The Experts below are selected from a list of 10652748 Experts worldwide ranked by ideXlab platform
Victor C Yang - One of the best experts on this subject based on the ideXlab platform.
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polyethylene glycol modified cross linked starch coated iron oxide nanoparticles for enhanced magnetic tumor targeting
Biomaterials, 2011Co-Authors: Adam Cole, Allan E David, Jianxin Wang, Craig J Galban, Hannah Hill, Victor C YangAbstract:While successful magnetic tumor targeting of iron oxide nanoparticles has been achieved in a number of models, the rapid blood clearance of magnetically suitable particles by the reticuloendothelial system (RES) limits their availability for targeting. This work aimed to develop a long-circulating magnetic iron oxide nanoparticle (MNP) platform capable of sustained tumor exposure via the circulation and, thus, enhanced magnetic tumor targeting. Aminated, cross-linked starch (DN) and aminosilane (A) coated MNPs were successfully modified with 5 kDa (A5, D5) or 20 kDa (A20, D20) polyethylene glycol (PEG) chains using simple N-Hydroxysuccinimide (NHS) chemistry and characterized. Identical PEG-weight analogues between platforms (A5 & D5, A20 & D20) were similar in size (140–190 nm) and relative PEG labeling (1.5% of surface amines – A5/D5, 0.4% – A20/D20), with all PEG-MNPs possessing magnetization properties suitable for magnetic targeting. Candidate PEG-MNPs were studied in RES simulations in vitro to predict long-circulating character. D5 and D20 performed best showing sustained size stability in cell culture medium at 37°C and 7 (D20) to 10 (D5) fold less uptake in RAW264.7 macrophages when compared to previously targeted, unmodified starch MNPs (D). Observations in vitro were validated in vivo, with D5 (7.29 hr) and D20 (11.75 hr) showing much longer half-lives than D (0.12 hr). Improved plasma stability enhanced tumor MNP exposure 100 (D5) to 150 (D20) fold as measured by plasma AUC0-∞ Sustained tumor exposure over 24 hours was visually confirmed in a 9L-glioma rat model (12 mg Fe/kg) using magnetic resonance imaging (MRI). Findings indicate that both D5 and D20 are promising MNP platforms for enhanced magnetic tumor targeting, warranting further study in tumor models.
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polyethylene glycol modified cross linked starch coated iron oxide nanoparticles for enhanced magnetic tumor targeting
Biomaterials, 2011Co-Authors: Adam Cole, Allan E David, Jianxin Wang, Craig J Galban, Hannah Hill, Victor C YangAbstract:While successful magnetic tumor targeting of iron oxide nanoparticles has been achieved in a number of models, the rapid blood clearance of magnetically suitable particles by the reticuloendothelial system (RES) limits their availability for targeting. This work aimed to develop a long-circulating magnetic iron oxide nanoparticle (MNP) platform capable of sustained tumor exposure via the circulation and, thus, potentially enhanced magnetic tumor targeting. Aminated, cross-linked starch (DN) and aminosilane (A) coated MNPs were successfully modified with 5 kDa (A5, D5) or 20 kDa (A20, D20) polyethylene glycol (PEG) chains using simple N-Hydroxysuccinimide (NHS) chemistry and characterized. Identical PEG-weight analogues between platforms (A5 & D5, A20 & D20) were similar in size (140-190 nm) and relative PEG labeling (1.5% of surface amines - A5/D5, 0.4% - A20/D20), with all PEG-MNPs possessing magnetization properties suitable for magnetic targeting. Candidate PEG-MNPs were studied in RES simulations in vitro to predict long-circulating character. D5 and D20 performed best showing sustained size stability in cell culture medium at 37 °C and 7 (D20) to 10 (D5) fold less uptake in RAW264.7 macrophages when compared to previously targeted, unmodified starch MNPs (D). Observations in vitro were validated in vivo, with D5 (7.29 h) and D20 (11.75 h) showing much longer half-lives than D (0.12 h). Improved plasma stability enhanced tumor MNP exposure 100 (D5) to 150 (D20) fold as measured by plasma AUC(0-∞). Sustained tumor exposure over 24 h was visually confirmed in a 9L-glioma rat model (12 mg Fe/kg) using magnetic resonance imaging (MRI). Findings indicate that a polyethylene glycol modified, cross-linked starch-coated MNP is a promising platform for enhanced magnetic tumor targeting, warranting further study in tumor models.
