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Mona K. Garvin - One of the best experts on this subject based on the ideXlab platform.
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Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy.
Investigative ophthalmology & visual science, 2016Co-Authors: Mark J. Kupersmith, Mary K Durbin, Mona K. Garvin, Jui-kai Wang, Randy H. KardonAbstract:PURPOSE Optical coherence tomography reveals retinal Ganglion Cell Layer (GCL) and retinal nerve fiber Layer (RNFL) thinning in chronic optic nerve injury. With acute optic nerve injury, as in acute nonarteritic anterior ischemic optic neuropathy (NAION), swelling obscures early demonstration of RNFL thinning, which might be used to evaluate therapies. We hypothesized that measurement of GCL plus inner plexiform Layer (IPL) thickness and trajectory of thinning would show it is an earlier and more accurate biomarker of early permanent neuronal injury. METHODS We prospectively studied 29 acute NAION eyes with standard automated perimetry and spectral domain (SD) optical coherence tomography for 6 months. We used a three-dimensional Layer segmentation (method 1) and a commercial proprietary (method 2), to compute the combined thickness of macular GCL+IPL and method 2 to compute peripapillary RNFL thickness. RESULTS At presentation, the mean GCL+IPL thickness (78.7 μm ± 8.9) for NAION eyes, did not differ from unaffected fellow eyes (83 μm ± 6.4), using method 1 while method 2 (66.8 μm ± 18.7) failed in 34% of NAION eyes. At 1 to 2 months, 12% had RNFL loss compared to baseline, while 68% of NAION eyes had GCL+IPL thinning. The Ganglion Cell Layer plus inner plexiform Layer reduction was greatest at 1 to 2 months (19.6 μm ± 12.6) and was minimally worse after month 3. Ganglion Cell Layer plus inner plexiform Layer thinning showed moderate to strong significant correlation with the visual acuity and mean deviation at each exam time. The retinal nerve fiber Layer was not thinned until month 3. CONCLUSIONS Ganglion Cell Layer plus inner plexiform Layer is acutely unaffected and provides a reliable measure of retinal neuronal structure using three-dimensional segmentation. Thinning develops within 1 to 2 months of onset, which is prior to RNFL swelling resolution. This suggests GCL+IPL measurement is better than the RNFL thickness to use as biomarker of early structural loss in NAION.
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retinal Ganglion Cell Layer thinning within one month of presentation for optic neuritis
Multiple Sclerosis Journal, 2016Co-Authors: Mark J. Kupersmith, Mary K Durbin, Mona K. Garvin, Jui-kai Wang, Randy H. KardonAbstract:Background: Spectral domain optical coherence tomography (SD-OCT) reveals retinal Ganglion Cell Layer plus inner plexiform Layer (GCL+IPL) and peripapillary retinal nerve fiber Layer (pRNFL) thinning in chronic optic nerve injury. At presentation, swelling of the pRNFL confounds evaluation of early axon loss. Objective: We studied whether the GCL+IPL thins before the pRNFL, the trajectory of GCL+IPL loss and relationship to vision. Methods: We prospectively evaluated 33 eyes (study) with new optic neuritis, using perimetry and SDOCT with investigative three-dimensional Layer segmentation and commercial two-dimensional segmentation to compute the GCL+IPL and pRNFL thickness. Results: At presentation, GCL+IPL thickness (82.4±8.8 µm) did not differ from unaffected fellow eyes (81.2±6.7 µm), via the three-dimensional method, while the two-dimensional method failed in 9% of study eyes. At 1–2 months, there was thinning of the pRNFL in 10% and of the GCL+IPL in 93% of study eyes. GCL+IPL reduction was greatest during the first 2 months. GCL+IPL thinning at 1–2 months correlated with GCL+IPL thinning at 6 months (r=0.84, P=0.01) and presentation visual acuity (r=0.48, P=0.006) and perimetric mean deviation (r=0.52, P=0.003). Conclusion: GGL+IPL is an early biomarker of structural injury in optic neuritis as thinning develops within 1–2 months of onset, prior to pRNFL thinning.
