The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Kohsuke Hayamizu - One of the best experts on this subject based on the ideXlab platform.
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effects of Garcinia cambogia extract on serum sex hormones in overweight subjects
Fitoterapia, 2008Co-Authors: Kohsuke Hayamizu, Izuru Kaneko, Manzhen Shen, Hironori Tomi, Madhu G Soni, Gen YoshinoAbstract:(-) Hydroxycitric acid (HCA), an active ingredient extracted from the Garcinia cambogia fruit rind, has been commonly used as a dietary supplement for weight management. Given the controversy over HCA related testicular toxicity in animal studies, we investigated changes in serum sex hormones levels as an extension of our previous double-blind placebo-controlled trial in human subjects, in which 44 participants received either G. cambogia extract (1667.3 mg/day equivalent to 1000 mg HCA/day) or placebo for 12 weeks. Compared to the placebo group, administration of the extract did not significantly alter the serum testosterone, estrone, and estradiol levels. Similarly, hematology, serum triacylglycerol and serum clinical pathology parameters did not reveal any significant adverse effects. The results of this preliminary investigation indicate that ingestion of G. cambogia extract at dose levels commonly recommended for human use does not affect serum sex hormone levels and blood parameters.
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dietary Garcinia cambogia does not modify skin properties of mice with or without excessive sucrose intake
Phytotherapy Research, 2005Co-Authors: Daichi Oikawa, Kohsuke Hayamizu, Hachidai Hirakawa, Yoshinori Nakamura, Nobuya Shiba, Tomonori Nakanishi, Hisao Iwamoto, Tetsuya Tachibana, Mitsuhiro FuruseAbstract:The influence of 3.3% Garcinia cambogia extract on the properties of mouse skin with or without 10% sucrose water loading was investigated. Mice (7-week-old) were given free access to a control diet or a diet containing Garcinia cambogia extract. They were also given water alone or both water and sucrose water. Their skin was compared by both biochemical and histological methods. The collagen and triacylglycerol contents were not significantly different among the four groups. Similarly, electron microscopy revealed no differences in the thickness of the dermis layer or the subcutaneous tissue layer. Mice given the diet containing Garcinia cambogia tended to have a reduced total number of adipocytes, but not significantly. These results suggest that Garcinia cambogia supplementation for at least 4 weeks does not induce a negative effect on skin properties in mice irrespective of excessive sucrose intake.
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effects of Garcinia cambogia hydroxycitric acid on visceral fat accumulation a double blind randomized placebo controlled trial
Current Therapeutic Research-clinical and Experimental, 2003Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Izuru Kaneko, Manzhen Shen, Yasuhide Okuhara, Norihiro Shigematsu, Mitsuhiro Furuse, Hironori Tomi, Gen Yoshino, Hiroyuki ShimasakiAbstract:Background: (-)-Hydroxycitric acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. Objective: The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist–hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty acid). Methods: This study was performed according to a double-blind, randomized, placebo-controlled, parallel-group design. Subjects aged 20 to 65 years with a visceral fat area 90 cm 2 were enrolled. Subjects were randomly assigned to receive treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day) or placebo. At the end of the treatment period, both groups were administered placebo for 4 weeks to assess any rebound effect. Each subject underwent a computed tomography scan at the umbilical level at –2, 0, 12, and 16 weeks. Results: Forty-four subjects were randomized at baseline, and 39 completed the study (G cambogia group, n 18; placebo group, n 21). At 16 weeks, the G cambogia group had significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group (all indices P 0.001). No severe adverse effect was observed at any time in the test period. There were no
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effect of Garcinia cambogia extract on serum leptin and insulin in mice
Fitoterapia, 2003Co-Authors: Kohsuke Hayamizu, Daichi Oikawa, Hachidai Hirakawa, Tomonori Nakanishi, Tetsuya Tachibana, Tomo Takagi, Mitsuhiro FuruseAbstract:In this study we examined the effects of 3.3% Garcinia cambogia extract on 10% sucrose loading in mice for 4 weeks. Treatment was found to have no effect on body weight, fat pad weight or serum glucose level. On the other hand, serum total cholesterol, triglycerides, NEFA were observed. Levels of serum insulin and leptin, as well as the leptin/WAT ratio, were lower in the treated mice than in the control. These findings suggested that G. cambogia extract efficiently improved glucose metabolism and displayed leptin-like activity.
