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Rui Wang - One of the best experts on this subject based on the ideXlab platform.
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A Study on the Antioxidant Activities in Different Parts of Gardenia jasminoides
2019Co-Authors: Rui Wang, Yaqin WeiAbstract:OBJECTIVE: The experiment attempts to study the antioxidant activity in different parts of Gardenia jasminoides including roots, stems, leaves, branches, flowers and fruits to explore the development and utilization of new medicinal parts of Gardenia jasminoides. METHODS: Apply microwave-assisted extraction( MAE) to extract total flavonoids from different parts of Gardenia jasminoides including roots, leaves, fruits, flowers and stems and register the ethanol concentration, extraction temperature and extraction time of microwave-assisted extraction.RESULT: The total polyphenols content in different parts of Gardenia jasminoides was arranged from high to low as: leaves, branches, fruits, flowers, stems, roots; the total flavonoids content in different parts of Gardenia jasminoides was arranged from high to low as: leaves, Branches, fruits, stems, roots, flowers; the DPPH radical scavenging activity(IC50) in different parts of Gardenia jasminoides was arranged from high to low as: leaves, branches, fruits, flowers, stems, roots; the dry extract rate was arranged from high to low as: fruits, leaves, branches, flowers, stems, roots.
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Gardenia jasminoides has therapeutic effects on l nna induced hypertension in vivo
Molecular Medicine Reports, 2017Co-Authors: Shaocheng Chen, Xin Zhao, Jun Qian, Yanhong Shi, Peng Sun, Rui WangAbstract:Gardenia jasminoides is a plant that has been used in traditional Chinese medicine. It has four key active components (genipin gentiobioside, geniposide, crocin 1 and crocin 2). The aim of the present study was to determine the anti‑hypertension effects of Gardenia jasminoidesin vivo. The chemical composition of Gardenia jasminoides was determined using liquid chromatography. The anti‑hypertensive effects of Gardenia jasminoides were determined by a L‑NG‑nitroarginine (L‑NNA)‑induced hypertension animal model. Both Gardenia jasminoides plants of the Jiangjin County variety (CJGJ) and the Lichuan City variety (HLGJ) were used. HLGJ contained more geniposide than CJGJ. L‑NNA was used to induce hypertension in mice, and the mice were subsequently treated with CJGJ and HLGJ. The Gardenia jasminoides‑treated mice exhibited lower systolic (SBP), diastolic (DBP) and mean blood pressure (MBP) than the experimental control mice. Additionally, HLGL has a more potent effect on SBP, MBP and DBP than CJGJ. Following Gardenia jasminoides treatment, the nitric oxide contents in serum, heart, liver, kidney and stomach of mice were higher than the L‑NNA‑induced control mice, and the malondialdehyde contents were lower; the levels in HLGJ‑treated mice were closer to those normal mice than the levels in CJGJ‑treated mice were. Serum levels of endothelin‑1 and vascular endothelial growth factor were reduced by HLGJ treatment in hypertensive mice, whereas the calcitonin gene‑related peptide level was raised. Reverse transcription‑polymerase chain reaction analysis of mouse heart and vessel tissue demonstrated that HLGJ‑treated mice exhibited higher heme oxygenase‑1, neuronal nitric oxide synthase (nNOS), endothelial NOS, Bax, caspase‑3, caspase‑8, caspase‑9 mRNA expression levels and lower adrenomedullin, receptor activity modifying protein, interleukin‑1β, tumor necrosis factor‑α, inducible NOS, Bcl‑2, monocyte chemoattractant protein‑1, nuclear factor‑κB and matrix metalloproteinase‑2 and ‑9 mRNA expression compared with control hypertensive mice and CJGJ‑treated mice. In conclusion, Gardenia jasminoides has anti‑hypertensive effects, and these effects may be associated with the active component, geniposide.
