a pH-related activation of an enzyme that is responsible, at least in part, for the conversion of mevalonic acid to the pentenoic acid or its precursor

  • Inhibition of trichothecene biosynthesis in Fusarium tricinctum by sodium bicarbonate
    Journal of Agricultural and Food Chemistry, 1993
    Co-Authors: Kurt S. Roinestad, Thomas J. Montville, Joseph D. Rosen
    Abstract:

    The effect of 0.11 M sodium bicarbonate on trichothecene mycotoxin formation was determined by analyzing cultures of Fusarium tricinctum NRRL 13426 incubated in peptone- and saccharose-supplemented Czapek-Dox broth in the presence and absence of the base. Sodium bicarbonate-treated cultures exhibited a 7-51-fold decrease in the production of diacetoxyscirpenol (DAS) and T-2 toxin. The production of 15-acetoxyscirpenol, acetyl T-2 toxin, and neosolaniol was completely inhibited by the sodium bicarbonate. The analysis method (which could also detect 3-acetyl-DAS, deoxynivalenol, HT-2 toxin, scirpentriol, T-2 tetrol, T-2 tetraacetate, and T-2 triol) employed cold on-column capillary gas chromatography/isobutane chemical ionization ion trap mass spectrometry of the underivatized mycotoxins.

Angelo Visconti - One of the best experts on this subject based on the ideXlab platform.

  • Isolation, characterization and biological activity of visoltricin, a novel metabolite of Fusarium tricinctum
    Journal of Agricultural and Food Chemistry, 1994
    Co-Authors: Angelo Visconti, Michele Solfrizzo
    Abstract:

    A novel compound, trivially named visoltricin, has been isolated from cultures of Fusarium tricinctum on corn. Its structure has been established by chemical reactions and spectroscopic methods (UV, IR, MS, 1 H NMR, and 13 C NMR) as 3- [1-methyl-4-(3-methyl-2-butenyl)imidazol-5-yl]-2-propenoic acid methyl ester (molecular formula C 13 H 18 N 2 O 2 ; molecular weight 234.297). It is the first imidazole derivative produced by a Fusarium species. About 30% of the tested isolates (33) of F. tricinctum from various substrates and geographic areas produced visoltricin when grown on corn. None of the 14 isolates tested from the United States produced the compound

  • Acuminatopyrone: Revised Structure and Production by Fusarium chlamydosporum and Fusarium tricinctum
    Journal of Natural Products, 1994
    Co-Authors: Angelo Visconti, Michele Solfrizzo, Alain Fruchier, John W. Apsimon
    Abstract:

    Acuminatopyrone, a recently described metabolite of Fusarium acuminatum was shown to be produced by several strains of Fusarium chlamydosporum and F. tricinctus isolated from various substrates in different countries. The structure of acuminatopyrone has been revised on the basis of NOEDIF and HETCOR nmr experiments, and shown to be 4-methoxy-7,8-dimethyl-2H-pyrano[4,3-b]pyridin-2-one. This structure is biosynthetically consistent with that of chlamydosporol and related compounds that are produced by the same fungal species

  • Toxicity of some Fusarium section Sporotrichiella strains in relation to mycotoxin production.
    Applied and Environmental Microbiology, 1992
    Co-Authors: Angelo Visconti, F Minervini, Michele Solfrizzo, C Bottalico, G Lucivero
    Abstract:

    The relationship between the toxicities of crude extracts and purified toxins of Fusarium spp. belonging to the section Sporotrichiella has been assessed. Toxicity was determined on the basis of death of Artemia salina larvae and of viability and blastogenic response of bovine and human lymphocytes. Trichothecene-producing strains of Fusarium sporotrichioides and Fusarium poae were toxic to A. salina and to lymphocyte blastogenesis. A strain of Fusarium tricinctum, producing visoltricin and chlamydosporol, induced differentiated activity in different bioassays (toxicity to A. salina but only minor activity against lymphocyte blastogenesis). Other, non-toxin-producing strains of Fusarium chlamydosporum, F. poae, and F. tricinctum were not active in the tested biosystems.

  • Identification of chlamydosporol, a mycotoxin isolated from a culture of Fusarium tricinctum
    Mycotoxin Research, 1991
    Co-Authors: Michele Solfrizzo, Angelo Visconti
    Abstract:

    Fusarium tricinctum strain (KF 260) isolated from wheat in Poland, produced on maize cultures a compound (C_11H_14O5, MW_226) toxic to Artemia salina . The compound, identified by various spectroscopical tecniques as 5-hydroxy-4-methoxy-6,8a-dimethyl-6, 7-dihydro-2H, 8aH-pyrano/2, 3-b/pyran-2-one, was identical to chlamydosporol, a mycotoxin recentlydiscovered in cultures of F._ chlamydosporum isolated from rice. The compound showed inhibitory effect on human lymphocyte proliferation at concentration of 25 μg/mL. LD_50 on A. salina was 56 μg/mL.

Thomas J. Montville - One of the best experts on this subject based on the ideXlab platform.

