The Experts below are selected from a list of 189 Experts worldwide ranked by ideXlab platform
John W. Nicholson - One of the best experts on this subject based on the ideXlab platform.
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Release of Sodium Fusidate from glass-ionomer dental cement
Journal of Materials Science: Materials in Medicine, 2010Co-Authors: Zoheb Mulla, Mark Edwards, John W. NicholsonAbstract:Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound Sodium Fusidate. Sodium Fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter × 2 mm depth) prepared. After curing for 1 hour at 37°C, specimens were placed in water and release of Sodium Fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of Sodium Fusidate was shown to occur by diffusion for each level of addition, as shown by M_t/M_∞ being linear with respect to √time in both cases. Diffusion coefficients were calculated as 4.4 × 10^−8 cm^2 s^−1 and 3.0 × 10^−8 cm^2 s^−1 for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the Sodium Fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total Sodium Fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine.
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Release of Sodium Fusidate from glass-ionomer dental cement.
Journal of materials science. Materials in medicine, 2010Co-Authors: Zoheb Mulla, Mark Edwards, John W. NicholsonAbstract:Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound Sodium Fusidate. Sodium Fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter x 2 mm depth) prepared. After curing for 1 hour at 37 degrees C, specimens were placed in water and release of Sodium Fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of Sodium Fusidate was shown to occur by diffusion for each level of addition, as shown by M(t)/M(infinity) being linear with respect to [square root]time in both cases. Diffusion coefficients were calculated as 4.4 x 10(-8) cm(2) s(-1) and 3.0 x 10(-8) cm(2) s(-1) for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the Sodium Fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total Sodium Fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine.
Zoheb Mulla - One of the best experts on this subject based on the ideXlab platform.
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Release of Sodium Fusidate from glass-ionomer dental cement
Journal of Materials Science: Materials in Medicine, 2010Co-Authors: Zoheb Mulla, Mark Edwards, John W. NicholsonAbstract:Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound Sodium Fusidate. Sodium Fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter × 2 mm depth) prepared. After curing for 1 hour at 37°C, specimens were placed in water and release of Sodium Fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of Sodium Fusidate was shown to occur by diffusion for each level of addition, as shown by M_t/M_∞ being linear with respect to √time in both cases. Diffusion coefficients were calculated as 4.4 × 10^−8 cm^2 s^−1 and 3.0 × 10^−8 cm^2 s^−1 for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the Sodium Fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total Sodium Fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine.
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Release of Sodium Fusidate from glass-ionomer dental cement.
Journal of materials science. Materials in medicine, 2010Co-Authors: Zoheb Mulla, Mark Edwards, John W. NicholsonAbstract:Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound Sodium Fusidate. Sodium Fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter x 2 mm depth) prepared. After curing for 1 hour at 37 degrees C, specimens were placed in water and release of Sodium Fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of Sodium Fusidate was shown to occur by diffusion for each level of addition, as shown by M(t)/M(infinity) being linear with respect to [square root]time in both cases. Diffusion coefficients were calculated as 4.4 x 10(-8) cm(2) s(-1) and 3.0 x 10(-8) cm(2) s(-1) for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the Sodium Fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total Sodium Fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine.
Mark Edwards - One of the best experts on this subject based on the ideXlab platform.
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Release of Sodium Fusidate from glass-ionomer dental cement
Journal of Materials Science: Materials in Medicine, 2010Co-Authors: Zoheb Mulla, Mark Edwards, John W. NicholsonAbstract:Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound Sodium Fusidate. Sodium Fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter × 2 mm depth) prepared. After curing for 1 hour at 37°C, specimens were placed in water and release of Sodium Fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of Sodium Fusidate was shown to occur by diffusion for each level of addition, as shown by M_t/M_∞ being linear with respect to √time in both cases. Diffusion coefficients were calculated as 4.4 × 10^−8 cm^2 s^−1 and 3.0 × 10^−8 cm^2 s^−1 for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the Sodium Fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total Sodium Fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine.
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Release of Sodium Fusidate from glass-ionomer dental cement.
Journal of materials science. Materials in medicine, 2010Co-Authors: Zoheb Mulla, Mark Edwards, John W. NicholsonAbstract:Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound Sodium Fusidate. Sodium Fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter x 2 mm depth) prepared. After curing for 1 hour at 37 degrees C, specimens were placed in water and release of Sodium Fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of Sodium Fusidate was shown to occur by diffusion for each level of addition, as shown by M(t)/M(infinity) being linear with respect to [square root]time in both cases. Diffusion coefficients were calculated as 4.4 x 10(-8) cm(2) s(-1) and 3.0 x 10(-8) cm(2) s(-1) for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the Sodium Fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total Sodium Fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine.
