The Experts below are selected from a list of 72 Experts worldwide ranked by ideXlab platform
Chen Z - One of the best experts on this subject based on the ideXlab platform.
-
Corticofugal modulation of somatosensory area II on acupuncture effect in nucleus ventralis posterolateralis of the thalamus
Acupuncture Research, 1992Co-Authors: Zheng X, Xu W, Chen ZAbstract:: In order to explore whether cortical somatosensory area 11 (SII) was involved in descending modulation of the effect of electroacupuncture (EA) on nucleus ventralis posterolateralis (VPL), the present study was designed to investigate the influence of topical application of lidocaine at SII on the EA effects in VPL nucleus. Experiments were performed on 23 adult cats anaesthetized with pentobarbital sodium (35-40 mg/kg i.p.) and immobilized with Gallamine Triethiodide. The single unit activities of VPL neurons were extracellularly recorded using glass microelectrodes. The results were as follows: 1. The nociceptive responses of VPL were obviously attenuated after EA at "Huantiao (G30)" and "Yanlingquan (G34)". The difference was statistically significant at 0-10 minutes after cessation of EA (n = 13, P 0.05). However, it exerted marked inhibition at 0-10 minutes after cessation of EA in the saline control group (n = 14, P < 0.05). There was a statistical difference between these two groups (P < 0.05). The results showed that SII was involved in descending modulation of acupuncture effect in VPL nucleus.
-
Role of nucleus parabrachialis medialis in the "renzhong" induced pressor response in rabbits
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1991Co-Authors: Chen Z, Qing D, Zheng Y, Xie BAbstract:: Experiments were performed on 18 rabbits, bivagotomized, Gallamine Triethiodide immobilized and artificially ventilated. The effects of electrical stimulation of "renzhong" (Du 26) area and NPBM, separately and simultaneously, on arterial blood pressure and heart rate were observed before and after electrolytic or chemical lesion of NPBM. Electrical stimulation of "renzhong" area or NPBM, separately could elicit an increase in arterial blood pressure; when both "renzhong" and NPBM were stimulated, the pressor response to NPBM stimulation could affect that of "renzhong" area's. But after electrolytic or chemical lesion of NPBM, stimulation of NPBM could no longer elicit pressor response. On the other hand, the pressor response induced by electrical stimulation of "renzhong" area decreased obviously, after lesion of NPBM or transection of brain stem between NPBM and Nucleus trigemini principalis. These results suggest that NPBM might take part in the pressor response of "renzhong" area stimulation.
-
Investigation on role of nucleus parabrachialis medialis in "renzhong" induced respiratory response in rabbits
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1990Co-Authors: Chen Z, Qing D, Zheng YAbstract:: Experiments were performed on 27 rabbits, bivagotomized, Gallamine Triethiodide immobilized and artificially ventilated. The effects of electric stimulation of "Renzhong" (Du26) area, NPBM separately, and "Renzhong" area and nucleus parabrachialis medialis (NPBM) simultaneously, on phrenic nerve discharge were observed before and after electolytic and chemical lesion of NPBM. Evoked potential (EP) could be recorded in NPBM during the electric stimulation "Renzhong" area. Electric stimulation of the same site of NPBM where the EP was recorded could induce respiratory response and change the effect of electric stimulation of "Renzhong" area on respiration. But after electrolytic and chemical lesion of NPBM, stimulation of NPBM could no longer induce the respiratory response mentioned above and could not change the "Renzhong" effect on respiration either. These results suggest that NPBM might take part in respiratory effects of "Renzhong" area stimulation, but is not essential to it.
G A E Mostafa - One of the best experts on this subject based on the ideXlab platform.
-
Gallamine tetraphenylborate modified carbon paste electrode for the potentiometric determination of Gallamine Triethiodide flaxedil
Journal of Pharmaceutical and Biomedical Analysis, 2003Co-Authors: M N Abbas, G A E MostafaAbstract:Abstract The construction and general performance of a novel modified carbon paste electrode for the determination of Gallamine Triethiodide have been developed. The electrode shows a stable, potentiometric response for Gallamine in the concentration range 1×10 −3 –2×10 −6 M at 25 °C independent of pH in the range 5–8. The electrode passes a near-Nernstian cationic slope of 17.0±0.7 mV and lower detection limit of 1×10 −6 M with a fast response time of 20–45 s. Selectivity coefficients for Gallamine relative to a number of interfering substances were investigated. There is a negligible interference from the studied cations, anions, and pharmaceutical excipients. The determination of Gallamine in aqueous solution shows an average recovery of 99.5% and a mean relative standard deviation (RSD) of 1.4% at 100 μg/ml. The direct determination of Gallamine in injection solution gave results that compare favorably with those obtained by the British pharmacopoeia method. Potentiometric titration of Gallamine with sodium tetraphenylborate and phosphotungstic acid as a titrant has been monitored with the modified carbon paste electrode as an end-point indicator electrode.
