Gadolinium Chelate

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Philippe Soyer - One of the best experts on this subject based on the ideXlab platform.

  • Rectal cancer in inflammatory bowel diseases: MR imaging findings
    Abdominal Imaging, 2014
    Co-Authors: Matthias Barral, Anthony Dohan, Christine Hoeffel, Mourad Boudiaf, Philippe Marteau, Valérie Laurent, Philippe Soyer
    Abstract:

    Purpose To retrospectively analyze the MR imaging features of rectal cancer in patients with inflammatory bowel diseases (IBD). Materials and methods The MR imaging examinations of 13 patients with IBD-related rectal cancer were retrospectively reviewed. MR imaging included T2-weighted, diffusion-weighted (DW), and Gadolinium Chelate-enhanced MR imaging. MR imaging findings were analyzed and compared with endoscopic and histopathological findings. Results Eight patients (8/13; 62%) had active IBD and five (5/13; 38%) had quiescent IBD on MR imaging. Two different tumor patterns were individualized including clearly visible soft-tissue mass (4/13; 31%) (Type 1 tumor) and marked circumferential rectal wall thickening (9/13; 69%) (Type 2 tumor). Twelve tumors (12/13; 92%) showed high signal intensity on T2-weighted MR images. All six tumors studied with DW-MR imaging (6/6; 100%) showed high signal on DW-MR imaging with restricted diffusion on apparent diffusion coefficient (ADC) map. On Gadolinium Chelate-enhanced MR imaging, heterogeneous enhancement was observed in one tumor (1/13; 8%), whereas 12 tumors (12/13; 92%) showed homogeneous enhancement. MR imaging showed pelvic fistula and intrapelvic abscess in association with four (4/13; 31%) and two tumors (2/13; 15%), respectively. Conclusion Our limited retrospective study demonstrates that rectal cancer in IBD patients can present as a circumferential wall thickening resembling inflammation and can occur in the absence of fistula or abscess. The use of T2-weighted and DW-MR imaging is recommended to improve rectal cancer detection in patients with long-standing IBD.

  • Solid-pseudopapillary tumor of the pancreas: MR imaging findings in 21 patients.
    Clinical Imaging, 2014
    Co-Authors: Youcef Guerrache, Anthony Dohan, Philippe Soyer, Mourad Boudiaf, Valérie Laurent, Sid Faraoun, Jean-pierre Tasu, Christophe Aubé, Julien Cazejust, Christine Hoeffel
    Abstract:

    PURPOSE: Solid-pseudopapillary tumor (SPT) of the pancreas is a rare, low-grade malignancy, which mostly occurs in adolescent and young adult females. The goal of this study was to retrospectively analyze the magnetic resonance (MR) imaging presentation of SPT of the pancreas. METHODS: We retrospectively reviewed the preoperative MR imaging examinations and the medical, surgical and histopathological records of 21 patients who underwent surgery for SPT of the pancreas. MR imaging included T1-weighted, T2-weighted, and Gadolinium Chelate-enhanced MR imaging. In addition, 10 patients had diffusion-weighted (DW) MR imaging. MR examinations were retrospectively reviewed for location, size, morphological features and signal intensity of the tumors. RESULTS: Nineteen women and 2 men (median age, 23 years; range, 14-59) were included. Seven patients (7/21; 33%) presented with abdominal symptoms. The median largest tumor diameter was 53mm (range, 32-141 mm). SPTs were located in the pancreatic head, body, and tail in 9 (9/21; 43%), 5 (5/21; 24%) and 7 (7/21, 33%) patients, respectively. All patients (21/21; 100%) had a single SPT. SPTs were more frequently oval (12/21; 57%), predominantly solid (12/21; 57%), fully encapsulated (16/21; 76%), larger than 30 mm (21/21; 100%), hypointense on T1-weighted MR images (21/21, 100%), hyperintense on T2-weighted MR images (21/21; 100%) and with an enhancing capsule after Gadolinium-Chelate administration (21/21; 100%). CONCLUSIONS: There is trend of appearance for SPT of the pancreas on MR imaging but that variations may be observed in a number of cases. SPT uniformly presents as a single, well-demarcated and encapsulated pancreatic mass.

