The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Yuji Matsuzawa - One of the best experts on this subject based on the ideXlab platform.
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the concept of metabolic syndrome contribution of Visceral Fat accumulation and its molecular mechanism
Journal of Atherosclerosis and Thrombosis, 2011Co-Authors: Yuji Matsuzawa, Tohru Funahashi, Tadashi NakamuraAbstract:Although abdominal obesity or Visceral obesity is considered to be one of the components of metabolic syndrome and to have an important role in a cluster of cardiovascular risks, there is no consensus about the definition and diagnostic criteria for this syndrome, probably because there is considerable disagreement about the location and definition of abdominal obesity or Visceral obesity.In this review article, the important role of Visceral Fat accumulation in the development of a variety of lifestyle-related diseases is shown, including cardiovascular disease based on our clinical studies using CT scans, and the mechanism of these disorders is discussed, focusing on adipocytokines, especially adiponectin.The importance of diagnosing metabolic syndrome, in which Visceral Fat accumulation plays an essential role in the development of multiple risk factors, should be emphasized because lifestyle modification for the reduction of Visceral Fat may be very effective for the reduction of risks of this type, namely metabolic syndrome in the narrow sense.
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relationship between Visceral Fat accumulation and urinary albumin creatinine ratio in middle aged japanese men
Atherosclerosis, 2010Co-Authors: Sachiko Tamba, Hitoshi Nishizawa, Yukiyoshi Okauchi, Tomoko Ogawa, Midori Noguchi, Hideaki Nakatsuji, Ken Kishida, Akihisa Imagawa, Tadashi Nakamura, Yuji MatsuzawaAbstract:Abstract Objective Chronic kidney disease including microalbuminuria relates to cardiovascular disease (CVD). Microalbuminuria is also known to be a marker of generalized endothelial dysfunction. The metabolic syndrome which encompasses Visceral Fat accumulation and various metabolic disorders, has also an increase in albuminuria and relates to CVD. However, the relationship between Visceral Fat accumulation and albuminuria remains to be defined. The present study investigated the relationship between Visceral Fat accumulation and urinary albumin-creatinine ratio (UACR) in Japanese men. Methods This study group comprised 1990 Japanese male subjects, who were employees of a city office, had undergone annual health check-up. Urinary albumin was collected from a single spot urine specimen collected anytime between morning and afternoon. Visceral Fat area was estimated (eVFA) by the bioelectrical impedance analysis method. Results Log-UACR correlated with age, log-body mass index (BMI), log-waist circumference (WC), log-eVFA, log-adiponectin, blood pressure, serum lipids and hemoglobin A1c (HbA1c). Stepwise multiple regression analysis identified log-eVFA, as well as HbA1c, blood pressure, log-TG, and age, as a significant determinant of log-UACR. Moreover, subjects with eVFA ≥100cm 2 had significantly higher UACR than those with eVFA 2 , irrespective of BMI. UACR was significantly worse in subjects with high numbers of metabolic risk factors, and moreover in subjects with eVFA ≥100cm 2 than in those with eVFA 2 . Conclusion These results suggested that Visceral Fat accumulation is associated with an increase in UACR. Evaluation of both Visceral Fat accumulation and urinary albumin may be important for preventing atherosclerotic diseases.
