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Cheng Chun Lee - One of the best experts on this subject based on the ideXlab platform.
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Impaired Gallbladder Function in spinal cord injury on quantitative Tc-99m DISIDA cholescintigraphy
Abdominal Imaging, 2003Co-Authors: Yi-chin Fong, H. C. Hsu, Shung-shung Sun, A. Kao, Cheng Chieh Lin, Cheng Chun LeeAbstract:Background: Patients with spinal cord injury (SCI) have increased prevalences of gallstones and acute acalculous cholecystitis. A possible explanation for the increased prevalence of gallstone disease in SCI patients is decreased Gallbladder motility causing Gallbladder stasis, a known risk factor for gallstone disease. We investigated Gallbladder Function in SCI. Methods: Twenty-five normal control subjects and 50 SCI patients were included in this study. Gallbladder Function was measured by technium 99m–labeled imino-diacetic acid analogue (Tc-99m DISIDA) cholescintigraphy and represented by the filling fraction (FF) and the ejection fraction (EF). The SCI patients were assigned to subgroups: old versus young, female versus male, high- versus low-level injury, and long versus short injury duration. Results: Forty-two percent of SCI patients had abnormal FFs and 54% of SCI patients had abnormal EFs. Significantly decreased FF and EF values were found in SCI patients, especially in those who were female and had high-level injuries. Conclusion: With the use of quantitative Tc-99m DISIDA cholescintigraphy, we found that SCI can significantly impair Gallbladder Function.
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Evidence of impaired Gallbladder Function in patients with non-insulin-dependent diabetes mellitus by quantitative cholescintigraphy.
Journal of Diabetes and Its Complications, 2002Co-Authors: Ching Chiang Yang, Shung-shung Sun, Cheng Chieh Lin, Albet Kao, Cheng Chun LeeAbstract:Abstract Non-insulin-dependent diabetes mellitus (NIDDM) is considered to predispose impaired Gallbladder Function and an increased prevalence of Gallbladder disease. The aim of this study was to evaluate the Gallbladder Function of patients with NIDDM by quantitative technetium-99m-labeled imino-diacetic acid analogue (Tc-99m DISIDA) cholescintigraphy. One hundred and forty-five NIDDM patients (100 males, 45 females; age: 58.7±9.5 years) with the absence of autonomic or peripheral neuropathy and without Gallbladder or liver disorders were enrolled in this study. The patients were categorized by blood sugar control (HbA 1c ≧10% as a poor blood sugar control group and HbA 1c
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Evaluation of Gallbladder Function in patients with non-diabetic chronic renal failure by quantitative radionuclide cholescintigraphy.
Hepato-gastroenterology, 2002Co-Authors: Min Tsung Kao, Cheng Chieh Lin, Chia-hung Kao, Horng-rong Chang, Cheng Chun LeeAbstract:BACKGROUND/AIMS: We investigated quantitatively the motor Function of the Gallbladder in patients with non-diabetic chronic renal failure by the Tc-99m DISIDA cholescintigraphy. METHODOLOGY: Twenty-four patients (13 males, 11 females; aged 62.0 +/- 16.2 years) with non-diabetic chronic renal failure were included in this study. All cases had normal Gallbladder diagnosed by ultrasonography and normal liver Function without symptoms or signs of cholecystitis. Fifteen normal controls (12 males, 3 females; aged 60.7 +/- 6.3 years) were also included for comparison. Gallbladder Function was represented as the filling fraction and the ejection fraction calculated using quantitative Tc-99m DISIDA cholescintigraphy and was compared in the groups. RESULTS: The results showed no significant difference (P > 0.05) between non-diabetic chronic renal failure and controls in filling fraction (64.3 +/- 31.0 vs. 74.9 +/- 9.5) and in ejection fraction (54.4 +/- 26.5 vs. 49.9 +/- 4.2) by the independent Student's t test. CONCLUSIONS: Non-diabetic chronic renal failure seems not to impair Gallbladder Function although non-diabetic chronic renal failure patients had a tendency toward a decreased filling fraction. The high variability of filling fraction and ejection fraction observed in our patients implies that the determinants of Gallbladder Functions in non-diabetic chronic renal failure patients may be multiple in nature.
Chia-hung Kao - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of Gallbladder Function in patients with non-diabetic chronic renal failure by quantitative radionuclide cholescintigraphy.