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Gardenia jasminoides has therapeutic effects on L‑NNA‑induced hypertension in vivo
Molecular medicine reports, 2017Co-Authors: Shaocheng Chen, Xin Zhao, Jun Qian, Yanhong Shi, Peng Sun, Rui WangAbstract:Gardenia jasminoides is a plant that has been used in traditional Chinese medicine. It has four key active components (genipin gentiobioside, geniposide, crocin 1 and crocin 2). The aim of the present study was to determine the anti‑hypertension effects of Gardenia jasminoidesin vivo. The chemical composition of Gardenia jasminoides was determined using liquid chromatography. The anti‑hypertensive effects of Gardenia jasminoides were determined by a L‑NG‑nitroarginine (L‑NNA)‑induced hypertension animal model. Both Gardenia jasminoides plants of the Jiangjin County variety (CJGJ) and the Lichuan City variety (HLGJ) were used. HLGJ contained more geniposide than CJGJ. L‑NNA was used to induce hypertension in mice, and the mice were subsequently treated with CJGJ and HLGJ. The Gardenia jasminoides‑treated mice exhibited lower systolic (SBP), diastolic (DBP) and mean blood pressure (MBP) than the experimental control mice. Additionally, HLGL has a more potent effect on SBP, MBP and DBP than CJGJ. Following Gardenia jasminoides treatment, the nitric oxide contents in serum, heart, liver, kidney and stomach of mice were higher than the L‑NNA‑induced control mice, and the malondialdehyde contents were lower; the levels in HLGJ‑treated mice were closer to those normal mice than the levels in CJGJ‑treated mice were. Serum levels of endothelin‑1 and vascular endothelial growth factor were reduced by HLGJ treatment in hypertensive mice, whereas the calcitonin gene‑related peptide level was raised. Reverse transcription‑polymerase chain reaction analysis of mouse heart and vessel tissue demonstrated that HLGJ‑treated mice exhibited higher heme oxygenase‑1, neuronal nitric oxide synthase (nNOS), endothelial NOS, Bax, caspase‑3, caspase‑8, caspase‑9 mRNA expression levels and lower adrenomedullin, receptor activity modifying protein, interleukin‑1β, tumor necrosis factor‑α, inducible NOS, Bcl‑2, monocyte chemoattractant protein‑1, nuclear factor‑κB and matrix metalloproteinase‑2 and ‑9 mRNA expression compared with control hypertensive mice and CJGJ‑treated mice. In conclusion, Gardenia jasminoides has anti‑hypertensive effects, and these effects may be associated with the active component, geniposide.
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Anticancer effects of Gardenia jasminoides in HepG2 human hepatoma cells
Biomedical Research-tokyo, 2017Co-Authors: Shaocheng Chen, Xin Zhao, Jun Qian, Yanhong Shi, Rui WangAbstract:Background: Gardenia jasminoides is a natural plant, it has many biological activities. Its ability of cancer cell apoptosis needs to be researched. Methods: In this study, the important biological activity materials were determined by high efficiency liquid chromatography. The in vitro anticancer effects were measured by MTT and RT-PCR assays in HepG2 human hepatoma cells. Results: Gardenia jasminoides contained 1.03% genipin gentiobioside, 5.90% gardenoside, 1.26% crocin 1 and 0.17% crocin 2. Gardenia jasminoides had significantly strong HepG2 cells inhibitory effects, and highest effect 80.2% is showed in 400 μg/mL concentration of Gardenia jasminoides which is remarkable. the Gardenia jasminoides also have the ability to increase the mRNA expression of caspase-3, caspase-8, caspase-9, Bax, TRAIL, Fas, Fas/FasL, p53, p21, IκB-α and decrease the Bcl-2, BclxL, XIAP, cIAP-1, cIAP-2, survivin, NF-κB expression in HepG2 cells. The higher concentration of Gardenia jasminoides also showed the higher increasing or decreasing mRNA expression effects in HepG2 cells. Conclusion: Gardenia jasminoides had a strong anticancer effect through its apoptosis inducing abilities in hepatic cancer; it could be used for the treatment as a medicine or health product in daily human life for good liver health.
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preventive effect of Gardenia jasminoides on hcl ethanol induced gastric injury in mice
Journal of Pharmacological Sciences, 2017Co-Authors: Shaocheng Chen, Xin Zhao, Jun Qian, Yanhong Shi, Peng Sun, Rui WangAbstract:The therapeutic effect on HCl/ethanol induced gastric injury of Gardenia jasminoides (JXGJ-1 and JXGJ-2) were determined by a animal model. JXGJ-2 group reduced area of its gastric injury as compared to the control group, JXGJ-2 also helped in decreasing the gastric secretion volume results raised in pH value. The NO contents in serum, heart, liver, kidney and stomach of JXGJ-2 group were more than JXGJ-1 and control groups. JXGJ-2 reduce cytokine levels as compared to JXGJ-1 and control group. The serum and gastric tissue SOD, GSH-Px, GSH levels in JXGJ-2 treated mice were higher than JXGJ-1 treated and control mice, but the MDA, PC levels showed the crosscurrents, these levels were close to normal mice. Gardenia jasminoides could increase the occludin, EGF, EGFR, VEGF, IκB-α, nNOS, eNOS, Cu/Zn-SOD, Mn-SOD, CAT, GSH-Px (GSH1) mRNA and protein expressions and decrease the p38MAPK (p38), NF-κB, Bcl-2, COX-2, iNOS expressions in gastric tissues unlike to the control mice, JXGJ-2 had much better effect than JXGJ-1. JXGJ-1contained the higher genipin gentiobioside and gardenoside, they might be the key components of gastric injury inhibition. Gardenia jasminoides had a remarkable effect on gastric injury, and they were derived from two important components of genipin gentiobioside and gardenoside.