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one year reductions in body weight and blood pressure but not in Visceral Fat accumulation and adiponectin improve urinary albumin to creatinine ratio in middle aged japanese men
Diabetes Care, 2010Co-Authors: Hideaki Nakatsuji, Tohru Funahashi, Hitoshi Nishizawa, Yukiyoshi Okauchi, Tomoko Ogawa, Midori Noguchi, Yuji Matsuzawa, Ken Kishida, Tadashi Nakamura, Iichiro ShimomuraAbstract:Microalbuminuria has been recognized recently as a risk factor for cardiovascular diseases as well as renal failure and is often found in subjects with metabolic syndrome. The relationship between Visceral Fat accumulation and microalbuminuria, urinary albumin-to-creatinine ratio (UACR), has not been fully clarified. Our cross-sectional study demonstrated that Visceral Fat accumulation is associated with increases in UACR. However, the accompanying obesity-related risk factors, especially hemoglobin A1c (HbA1c) and elevated blood pressure, strongly increased the risk of UACR (1). We have reported that reductions in both body weight and estimated Visceral Fat area (eVFA) measured by the bioelectrical impedance analysis method (2) were accompanied by reductions in the number of obesity-related cardiovascular risk factors (3) and increases in serum levels of adiponectin (4) in our longitudinal Amagasaki Visceral Fat Study, in which intensive risk factor–oriented health promotion programs were …
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decreases in serum triacylglycerol and Visceral Fat mediated by dietary soybean β conglycinin
Journal of Atherosclerosis and Thrombosis, 2006Co-Authors: Mitsutaka Kohno, Motohiko Hirotsuka, Makoto Kito, Yuji MatsuzawaAbstract:Soy protein isolate (SPI) is known to reduce the risk of heart disease by lowering serum cholesterol and triacylglycerol (TG) levels. Soybean β-conglycinin, which is a component of SPI, might be the active ingredient that prevents and/or ameliorates lifestyle-related diseases, such as hyperlipidemia and obesity. This study aimed to determine the efficacy of soybean β-conglycinin for lowering the human serum TG level and Visceral Fat. Randomized double-blind placebo-controlled designs were used to test the effect of dietary β-conglycinin, which was taken in the form of candy. [Test 1]In order to examine the serum TG level, 138 volunteers aged 26 to 69 years with TG concentrations above 1.69 mmol/L participated in the study. The subjects were divided at random into two different groups: the test group only consumed the experimental candy containing β-conglycinin and the placebo group only consumed the placebo candy containing casein. The test period consisted of a 2-wk pre-evaluation phase to screen the participants, a 12-wk consumption period and a 4-wk post-evaluation phase. The serum TG concentrations were significantly reduced in the test group, compared with the placebo group, after consuming the experimental candy. [Test 2]In order to measure Visceral Fat by means of CT scanning, 102 volunteers aged 26 to 69 years with body mass indices (BMI) between 25 and 30 participated in the study. The subjects were divided at random into two different groups as for Test 1. The test period consisted of a 2-wk pre-evaluation phase to screen the participants, a 20-wk consumption period and a 4-wk post-evaluation phase. A significant reduction in Visceral Fat only occurred in the β-conglycinin group. This study showed that β-conglycinin is an effective food ingredient that will be of use to reduce high serum TG concentrations and to prevent obesity.
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association of Visceral Fat accumulation and plasma adiponectin with colorectal adenoma evidence for participation of insulin resistance
Clinical Cancer Research, 2005Co-Authors: Sayaka Otake, Tadashi Nakamura, Hiroaki Takeda, Yasukuni Suzuki, Tadahisa Fukui, Shinichiro Watanabe, Katsuyoshi Ishihama, Takafumi Saito, Hitoshi Togashi, Yuji MatsuzawaAbstract:Purpose: Colorectal carcinogenesis is thought to be related to abdominal obesity and insulin resistance. To investigate whether Visceral Fat accumulation contributes to colorectal carcinogenesis, we examined its accumulation and the levels of the adipose tissue–derived hormone adiponectin in Japanese patients with colorectal adenoma. Experimental Design: Fifty-one consecutive Japanese patients ages ≥40 years and with colorectal adenoma were subjected to measurement of Visceral Fat area by computed tomography scanning and plasma adiponectin concentration. The patients also underwent the 75-g oral glucose tolerance test. Insulin resistance was calculated by the homeostasis metabolic assessment (HOMA-IR) method. The controls were 52 Japanese subjects ages ≥40 years and without colorectal polyp. Cigarette smokers and subjects who consumed alcohol (≥30 g ethanol/d) were excluded. Results: The patients with colorectal adenoma showed significantly more Visceral Fat area and significantly less plasma adiponectin concentration in comparison with the controls [odds ratio (OR), 2.19; 95% confidence interval (95% CI), 1.47-3.28; P < 0.001 and OR, 0.24; 95% CI, 0.14-0.41; P < 0.001, respectively] by logistic regression analysis. HOMA-IR index was also associated with colorectal adenoma (OR 2.60; 95% CI, 1.20-5.64; P = 0.040). Visceral Fat area and adiponectin were associated with adenoma number (1, 2, ≥ 3), the size of the largest adenoma (<10 and ≥10 mm), and adenoma histology (tubular and tubulovillous/villous). Conclusions: These results suggest an association of Visceral Fat accumulation and decreased plasma adiponectin concentration with colorectal adenoma in Japanese patients. This study may offer a new insight to understanding the relationship of colorectal carcinogenesis with abdominal obesity and insulin resistance.