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No-observed-Adverse-Effect Level(NOAEL) and Sequential-High-Doses Administration Study on Garcinia cambogia Extract in Humans
Journal of Oleo Science, 2002Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Izuru Kaneko, Manzhen Shen, Yasuhide Okuhara, Hiroyuki Sakaguchi, Norihiro Shigematsu, Hiroyuki ShimasakiAbstract:(−)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss in humans, and is the principal acid in the rinds of Garcinia cambogia, a fruit native to Asia. NOAEL (no-observed-adverse-effect level) of G. cambogia extract was determined in the present study and examination was made of adverse effects of high-dose administration to 44 healthy volunteers who had received 4000 mg HCA. No adverse effect was noted in any subjects. NOAEL of G. cambogia extract was estimated as more than 4000 mg HCA. Sequential-high-doses administration study was condusted in subjects who had been given 3000 mg HCA daily for 10 days. Blood samples were used to obtain clinical data before and after treatment. The clinical data were essentially the same for either time. G. cambogia extract at more than 3000 mg HCA may be considered safe for healthy persons.
Fujian Zhang - One of the best experts on this subject based on the ideXlab platform.
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clinical grade Garcinia cambogia extract removes calcium oxalate kidney stones in both genetic and non genetic drosophila models of nephrolithiasis
Social Science Research Network, 2019Co-Authors: Qiuxia Fan, Xiaoming Feng, Xizhen Hong, Siqiao Gong, Jianwei Tian, Fan Fan Hou, Fujian ZhangAbstract:BackgroundKidney stone formers with family history have a high rate of stone recurrence after kidney stone removal surgery and there is no effective medication available for treatment. It has been shown that hydroxycitric acid (HCA)-the major component of Garcinia cambogia extract, induces dissolution of the calcium oxalate crystal in vitro, suggesting that clinical-grade Garcinia cambogia has the potential to treat calcium oxalate kidney stone. In this study, we used the Drosophila genetic and non-genetic nephrolithiasis model to evaluate the effect of Garcinia cambogia and HCA on the prevention and removal of calcium oxalate stones in vivo. Methods: WT flies were reared in fly food with different concentrations of GCE for one week．The effect of GCE on preventing the formation of calcium oxalate stone was examined. WT and v-ATPase gene knockdown flies were reared in fly food containing 0.3% NaOx for one week, then fed different concentrations of GCE for one week．The effect of GCE on the removal of calcium oxalate stone was examined. Findings: Garcinia cambogia extract efficiently removes calcium oxalate kidney stones from Malpighian tubules in both genetic and non-genetic Drosophila models of nephrolithiasis in vivo. HCA directly dissolves calcium oxalate stones in Drosophila Malpighian tubules ex vivo. Interpretation: Clinical-grade Garcinia cambogia extract removes calcium oxalate kidney stones from Drosophila Malpighian tubules via directly dissolving calcium oxalate stones by HCA. Our study strongly suggests that clinical-grade Garcinia cambogia extract could be used to treat patients with nephrolithiasis in the future. Funding Statement: F.J.Z. was supported by grants from National Key Research Plan (2017YFA0104602) and F.F.H was supported by the National Key Technology Support Program of China (2013BAI09B06 and 2015BAI2B07), the State Key Program of National Natural Science Foundation of China (81430016), the Major International (Regional) Joint Research Project of National Natural Science Foundation of China (81620108003), the Major Scientific and Technological Planning Project of Guangzhou (15020010), and the Guangzhou Clinical Research Center for Chronic Kidney Disease Program (7415695988305). Declaration of Interests: The authors declare that they have no competing interests. Ethics Approval Statement: The authors state: "Not applicable"
Mitsuhiro Furuse - One of the best experts on this subject based on the ideXlab platform.