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Reproducibility of SD-OCT-based Ganglion Cell-Layer thickness in glaucoma using two different segmentation algorithms.
Investigative Ophthalmology & Visual Science, 2013Co-Authors: Mona K. Garvin, Milan Sonka, Michael D. Abràmoff, Kyungmoo Lee, Trudy L. Burns, Young H. KwonAbstract:PURPOSE To compare the reproducibility of spectral-domain optical coherence tomography (SD-OCT)-based Ganglion Cell-Layer-plus-inner plexiform-Layer (GCL+IPL) thickness measurements for glaucoma patients obtained using both a publicly available and a commercially available algorithm. METHODS Macula SD-OCT volumes (200 × 200 × 1024 voxels, 6 × 6 × 2 mm(3)) were obtained prospectively from both eyes of patients with open-angle glaucoma or with suspected glaucoma on two separate visits within 4 months. The combined GCL+IPL thickness was computed for each SD-OCT volume within an elliptical annulus centered at the fovea, based on two algorithms: (1) a previously published graph-theoretical Layer segmentation approach developed at the University of Iowa, and (2) a Ganglion Cell analysis module of version 6 of Cirrus software. The mean overall thickness of the elliptical annulus was computed as was the thickness within six sectors. For statistical analyses, eyes with an SD-OCT volume with low signal strength (
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Association of visual function and Ganglion Cell Layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy
Vision research, 2010Co-Authors: Hille W. Van Dijk, Mona K. Garvin, Frank D. Verbraak, Marilette Stehouwer, Pauline H. B. Kok, Milan Sonka, J. Hans Devries, Reinier O. Schlingemann, Michael D. AbràmoffAbstract:Abstract Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain–optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the Ganglion Cell Layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p
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decreased retinal Ganglion Cell Layer thickness in patients with type 1 diabetes
Investigative Ophthalmology & Visual Science, 2010Co-Authors: Hille W. Van Dijk, Mona K. Garvin, Frank D. Verbraak, Pauline H. B. Kok, Milan Sonka, Kyungmoo Lee, Hans J Devries, Robert P J Michels, Mirjam E J Van Velthoven, Reinier O. SchlingemannAbstract:PURPOSE. To determine which retinal Layers are most affected by diabetes and contribute to thinning of the inner retina and to investigate the relationship between retinal Layer thickness (LT) and diabetes duration, diabetic retinopathy (DR) status, age, glycosylated hemoglobin (HbA1c), and the sex of the individual, in patients with type 1 diabetes who have no or minimal DR. METHODS. Mean LT was calculated for the individual retinal Layers after automated segmentation of spectral domain-optical coherence tomography scans of patients with diabetes and compared with that in control subjects. Multiple linear regression analysis was used to determine the relationship between LT and HbA1c, age, sex, diabetes duration, and DR status. RESULTS. In patients with minimal DR, the mean Ganglion Cell Layer (GCL) in the pericentral area was 5.1 m thinner (95% confidence interval [CI], 1.1‐9.1 m), and in the peripheral macula, the mean retinal nerve fiber Layer (RNFL) was 3.7 m thinner (95% CI, 1.3‐6.1 m) than in the control subjects. There was a significant linear correlation (R 0.53, P 0.01) between GCL thickness and diabetes duration in the pooled group of patients. Multiple linear regression analysis (R 0.62, P 0.01) showed that DR status was the most important explanatory variable. CONCLUSIONS. This study demonstrates GCL thinning in the pericentral area and corresponding loss of RNFL thickness in the peripheral macula in patients with type 1 diabetes and no or minimal DR compared with control subjects. These results support the concept that diabetes has an early neurodegenerative effect on the retina, which occurs even though the vascular component of DR is minimal. (Invest Ophthalmol Vis Sci. 2010;51:3660‐3665) DOI:10.1167/iovs.09-5041
Mary K Durbin - One of the best experts on this subject based on the ideXlab platform.
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Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy.