Tadashi Nakamura - One of the best experts on this subject based on the ideXlab platform.
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the concept of metabolic syndrome contribution of Visceral Fat accumulation and its molecular mechanism
Journal of Atherosclerosis and Thrombosis, 2011Co-Authors: Yuji Matsuzawa, Tohru Funahashi, Tadashi NakamuraAbstract:Although abdominal obesity or Visceral obesity is considered to be one of the components of metabolic syndrome and to have an important role in a cluster of cardiovascular risks, there is no consensus about the definition and diagnostic criteria for this syndrome, probably because there is considerable disagreement about the location and definition of abdominal obesity or Visceral obesity.In this review article, the important role of Visceral Fat accumulation in the development of a variety of lifestyle-related diseases is shown, including cardiovascular disease based on our clinical studies using CT scans, and the mechanism of these disorders is discussed, focusing on adipocytokines, especially adiponectin.The importance of diagnosing metabolic syndrome, in which Visceral Fat accumulation plays an essential role in the development of multiple risk factors, should be emphasized because lifestyle modification for the reduction of Visceral Fat may be very effective for the reduction of risks of this type, namely metabolic syndrome in the narrow sense.
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relationship between Visceral Fat accumulation and urinary albumin creatinine ratio in middle aged japanese men
Atherosclerosis, 2010Co-Authors: Sachiko Tamba, Hitoshi Nishizawa, Yukiyoshi Okauchi, Tomoko Ogawa, Midori Noguchi, Hideaki Nakatsuji, Ken Kishida, Akihisa Imagawa, Tadashi Nakamura, Yuji MatsuzawaAbstract:Abstract Objective Chronic kidney disease including microalbuminuria relates to cardiovascular disease (CVD). Microalbuminuria is also known to be a marker of generalized endothelial dysfunction. The metabolic syndrome which encompasses Visceral Fat accumulation and various metabolic disorders, has also an increase in albuminuria and relates to CVD. However, the relationship between Visceral Fat accumulation and albuminuria remains to be defined. The present study investigated the relationship between Visceral Fat accumulation and urinary albumin-creatinine ratio (UACR) in Japanese men. Methods This study group comprised 1990 Japanese male subjects, who were employees of a city office, had undergone annual health check-up. Urinary albumin was collected from a single spot urine specimen collected anytime between morning and afternoon. Visceral Fat area was estimated (eVFA) by the bioelectrical impedance analysis method. Results Log-UACR correlated with age, log-body mass index (BMI), log-waist circumference (WC), log-eVFA, log-adiponectin, blood pressure, serum lipids and hemoglobin A1c (HbA1c). Stepwise multiple regression analysis identified log-eVFA, as well as HbA1c, blood pressure, log-TG, and age, as a significant determinant of log-UACR. Moreover, subjects with eVFA ≥100cm 2 had significantly higher UACR than those with eVFA 2 , irrespective of BMI. UACR was significantly worse in subjects with high numbers of metabolic risk factors, and moreover in subjects with eVFA ≥100cm 2 than in those with eVFA 2 . Conclusion These results suggested that Visceral Fat accumulation is associated with an increase in UACR. Evaluation of both Visceral Fat accumulation and urinary albumin may be important for preventing atherosclerotic diseases.