Weigang Wang - One of the best experts on this subject based on the ideXlab platform.
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Gardenia jasminoides Ellis: Ethnopharmacology, phytochemistry, and pharmacological and industrial applications of an important traditional Chinese medicine.
Journal of Ethnopharmacology, 2020Co-Authors: Liping Chen, Wendi Tao, Xiuyu Tian, Zhiqiang Yang, Peng Wang, Weigang WangAbstract:Abstract Ethnopharmacological relevance Gardenia jasminoides Ellis is a popular shrub in the Rubiaceae family. The desiccative ripe fruits of this plant (called Zhizi in China) are well known and frequently used not only as an excellent natural colourant, but also as an important traditional medicine for the treatment of different diseases, such as reducing fire except vexed, clearing away heat evil, and cooling blood and eliminating stasis to activate blood circulation. It has also been declared as the first batch of dual-purpose plants used for food and medical functions in China. Aim of the study: This review aims to provide a critical and systematic summary of the traditional uses, ethnopharmacology, phytochemistry, pharmacology, toxicity and industrial applications of Gardenia jasminoides Ellis and briefly proposes several suggestions for future application prospects. Materials and methods The related information on Gardenia jasminoides Ellis was obtained from internationally recognized scientific databases through the Internet (PubMed, CNKI, Google Scholar, Baidu Scholar, Web of Science, Medline Plus, ACS, Elsevier and Flora of China) and libraries. Results Approximately 162 chemical compounds have been isolated and identified from this herb. Among them, iridoid glycosides and yellow pigment are generally considered the main bioactive and characteristic ingredients. Various pharmacological properties, such as a beneficial effect on the nervous, cardiovascular and digestive systems, hepatoprotective activity, antidepressant activity, and anti-inflammatory activity, were also validated in vitro and in vivo. Moreover, geniposide and genipin are the most important iridoid compounds isolated from Gardenia jasminoides Ellis, and genipin is the aglycone of geniposide. As the predominant active ingredient with a distinct pharmacological activity, genipin is also an outstanding biological crosslinking agent. Gardenia yellow pigment has also been widely used as an excellent natural dye-stuff. Hence, Gardenia jasminoides Ellis has been applied to many other fields, including the food industry, textile industry and chemical industry, in addition to its predominant medicinal uses. Conclusions According to this review, Gardenia jasminoides Ellis is outstanding traditional medical plant used in medicine and food. Pharmacological investigations support the traditional use of this herb and may validate the folk medicinal use of Gardenia jasminoides Ellis to treat different diseases. Iridoid glycosides are potential medicines. Gardenia yellow pigment has been the most important source of a natural colourant for food, cloth and paint for thousands of years. This herb has made great contributions to human survival and development. Moreover, it has also achieved outstanding progress in human life and even in art. Although Gardenia jasminoides Ellis has extremely high and comprehensive utilization values, it is still far from being completely explored. Therefore, the comprehensive development of Gardenia jasminoides Ellis deserves further analysis.
Xin-sheng Yao - One of the best experts on this subject based on the ideXlab platform.
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Two new iridoid glycosides from the fruit of Gardenia jasminoides.
Natural Product Research, 2020Co-Authors: Yu-dan Mei, Ling-xian Liu, Cao Zeyu, Dan-feng Shi, Xin-sheng YaoAbstract:Two new iridoid glycosides, 2′-O-cis-coumaroylgardoside (1), and 6′-O-caffeoylioxide (2), were isolated from the fruit of Gardenia jasminoides. The structures of these compounds were elucidated bas...
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Two new triterpenoids from Gardenia jasminoides fruits
2018Co-Authors: Weiyang Zhang, Yingnan Jiang, Yu Zhang, Dabo Pan, Dan Zhang, Xin-sheng YaoAbstract:A new cycloartane triterpenoid, named gardenolic acid C (1), a new ursane triterpenoid, named 3β,16β,21β,23,24-pentahydroxy urs-12,18,20-trien-28-oic acid γ-lactone (2), together with three know triterpenoids, gardenolic acid A (3), gardenolic acid B (4), and 3α,16β,23,24-tetrahydroxy-28-nor-ursane-12,17,19,21-tetraen (5) were isolated from the fruits of Gardenia jasminoides Ellis. The structures of these compounds were elucidated by analyses of spectroscopic data. All isolates were evaluated for their neuroprotective effects in vitro.