Investigative ophthalmology & visual science, 2016Co-Authors: Mark J. Kupersmith, Mary K Durbin, Mona K. Garvin, Jui-kai Wang, Randy H. KardonAbstract:PURPOSE Optical coherence tomography reveals retinal Ganglion Cell Layer (GCL) and retinal nerve fiber Layer (RNFL) thinning in chronic optic nerve injury. With acute optic nerve injury, as in acute nonarteritic anterior ischemic optic neuropathy (NAION), swelling obscures early demonstration of RNFL thinning, which might be used to evaluate therapies. We hypothesized that measurement of GCL plus inner plexiform Layer (IPL) thickness and trajectory of thinning would show it is an earlier and more accurate biomarker of early permanent neuronal injury. METHODS We prospectively studied 29 acute NAION eyes with standard automated perimetry and spectral domain (SD) optical coherence tomography for 6 months. We used a three-dimensional Layer segmentation (method 1) and a commercial proprietary (method 2), to compute the combined thickness of macular GCL+IPL and method 2 to compute peripapillary RNFL thickness. RESULTS At presentation, the mean GCL+IPL thickness (78.7 μm ± 8.9) for NAION eyes, did not differ from unaffected fellow eyes (83 μm ± 6.4), using method 1 while method 2 (66.8 μm ± 18.7) failed in 34% of NAION eyes. At 1 to 2 months, 12% had RNFL loss compared to baseline, while 68% of NAION eyes had GCL+IPL thinning. The Ganglion Cell Layer plus inner plexiform Layer reduction was greatest at 1 to 2 months (19.6 μm ± 12.6) and was minimally worse after month 3. Ganglion Cell Layer plus inner plexiform Layer thinning showed moderate to strong significant correlation with the visual acuity and mean deviation at each exam time. The retinal nerve fiber Layer was not thinned until month 3. CONCLUSIONS Ganglion Cell Layer plus inner plexiform Layer is acutely unaffected and provides a reliable measure of retinal neuronal structure using three-dimensional segmentation. Thinning develops within 1 to 2 months of onset, which is prior to RNFL swelling resolution. This suggests GCL+IPL measurement is better than the RNFL thickness to use as biomarker of early structural loss in NAION.
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retinal Ganglion Cell Layer thinning within one month of presentation for optic neuritis
Multiple Sclerosis Journal, 2016Co-Authors: Mark J. Kupersmith, Mary K Durbin, Mona K. Garvin, Jui-kai Wang, Randy H. KardonAbstract:Background: Spectral domain optical coherence tomography (SD-OCT) reveals retinal Ganglion Cell Layer plus inner plexiform Layer (GCL+IPL) and peripapillary retinal nerve fiber Layer (pRNFL) thinning in chronic optic nerve injury. At presentation, swelling of the pRNFL confounds evaluation of early axon loss. Objective: We studied whether the GCL+IPL thins before the pRNFL, the trajectory of GCL+IPL loss and relationship to vision. Methods: We prospectively evaluated 33 eyes (study) with new optic neuritis, using perimetry and SDOCT with investigative three-dimensional Layer segmentation and commercial two-dimensional segmentation to compute the GCL+IPL and pRNFL thickness. Results: At presentation, GCL+IPL thickness (82.4±8.8 µm) did not differ from unaffected fellow eyes (81.2±6.7 µm), via the three-dimensional method, while the two-dimensional method failed in 9% of study eyes. At 1–2 months, there was thinning of the pRNFL in 10% and of the GCL+IPL in 93% of study eyes. GCL+IPL reduction was greatest during the first 2 months. GCL+IPL thinning at 1–2 months correlated with GCL+IPL thinning at 6 months (r=0.84, P=0.01) and presentation visual acuity (r=0.48, P=0.006) and perimetric mean deviation (r=0.52, P=0.003). Conclusion: GGL+IPL is an early biomarker of structural injury in optic neuritis as thinning develops within 1–2 months of onset, prior to pRNFL thinning.