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one year reductions in body weight and blood pressure but not in Visceral Fat accumulation and adiponectin improve urinary albumin to creatinine ratio in middle aged japanese men
Diabetes Care, 2010Co-Authors: Hideaki Nakatsuji, Tohru Funahashi, Hitoshi Nishizawa, Yukiyoshi Okauchi, Tomoko Ogawa, Midori Noguchi, Yuji Matsuzawa, Ken Kishida, Tadashi Nakamura, Iichiro ShimomuraAbstract:Microalbuminuria has been recognized recently as a risk factor for cardiovascular diseases as well as renal failure and is often found in subjects with metabolic syndrome. The relationship between Visceral Fat accumulation and microalbuminuria, urinary albumin-to-creatinine ratio (UACR), has not been fully clarified. Our cross-sectional study demonstrated that Visceral Fat accumulation is associated with increases in UACR. However, the accompanying obesity-related risk factors, especially hemoglobin A1c (HbA1c) and elevated blood pressure, strongly increased the risk of UACR (1). We have reported that reductions in both body weight and estimated Visceral Fat area (eVFA) measured by the bioelectrical impedance analysis method (2) were accompanied by reductions in the number of obesity-related cardiovascular risk factors (3) and increases in serum levels of adiponectin (4) in our longitudinal Amagasaki Visceral Fat Study, in which intensive risk factor–oriented health promotion programs were …
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association of Visceral Fat accumulation and plasma adiponectin with colorectal adenoma evidence for participation of insulin resistance
Clinical Cancer Research, 2005Co-Authors: Sayaka Otake, Tadashi Nakamura, Hiroaki Takeda, Yasukuni Suzuki, Tadahisa Fukui, Shinichiro Watanabe, Katsuyoshi Ishihama, Takafumi Saito, Hitoshi Togashi, Yuji MatsuzawaAbstract:Purpose: Colorectal carcinogenesis is thought to be related to abdominal obesity and insulin resistance. To investigate whether Visceral Fat accumulation contributes to colorectal carcinogenesis, we examined its accumulation and the levels of the adipose tissue–derived hormone adiponectin in Japanese patients with colorectal adenoma. Experimental Design: Fifty-one consecutive Japanese patients ages ≥40 years and with colorectal adenoma were subjected to measurement of Visceral Fat area by computed tomography scanning and plasma adiponectin concentration. The patients also underwent the 75-g oral glucose tolerance test. Insulin resistance was calculated by the homeostasis metabolic assessment (HOMA-IR) method. The controls were 52 Japanese subjects ages ≥40 years and without colorectal polyp. Cigarette smokers and subjects who consumed alcohol (≥30 g ethanol/d) were excluded. Results: The patients with colorectal adenoma showed significantly more Visceral Fat area and significantly less plasma adiponectin concentration in comparison with the controls [odds ratio (OR), 2.19; 95% confidence interval (95% CI), 1.47-3.28; P < 0.001 and OR, 0.24; 95% CI, 0.14-0.41; P < 0.001, respectively] by logistic regression analysis. HOMA-IR index was also associated with colorectal adenoma (OR 2.60; 95% CI, 1.20-5.64; P = 0.040). Visceral Fat area and adiponectin were associated with adenoma number (1, 2, ≥ 3), the size of the largest adenoma (<10 and ≥10 mm), and adenoma histology (tubular and tubulovillous/villous). Conclusions: These results suggest an association of Visceral Fat accumulation and decreased plasma adiponectin concentration with colorectal adenoma in Japanese patients. This study may offer a new insight to understanding the relationship of colorectal carcinogenesis with abdominal obesity and insulin resistance.
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a new simple method for the measurement of Visceral Fat accumulation by bioelectrical impedance
Diabetes Care, 2005Co-Authors: Kazuhisa Maeda, Tohru Funahashi, Yuji Matsuzawa, Tadashi Nakamura, Makoto Nishida, Tohru Yamaguchi, Mitsuhiro Katashima, Tomohiro Onda, Akiko Okumiya, Iichiro ShimomuraAbstract:We and others (1–9) have shown that the accumulation of Visceral Fat is associated with multiple risk factor syndrome more closely than with the BMI itself or the amount of subcutaneous Fat. In these studies, computed tomography (CT) scan at the umbilical level (10) was used for the assessment of Visceral Fat area (VFA). However, the method is not cost-effective and/or radiation exposure is problematic; thus, it is often unsuitable for screening large groups of individuals. There is a need for a simple and noninvasive method to assess Visceral Fat accumulation. The bioelectrical impedance analysis (BIA) method, which is based on the electric resistance difference between the Fat and components of other organs (11–14), should meet this need. Conventional BIA approaches have estimated total Fat content but not regional Fat distribution (11–13). Recently, attempts to assess the amount of abdominal subcutaneous Fat by the local BIA method were reported (14). Here, we developed a new technique to specifically evaluate VFA by using the abdominal BIA method. The study subjects were 59 healthy volunteers and 32 inpatients with suspected cardiovascular disease at Osaka University Hospital. Waist circumference (Wc) at the umbilical level was measured in the late exhalation phase while standing. All subjects underwent the abdominal BIA method to estimate VFA. The voltage occurring at the flank to the flow of current between the umbilicus and the back correlates significantly …
Iichiro Shimomura - One of the best experts on this subject based on the ideXlab platform.