Jianxin Wang - One of the best experts on this subject based on the ideXlab platform.
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polyethylene glycol modified cross linked starch coated iron oxide nanoparticles for enhanced magnetic tumor targeting
Biomaterials, 2011Co-Authors: Adam Cole, Allan E David, Jianxin Wang, Craig J Galban, Hannah Hill, Victor C YangAbstract:While successful magnetic tumor targeting of iron oxide nanoparticles has been achieved in a number of models, the rapid blood clearance of magnetically suitable particles by the reticuloendothelial system (RES) limits their availability for targeting. This work aimed to develop a long-circulating magnetic iron oxide nanoparticle (MNP) platform capable of sustained tumor exposure via the circulation and, thus, enhanced magnetic tumor targeting. Aminated, cross-linked starch (DN) and aminosilane (A) coated MNPs were successfully modified with 5 kDa (A5, D5) or 20 kDa (A20, D20) polyethylene glycol (PEG) chains using simple N-Hydroxysuccinimide (NHS) chemistry and characterized. Identical PEG-weight analogues between platforms (A5 & D5, A20 & D20) were similar in size (140–190 nm) and relative PEG labeling (1.5% of surface amines – A5/D5, 0.4% – A20/D20), with all PEG-MNPs possessing magnetization properties suitable for magnetic targeting. Candidate PEG-MNPs were studied in RES simulations in vitro to predict long-circulating character. D5 and D20 performed best showing sustained size stability in cell culture medium at 37°C and 7 (D20) to 10 (D5) fold less uptake in RAW264.7 macrophages when compared to previously targeted, unmodified starch MNPs (D). Observations in vitro were validated in vivo, with D5 (7.29 hr) and D20 (11.75 hr) showing much longer half-lives than D (0.12 hr). Improved plasma stability enhanced tumor MNP exposure 100 (D5) to 150 (D20) fold as measured by plasma AUC0-∞ Sustained tumor exposure over 24 hours was visually confirmed in a 9L-glioma rat model (12 mg Fe/kg) using magnetic resonance imaging (MRI). Findings indicate that both D5 and D20 are promising MNP platforms for enhanced magnetic tumor targeting, warranting further study in tumor models.
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polyethylene glycol modified cross linked starch coated iron oxide nanoparticles for enhanced magnetic tumor targeting
Biomaterials, 2011Co-Authors: Adam Cole, Allan E David, Jianxin Wang, Craig J Galban, Hannah Hill, Victor C YangAbstract:While successful magnetic tumor targeting of iron oxide nanoparticles has been achieved in a number of models, the rapid blood clearance of magnetically suitable particles by the reticuloendothelial system (RES) limits their availability for targeting. This work aimed to develop a long-circulating magnetic iron oxide nanoparticle (MNP) platform capable of sustained tumor exposure via the circulation and, thus, potentially enhanced magnetic tumor targeting. Aminated, cross-linked starch (DN) and aminosilane (A) coated MNPs were successfully modified with 5 kDa (A5, D5) or 20 kDa (A20, D20) polyethylene glycol (PEG) chains using simple N-Hydroxysuccinimide (NHS) chemistry and characterized. Identical PEG-weight analogues between platforms (A5 & D5, A20 & D20) were similar in size (140-190 nm) and relative PEG labeling (1.5% of surface amines - A5/D5, 0.4% - A20/D20), with all PEG-MNPs possessing magnetization properties suitable for magnetic targeting. Candidate PEG-MNPs were studied in RES simulations in vitro to predict long-circulating character. D5 and D20 performed best showing sustained size stability in cell culture medium at 37 °C and 7 (D20) to 10 (D5) fold less uptake in RAW264.7 macrophages when compared to previously targeted, unmodified starch MNPs (D). Observations in vitro were validated in vivo, with D5 (7.29 h) and D20 (11.75 h) showing much longer half-lives than D (0.12 h). Improved plasma stability enhanced tumor MNP exposure 100 (D5) to 150 (D20) fold as measured by plasma AUC(0-∞). Sustained tumor exposure over 24 h was visually confirmed in a 9L-glioma rat model (12 mg Fe/kg) using magnetic resonance imaging (MRI). Findings indicate that a polyethylene glycol modified, cross-linked starch-coated MNP is a promising platform for enhanced magnetic tumor targeting, warranting further study in tumor models.