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optical coherence tomography segmentation reveals Ganglion Cell Layer pathology after optic neuritis
Brain, 2012Co-Authors: Shiv Saidha, Etona Ford, Jonathan D Oakley, Scott A Meyer, Mary K Durbin, John N Ratchford, Ciprian M. Crainiceanu, Scott D Newsome, Michael J. Levy, Elliot M FrohmanAbstract:Post-mortem Ganglion Cell dropout has been observed in multiple sclerosis; however, longitudinal in vivo assessment of retinal neuronal Layers following acute optic neuritis remains largely unexplored. Peripapillary retinal nerve fibre Layer thickness, measured by optical coherence tomography, has been proposed as an outcome measure in studies of neuroprotective agents in multiple sclerosis, yet potential swelling during the acute stages of optic neuritis may confound baseline measurements. The objective of this study was to ascertain whether patients with multiple sclerosis or neuromyelitis optica develop retinal neuronal Layer pathology following acute optic neuritis, and to systematically characterize such changes in vivo over time. Spectral domain optical coherence tomography imaging, including automated retinal Layer segmentation, was performed serially in 20 participants during the acute phase of optic neuritis, and again 3 and 6 months later. Imaging was performed cross-sectionally in 98 multiple sclerosis participants, 22 neuromyelitis optica participants and 72 healthy controls. Neuronal thinning was observed in the Ganglion Cell Layer of eyes affected by acute optic neuritis 3 and 6 months after onset ( P < 0.001). Baseline Ganglion Cell Layer thicknesses did not demonstrate swelling when compared with contralateral unaffected eyes, whereas peripapillary retinal nerve fibre Layer oedema was observed in affected eyes ( P = 0.008) and subsequently thinned over the course of this study. Ganglion Cell Layer thickness was lower in both participants with multiple sclerosis and participants with neuromyelitis optica, with and without a history of optic neuritis, when compared with healthy controls ( P < 0.001) and correlated with visual function. Of all patient groups investigated, those with neuromyelitis optica and a history of optic neuritis exhibited the greatest reduction in Ganglion Cell Layer thickness. Results from our in vivo longitudinal study demonstrate retinal neuronal Layer thinning following acute optic neuritis, corroborating the hypothesis that axonal injury may cause neuronal pathology in multiple sclerosis. Further, these data provide evidence of subclinical disease activity, in both participants with multiple sclerosis and with neuromyelitis optica without a history of optic neuritis, a disease in which subclinical disease activity has not been widely appreciated. No pathology was seen in the inner or outer nuclear Layers of eyes with optic neuritis, suggesting that retrograde degeneration after optic neuritis may not extend into the deeper retinal Layers. The subsequent thinning of the Ganglion Cell Layer following acute optic neuritis, in the absence of evidence of baseline swelling, suggests the potential utility of quantitative optical coherence tomography retinal Layer segmentation to monitor neuroprotective effects of novel agents in therapeutic trials.
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Optical coherence tomography segmentation reveals Ganglion Cell Layer pathology after optic neuritis
Brain, 2011Co-Authors: Stephanie B. Syc, Jonathan D Oakley, Mary K Durbin, John N Ratchford, Ciprian M. Crainiceanu, Scott D Newsome, Shiv Saidha, Michael J. Levy, E’tona Ford, Scott A MeyerAbstract:Post-mortem Ganglion Cell dropout has been observed in multiple sclerosis; however, longitudinal in vivo assessment of retinal neuronal Layers following acute optic neuritis remains largely unexplored. Peripapillary retinal nerve fibre Layer thickness, measured by optical coherence tomography, has been proposed as an outcome measure in studies of neuroprotective agents in multiple sclerosis, yet potential swelling during the acute stages of optic neuritis may confound baseline measurements. The objective of this study was to ascertain whether patients with multiple sclerosis or neuromyelitis optica develop retinal neuronal Layer pathology following acute optic neuritis, and to systematically characterize such changes in vivo over time. Spectral domain optical coherence tomography imaging, including automated retinal Layer segmentation, was performed serially in 20 participants during the acute phase of optic neuritis, and again 3 and 6 months later. Imaging was performed cross-sectionally in 98 multiple sclerosis participants, 22 neuromyelitis optica participants and 72 healthy controls. Neuronal thinning was observed in the Ganglion Cell Layer of eyes affected by acute optic neuritis 3 and 6 months after onset ( P
Scott A Meyer - One of the best experts on this subject based on the ideXlab platform.