  • Mechanism for sodium bicarbonate inhibition of trichothecene biosynthesis in Fusarium tricinctum
    Journal of Agricultural and Food Chemistry, 1994
    Co-Authors: Kurt S. Roinestad, Thomas J. Montville, Joseph D. Rosen
    Abstract:

    Treatment of Fusarium tricinctum NRRL 13426 cultures with dilute sodium bicarbonate resulted in dramatic reductions in the production of trichothecene mycotoxins, geraniol, and carotenoids. All of these compounds are biosynthesized from mevalonic acid (I). In addition, three apparent mevalonic acid metabolites were found in the bicarbonate-treated cultures at concentrations of several parts per million each. Two of these compounds were tentatively identified as 3-methyl-4-oxo-2-pentenoic acid (IV) and its rearrangement product, 4,5-dimethyl-5-hydroxy-2(5H)-furanone (VI). These results suggest a pH-related inhibition of mevalonate kinase or a pH-related activation of an enzyme that is responsible, at least in part, for the conversion of mevalonic acid to the pentenoic acid or its precursor

  • Inhibition of trichothecene biosynthesis in Fusarium tricinctum by sodium bicarbonate
    Journal of Agricultural and Food Chemistry, 1993
    Co-Authors: Kurt S. Roinestad, Thomas J. Montville, Joseph D. Rosen
    Abstract:

    The effect of 0.11 M sodium bicarbonate on trichothecene mycotoxin formation was determined by analyzing cultures of Fusarium tricinctum NRRL 13426 incubated in peptone- and saccharose-supplemented Czapek-Dox broth in the presence and absence of the base. Sodium bicarbonate-treated cultures exhibited a 7-51-fold decrease in the production of diacetoxyscirpenol (DAS) and T-2 toxin. The production of 15-acetoxyscirpenol, acetyl T-2 toxin, and neosolaniol was completely inhibited by the sodium bicarbonate. The analysis method (which could also detect 3-acetyl-DAS, deoxynivalenol, HT-2 toxin, scirpentriol, T-2 tetrol, T-2 tetraacetate, and T-2 triol) employed cold on-column capillary gas chromatography/isobutane chemical ionization ion trap mass spectrometry of the underivatized mycotoxins.

Michele Solfrizzo - One of the best experts on this subject based on the ideXlab platform.

  • Isolation, characterization and biological activity of visoltricin, a novel metabolite of Fusarium tricinctum
    Journal of Agricultural and Food Chemistry, 1994
    Co-Authors: Angelo Visconti, Michele Solfrizzo
    Abstract:

    A novel compound, trivially named visoltricin, has been isolated from cultures of Fusarium tricinctum on corn. Its structure has been established by chemical reactions and spectroscopic methods (UV, IR, MS, 1 H NMR, and 13 C NMR) as 3- [1-methyl-4-(3-methyl-2-butenyl)imidazol-5-yl]-2-propenoic acid methyl ester (molecular formula C 13 H 18 N 2 O 2 ; molecular weight 234.297). It is the first imidazole derivative produced by a Fusarium species. About 30% of the tested isolates (33) of F. tricinctum from various substrates and geographic areas produced visoltricin when grown on corn. None of the 14 isolates tested from the United States produced the compound

  • Acuminatopyrone: Revised Structure and Production by Fusarium chlamydosporum and Fusarium tricinctum
    Journal of Natural Products, 1994
    Co-Authors: Angelo Visconti, Michele Solfrizzo, Alain Fruchier, John W. Apsimon
    Abstract:

    Acuminatopyrone, a recently described metabolite of Fusarium acuminatum was shown to be produced by several strains of Fusarium chlamydosporum and F. tricinctus isolated from various substrates in different countries. The structure of acuminatopyrone has been revised on the basis of NOEDIF and HETCOR nmr experiments, and shown to be 4-methoxy-7,8-dimethyl-2H-pyrano[4,3-b]pyridin-2-one. This structure is biosynthetically consistent with that of chlamydosporol and related compounds that are produced by the same fungal species

  • Toxicity of some Fusarium section Sporotrichiella strains in relation to mycotoxin production.
    Applied and Environmental Microbiology, 1992
    Co-Authors: Angelo Visconti, F Minervini, Michele Solfrizzo, C Bottalico, G Lucivero
    Abstract:

    The relationship between the toxicities of crude extracts and purified toxins of Fusarium spp. belonging to the section Sporotrichiella has been assessed. Toxicity was determined on the basis of death of Artemia salina larvae and of viability and blastogenic response of bovine and human lymphocytes. Trichothecene-producing strains of Fusarium sporotrichioides and Fusarium poae were toxic to A. salina and to lymphocyte blastogenesis. A strain of Fusarium tricinctum, producing visoltricin and chlamydosporol, induced differentiated activity in different bioassays (toxicity to A. salina but only minor activity against lymphocyte blastogenesis). Other, non-toxin-producing strains of Fusarium chlamydosporum, F. poae, and F. tricinctum were not active in the tested biosystems.

  • Identification of chlamydosporol, a mycotoxin isolated from a culture of Fusarium tricinctum
    Mycotoxin Research, 1991
    Co-Authors: Michele Solfrizzo, Angelo Visconti
    Abstract:

    Fusarium tricinctum strain (KF 260) isolated from wheat in Poland, produced on maize cultures a compound (C_11H_14O5, MW_226) toxic to Artemia salina . The compound, identified by various spectroscopical tecniques as 5-hydroxy-4-methoxy-6,8a-dimethyl-6, 7-dihydro-2H, 8aH-pyrano/2, 3-b/pyran-2-one, was identical to chlamydosporol, a mycotoxin recentlydiscovered in cultures of F._ chlamydosporum isolated from rice. The compound showed inhibitory effect on human lymphocyte proliferation at concentration of 25 μg/mL. LD_50 on A. salina was 56 μg/mL.

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