Nicholson, John W. - One of the best experts on this subject based on the ideXlab platform.
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Release of Sodium Fusidate from glass-ionomer dental cement
'Springer Science and Business Media LLC', 2010Co-Authors: Mulla Zoheb, Edwards Mark, Nicholson, John W.Abstract:Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound Sodium Fusidate. Sodium Fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter 9 2 mm depth)prepared. After curing for 1 hour at 37 deg C, specimens were placed in water and release of Sodium Fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of Sodium Fusidate was shown to occur by diffusion for each level of addition, as shown by Mt/M infinity being linear with respect to Htime in both cases. Diffusion coefficients were calculated as 4.4 9 10-8 cm2 s-1 and 3.0 9 10-8 cm2 s-1 for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the Sodium Fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total Sodium Fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine
Charlene Argáez - One of the best experts on this subject based on the ideXlab platform.
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Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines [Internet]
2017Co-Authors: Srabani Banerjee, Charlene ArgáezAbstract:It is estimated that worldwide, 7% to 10% of hospitalized patients are affected by skin and soft tissue infections caused by microbial invasion of the skin and underlying soft tissues. Surgical site infections (SSIs) occur in approximately 2% to 5% of patients undergoing clean extra-abdominal surgeries and in up to 20% of patients undergoing intra-abdominal surgeries. Infections lead to delay in healing, increased morbidity, and prolonged hospital stay which will impact health care resources. The bacteria, Staphylococcus aureus (S. aureus) is one of the most common causes of health care-associated infections such as SSIs, exit site infections (ESIs) in dialysis patients, and infections in patients in intensive care units (ICU). It is estimated that 20% of healthy people are chronic carriers of S. aureus, 30% are intermittent carriers, and 50% are not susceptible. The risk of infection is reported to be 2 to 12 times higher in S. aureus nasal carriers compared to non-carriers. It has been reported that nasal decolonization of patients with S. aureus significantly reduces infections caused by S. aureus. It has been reported that 18% to 25% of patients undergoing elective orthopedic surgery are nasal carriers of S. aureus and carriers are more likely to experience SSIs. One systematic review has reported that 26% of patients undergoing hemodialysis are nasal carriers of S. aureus. For patients with nasal S. aureus carriage, who were undergoing dialysis, colonization with the same bacteria was reported at the dialysis catheter exit site. Patients with S. aureus colonization are at a greater risk of developing S. aureus infection in the ICU. Topical antibiotics assist in preventing infections caused by bacteria. A variety of topical antibiotics are available such as bacitracin, mupirocin, gramicidin, fusidic acid and gentamycin. There is however some concern regarding the use of antibiotics because of the possible development of antibacterial resistance in the long term.The purpose of this report is to review the existing evidence on the clinical effectiveness of prevention of skin or wound infection with the topical antibiotics: polymyxin B sulfate-bacitracin (Polysporin ointment), polymyxin B sulfate-gramicidin (Polysporin cream), polymyxin B sulfate-bacitracin-gramicidin (Polysporin triple ointment), bacitracin (Bacitin ointment), mupirocin (Bactroban cream/ointment), silver sulfadiazine (Flamazine cream), fusidic acid/Fusidate Sodium (Fucidin cream/ointment), and fusidic acid 2% with hydrocortisone (Fucidin H). Additionally, this report aims to review evidence-based guidelines for the prevention of skin or wound infection using these topical antibiotics.
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Topical Antibiotics for Impetigo: A Review of the Clinical Effectiveness and Guidelines
2017Co-Authors: Rob Edge, Charlene ArgáezAbstract:The purpose of this report is to retrieve and review the existing clinical effectiveness evidence on the treatment of patients with impetigo with the topical antibiotics: polymyxin B sulfate-bacitracin (Polysporin ointment), polymyxin B sulfate-gramicidin (Polysporin cream), polymyxin B sulfate-bacitracin-gramicidin (Polysporin triple ointment), bacitracin (Bacitin ointment), mupirocin (Bactroban cream/ointment), silver sufadiazine (Flamazine cream), fusidic acid/Fusidate Sodium (Fucidin cream/ointment), and fusidic acid 2% with hydrocortisone (Fucidin H), compared to each other, placebo or oral antibiotics. Additionally, this report aims to retrieve and review evidence-based guidelines for the treatment of impetigo using topical antibiotics.