Abdulaziz A Aljafari - One of the best experts on this subject based on the ideXlab platform.
-
the inhibitory effect of the neuromuscular blocking agent Gallamine Triethiodide on camel retina acetylcholinesterase activity
Toxicology Letters, 1997Co-Authors: Abdulaziz A AljafariAbstract:Abstract The present investigation addresses the mode of inhibition of the camel retinal acetylcholinesterase (AChE) activity by Gallamine Triethiodide, which is known to be a specific non-depolarizing neuromuscular blocking agent and polar cholinergic antagonist. This study gave the following results: it was found that Gallamine (GA) reversibly inhibited the AChE activity in a concentration dependent manner, the IC5o being about 0.633 mM. The Km for the hydrolysis of acetylthiocholine iodide by AChE was found to be 0.0803 mM in the control system, and the value increased by 19–463% in the GA (0.125–1.0 mM) treated systems. The Vmax was 0.649 μmol/min per mg protein for the control as well as GA treated systems. Dixon as well as Lineweaver-Burk plots and their secondary replots indicated that the nature of the inhibition is of the reversible competitive type. The Ki, value was estimated as 0.160 mM. The Ki, value increased with an increase in substrate concentration. The turnover number (cat) and specificity constant (Ksp) were 62.1 min-1 and 7.73 x 105 (M-min)-1 in the control system while the value for one parameter (Agp) was decreased by 25–83% in the GA (0.125–1.0 mM) treated systems
Moustafa M Abdelfattah - One of the best experts on this subject based on the ideXlab platform.
-
cathodic adsorptive stripping voltammetric determination of muscle relaxant Gallamine Triethiodide flaxedil
Journal of Pharmaceutical and Biomedical Analysis, 2001Co-Authors: M A Ghandour, Moustafa M AbdelfattahAbstract:Abstract A senstive and simple voltammetric method of analysis is developed for the determination of trace amounts of Gallamine triethiode in phosphate media. This method is based on controlled adsorptive preconcentration of the relaxant onto a Hanging Mercury Drop Electrode (HMDE) whereby mercurous iodide salt(s) are formed. The technique used is Cathodic Linear Sweep Stripping Voltammetry (CLSSV). The adsorptive response was evaluated with respect to preconcentration time and potential. As little as 3×10 −9 mol dm −3 i.e. 2.7 ppb flaxedil (proconcentration time 300 seconds) can be determined successfully. The application of this method was tested in the determination of flaxedil in pharmaceutical preparation (ampoules).
Zheng Y - One of the best experts on this subject based on the ideXlab platform.
-
Role of nucleus parabrachialis medialis in the "renzhong" induced pressor response in rabbits
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1991Co-Authors: Chen Z, Qing D, Zheng Y, Xie BAbstract:: Experiments were performed on 18 rabbits, bivagotomized, Gallamine Triethiodide immobilized and artificially ventilated. The effects of electrical stimulation of "renzhong" (Du 26) area and NPBM, separately and simultaneously, on arterial blood pressure and heart rate were observed before and after electrolytic or chemical lesion of NPBM. Electrical stimulation of "renzhong" area or NPBM, separately could elicit an increase in arterial blood pressure; when both "renzhong" and NPBM were stimulated, the pressor response to NPBM stimulation could affect that of "renzhong" area's. But after electrolytic or chemical lesion of NPBM, stimulation of NPBM could no longer elicit pressor response. On the other hand, the pressor response induced by electrical stimulation of "renzhong" area decreased obviously, after lesion of NPBM or transection of brain stem between NPBM and Nucleus trigemini principalis. These results suggest that NPBM might take part in the pressor response of "renzhong" area stimulation.
-
Investigation on role of nucleus parabrachialis medialis in "renzhong" induced respiratory response in rabbits
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1990Co-Authors: Chen Z, Qing D, Zheng YAbstract:: Experiments were performed on 27 rabbits, bivagotomized, Gallamine Triethiodide immobilized and artificially ventilated. The effects of electric stimulation of "Renzhong" (Du26) area, NPBM separately, and "Renzhong" area and nucleus parabrachialis medialis (NPBM) simultaneously, on phrenic nerve discharge were observed before and after electolytic and chemical lesion of NPBM. Evoked potential (EP) could be recorded in NPBM during the electric stimulation "Renzhong" area. Electric stimulation of the same site of NPBM where the EP was recorded could induce respiratory response and change the effect of electric stimulation of "Renzhong" area on respiration. But after electrolytic and chemical lesion of NPBM, stimulation of NPBM could no longer induce the respiratory response mentioned above and could not change the "Renzhong" effect on respiration either. These results suggest that NPBM might take part in respiratory effects of "Renzhong" area stimulation, but is not essential to it.
