The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
Martin J. Collen - One of the best experts on this subject based on the ideXlab platform.
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Idiopathic Gastric Acid Hypersecretion Comparison with Zollinger-Ellison Syndrome
Digestive Diseases and Sciences, 1994Co-Authors: Martin J. Collen, Robert T. JensenAbstract:Many patients with Acid-peptic disease have idiopathic Gastric Acid hypersecretion defined as a basal Acid output >10.0 meq/hr; however, a significant proportion have basal Acid outputs >15.0 meq/hr, which is within the range found in Zollinger-Ellison syndrome. Although idiopathic Gastric Acid hypersecretion is more common than Zollinger-Ellison syndrome, it is important that these two disorders be differentiated because of differences in treatment and natural history. In the present study, we compared 124 patients with idiopathic Gastric Acid hypersecretion and 137 patients with Zollinger-Ellison syndrome. There were no significant differences with regard to age at diagnosis, history of upper gastrointestinal hemorrhage, nausea, vomiting, and family history of duodenal ulcer and other Acid-peptic disease. However, significant differences were observed between patients with idiopathic Gastric Acid hypersecretion and patients with Zollinger-Ellison syndrome with regard to percentage of males: 77% compared to 64% (P=0.008), mean serum gastrin: 60 pg/ml compared to 3679 pg/ml (normal 10.0 meq/hr) and Zollinger-Ellison syndrome (basal Acid output >15.0 meq/hr). When 45 patients with idiopathic Gastric Acid hypersecretion and 39 patients with Zollinger-Ellison syndrome with basal Acid outputs 15.1–30.0 meq/hr were compared, the main significant differences were with regard to mean serum gastrin: 69 pg/ml compared to 655 pg/ml (P
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bleeding duodenal ulcer role of Gastric Acid hypersecretion
Digestive Diseases and Sciences, 1993Co-Authors: Martin J. Collen, Anthony N Kalloo, Michael J SheridanAbstract:Basal Gastric Acid output was analyzed prospectively in 110 patients with endoscopically documented duodenal ulcer disease to determine the frequency of Gastric Acid hypersecretion in patients with bleeding versus nonbleeding ulcers. Thirty-eight patients with stigmata of an actively or recently bleeding duodenal ulcer had a mean basal output of 12.6±8.9 meq/hr. In comparison, 72 patients with nonbleeding duodenal ulcers (and no history of prior bleeding) had a significantly lower mean basal Acid output of 8.7±7.5 meq/hr (P<0.05). Twenty-four of the 38 patients (63%) with bleeding and 28 of the 72 (39%) with nonbleeding duodenal ulcers had Gastric Acid hypersecretion, defined as a basal Acid output of greater than 10.0 meq/hr. There was a statistically significant association between bleeding duodenal ulcer and Acid hypersecretion (P=0.01). All 110 patients were treated with standard doses of H2-receptor antagonists for eight weeks. In that time, 87 patients healed and 23 patients (14 with prior bleeding and nine with nonbleeding duodenal ulcers) remained unhealed. Significantly more patients who had bled had nonhealing duodenal ulcers (P=0.004). Irrespective of bleeding history, all 23 patients with nonhealing duodenal ulcers at eight weeks had basal Acid outputs of greater than 10.0 meq/hr (range 10.1–49.1 meq/hr). These 23 patients with nonhealing duodenal ulcers were treated with increased doses of ranitidine (mean 690 mg/day, range 600–1200 mg/day) for up to eight additional weeks. All were observed to have complete endoscopic healing documented within that period. These results suggest that bleeding duodenal ulcers are often associated with Gastric Acid hypersecretion and that these ulcers are less likely to heal after eight weeks of standard dose H2-receptor antagonist therapy. Similarly, nonbleeding duodenal ulcers associated with Gastric Acid hypersecretion are also less likely to heal after standard doses of antisecretory therapy.
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Idiopathic Gastric Acid Hypersecretion
Handbook of experimental pharmacology, 1991Co-Authors: Martin J. CollenAbstract:Many patients with Acid-peptic disease have idiopathic Gastric Acid hypersecretion defined as a basal Acid output >10.0 meq/hr; however, a significant proportion have basal Acid outputs >15.0 meq/hr, which is within the range found in Zollinger-Ellison syndrome. Although idiopathic Gastric Acid hypersecretion is more common than Zollinger-Ellison syndrome, it is important that these two disorders be differentiated because of differences in treatment and natural history. In the present study, we compared 124 patients with idiopathic Gastric Acid hypersecretion and 137 patients with Zollinger-Ellison syndrome. There were no significant differences with regard to age at diagnosis, history of upper gastrointestinal hemorrhage, nausea, vomiting, and family history of duodenal ulcer and other Acid-peptic disease. However, significant differences were observed between patients with idiopathic Gastric Acid hypersecretion and patients with Zollinger-Ellison syndrome with regard to percentage of males: 77% compared to 64% (P=0.008), mean serum gastrin: 60 pg/ml compared to 3679 pg/ml (normal 10.0 meq/hr) and Zollinger-Ellison syndrome (basal Acid output >15.0 meq/hr). When 45 patients with idiopathic Gastric Acid hypersecretion and 39 patients with Zollinger-Ellison syndrome with basal Acid outputs 15.1–30.0 meq/hr were compared, the main significant differences were with regard to mean serum gastrin: 69 pg/ml compared to 655 pg/ml (P
Atr Axon - One of the best experts on this subject based on the ideXlab platform.