Ali Dadkhodaie - One of the best experts on this subject based on the ideXlab platform.
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The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for seed yield of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G21; P
2018Co-Authors: Zolfaghar Shahriari, Bahram Heidari, Ali DadkhodaieAbstract:The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for seed yield of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G21; P. lanceolata, G22-G26; P. coronopus, G27- G28; P. lagopus, G29- G30) under 10 environments (E) to rank test environments relative to an ideal test environments (represented by center of concentric circles).
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The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for mucilage yield of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G2
2018Co-Authors: Zolfaghar Shahriari, Bahram Heidari, Ali DadkhodaieAbstract:The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for mucilage yield of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G21; P. lanceolata, G22-G26; P. coronopus, G27- G28; P. lagopus, G29- G30) under 10 environments (E) to rank test environments relative to an ideal test environments (represented by center of concentric circles).
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The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for mucilage content of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-
2018Co-Authors: Zolfaghar Shahriari, Bahram Heidari, Ali DadkhodaieAbstract:The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for mucilage content of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G21; P. lanceolata, G22-G26; P. coronopus, G27- G28; P. lagopus, G29- G30) under 10 environments (E) to rank test environments relative to an ideal test environments (represented by center of concentric circles).
Adam Cole - One of the best experts on this subject based on the ideXlab platform.
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polyethylene glycol modified cross linked starch coated iron oxide nanoparticles for enhanced magnetic tumor targeting
Biomaterials, 2011Co-Authors: Adam Cole, Allan E David, Jianxin Wang, Craig J Galban, Hannah Hill, Victor C YangAbstract:While successful magnetic tumor targeting of iron oxide nanoparticles has been achieved in a number of models, the rapid blood clearance of magnetically suitable particles by the reticuloendothelial system (RES) limits their availability for targeting. This work aimed to develop a long-circulating magnetic iron oxide nanoparticle (MNP) platform capable of sustained tumor exposure via the circulation and, thus, enhanced magnetic tumor targeting. Aminated, cross-linked starch (DN) and aminosilane (A) coated MNPs were successfully modified with 5 kDa (A5, D5) or 20 kDa (A20, D20) polyethylene glycol (PEG) chains using simple N-Hydroxysuccinimide (NHS) chemistry and characterized. Identical PEG-weight analogues between platforms (A5 & D5, A20 & D20) were similar in size (140–190 nm) and relative PEG labeling (1.5% of surface amines – A5/D5, 0.4% – A20/D20), with all PEG-MNPs possessing magnetization properties suitable for magnetic targeting. Candidate PEG-MNPs were studied in RES simulations in vitro to predict long-circulating character. D5 and D20 performed best showing sustained size stability in cell culture medium at 37°C and 7 (D20) to 10 (D5) fold less uptake in RAW264.7 macrophages when compared to previously targeted, unmodified starch MNPs (D). Observations in vitro were validated in vivo, with D5 (7.29 hr) and D20 (11.75 hr) showing much longer half-lives than D (0.12 hr). Improved plasma stability enhanced tumor MNP exposure 100 (D5) to 150 (D20) fold as measured by plasma AUC0-∞ Sustained tumor exposure over 24 hours was visually confirmed in a 9L-glioma rat model (12 mg Fe/kg) using magnetic resonance imaging (MRI). Findings indicate that both D5 and D20 are promising MNP platforms for enhanced magnetic tumor targeting, warranting further study in tumor models.
