The Experts below are selected from a list of 249 Experts worldwide ranked by ideXlab platform
Valérie Vilgrain - One of the best experts on this subject based on the ideXlab platform.
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Focal Nodular Hyperplasia
European journal of radiology, 2006Co-Authors: Valérie VilgrainAbstract:Focal Nodular Hyperplasia is the second most common benign liver tumor after hemangioma and occurs predominantly in young women. Imaging techniques are crucial in the diagnosis of this lesion. In this article, we will present the imaging findings of the classic and non-classic FNHs. The role of percutaneous biopsy will also be detailed.
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Focal Nodular Hyperplasia inducing hepatic vein obstruction.
AJR. American journal of roentgenology, 2002Co-Authors: Anne-sophie Rangheard, Valérie Vilgrain, Pascale Audet, Dermot O'toole, Marie-pierre Vullierme, Dominique Valla, Jacques Belghiti, Yves MenuAbstract:OBJECTIVE. The records of 10 patients with focal Nodular Hyperplasia inducing intrahepatic vein obstruction were reviewed. The purpose of this study was to describe and emphasize the imaging features of these findings.CONCLUSION. Focal Nodular Hyperplasia may be responsible for hepatic vein obstruction with hepatic vein collaterals. The relatively large size and central location of the lesions seem to play important roles in the obstruction of the hepatic veins.
Pablo R. Ros - One of the best experts on this subject based on the ideXlab platform.
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CT and MR imaging findings in focal Nodular Hyperplasia of the liver: radiologic-pathologic correlation.
AJR. American journal of roentgenology, 2000Co-Authors: Koenraad J. Mortele, M. Praet, H. Van Vlierberghe, Marc Kunnen, Pablo R. RosAbstract:687 ew imaging techniques, such as triple phase spiral CT and fast MR imaging, have markedly increased the detection of focal Nodular Hyperplasia, the second most common benign hepatic tumor. Although atypical imaging features are the exception rather than the rule, it is sometimes difficult to differentiate focal Nodular Hyperplasia lacking characteristic findings from other primary and secondary hepatic lesions [1]. The purpose of this essay, in which all illustrated atypical cases are pathologically proven, is to present the spectrum of common and uncommon patterns encountered in CT and MR imaging of focal Nodular Hyperplasia, in correlation with the pathologic features. Atypically, focal Nodular Hyperplasia may present as a large lesion, sometimes multiple in localization, and may show internal necrosis, hemorrhagic foci, and fatty infiltration. Other rare imaging features include nonvisualization of the central scar, nonenhancement of the central scar, and pseudocapsular enhancement on delayed imaging. Because familiarity with these varied CT and MR imaging features is essential for an accurate diagnosis, it is important for radiologists not only to be aware of these uncommon appearances of focal Nodular Hyperplasia but also to understand the radiologic–pathologic correlation.
Paulette Bioulac-sage - One of the best experts on this subject based on the ideXlab platform.
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Pictures of focal Nodular Hyperplasia and hepatocellular adenomas
World journal of hepatology, 2014Co-Authors: Christine Sempoux, Charles Balabaud, Paulette Bioulac-sageAbstract:This practical atlas aims to help liver and non liver pathologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal Nodular Hyperplasia and of hepatocellular adenoma, including hepatocellular adenomas subtypes with references to clinical and imaging data. Each step is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different looking areas adequately sampled for paraffin inclusion. Routine histology includes HE, trichrome and cytokeratin 7. Immunohistochemistry includes glutamine synthase and according to the above results additional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be realized to differentiate focal Nodular Hyperplasia from hepatocellular adenoma subtypes. Clues for differential diagnosis and pitfalls are explained and illustrated.
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Multiple telangiectatic focal Nodular Hyperplasia: vascular abnormalities.
Virchows Archiv : an international journal of pathology, 2003Co-Authors: Sébastien Lepreux, Christophe Laurent, Brigitte Le Bail, Jean Saric, Charles Balabaud, Paulette Bioulac-sageAbstract:The aim of this study was to look for vascular abnormalities in the liver of patients with multiple telangiectatic focal Nodular Hyperplasia. Four patients, all women on oral contraceptives, were included in this study. In none of the cases was the diagnosis of multiple telangiectatic focal Nodular Hyperplasia made preoperatively. In the nodules, the pathological aspect was quite characteristic with dilated sinusoidal areas surrounding compact areas. Compact areas comprised portal tract-like structures with vessels, mainly thickened arteries, usually amidst an inflammatory reaction. A ductular reaction of varied intensity was present in three cases. The non-Nodular liver was grossly normal. However, in rare areas, there were obvious or minor vascular abnormalities looking like minimal abnormalities seen inside telangiectatic nodules. These results seem to support the concept that multiple telangiectatic focal Nodular Hyperplasia is a non-specific reaction to focal ischemia induced by various mechanisms such as hepatic vein thrombosis induced, perhaps, by oral contraceptives.
Koenraad J. Mortele - One of the best experts on this subject based on the ideXlab platform.
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CT and MR imaging findings in focal Nodular Hyperplasia of the liver: radiologic-pathologic correlation.
AJR. American journal of roentgenology, 2000Co-Authors: Koenraad J. Mortele, M. Praet, H. Van Vlierberghe, Marc Kunnen, Pablo R. RosAbstract:687 ew imaging techniques, such as triple phase spiral CT and fast MR imaging, have markedly increased the detection of focal Nodular Hyperplasia, the second most common benign hepatic tumor. Although atypical imaging features are the exception rather than the rule, it is sometimes difficult to differentiate focal Nodular Hyperplasia lacking characteristic findings from other primary and secondary hepatic lesions [1]. The purpose of this essay, in which all illustrated atypical cases are pathologically proven, is to present the spectrum of common and uncommon patterns encountered in CT and MR imaging of focal Nodular Hyperplasia, in correlation with the pathologic features. Atypically, focal Nodular Hyperplasia may present as a large lesion, sometimes multiple in localization, and may show internal necrosis, hemorrhagic foci, and fatty infiltration. Other rare imaging features include nonvisualization of the central scar, nonenhancement of the central scar, and pseudocapsular enhancement on delayed imaging. Because familiarity with these varied CT and MR imaging features is essential for an accurate diagnosis, it is important for radiologists not only to be aware of these uncommon appearances of focal Nodular Hyperplasia but also to understand the radiologic–pathologic correlation.
Christine Sempoux - One of the best experts on this subject based on the ideXlab platform.
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Pictures of focal Nodular Hyperplasia and hepatocellular adenomas
World journal of hepatology, 2014Co-Authors: Christine Sempoux, Charles Balabaud, Paulette Bioulac-sageAbstract:This practical atlas aims to help liver and non liver pathologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal Nodular Hyperplasia and of hepatocellular adenoma, including hepatocellular adenomas subtypes with references to clinical and imaging data. Each step is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different looking areas adequately sampled for paraffin inclusion. Routine histology includes HE, trichrome and cytokeratin 7. Immunohistochemistry includes glutamine synthase and according to the above results additional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be realized to differentiate focal Nodular Hyperplasia from hepatocellular adenoma subtypes. Clues for differential diagnosis and pitfalls are explained and illustrated.