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Review article:methods of measuring Gastric Acid secretion
Alimentary Pharmacology and Therapeutics, 2011Co-Authors: Tilak Ghosh, David Ian Lewis, Simon Everett, Atr AxonAbstract:Background: Gastric Acid has an important pathophysiological role in human beings. Numerous methods have been evaluated over the years in an attempt to measure Gastric Acid and stomach Acidity, to study the role of Gastric Acid in gastrointestinal diseases in humans and to evaluate the effects of Acid suppressing drugs. Aim: To review methods which have been used to measure Gastric Acid and Gastric Acidity. Methods: Searches of the electronic databases PUBMED, MEDLINE and EMBASE, were performed with articles restricted to English language and human subjects. References were also identified from the bibliographies of selected articles. Results: Methods for measuring Gastric Acid include both invasive and non invasive techniques. Invasive tests include the conventional 'tube' tests, Gastric pH measurement techniques and endoscopic methods. Non invasive methods use urinary analysis, breath analysis, serum pepsinogens assay, scintigraphic techniques, impedence tomography and alkaline tide for measurement of Gastric Acid. Conclusions: Several methods of measuring Gastric Acid exist. Invasive tube tests are uncomfortable and time consuming whereas most of the non-invasive methods are at best semi quantitative and useful in detecting low or absent Acid secretion. Further attempts to explore new methods for measuring Gastric Acid are therefore warranted.
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Review article: methods of measuring Gastric Acid secretion
Alimentary Pharmacology & Therapeutics, 2011Co-Authors: Tilak Ghosh, Atr Axon, David A. Lewis, S M EverettAbstract:Aliment Pharmacol Ther 2011; 33: 768–781 Summary Background Gastric Acid has an important pathophysiological role in human beings. Numerous methods have been evaluated over the years in an attempt to measure Gastric Acid and stomach Acidity, to study the role of Gastric Acid in gastrointestinal diseases in humans and to evaluate the effects of Acid suppressing drugs. Aim To review methods that have been used to measure Gastric Acid and Gastric Acidity. Methods Searches of the electronic databases PUBMED, MEDLINE and EMBASE, were performed with articles restricted to English language and human subjects. References were also identified from the bibliographies of selected articles. Results Methods for measuring Gastric Acid include both invasive and non-invasive techniques. Invasive tests include the conventional Gastric Acid aspiration tests, Gastric pH measurement techniques and endoscopic methods. Non-invasive methods use urinary analysis, breath analysis, serum pepsinogens assay, scintigraphic techniques, impedence tomography and alkaline tide for measurement of Gastric Acid. Conclusions Several methods of measuring Gastric Acid exist. Invasive tube tests are uncomfortable and time consuming, whereas most of the non-invasive methods are at best semiquantitative and useful in detecting low or absent Acid secretion. Further attempts to explore new methods for measuring Gastric Acid are therefore warranted.
Robert T. Jensen - One of the best experts on this subject based on the ideXlab platform.
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Gastric Acid hypersecretory states: Recent insights and advances
Current Gastroenterology Reports, 2009Co-Authors: Nauramy Osefo, Robert T. JensenAbstract:Gastric Acid hypersecretory states are characterized by basal hypersecretion of Gastric Acid and historically include disorders associated with hypergastrinemia, hyperhistaminemia, and those of unknown etiology. Although Gastric Acid secretion is infrequently measured, it is important to recognize the role of Gastric hypersecretion in the symptoms of these disorders because they share several features of pathogenesis and treatment. In this article, recent important articles reporting insights into their diagnosis, pathogenesis, and treatment are reviewed. Particular attention is paid to Zollinger-Ellison syndrome, because it has the most extreme Acid hypersecretion of this group of disorders and because numerous recent articles deal with various aspects of the diagnosis, molecular pathogenesis, and treatment of the gastrinoma itself or the Acid hypersecretion. Two new hypersecretory disorders are reviewed: rebound Acid hypersecretion after the use of proton pump inhibitors and Acid hypersecretion with cysteamine treatment in children with cystinosis.