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polyethylene glycol modified cross linked starch coated iron oxide nanoparticles for enhanced magnetic tumor targeting
Biomaterials, 2011Co-Authors: Adam Cole, Allan E David, Jianxin Wang, Craig J Galban, Hannah Hill, Victor C YangAbstract:While successful magnetic tumor targeting of iron oxide nanoparticles has been achieved in a number of models, the rapid blood clearance of magnetically suitable particles by the reticuloendothelial system (RES) limits their availability for targeting. This work aimed to develop a long-circulating magnetic iron oxide nanoparticle (MNP) platform capable of sustained tumor exposure via the circulation and, thus, potentially enhanced magnetic tumor targeting. Aminated, cross-linked starch (DN) and aminosilane (A) coated MNPs were successfully modified with 5 kDa (A5, D5) or 20 kDa (A20, D20) polyethylene glycol (PEG) chains using simple N-Hydroxysuccinimide (NHS) chemistry and characterized. Identical PEG-weight analogues between platforms (A5 & D5, A20 & D20) were similar in size (140-190 nm) and relative PEG labeling (1.5% of surface amines - A5/D5, 0.4% - A20/D20), with all PEG-MNPs possessing magnetization properties suitable for magnetic targeting. Candidate PEG-MNPs were studied in RES simulations in vitro to predict long-circulating character. D5 and D20 performed best showing sustained size stability in cell culture medium at 37 °C and 7 (D20) to 10 (D5) fold less uptake in RAW264.7 macrophages when compared to previously targeted, unmodified starch MNPs (D). Observations in vitro were validated in vivo, with D5 (7.29 h) and D20 (11.75 h) showing much longer half-lives than D (0.12 h). Improved plasma stability enhanced tumor MNP exposure 100 (D5) to 150 (D20) fold as measured by plasma AUC(0-∞). Sustained tumor exposure over 24 h was visually confirmed in a 9L-glioma rat model (12 mg Fe/kg) using magnetic resonance imaging (MRI). Findings indicate that a polyethylene glycol modified, cross-linked starch-coated MNP is a promising platform for enhanced magnetic tumor targeting, warranting further study in tumor models.
Zolfaghar Shahriari - One of the best experts on this subject based on the ideXlab platform.
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The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for seed yield of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G21; P
2018Co-Authors: Zolfaghar Shahriari, Bahram Heidari, Ali DadkhodaieAbstract:The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for seed yield of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G21; P. lanceolata, G22-G26; P. coronopus, G27- G28; P. lagopus, G29- G30) under 10 environments (E) to rank test environments relative to an ideal test environments (represented by center of concentric circles).
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The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for mucilage yield of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G2
2018Co-Authors: Zolfaghar Shahriari, Bahram Heidari, Ali DadkhodaieAbstract:The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for mucilage yield of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G21; P. lanceolata, G22-G26; P. coronopus, G27- G28; P. lagopus, G29- G30) under 10 environments (E) to rank test environments relative to an ideal test environments (represented by center of concentric circles).
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The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for mucilage content of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-
2018Co-Authors: Zolfaghar Shahriari, Bahram Heidari, Ali DadkhodaieAbstract:The discrimination and representativeness view of the GGE biplot based on environment-focused scaling for mucilage content of 30 Plantago genotypes (P. major, G1- G7; P. officinalis, G8-G10; P. amplexicaulis, G11; P. ovata, G12-G16; P. psyllium, G17-G21; P. lanceolata, G22-G26; P. coronopus, G27- G28; P. lagopus, G29- G30) under 10 environments (E) to rank test environments relative to an ideal test environments (represented by center of concentric circles).