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optical coherence tomography segmentation reveals Ganglion Cell Layer pathology after optic neuritis
Brain, 2012Co-Authors: Shiv Saidha, Etona Ford, Jonathan D Oakley, Scott A Meyer, Mary K Durbin, John N Ratchford, Ciprian M. Crainiceanu, Scott D Newsome, Michael J. Levy, Elliot M FrohmanAbstract:Post-mortem Ganglion Cell dropout has been observed in multiple sclerosis; however, longitudinal in vivo assessment of retinal neuronal Layers following acute optic neuritis remains largely unexplored. Peripapillary retinal nerve fibre Layer thickness, measured by optical coherence tomography, has been proposed as an outcome measure in studies of neuroprotective agents in multiple sclerosis, yet potential swelling during the acute stages of optic neuritis may confound baseline measurements. The objective of this study was to ascertain whether patients with multiple sclerosis or neuromyelitis optica develop retinal neuronal Layer pathology following acute optic neuritis, and to systematically characterize such changes in vivo over time. Spectral domain optical coherence tomography imaging, including automated retinal Layer segmentation, was performed serially in 20 participants during the acute phase of optic neuritis, and again 3 and 6 months later. Imaging was performed cross-sectionally in 98 multiple sclerosis participants, 22 neuromyelitis optica participants and 72 healthy controls. Neuronal thinning was observed in the Ganglion Cell Layer of eyes affected by acute optic neuritis 3 and 6 months after onset ( P < 0.001). Baseline Ganglion Cell Layer thicknesses did not demonstrate swelling when compared with contralateral unaffected eyes, whereas peripapillary retinal nerve fibre Layer oedema was observed in affected eyes ( P = 0.008) and subsequently thinned over the course of this study. Ganglion Cell Layer thickness was lower in both participants with multiple sclerosis and participants with neuromyelitis optica, with and without a history of optic neuritis, when compared with healthy controls ( P < 0.001) and correlated with visual function. Of all patient groups investigated, those with neuromyelitis optica and a history of optic neuritis exhibited the greatest reduction in Ganglion Cell Layer thickness. Results from our in vivo longitudinal study demonstrate retinal neuronal Layer thinning following acute optic neuritis, corroborating the hypothesis that axonal injury may cause neuronal pathology in multiple sclerosis. Further, these data provide evidence of subclinical disease activity, in both participants with multiple sclerosis and with neuromyelitis optica without a history of optic neuritis, a disease in which subclinical disease activity has not been widely appreciated. No pathology was seen in the inner or outer nuclear Layers of eyes with optic neuritis, suggesting that retrograde degeneration after optic neuritis may not extend into the deeper retinal Layers. The subsequent thinning of the Ganglion Cell Layer following acute optic neuritis, in the absence of evidence of baseline swelling, suggests the potential utility of quantitative optical coherence tomography retinal Layer segmentation to monitor neuroprotective effects of novel agents in therapeutic trials.
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Optical coherence tomography segmentation reveals Ganglion Cell Layer pathology after optic neuritis
Brain, 2011Co-Authors: Stephanie B. Syc, Jonathan D Oakley, Mary K Durbin, John N Ratchford, Ciprian M. Crainiceanu, Scott D Newsome, Shiv Saidha, Michael J. Levy, E’tona Ford, Scott A MeyerAbstract:Post-mortem Ganglion Cell dropout has been observed in multiple sclerosis; however, longitudinal in vivo assessment of retinal neuronal Layers following acute optic neuritis remains largely unexplored. Peripapillary retinal nerve fibre Layer thickness, measured by optical coherence tomography, has been proposed as an outcome measure in studies of neuroprotective agents in multiple sclerosis, yet potential swelling during the acute stages of optic neuritis may confound baseline measurements. The objective of this study was to ascertain whether patients with multiple sclerosis or neuromyelitis optica develop retinal neuronal Layer pathology following acute optic neuritis, and to systematically characterize such changes in vivo over time. Spectral domain optical coherence tomography imaging, including automated retinal Layer segmentation, was performed serially in 20 participants during the acute phase of optic neuritis, and again 3 and 6 months later. Imaging was performed cross-sectionally in 98 multiple sclerosis participants, 22 neuromyelitis optica participants and 72 healthy controls. Neuronal thinning was observed in the Ganglion Cell Layer of eyes affected by acute optic neuritis 3 and 6 months after onset ( P
Frank D. Verbraak - One of the best experts on this subject based on the ideXlab platform.