Hepato-gastroenterology, 2002Co-Authors: Min Tsung Kao, Cheng Chieh Lin, Chia-hung Kao, Horng-rong Chang, Cheng Chun LeeAbstract:BACKGROUND/AIMS: We investigated quantitatively the motor Function of the Gallbladder in patients with non-diabetic chronic renal failure by the Tc-99m DISIDA cholescintigraphy. METHODOLOGY: Twenty-four patients (13 males, 11 females; aged 62.0 +/- 16.2 years) with non-diabetic chronic renal failure were included in this study. All cases had normal Gallbladder diagnosed by ultrasonography and normal liver Function without symptoms or signs of cholecystitis. Fifteen normal controls (12 males, 3 females; aged 60.7 +/- 6.3 years) were also included for comparison. Gallbladder Function was represented as the filling fraction and the ejection fraction calculated using quantitative Tc-99m DISIDA cholescintigraphy and was compared in the groups. RESULTS: The results showed no significant difference (P > 0.05) between non-diabetic chronic renal failure and controls in filling fraction (64.3 +/- 31.0 vs. 74.9 +/- 9.5) and in ejection fraction (54.4 +/- 26.5 vs. 49.9 +/- 4.2) by the independent Student's t test. CONCLUSIONS: Non-diabetic chronic renal failure seems not to impair Gallbladder Function although non-diabetic chronic renal failure patients had a tendency toward a decreased filling fraction. The high variability of filling fraction and ejection fraction observed in our patients implies that the determinants of Gallbladder Functions in non-diabetic chronic renal failure patients may be multiple in nature.
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Evidence of impaired Gallbladder Function in patients with liver cirrhosis by quantitative radionuclide cholescintigraphy
The American Journal of Gastroenterology, 2000Co-Authors: Chia-hung Kao, Jih-fang Hsieh, Shih-chuan Tsai, Shy-den ChenAbstract:OBJECTIVE: The aim of this study was to understand Gallbladder Function in liver cirrhosis. METHODS: Gallbladder Function was measured in 45 patients with liver cirrhosis by Tc-99m-labeled imino-diacetic acid analog cholescintigraphy. Gallbladder Function was represented by the filling fraction and the ejection fraction (EF). The patients were divided into three groups, based on cirrhotic severity, using the modified Child's classification: A = good, B = fair, and C = poor. Fifteen normal control subjects were selected for comparison. RESULTS: There were no significant differences in filling fraction among all of the study groups. Normal controls had significantly higher 60-min EF values than did liver cirrhosis patients. Among the liver cirrhosis patients, class A patients had the highest EF values, and class C patients had the lowest EF values. CONCLUSIONS: We found that liver cirrhosis may significantly impair the Gallbladder emptying, based on the evidence of quantitative Tc-99m-labeled imino-diacetic acid analog cholescintigraphy findings.
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Evaluation of Gallbladder Function by quantitative radionuclide cholescintigraphy in patients with Gallbladder sludge or stones.
Nuclear Medicine Communications, 1994Co-Authors: Chia-hung Kao, Shyh-jen WangAbstract:Thirteen patients with Gallbladder sludge, 14 patients with gallstones and 24 control cases with normal Gallbladders were included in the study. Gallbladder Function was represented as the filling fraction (FF) and the ejection fraction (EF) calculated using quantitative 99Tcm-DISIDA cholescintigraphy and compared in the groups. The results showed that (1) the patients with normal Gallbladders had the highest FF and EF, (2) those with gallstones had the lowest FF, (3) the patients with Gallbladder sludge had the lowest EF, and (4) the coefficient of variation (CV) of FF and EF of the normal controls were less than those for the patients with gallstones or sludge. There was only a statistically significant difference between the normal controls and the patients with gallstones for FF. However, no significant differences existed among the three groups for EF. In our preliminary results, we found that Gallbladder sludge or stones may impair Gallbladder Function, especially FF, as evidenced by noninvasive and quantitative 99Tcm-DISIDA cholescintigraphy, and the higher CV value suggests that Gallbladder Function in patients with gallstones or sludge is more variable.
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The evaluation of Gallbladder Function by quantitative radionuclide cholescintigraphy before and after ESWL for gallstones: preliminary report.