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dietary Garcinia cambogia does not modify skin properties of mice with or without excessive sucrose intake
Phytotherapy Research, 2005Co-Authors: Daichi Oikawa, Kohsuke Hayamizu, Hachidai Hirakawa, Yoshinori Nakamura, Nobuya Shiba, Tomonori Nakanishi, Hisao Iwamoto, Tetsuya Tachibana, Mitsuhiro FuruseAbstract:The influence of 3.3% Garcinia cambogia extract on the properties of mouse skin with or without 10% sucrose water loading was investigated. Mice (7-week-old) were given free access to a control diet or a diet containing Garcinia cambogia extract. They were also given water alone or both water and sucrose water. Their skin was compared by both biochemical and histological methods. The collagen and triacylglycerol contents were not significantly different among the four groups. Similarly, electron microscopy revealed no differences in the thickness of the dermis layer or the subcutaneous tissue layer. Mice given the diet containing Garcinia cambogia tended to have a reduced total number of adipocytes, but not significantly. These results suggest that Garcinia cambogia supplementation for at least 4 weeks does not induce a negative effect on skin properties in mice irrespective of excessive sucrose intake.
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effects of Garcinia cambogia hydroxycitric acid on visceral fat accumulation a double blind randomized placebo controlled trial
Current Therapeutic Research-clinical and Experimental, 2003Co-Authors: Kohsuke Hayamizu, Yuri Ishii, Izuru Kaneko, Manzhen Shen, Yasuhide Okuhara, Norihiro Shigematsu, Mitsuhiro Furuse, Hironori Tomi, Gen Yoshino, Hiroyuki ShimasakiAbstract:Background: (-)-Hydroxycitric acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. Objective: The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist–hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty acid). Methods: This study was performed according to a double-blind, randomized, placebo-controlled, parallel-group design. Subjects aged 20 to 65 years with a visceral fat area 90 cm 2 were enrolled. Subjects were randomly assigned to receive treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day) or placebo. At the end of the treatment period, both groups were administered placebo for 4 weeks to assess any rebound effect. Each subject underwent a computed tomography scan at the umbilical level at –2, 0, 12, and 16 weeks. Results: Forty-four subjects were randomized at baseline, and 39 completed the study (G cambogia group, n 18; placebo group, n 21). At 16 weeks, the G cambogia group had significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group (all indices P 0.001). No severe adverse effect was observed at any time in the test period. There were no
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effect of Garcinia cambogia extract on serum leptin and insulin in mice
Fitoterapia, 2003Co-Authors: Kohsuke Hayamizu, Daichi Oikawa, Hachidai Hirakawa, Tomonori Nakanishi, Tetsuya Tachibana, Tomo Takagi, Mitsuhiro FuruseAbstract:In this study we examined the effects of 3.3% Garcinia cambogia extract on 10% sucrose loading in mice for 4 weeks. Treatment was found to have no effect on body weight, fat pad weight or serum glucose level. On the other hand, serum total cholesterol, triglycerides, NEFA were observed. Levels of serum insulin and leptin, as well as the leptin/WAT ratio, were lower in the treated mice than in the control. These findings suggested that G. cambogia extract efficiently improved glucose metabolism and displayed leptin-like activity.
Taesun Park - One of the best experts on this subject based on the ideXlab platform.