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Ganglion Cell Layer measurements correlate with disease severity in patients with alzheimer s disease
Acta Ophthalmologica, 2016Co-Authors: Jurre Den Haan, Lisanne J Balk, Frank D. VerbraakAbstract:Purpose To evaluate the thickness of the 10 retinal Layers of patients with Alzheimer's disease (AD) using a new segmentation technology of the Spectralis optical coherence tomography (OCT) and to determine whether the thickness of specific Layers predicts neurodegeneration or AD severity. Methods Patients with AD (n = 150) and age-matched healthy controls (n = 75) were analysed using the segmentation application prototype to automatically segment all retinal Layers in a macular scan. Thicknesses of each Layer were compared between patients with AD and controls, and between patients with disease durations of less than or at least 3 years. Associations between retinal Layer thicknesses, disease duration and AD severity were evaluated. Results Patients with AD had reduced thickness in the retinal nerve fibre, Ganglion Cell, inner plexiform and outer nuclear Layers (p < 0.05). The inner retinal Layers were more affected in patients with long disease duration. Ganglion Cell and retinal nerve fibre Layer thicknesses were inversely correlated with AD duration and severity. Ganglion Cell and inner plexiform Layers thicknesses were predictive of axonal damage. Conclusions The segmentation application revealed Ganglion Cell and retinal Layer atrophy in patients with AD compared with controls, especially in the inner Layers of patients with long disease duration. Ganglion Cell Layer reduction was associated with increased axonal damage and may predict greater disease severity.
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Association of visual function and Ganglion Cell Layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy
Vision research, 2010Co-Authors: Hille W. Van Dijk, Mona K. Garvin, Frank D. Verbraak, Marilette Stehouwer, Pauline H. B. Kok, Milan Sonka, J. Hans Devries, Reinier O. Schlingemann, Michael D. AbràmoffAbstract:Abstract Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain–optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the Ganglion Cell Layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p
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decreased retinal Ganglion Cell Layer thickness in patients with type 1 diabetes
Investigative Ophthalmology & Visual Science, 2010Co-Authors: Hille W. Van Dijk, Mona K. Garvin, Frank D. Verbraak, Pauline H. B. Kok, Milan Sonka, Kyungmoo Lee, Hans J Devries, Robert P J Michels, Mirjam E J Van Velthoven, Reinier O. SchlingemannAbstract:PURPOSE. To determine which retinal Layers are most affected by diabetes and contribute to thinning of the inner retina and to investigate the relationship between retinal Layer thickness (LT) and diabetes duration, diabetic retinopathy (DR) status, age, glycosylated hemoglobin (HbA1c), and the sex of the individual, in patients with type 1 diabetes who have no or minimal DR. METHODS. Mean LT was calculated for the individual retinal Layers after automated segmentation of spectral domain-optical coherence tomography scans of patients with diabetes and compared with that in control subjects. Multiple linear regression analysis was used to determine the relationship between LT and HbA1c, age, sex, diabetes duration, and DR status. RESULTS. In patients with minimal DR, the mean Ganglion Cell Layer (GCL) in the pericentral area was 5.1 m thinner (95% confidence interval [CI], 1.1‐9.1 m), and in the peripheral macula, the mean retinal nerve fiber Layer (RNFL) was 3.7 m thinner (95% CI, 1.3‐6.1 m) than in the control subjects. There was a significant linear correlation (R 0.53, P 0.01) between GCL thickness and diabetes duration in the pooled group of patients. Multiple linear regression analysis (R 0.62, P 0.01) showed that DR status was the most important explanatory variable. CONCLUSIONS. This study demonstrates GCL thinning in the pericentral area and corresponding loss of RNFL thickness in the peripheral macula in patients with type 1 diabetes and no or minimal DR compared with control subjects. These results support the concept that diabetes has an early neurodegenerative effect on the retina, which occurs even though the vascular component of DR is minimal. (Invest Ophthalmol Vis Sci. 2010;51:3660‐3665) DOI:10.1167/iovs.09-5041
Milan Sonka - One of the best experts on this subject based on the ideXlab platform.