  • Angiolipoma of the labia majora: MR imaging findings with histopathological correlation
    Clinical Imaging, 2013
    Co-Authors: Rebecca Jourjon, Anthony Dohan, Jean-philippe Brouland, Youcef Guerrache, Afchine Fazel, Philippe Soyer
    Abstract:

    Benign soft tissue tumors of the vulva are relatively rare in adult patients. We present the magnetic resonance (MR) imaging features of an angiolipoma of the labia majora that developed in a 58-year-old woman. MR imaging showed a well-circumscribed lesion that was hyperintense on T1-weighted and T2-weighted MR images, and hypointense on fat-suppressed MR images, consistent with fat content. High apparent diffusion coefficient was noticed on diffusion-weighted MR images. Dynamic Gadolinium-Chelate enhanced MR imaging showed progressive enhancement. Histopathologically, the lesion was predominantly made of mature adipose tissue and contained thin walled vascular channels consistent with angiolipoma.

  • prospective evaluation of magnetic resonance enterography for the detection of mesenteric small bowel tumours
    European Radiology, 2013
    Co-Authors: Elisa Amzallagbellenger, Philippe Soyer, Coralie Barbe, Mariedaniele Diebold, Guillaume Cadiot, Christine Hoeffel
    Abstract:

    Purpose To prospectively evaluate magnetic resonance (MR) enterography for detecting mesenteric small-bowel tumours (MSBTs) and assess the added value of Gadolinium-Chelate injection.

  • preoperative detection of hepatic metastases comparison of diffusion weighted t2 weighted fast spin echo and Gadolinium enhanced mr imaging using surgical and histopathologic findings as standard of reference
    European Journal of Radiology, 2011
    Co-Authors: Philippe Soyer, Djamel Tiah, M Boudiaf, Vinciane Place, Marc Sirol, Karine Pautrat, Alexandre Vignaud, Fabrice Staub, L Hamzi, Florent Duchat
    Abstract:

    Abstract Purpose The purpose of this study was to retrospectively compare the respective sensitivities of diffusion-weighted (DW), T2-weighted fast spin-echo (T2WFSE) and Gadolinium Chelate-enhanced MR imaging in the preoperative detection of hepatic metastases using intraoperative ultrasonographic and histopathologic findings as the standard of reference. Materials and methods Twenty-seven patients with 64 surgically and histopathologically proven hepatic metastases had MR imaging of the liver, including DW, T2WFSE and dynamic Gadolinium Chelate-enhanced MR imaging. Images from each MR sequence were separately analyzed by two readers with disagreements resolved by consensus readings. The findings on MR images were compared with intraoperative ultrasonographic and histopathologic findings on a lesion-by-lesion basis to determine the sensitivity of each MR sequence. Statistical review of the lesion-by-lesion analysis was performed with the McNemar test. Results DW, T2WFSE and Gadolinium Chelate-enhanced MR imaging allowed the depiction of 54/64 (84.4%; 95% CI: 73.1–92.2%), 44/64 (68.8%; 95% CI: 55.9–79.8%), and 51/64 (79.7%; 95% CI: 67.8–88.7%) hepatic metastases respectively. DW MR images allowed depiction of significantly more hepatic metastases than did T2WFSE and was equivalent to Gadolinium Chelate-enhanced MR imaging (P = .002 and P = .375, respectively). Conclusion DW MR imaging is superior to T2WFSE imaging and equivalent to Gadolinium Chelate-enhanced MR imaging for the preoperative detection of hepatic metastases. Further studies however are needed to determine at what extent DW MR imaging can be used as an alternative to Gadolinium Chelate-enhanced MR imaging for the preoperative depiction of hepatic metastases.

Massimo Filippi - One of the best experts on this subject based on the ideXlab platform.

  • three subsequent single doses of Gadolinium Chelate for brain mr imaging in multiple sclerosis
    American Journal of Neuroradiology, 2003
    Co-Authors: Francesco Sardanelli, A. Iozzelli, C Losacco, A. Murialdo, Massimo Filippi
    Abstract:

    BACKGROUND AND PURPOSE: A triple-dose (TD) of Gadolinium Chelate is highly sensitive approach for detecting lesion activity in multiple sclerosis (MS). However, individual TD injections do not provide data on the severity of the pathologic process in a population of lesions, and its clinical use is limited by the cost-benefit considerations. Our aim was to determine whether the use of three subsequent single doses (SD) of a Gadolinium Chelate in brain MR imaging is useful in detecting MS lesions with different patterns of enhancement. METHODS: In 10 patients, T1-weighted spin-echo images were acquired before and after three intravenous administrations of 0.1 mmol/kg of gadodiamide. RESULTS: In all patients, SD images showed six enhancing lesions; double-dose (DD) images, 13; and TD images, 22. Differences between SD and TD and between DD and TD were significant (P <.018). Six lesions (27%) enhanced with all the three doses; seven (32%), with both DD and TD; and nine (41%), with only TD. Proportions of patients with at least one enhancing lesion were, for SD, four of 10; DD, seven of 10; and TD, nine of 10. In defining active disease in these nine patients, we needed only 19 SDs versus the 30 SDs that would have been needed if individual TD injections were used. CONCLUSION: With three subsequent SD injections, the number of enhancing lesions progressively increases. This approach allows the distinction of three levels of enhancement, and it reduces the amount of contrast agent needed to distinguish patients with active MS from those with nonactive MS.

  • Three Subsequent Single Doses of Gadolinium Chelate for Brain MR Imaging in Multiple Sclerosis
    AJNR. American journal of neuroradiology, 2003
    Co-Authors: Francesco Sardanelli, A. Iozzelli, C Losacco, A. Murialdo, Massimo Filippi
    Abstract:

    BACKGROUND AND PURPOSE: A triple-dose (TD) of Gadolinium Chelate is highly sensitive approach for detecting lesion activity in multiple sclerosis (MS). However, individual TD injections do not provide data on the severity of the pathologic process in a population of lesions, and its clinical use is limited by the cost-benefit considerations. Our aim was to determine whether the use of three subsequent single doses (SD) of a Gadolinium Chelate in brain MR imaging is useful in detecting MS lesions with different patterns of enhancement. METHODS: In 10 patients, T1-weighted spin-echo images were acquired before and after three intravenous administrations of 0.1 mmol/kg of gadodiamide. RESULTS: In all patients, SD images showed six enhancing lesions; double-dose (DD) images, 13; and TD images, 22. Differences between SD and TD and between DD and TD were significant (P

A. Scherrer - One of the best experts on this subject based on the ideXlab platform.

  • nontumorous hepatic pseudolesion around the falciform ligament prevalence on Gadolinium Chelate enhanced mr examination
    American Journal of Roentgenology, 1997
    Co-Authors: L Spelle, Philippe Soyer, A. Scherrer, Y Rondeau, M Gouhiri, R Rymer
    Abstract:

    Our objective was to determine the prevalence of nontumorous hepatic pseudolesions seen around the falciform ligament on dynamic spoiled three-dimensional (3D) gradient-recalled echo (GRE) MR imaging obtained during i.v. injection of a Gadolinium Chelate.The Gadolinium Chelate-enhanced spoiled 3D GRE examinations of the liver of 103 patients were prospectively analyzed by two readers for the presence of a nontumorous hepatic pseudolesion around the falciform ligament to determine the prevalence of this finding. For all pseudolesions, pathologic examination or follow-up imaging studies excluded true tumors.A total of 15 nontumorous hepatic pseudolesions were found on 13 (13%) of 103 examinations. The size of pseudolesions ranged from 5 to 15 mm (mean, 9 mm). Twelve pseudolesions were located in segment IV, and three were in segment III. On two MR examinations, two pseudolesions (one in segment IV and one in segment III) were found. Fourteen (93%) of 15 pseudolesions were seen during the arterial phase of t...

  • MR imaging of the liver: Effect of portal hypertension on hepatic parenchymal enhancement using a Gadolinium Chelate
    Journal of magnetic resonance imaging : JMRI, 1997
    Co-Authors: Philippe Soyer, Anne-charlotte Dufresne, E Somveille, A. Scherrer
    Abstract:

    The purpose of this study was to prospectively investigate the extent to which reduced portal blood flow in patients with hepatic cirrhosis and portal hypertension affects hepatic parenchymal enhancement during Gadolinium-Chelate-enhanced dynamic MR imaging. Breath-hold three-dimensional (3D) spoiled gradientrecalled echo (GRE) MR imaging technique obtained after intravenous administration of a Gadolinium Chelate was used to measure hepatic parenchymal enhancement and time to peak enhancement in 20 patients with hepatic cirrhosis and clinical evidence of portal hypertension (group 1) and in 20 control subjects without portal hypertension (group 2) who were matched for age, sex, and body weight. Mean peak hepatic enhancement values ± SD and times to peak enhancement ± SD were determined for both groups of patients. Mean peak enhancement value (±SD) was 78.7% ± 36.2 in group 1 and 91.6% ± 46.2 in group 2 (not significant). However, in the nine patients in group 1 with splenomegaly, mean peak enhancement value was 61.3% ± 14.4, whereas it was 93.0% ± 42.7 in the 11 patients without splenomegaly (P < .05). Mean time to peak enhancement was 84 seconds ± 23 in group 1 and 54.0 sec ± 25.0 in group 2 (P < .01). Our results show that mean peak enhancement value of hepatic parenchyma after intravenous administration of a Gadolinium Chelate is significantly altered for patients with portal hypertension and splenomegaly. In addition, the time to peak enhancement is delayed significantly when portal hypertension is present. Thus, it is possible that the optimal time for imaging the liver during the portal phase must be tailored to the status of the portal system of the patient.

  • Magnetic resonance imaging of the spleen: Influence of the dose of a Gadolinium Chelate on the degree of parenchymal enhancement
    Academic Radiology, 1996
    Co-Authors: Philippe Soyer, A. Scherrer
    Abstract:

    Abstract Rationale and Objectives. We examined how the dose of an intravenous (IV) Gadolinium Chelate (gadoterate meglumine) would affect the degree of splenic enhancement on magnetic resonance (MR) imaging. Methods Forty patients had breath-hold three-dimensional fast spoiled gradient-recalled MR imaging of the abdomen done before and after IV administration of one of four doses of gadoterate meglumine (0.075, 0.100, 0.150, or 0.200 mmol/kg). Peak enhancement values and the time to peak enhancement of splenic parenchyma were compared (values are reported as means ± standard deviations). Results Peak enhancement values were 154 ± 99%, 215 ± 109%, 276 ± 170%, and 349 ± 144 ± for the doses of 0.075, 0.100, 0.150, and 0.200 mmol/kg, respectively. A high correlation was found between the dose and mean peak enhancement values (R2 = .998), which varied as a linear function of the dose. The mean times to peak enhancement obtained with the four doses were not significantly different. Conclusion Using doses ranging from 0.075 to 0.200 mmol/kg, the peak enhancement of splenic parenchyma is a linear function of the dose of the Gadolinium Chelate administered. The time to peak splenic enhancement is not affected.

  • Gadolinium Chelate on the Degree of Parenchymal Enhancement
    1996
    Co-Authors: Philippe Soyer, A. Scherrer
    Abstract:

    Rationale and Objectives. We examined how the dose of an intravenous (IV) Gadolinium Chelate (gadoterate meglumine) would affect the degree of splenic enhancement on magnetic resonance (MR) imaging. Methods. Forty patients had breath-hold three-dimensional fast spoiled gradient-recalled MR imaging of the abdomen done before and after IV administration of one of four doses of gadoterate meglumine (0.075, 0.100, 0.150, or 0.200 mmol/kg). Peak enhancement values and the time to peak enhancement of splenic parenchyma were compared (values are reported as means + standard deviations). Results. Peak enhancement values were 154 -+ 99%, 215 + 109%, 276 + 170%, and 349 -+ 144+_ for the doses of 0.075, 0.100, 0.150, and 0.200 mmol/ kg, respectively. A high correlation was found between the dose and mean peak enhancement values (R 2 = .998), which varied as a linear function of the dose. The mean times to peak enhancement obtained with the four doses were not significantly different. Conclusion. Using doses ranging from 0.075 to 0.200 mmol/kg, the peak enhancement of splenic parenchyma is a linear function of the dose of the Gadolinium Chelate administered. The time to peak splenic enhancement is not affected.

  • Focal nodular hyperplasia of the liver: assessment of hemodynamic and angioarchitectural patterns with Gadolinium Chelate-enhanced 3D spoiled gradient-recalled MRI and maximum intensity projection reformatted images.
    Journal of computer assisted tomography, 1996
    Co-Authors: Philippe Soyer, Anne-charlotte Dufresne, E Somveille, A. Scherrer
    Abstract:

    Purpose Our goal was to determine the relative merits of Gadolinium Chelate-enhanced 3D spoiled gradient-recalled (GRE) MRI versus maximum intensity projection (MIP) reformatted images in assessing the morphologic, hemodynamic, and angioarchitectural patterns of focal nodular hyperplasia (FNH) of the liver. Method Ten consecutive patients with 10 FNHs had prospectively Gadolinium Chelate-enhanced 3D spoiled GRE MRI (TR/TE/FA = 10.1/1.9/30) of the liver at 1.5 T. Gadolinium Chelate-enhanced 3D spoiled GRE source images and MIP reformatted images were separately analyzed with respect to morphologic and hemodynamic features and angioarchitectural patterns by two independent readers. Results Gadolinium Chelate-enhanced 3D spoiled GRE source images and MIP reformatted images showed the most intense degrees of enhancement of FNH during the arterial phase of hepatic parenchymal enhancement in all cases. Gadolinium Chelate-enhanced 3D spoiled GRE source images were superior to MIP reformatted images for the assessment of morphologic features of FNH (p Conclusion The combination of Gadolinium Chelate-enhanced 3D spoiled GRE source images and MIP reformatted images allows the analysis of morphologic, hemodynamic, and angioarchitectural patterns of FNH of the liver. Further study and comparison with currently applied strategies will determine the value of these two techniques for diagnosing FNH of the liver.

Richard C Semelka - One of the best experts on this subject based on the ideXlab platform.

  • bone metastases evaluation of acuity of lesions using dynamic Gadolinium Chelate enhancement preliminary results
    Journal of Magnetic Resonance Imaging, 2011
    Co-Authors: Meredith Northam, Rafael O P De Campos, Miguel Ramalho, Vasco Heredia, Carlos A Gonzalez, Rafael M Azevedo, Richard C Semelka
    Abstract:

    Purpose: To evaluate whether enhancement on serial dynamic Gadolinium-enhanced abdominal–pelvic MR imaging (DCE-MRI) can determine the acuity of bone metastases. Materials and Methods: Twenty consecutive patients who underwent abdominal–pelvic DCE-MRI for evaluation/staging of a proven cancer and had bone metastases were included. Two radiologists analyzed in consensus 59 DCE-MRIs of these patients. Region of interest measurements were performed in up to three lesions on noncontrast T1-weighted, serial hepatic arterial dominant phase (HADP), early hepatic venous phase (EHVF), and interstitial phase (IP) postGadolinium images, and the percentage enhancement of 134 lesions was calculated. The coordinator separately and retrospectively sorted the lesions into three groups based on the imaging and clinical information: acute/active, subacute, and chronic metastases. Results: The mean percentage enhancement of the bone metastases classified as acute/active, subacute, and chronic in the HADP, EHVP and IP were respectively (%): 134, 107, 99; 87, 86, 87; and 39, 65, 73. In the HADP, acute/active lesions enhanced significantly more than both subacute (1.53-fold) and chronic (3.4-fold) lesions (P < 0.01). Time intensity curves were significantly different between these three entities as well. Conclusion: The enhancement on arterial phase images and the time–intensity curves were different for acute/active, subacute, and chronic bone metastases. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.

  • risk of nephrogenic systemic fibrosis evaluation of Gadolinium Chelate contrast agents at four american universities
    Radiology, 2008
    Co-Authors: Rebecca Wertman, Diego R. Martin, Ersan Altun, D G Mitchell, John R Leyendecker, Ryan Omalley, Daniel J Parsons, Edwin R Fuller, Richard C Semelka
    Abstract:

    Purpose: To retrospectively determine the benchmark incidence of nephrogenic systemic fibrosis (NSF) related to the confirmed use of different Gadolinium Chelate contrast agents at four U.S. university tertiary care centers. Materials and Methods: Institutional review board approval was obtained for this HIPAA-compliant multi-institutional study; the requirement for informed patient consent was waived. Patients who had a diagnosis of NSF between January 2000 and December 2006 were identified at four tertiary care centers with renal transplant and dialysis services. A standard checklist was used to acquire reliable data from the four centers. The diagnosis of NSF was confirmed histopathologically in all patients. The association of NSF development with Gadolinium Chelate contrast agent administration in each patient was assessed. The type and cumulative dose of contrast agent administered to each patient with NSF were determined at each center by using the standard checklist. The benchmark incidence of NSF...