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one year reductions in body weight and blood pressure but not in Visceral Fat accumulation and adiponectin improve urinary albumin to creatinine ratio in middle aged japanese men
Diabetes Care, 2010Co-Authors: Hideaki Nakatsuji, Tohru Funahashi, Hitoshi Nishizawa, Yukiyoshi Okauchi, Tomoko Ogawa, Midori Noguchi, Yuji Matsuzawa, Ken Kishida, Tadashi Nakamura, Iichiro ShimomuraAbstract:Microalbuminuria has been recognized recently as a risk factor for cardiovascular diseases as well as renal failure and is often found in subjects with metabolic syndrome. The relationship between Visceral Fat accumulation and microalbuminuria, urinary albumin-to-creatinine ratio (UACR), has not been fully clarified. Our cross-sectional study demonstrated that Visceral Fat accumulation is associated with increases in UACR. However, the accompanying obesity-related risk factors, especially hemoglobin A1c (HbA1c) and elevated blood pressure, strongly increased the risk of UACR (1). We have reported that reductions in both body weight and estimated Visceral Fat area (eVFA) measured by the bioelectrical impedance analysis method (2) were accompanied by reductions in the number of obesity-related cardiovascular risk factors (3) and increases in serum levels of adiponectin (4) in our longitudinal Amagasaki Visceral Fat Study, in which intensive risk factor–oriented health promotion programs were …
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systemic oxidative stress is associated with Visceral Fat accumulation and the metabolic syndrome
Circulation, 2006Co-Authors: Koichi Fujita, Tohru Funahashi, Hitoshi Nishizawa, Iichiro Shimomura, Michio ShimabukuroAbstract:Background The metabolic syndrome (MetS) is a major target for prevention of atherosclerotic cardiovascular diseases and Visceral Fat accumulation is an underlying component of MetS. The aim of this study was to investigate the association of systemic oxidative stress with Visceral Fat accumulation and MetS. Methods and Results The study group consisted of Japanese men (n=44; 51.2±11.4 years) and women (n=61; 55.4 ±13.4 years). Urinary 8-epi-prostaglandin F2α (8-epi-PGF2 α) concentration, a biomarker of systemic oxidative stress, was significantly high in the subjects with MetS. As the urinary concentration of 8-epi-PGF2α increased, the number of criteria for MetS were significantly met (abdominal obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and high fasting glucose). Among parameters associated with MetS, the correlation coefficient of Visceral Fat area (VFA) with urinary 8-epi-PGF2α concentration was the highest (r=0.636, p<0.0001). In non-obese subjects, the correlation coefficient of VFA with urinary 8-epi-PGF2α concentration was higher (r=0.728, p<0.0001), although there was no significant correlation between subcutaneous Fat area and urinary 8-epi-PGF2 α. Stepwise multiple regression analysis identified VFA as the strongest and independent determinant of urinary 8-epi-PGF2 α (p<0.0001) followed by adiponectin (p=0.0212) and, high sensitive C-reactive protein (p=0.0365). Conclusions Systemic oxidative stress, as measured by urinary 8-epi-PGF2α , is strongly associated with Visceral Fat accumulation and MetS. (Circ J 2006; 70: 1437 - 1442)
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a new simple method for the measurement of Visceral Fat accumulation by bioelectrical impedance
Diabetes Care, 2005Co-Authors: Kazuhisa Maeda, Tohru Funahashi, Yuji Matsuzawa, Tadashi Nakamura, Makoto Nishida, Tohru Yamaguchi, Mitsuhiro Katashima, Tomohiro Onda, Akiko Okumiya, Iichiro ShimomuraAbstract:We and others (1–9) have shown that the accumulation of Visceral Fat is associated with multiple risk factor syndrome more closely than with the BMI itself or the amount of subcutaneous Fat. In these studies, computed tomography (CT) scan at the umbilical level (10) was used for the assessment of Visceral Fat area (VFA). However, the method is not cost-effective and/or radiation exposure is problematic; thus, it is often unsuitable for screening large groups of individuals. There is a need for a simple and noninvasive method to assess Visceral Fat accumulation. The