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Reproducibility of SD-OCT-based Ganglion Cell-Layer thickness in glaucoma using two different segmentation algorithms.
Investigative Ophthalmology & Visual Science, 2013Co-Authors: Mona K. Garvin, Milan Sonka, Michael D. Abràmoff, Kyungmoo Lee, Trudy L. Burns, Young H. KwonAbstract:PURPOSE To compare the reproducibility of spectral-domain optical coherence tomography (SD-OCT)-based Ganglion Cell-Layer-plus-inner plexiform-Layer (GCL+IPL) thickness measurements for glaucoma patients obtained using both a publicly available and a commercially available algorithm. METHODS Macula SD-OCT volumes (200 × 200 × 1024 voxels, 6 × 6 × 2 mm(3)) were obtained prospectively from both eyes of patients with open-angle glaucoma or with suspected glaucoma on two separate visits within 4 months. The combined GCL+IPL thickness was computed for each SD-OCT volume within an elliptical annulus centered at the fovea, based on two algorithms: (1) a previously published graph-theoretical Layer segmentation approach developed at the University of Iowa, and (2) a Ganglion Cell analysis module of version 6 of Cirrus software. The mean overall thickness of the elliptical annulus was computed as was the thickness within six sectors. For statistical analyses, eyes with an SD-OCT volume with low signal strength (
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Association of visual function and Ganglion Cell Layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy
Vision research, 2010Co-Authors: Hille W. Van Dijk, Mona K. Garvin, Frank D. Verbraak, Marilette Stehouwer, Pauline H. B. Kok, Milan Sonka, J. Hans Devries, Reinier O. Schlingemann, Michael D. AbràmoffAbstract:Abstract Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain–optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the Ganglion Cell Layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p
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decreased retinal Ganglion Cell Layer thickness in patients with type 1 diabetes
Investigative Ophthalmology & Visual Science, 2010Co-Authors: Hille W. Van Dijk, Mona K. Garvin, Frank D. Verbraak, Pauline H. B. Kok, Milan Sonka, Kyungmoo Lee, Hans J Devries, Robert P J Michels, Mirjam E J Van Velthoven, Reinier O. SchlingemannAbstract:PURPOSE. To determine which retinal Layers are most affected by diabetes and contribute to thinning of the inner retina and to investigate the relationship between retinal Layer thickness (LT) and diabetes duration, diabetic retinopathy (DR) status, age, glycosylated hemoglobin (HbA1c), and the sex of the individual, in patients with type 1 diabetes who have no or minimal DR. METHODS. Mean LT was calculated for the individual retinal Layers after automated segmentation of spectral domain-optical coherence tomography scans of patients with diabetes and compared with that in control subjects. Multiple linear regression analysis was used to determine the relationship between LT and HbA1c, age, sex, diabetes duration, and DR status. RESULTS. In patients with minimal DR, the mean Ganglion Cell Layer (GCL) in the pericentral area was 5.1 m thinner (95% confidence interval [CI], 1.1‐9.1 m), and in the peripheral macula, the mean retinal nerve fiber Layer (RNFL) was 3.7 m thinner (95% CI, 1.3‐6.1 m) than in the control subjects. There was a significant linear correlation (R 0.53, P 0.01) between GCL thickness and diabetes duration in the pooled group of patients. Multiple linear regression analysis (R 0.62, P 0.01) showed that DR status was the most important explanatory variable. CONCLUSIONS. This study demonstrates GCL thinning in the pericentral area and corresponding loss of RNFL thickness in the peripheral macula in patients with type 1 diabetes and no or minimal DR compared with control subjects. These results support the concept that diabetes has an early neurodegenerative effect on the retina, which occurs even though the vascular component of DR is minimal. (Invest Ophthalmol Vis Sci. 2010;51:3660‐3665) DOI:10.1167/iovs.09-5041