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Garcinia cambogia extract ameliorates visceral adiposity in c57bl 6j mice fed on a high fat diet
Bioscience Biotechnology and Biochemistry, 2008Co-Authors: Keun Young Kim, Hye Nam Lee, Yun Jung Kim, Taesun ParkAbstract:The aim of present study is to evaluate the effects of Garcinia cambogia on the mRNA levels of the various genes involved in adipogenesis, as well as on body weight gain, visceral fat accumulation, and other biochemical markers of obesity in obesity-prone C57BL/6J mice. Consumption of the Garcinia cambogia extract effectively lowered the body weight gain, visceral fat accumulation, blood and hepatic lipid concentrations, and plasma insulin and leptin levels in a high-fat diet (HFD)-induced obesity mouse model. The Garcinia cambogia extract reversed the HFD-induced changes in the expression pattern of such epididymal adipose tissue genes as adipocyte protein aP2 (aP2), sterol regulatory element-binding factor 1c (SREBP1c), peroxisome proliferator-activated receptor gamma2 (PPARgamma2), and CCAT/enhancer-binding protein alpha (C/EBPalpha). These findings suggest that the Garcinia cambogia extract ameliorated HFD-induced obesity, probably by modulating multiple genes associated with adipogenesis, such as aP2, SREBP1c, PPARgamma2, and C/EBPalpha in the visceral fat tissue of mice.
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a mixture of the aqueous extract of Garcinia cambogia soy peptide and l carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet
Genes and Nutrition, 2008Co-Authors: Yun Jung Kim, Keun Young Kim, Minsun Kim, Jin Hee Lee, Kang Pyo Lee, Taesun ParkAbstract:The aim of the present study was to investigate the anti-obesity effect of a mixture composed of Garcinia cambogia extract, soypeptide, and l-carnitine (1.2:0.3:0.02, w/w/w) in rats rendered obese by a high-fat diet (HFD). Sprague-Dawley rats were fed either the high-fat control diet (CD) or the 0.38% mixture-supplemented HFD (CD + M) for 9 weeks. The mixture significantly reduced body weight gain and the accumulation of visceral fat mass in a rat model of HFD-induced obesity. Moreover, the mixture effectively lowered blood and hepatic lipid concentrations and serum glucose, insulin, c-peptide, and leptin levels in rats with HFD-induced obesity. Results from real-time reverse transcription-polymerase chain reaction analyses indicated that the expression levels of leptin, tumor necrosis factor-alpha (TNF-α), and sterol regulatory element binding protein 1c (SREBP1c) genes in the epididymal fat tissue of rats fed the CD + M diet were 0.4-, 0.6-, and 0.48-fold, respectively, of those found in the CD rats (P < 0.05), while expression of the uncoupling protein 2 (UCP2) gene in epididymal adipose tissue was 1.25-fold (P < 0.05) of that found in CD rats. In conclusion, a mixture composed of G. cambogia extract, soy peptide, and l-carnitine attenuated visceral fat accumulation and improved dyslipidemia in a rat model with HFD-induced obesity.
Abraham Zachariah - One of the best experts on this subject based on the ideXlab platform.
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evaluation and characterization of malabar tamarind Garcinia cambogia gaertn desr seed oil
Journal of Food Science and Technology-mysore, 2015Co-Authors: Tharachand Choppa, Chinnadurai Immanuel Selvaraj, Abraham ZachariahAbstract:The objective of this study is to evaluate the chemical compounds present in the Malabar tamarind seed oil. The oil was extracted from the seeds of Malabar tamarind fruits collected from NBPGR Regional station, Thrissur. The seeds yielded 46.5 % of oil. Parameters such as the peroxide value, iodine value, saponification value, and acid value of the extracted Malabar tamarind seed oil were determined. These values were used to predict the quality of fatty acid methyl esters present in the oil. UV absorption spectroscopy of the oil showed hypsochromic shift, and the maximum absorbance was at 269 nm. The Fourier Transform Infrared Spectrum revealed the presence of olefin hydrogen and carbonyl group of ester compounds in the oil sample. The evaluation of the chemical compounds in the oil using gas chromatography coupled with mass spectrometry (GC-MS) revealed that, a total of five fatty acid methyl esters were present in the oil sample. Among the five fatty acid esters present in the Malabar tamarind seed oil, Methyl 16-methyl heptadecanoate (54.57 %) was found to be the predominant compound. This study also supports the presence of olefins in the long chain fatty acids from Nuclear Magnetic Resonance (NMR) data. There is a significant correlation between the properties and the characteristic profile of the oil sample. This study is the first report that shows Malabar tamarind as a promising source of oil seeds.