  • Current Protocols in Magnetic Resonance Imaging - MRI of the Liver
    Current Protocols in Magnetic Resonance Imaging, 2001
    Co-Authors: Laurie Fisher, Richard C Semelka, Kathy Wilber
    Abstract:

    High-quality diagnostic magnetic resonance images require the use of fast scanning techniques, with the intention of generating images that demonstrate consistent display of disease processes. Respiration and bowel peristalsis are the major artifacts that have lessened the reproducibility of magnetic resonance imaging (MRI). Breathing-independent sequences and breath-hold sequences form the foundation of high-quality MRI studies of the abdomen. Disease conspicuity depends on the principle of maximizing the difference in signal intensities between diseased tissues and the background tissue. Gadolinium Chelate enhancement may be routinely useful since it facilitates detection and characterization of disease.

  • Sequential use of Gadolinium Chelate and mangafodipir trisodium for the assessment of focal liver lesions: initial observations.
    Magnetic resonance imaging, 2000
    Co-Authors: Diego R. Martin, Richard C Semelka, Jae-joon Chung, N. Cem Balci, Kathy Wilber
    Abstract:

    The purpose of this study was to assess the feasibility of sequential administration of 2 different MR imaging contrast agents using a single visit protocol to image focal liver abnormalities. Twenty-one patients with known or suspected liver lesions were included in the study. All patients received a bolus intravenous injection of Gadolinium Chelate (Gd) and dynamically enhanced imaging performed. The patients then received an injection of mangafodipir trisodium (Mn) contrast and a second scan performed with an average delay of 62 min after the Gd bolus injection. The images were evaluated to determine the appearance of liver lesions after administration of each contrast agent, and for evidence of prior Gd administration adversely affecting evaluation of images acquired after Mn administration. Focal liver lesions were present in 19 patients, including 8 with liver metastases, 1 with liver lymphoma, 6 with hemangiomas, 3 with focal nodular hyperplasia (FNH), and 1 with hepatic abscess. In 2 other patients no liver lesions were identified in either the post-Gd or post-Gd-post-Mn scans. All malignant lesions identified on the post-Gd scan were also identified on post-Gd-post-Mn scans. Although the potential benefit for increasing detection sensitivity for hepatic metastases was not demonstrated, this is a preliminary series. This study does demonstrate the practicality for use a single visit sequential Gd-Mn protocol described here, with possible application of this technique for further assessment of the utility of combining Gd and Mn for detection of liver metastases.

  • Sequential use of ferumoxide particles and Gadolinium Chelate for the evaluation of focal liver lesions on MRI.
    Journal of magnetic resonance imaging : JMRI, 1998
    Co-Authors: Richard C Semelka, Joseph K. T. Lee, Suvipapun Worawattanakul, Tara C. Noone, Richard H. Patt, Susan M. Ascher
    Abstract:

    This study describes the sequential use of ferumoxide (superparamagnetic iron oxide) particles and nonspecific extracellular Gadolinium Chelate (Gd) for evaluation of focal liver lesions on MRI to evaluate order of contrast administration and imaging effect of the first contrast agent on sequences acquired after the second contrast agent. Thirteen patients underwent MR examinations that included ferumoxide and Gd. The order and timing of administration were as follows: separate sessions (three patients; Gd study 4-19 days before ferumoxide study), same session, Gd first (seven patients; Gd study 1-2 hours before ferumoxide study), and same session, ferumoxide first (three patients; ferumoxide administered less than 1 hour before Gd study). Postcontrast sequences were reviewed in a randomized, blinded fashion by two separate investigators. Determination was made regarding whether (a) the presence of the first agent administered could be detected on sequences obtained after the second agent and (b) the presence of the first agent interfered with the image quality of those sequences. No evidence for the presence of Gd was appreciated by either observer on postferumoxide sequences acquired in separate session studies. In same session, Gd first studies, the presence of Gd was observed in six of seven patients on T1-weighted spoiled gradient-echo (SGE) images obtained after ferumoxide administration. The presence of Gd was not apparent in seven of seven patients on T2-weighted fat-suppressed images obtained after ferumoxide. In same session, ferumoxide first studies, the presence of ferumoxide was appreciated on post-Gd sequences in two of three patients. The presence of ferumoxide did not appreciably diminish image quality on those sequences. Exact agreement was achieved by the independent investigators. Our results suggest that Gd and ferumoxide can be administered sequentially within one study session without substantial loss of diagnostic information obtained on sequences performed after administration of the second contrast agent. Administrating Gd first resulted in less of an effect of the visualization of the first agent on sequences acquired after the second agent.

Val M. Runge - One of the best experts on this subject based on the ideXlab platform.