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chemical constituents from the fruits of Gardenia jasminoides ellis
Fitoterapia, 2012Co-Authors: Xiaolin Feng, Hao Gao, Yi Dai, Xiao-jun Huang, Zuolei Xie, Hiroshi Kurihara, Yi Zhong, Xin-sheng YaoAbstract:Abstract A new lignan glucoside, (+)-(7S,8R,8′R)-lyoniresinol 9-O-β-D-(6″-O-trans-sinapoyl)glucopyranoside (1), and a new iridoid glucoside, 10-O-trans-sinapoylgeniposide (2), together with eight known compounds, were isolated from the fruits of Gardenia jasminoides Ellis. The structures of the isolates were elucidated by extensive spectroscopic studies, including UV, IR, 1D and 2D NMR, ESI-MS, HR-ESI-MS, and CD experiments. The short-term-memory-enhancement activities of some compounds were evaluated on an Aβ transgenic drosophila model.
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Guaiane-type sesquiterpenoid glucosides from Gardenia jasminoides Ellis.
Magnetic Resonance in Chemistry, 2011Co-Authors: Hao Gao, Gao-keng Xiao, Hua-jie Zhu, Yi Dai, Xin-sheng YaoAbstract:Two new guaiane-type sesquiterpenoid glucosides (1 and 2) were isolated from the fruit of Gardenia jasminoides Ellis. Their structures were elucidated to be (1R,7R,10S)-11-O-beta-D-glucopyranosyl-4-guaien-3-one (1) and (1R, 7R, 10S)-7-hydroxy-11-O-beta-D-glucopyranosyl-4-guaien-3-one (2) by one- and two-dimensional NMR techniques ((1)H NMR, (13)C NMR, HSQC, HMBC and NOESY), MS, CD spectrometry and chemical methods. Copyright (C) 2011 John Wiley & Sons,
Gao Xin - One of the best experts on this subject based on the ideXlab platform.
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Effect of Gardenia jasminoides Ellis on serum IL-1β and TNF-α of rheumatoid arthritis rats
Chinese Traditional Patent Medicine, 2005Co-Authors: Gao XinAbstract:AIM To study the effect of Gardenia jasminoides Ellis on serum IL-1β and TNF-α level of rheumatoid arthritis rats, as well as its mechanism. METHODS An experimental type Ⅱ collagen-induced arthritic rats was established. The inhibitory effects on paw edema were observed, and serum IL-1β and TNF-α levels were determined in experimental rats. RESULTS Compared with models, Gardenia jasminoides Ellis inhibited paw edema on rats significantly, and the levels of serum IL-1β and TNF-α showed markedly decrease by Gardenia jasminoides Ellis at high dose to medium dose( P 0.01). CONCLUSION Gardenia jasminoides Ellis could significantly lower serum IL-1β and TNF-α levels in rheumatoid arthritis rats, and its effect has a close relation with inhibitory development of rheumatoid arthritis.
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Effect of Gardenia jasminoides Ellis on serum IL-1 β and TNF-α of rheumatoid arthritis rats
2005Co-Authors: Gao XinAbstract:To study the effect of Gardenia jasminoides Ellis on serum IL-1 β and TNF-α level of rheumatoid arthritis rats,as well as the mechanism of this drug.To establish an experimental type II collagen-induced arthritic rats. The inhibitory effects on paw edema were observed, and serum IL-1 β and TNF-α levels were determined in experimental rats.Compared with modes, Gardenia jasminoides Ellis inhibited paw edema on rats significantly, and the levels of serum IL-1 β and TNF-α showed significantly decrease by Gardenia jasminoides Ellis at high dose or medium dose(P0.01).[Conclusion]Gardenia jasminoides Ellis could significantly lower serum IL-1 β and TNF-α levels in rheumatoid arthritis rats, and this effect had a close relation with inhibitory development of rheumatoid arthritis by the agent.
Tunghu Tsai - One of the best experts on this subject based on the ideXlab platform.
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Identification and determination of geniposide contained in Gardenia jasminoides and in two preparations of mixed traditional Chinese medicines
Journal of Chromatography A, 2002Co-Authors: Tong-rong Tsai, Ting-yu Tseng, Chieh Fu Chen, Tunghu TsaiAbstract:A high-performance liquid chromatographic method was applied to the determination of the geniposide concentration in Gardenia fruit and preparations of traditional Chinese medicine using a mobile phase of acetonitrile–methanol–5 mM monosodium phosphate (pH 4.6) (5:15:80, v/v/v). Intra-assay and inter-assay accuracy and precision of the analyses were ≤10% in the range of 0.1 through 50 μg/ml. The presence of geniposide in the medicinal herb and its preparations was ascertained by retention time, spiking with an authentic standard, change of detection wavelength and change of the composition of the mobile phase. The concentration of geniposide in the fruit of Gardenia jasminoides Ellis var. grandiflora Nakai is higher than that in Gardenia jasminoides Ellis. The concentration of geniposide in the traditional Chinese herbal medicine preparations, Huang-Lian-Jiee-Dwu-Tang (66.27±1.98 mg/g) and In-Chern-Hau-Tang (68.54±2.62 mg/g) was less than in the herb Gardenia jasminoides Ellis (73.44±2.62 mg/g) itself.