bioelectrical impedance analysis (BIA) method, which is based on the electric resistance difference between the Fat and components of other organs (11–14), should meet this need. Conventional BIA approaches have estimated total Fat content but not regional Fat distribution (11–13). Recently, attempts to assess the amount of abdominal subcutaneous Fat by the local BIA method were reported (14). Here, we developed a new technique to specifically evaluate VFA by using the abdominal BIA method. The study subjects were 59 healthy volunteers and 32 inpatients with suspected cardiovascular disease at Osaka University Hospital. Waist circumference (Wc) at the umbilical level was measured in the late exhalation phase while standing. All subjects underwent the abdominal BIA method to estimate VFA. The voltage occurring at the flank to the flow of current between the umbilicus and the back correlates significantly …
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enhanced expression of pai 1 in Visceral Fat possible contributor to vascular disease in obesity
Nature Medicine, 1996Co-Authors: Iichiro Shimomura, T Funahashi, Masahiko Takahashi, Kazuhisa Maeda, Kazuaki Kotani, T Nakamura, Shizuya Yamashita, M Miura, Y Fukuda, Kaoru TakemuraAbstract:The presence of obesity increases the risk of thrombotic vascular diseases. The role of Fat accumulation and its effect on plasminogen activator inhibitor-1 (PAI-1) levels was investigated in humans and animals. Plasma PAI-1 levels were closely correlated with Visceral Fat area but not with subcutaneous Fat area in human subjects. PAI-1 mRNA was detected in both types of Fat tissue in obese rats but increased only in Visceral Fat during the development of obesity. These data suggest that an enhanced expression of the PAI-1 gene in Visceral Fat may increase plasma levels and may have a role in the development of vascular disease in Visceral obesity.
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contribution of Visceral Fat accumulation to the development of coronary artery disease in non obese men
Atherosclerosis, 1994Co-Authors: Tadashi Nakamura, Iichiro Shimomura, Kazuaki Kotani, Katsuto Tokunaga, Makoto Nishida, Shingo Yoshida, A Waliul H M Islam, Y Keno, T Kobatake, Yoshiyuki NagaiAbstract:Associations between intra-abdominal Visceral Fat accumulations and coronary risk factors were studied in a sample of 29 non-obese men aged 57 ± 10 years with coronary artery disease (CAD). Their body mass indexes (BMI) were 23.8 ± 1.5 (range 18.7–26.3). The Visceral Fat area (VFA) and the subcutaneous Fat area (SFA) were measured at the level of the umbilicus by computed tomography. In patients with CAD, the average VFA was significantly increased compared with that in 54 control subjects without CAD, matched for sex, age, and BMI (117.2 ± 53.1 vs. 93.8 ± 38.6 cm2, P < 0.05). However, their average SFA was not statistically different (111.2 ± 33.3 vs. 106.3 ± 35.7 cm2, N.S.). Eleven CAD patients (38%) and nine control subjects (17%) had greater than 2S. D. higher than the mean VFA obtained from 22 healthy subjects extracted from the control subjects. Accordingly, the proportion of the subjects with high VFA was significantly higher in the CAD group. This group also had significantly higher levels of plasma glucose and insulin areas than controls determined by oral glucose tolerance tests. This may be due to insulin resistance. The proportion of the subjects with multiple risk factors including hyperlipidemia, hyperglycemia, and hypertension was significantly higher in the CAD patients with high VFA compared with the control subjects with normal VFA (CAD with high VFA 82% and control with normal VFA 33%). These findings suggest that Visceral Fat accumulations may play an important role in the occurrence of CAD regardless of obesity. Accordingly, we propose the term ‘Visceral Fat syndrome’, which encompasses Visceral Fat accumulation, glucose intolerance, hyperlipidemia, and hypertension. Patients with this syndrome have increased susceptibility to coronary sclerosis from these risk factors based on Visceral Fat accumulation.
Tamara B Harris - One of the best experts on this subject based on the ideXlab platform.