Abdominal Imaging, 1993Co-Authors: Chia-hung Kao, Shyh-jen Wang, Tse-jia LiuAbstract:We assessed changes of Gallbladder Function including concentration and contraction in patients with gallstones after extracorporeal shock-wave lithotripsy (ESWL). The abilities of concentration and contraction were expressed as filling fraction (FF) at 90 min and ejection fraction (EF) at 30 min after a fatty diet by Tc-99m DISIDA Cholescintigraphy. A total of 12 patients who had symptomatic gallstones without cholecystitis were included in our study. ESWL failed in three cases: FF decreased in two of three cases and increased in one of three cases, whereas EF decreased in two of three cases and increased in one of three cases. In another nine cases, ESWL was successful and the gallstones were fragmented. One month after ESWL, in three of these nine cases, the gallstones had completely disappeared. In the three cases at 1 month after ESWL, FF decreased in two of three cases and increased in one of three cases, whereas EF decreased in one of three cases and increased in two of three cases. In the remaining six cases after ESWL, there were still some residual stone fragments in the Gallbladder. In these six cases after 6 months, no fragments were found in the Gallbladders, the third Tc-99m DISIDA Cholescintigraphy was performed. In these six cases, the changes of FF and EF, before ESWL, 1 month after ESWL, and 6 months after ESWL, were irregular and fluctuant. However, no significant improvement of Gallbladder Function was demonstrated even when ESWL was successful. In our preliminary results, we found that not only the residual stone fragments but also the procedure of ESWL may impair Gallbladder Function by evidence of a noninvasive and quantitative Tc-99m DISIDA Cholescintigraphy.
Jochen H H Ehrich - One of the best experts on this subject based on the ideXlab platform.
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Ultrasonographic evaluation of Gallbladder Function in patients with Schistosoma mansoni infection.
Tropical Doctor, 1990Co-Authors: Q. M. Ali, I. M. Abdel-rahim, E Doehring-schwertfegar, R. Kardorff, M El Sheikh, D. Franke, Jochen H H EhrichAbstract:Gallbladder Function was studied in 22 patients with portal hypertension due to advanced Schistosoma mansoni infection and in 17 healthy adults. The fasting volume of the Gallbladder was significantly less in patients than in controls. The Gallbladder wall was grossly thickened in the study group. There was a significant difference between the patients and controls in the reduction of Gallbladder volume following a fatty meal. Although the portal vein diameter and the splenic volume were significantly larger in study patients, no significant correlation could be detected between the reduction in volume or wall thickness of the Gallbladder and any of the relevant sonographic features of schistosomiasis-induced portal hypertension.
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Ultrasonographic evaluation of Gallbladder Function in patients with Schistosoma mansoni infection.
Tropical Doctor, 1990Co-Authors: I. M. Abdel-rahim, E Doehring-schwertfegar, R. Kardorff, M El Sheikh, D. Franke, Jochen H H EhrichAbstract:Gallbladder Function was studied in 22 patients with portal hypertension due to advanced Schistosoma mansoni infection and in 17 healthy adults. The fasting volume of the Gallbladder was significan...
Muhammad Hayder Ali - One of the best experts on this subject based on the ideXlab platform.
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a systemic literature review of the effect of proton pump inhibitors on Gallbladder Function
The Journal of medical research, 2020Co-Authors: Mamoona Javed, Muhammad Saad Tanveer, Muhammad Hayder AliAbstract:Objective: To determine the association between proton pump inhibitors and Gallbladder Function Methods: A systematic search of Medline, Embase and CENTRAL (inception to April 2020) was conducted to capture the relevant studies. A comprehensive inclusion-exclusion criterion was developed and implemented to screen the titles and abstracts. . We, however, found no eligible studies. Results: The systematic search identified 38 unique articles for title and abstract screening. Of which, five were included as potentially relevant studies. However, upon full-text screening, none of them met our inclusion criteria. This review is, therefore, an empty systematic review. Conclusion: There are no good quality studies determining the effect of proton pump inhibitors on Gallbladder Function. Given the common use of proton pump inhibitors and their potential impact on Gallbladder Function, there is an urgent need for conducting clinical studies to address this gap in the evidence.
Muhammad Saad Tanveer - One of the best experts on this subject based on the ideXlab platform.
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a systemic literature review of the effect of proton pump inhibitors on Gallbladder Function
The Journal of medical research, 2020Co-Authors: Mamoona Javed, Muhammad Saad Tanveer, Muhammad Hayder AliAbstract:Objective: To determine the association between proton pump inhibitors and Gallbladder Function Methods: A systematic search of Medline, Embase and CENTRAL (inception to April 2020) was conducted to capture the relevant studies. A comprehensive inclusion-exclusion criterion was developed and implemented to screen the titles and abstracts. . We, however, found no eligible studies. Results: The systematic search identified 38 unique articles for title and abstract screening. Of which, five were included as potentially relevant studies. However, upon full-text screening, none of them met our inclusion criteria. This review is, therefore, an empty systematic review. Conclusion: There are no good quality studies determining the effect of proton pump inhibitors on Gallbladder Function. Given the common use of proton pump inhibitors and their potential impact on Gallbladder Function, there is an urgent need for conducting clinical studies to address this gap in the evidence.