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the influence of abdominal Visceral Fat on inflammatory pathways and mortality risk in obstructive lung disease
The American Journal of Clinical Nutrition, 2012Co-Authors: Bram Van Den Borst, Harry R Gosker, Annemarie Koster, Binbing Yu, Stephen B Kritchevsky, Bernd Meibohm, Thomas B Rice, Michael G Shlipak, Sachin Yende, Tamara B HarrisAbstract:Background: Low-grade systemic inflammation, particularly elevated IL-6, predicts mortality in chronic obstructive pulmonary disease (COPD). Although altered body composition, especially increased Visceral Fat (VF) mass, could be a significant contributor to low-grade systemic inflammation, this remains unexplored in COPD. Objective: The objective was to investigate COPD-specific effects on VF and plasma adipocytokines and their predictive value for mortality. Design: Within the Health, Aging, and Body Composition (Health ABC) Study, an observational study in community-dwelling older persons, we used propensity scores to match n = 729 persons with normal lung function to n = 243 persons with obstructive lung disease (OLD; defined as the ratio of forced expiratory volume in 1 s to forced vital capacity < lower limit of normal). Matching was based on age, sex, race, clinic site, BMI, and smoking status. Within this well-balanced match, we compared computed tomography–acquired Visceral Fat area (VFA) and plasma adipocytokines, analyzed independent associations of VFA and OLD status on plasma adipocytokines, and studied their predictive value for 9.4-y mortality. Results: Whereas whole-body Fat mass was comparable between groups, persons with OLD had increased VFA and higher plasma IL-6, adiponectin, and plasminogen activator inhibitor 1 (PAI-1). Both OLD status and VFA were independently positively associated with IL-6. Adiponectin was positively associated with OLD status but negatively associated with VFA. PAI-1 was no longer associated with OLD status after VFA was accounted for. Participants with OLD had increased risk of all-cause, respiratory, and cardiovascular mortality, of which IL-6 was identified as an independent predictor. Conclusion: Our data suggest that excessive abdominal Visceral Fat contributes to increased plasma IL-6, which, in turn, is strongly associated with all-cause and cause-specific mortality in older persons with OLD.
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waist circumference and sagittal diameter reflect total body Fat better than Visceral Fat in older men and women the health aging and body composition study
Annals of the New York Academy of Sciences, 2006Co-Authors: Tamara B Harris, F Tylavsky, Marjolein Visser, T. Fuerst, Jane A Cauley, James E Everhart, Mauro Zamboni, Dennis R Taaffe, Helaine E Resnick, Ann ScherzingerAbstract:: The validity of waist circumference and sagittal diameter as surrogate measures of Visceral Fat were assessed using preliminary cross-sectional data from the Health, Aging and Body Composition Study, a cohort of 3,075 men and women aged 70–79. Weight, body mass index, waist circumference, waist/thigh ratio, and sagittal diameter were compared by correlation, graphical analysis, and regression to total body Fat as measured by dual-energy X-ray absorptiometry (Hologic 4500A), and to Visceral Fat area as measured by computerized tomography. We included 2,830 persons, 1,439 women and 1,391 men with complete data on all measurements. For both men and women, all measurements were strongly correlated with both total body Fat and Visceral Fat except the waist/thigh ratio. However, waist circumference, sagittal diameter, weight, and body mass index were more closely related to total body Fat than to Visceral Fat area (R2 for the linear regression of waist circumference on total body Fat was 0.69 in women and men; R2 for linear regression of waist circumference on Visceral Fat area was 0.40 in women, and 0.49 in men). These data suggest that the contribution of Visceral Fat to health risks will be better assessed by directly measuring this Fat depot.
Masanori Nishinaga - One of the best experts on this subject based on the ideXlab platform.
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abdominal Visceral Fat thickness measured by ultrasonography predicts the presence and severity of coronary artery disease
Ultrasound in Medicine and Biology, 2010Co-Authors: Kosuke Hamagawa, Yoshihisa Matsumura, Toru Kubo, Kayo Hayato, Makoto Okawa, Katsutoshi Tanioka, Naohito Yamasaki, Hiroaki Kitaoka, Toshikazu Yabe, Masanori NishinagaAbstract:Abdominal Visceral Fat plays a critical role in the pathogenesis of metabolic syndrome, which is a risk factor for coronary artery disease (CAD). Ultrasonography (US) distinctively quantifies Visceral Fat and subcutaneous Fat. We measured the maximum preperitoneal Visceral Fat thickness (Vmax) and the minimum subcutaneous Fat thickness (Smin) by US in 185 patients who underwent coronary angiography. Although the 144 patients with CAD had larger Vmax (8.8 ± 3.6 vs. 6.4 ± 2.8 mm; p < 0.001) than those without, there was no difference in Smin. Vmax of 6.9 mm or higher was an independent predictor of CAD (odds ratio, 3.710, p = 0.008) by multiple logistic regression analysis. Vmax significantly correlated with the number of diseased vessels. Assessment of abdominal Visceral Fat by US gives us incremental information beyond conventional risk factors for predicting CAD in routine clinical practice. (E-mail: matsumur@kochi-u.ac.jp)