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Idiopathic Gastric Acid Hypersecretion Comparison with Zollinger-Ellison Syndrome
Digestive Diseases and Sciences, 1994Co-Authors: Martin J. Collen, Robert T. JensenAbstract:Many patients with Acid-peptic disease have idiopathic Gastric Acid hypersecretion defined as a basal Acid output >10.0 meq/hr; however, a significant proportion have basal Acid outputs >15.0 meq/hr, which is within the range found in Zollinger-Ellison syndrome. Although idiopathic Gastric Acid hypersecretion is more common than Zollinger-Ellison syndrome, it is important that these two disorders be differentiated because of differences in treatment and natural history. In the present study, we compared 124 patients with idiopathic Gastric Acid hypersecretion and 137 patients with Zollinger-Ellison syndrome. There were no significant differences with regard to age at diagnosis, history of upper gastrointestinal hemorrhage, nausea, vomiting, and family history of duodenal ulcer and other Acid-peptic disease. However, significant differences were observed between patients with idiopathic Gastric Acid hypersecretion and patients with Zollinger-Ellison syndrome with regard to percentage of males: 77% compared to 64% (P=0.008), mean serum gastrin: 60 pg/ml compared to 3679 pg/ml (normal 10.0 meq/hr) and Zollinger-Ellison syndrome (basal Acid output >15.0 meq/hr). When 45 patients with idiopathic Gastric Acid hypersecretion and 39 patients with Zollinger-Ellison syndrome with basal Acid outputs 15.1–30.0 meq/hr were compared, the main significant differences were with regard to mean serum gastrin: 69 pg/ml compared to 655 pg/ml (P
Tilak Ghosh - One of the best experts on this subject based on the ideXlab platform.
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Review article:methods of measuring Gastric Acid secretion
Alimentary Pharmacology and Therapeutics, 2011Co-Authors: Tilak Ghosh, David Ian Lewis, Simon Everett, Atr AxonAbstract:Background: Gastric Acid has an important pathophysiological role in human beings. Numerous methods have been evaluated over the years in an attempt to measure Gastric Acid and stomach Acidity, to study the role of Gastric Acid in gastrointestinal diseases in humans and to evaluate the effects of Acid suppressing drugs. Aim: To review methods which have been used to measure Gastric Acid and Gastric Acidity. Methods: Searches of the electronic databases PUBMED, MEDLINE and EMBASE, were performed with articles restricted to English language and human subjects. References were also identified from the bibliographies of selected articles. Results: Methods for measuring Gastric Acid include both invasive and non invasive techniques. Invasive tests include the conventional 'tube' tests, Gastric pH measurement techniques and endoscopic methods. Non invasive methods use urinary analysis, breath analysis, serum pepsinogens assay, scintigraphic techniques, impedence tomography and alkaline tide for measurement of Gastric Acid. Conclusions: Several methods of measuring Gastric Acid exist. Invasive tube tests are uncomfortable and time consuming whereas most of the non-invasive methods are at best semi quantitative and useful in detecting low or absent Acid secretion. Further attempts to explore new methods for measuring Gastric Acid are therefore warranted.
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Review article: methods of measuring Gastric Acid secretion
Alimentary Pharmacology & Therapeutics, 2011Co-Authors: Tilak Ghosh, Atr Axon, David A. Lewis, S M EverettAbstract:Aliment Pharmacol Ther 2011; 33: 768–781 Summary Background Gastric Acid has an important pathophysiological role in human beings. Numerous methods have been evaluated over the years in an attempt to measure Gastric Acid and stomach Acidity, to study the role of Gastric Acid in gastrointestinal diseases in humans and to evaluate the effects of Acid suppressing drugs. Aim To review methods that have been used to measure Gastric Acid and Gastric Acidity. Methods Searches of the electronic databases PUBMED, MEDLINE and EMBASE, were performed with articles restricted to English language and human subjects. References were also identified from the bibliographies of selected articles. Results Methods for measuring Gastric Acid include both invasive and non-invasive techniques. Invasive tests include the conventional Gastric Acid aspiration tests, Gastric pH measurement techniques and endoscopic methods. Non-invasive methods use urinary analysis, breath analysis, serum pepsinogens assay, scintigraphic techniques, impedence tomography and alkaline tide for measurement of Gastric Acid. Conclusions Several methods of measuring Gastric Acid exist. Invasive tube tests are uncomfortable and time consuming, whereas most of the non-invasive methods are at best semiquantitative and useful in detecting low or absent Acid secretion. Further attempts to explore new methods for measuring Gastric Acid are therefore warranted.
Tsutomu Chiba - One of the best experts on this subject based on the ideXlab platform.
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helicobacter pylori independent chronological change in Gastric Acid secretion in the japanese
Gut, 1997Co-Authors: Yoshikazu Kinoshita, Chiharu Kawanami, Kiyohiko Kishi, Hirohisa Nakata, Y Seino, Tsutomu ChibaAbstract:Background —Gastric Acid secretion in Japanese subjects decreases with aging. One of the possible causative mechanisms of this attenuated Acid secretion is speculated to be a Helicobacter pylori induced chronic gastritis. The infection rate of this microorganism has decreased recently in Japan. Aims —To investigate whether Gastric Acid secretion has altered over the past 20 years, and if so, what the influence of H pylori infection might be in the Japanese population. Subjects and methods —Gastric Acid secretion, serum gastrin and pepsinogen I and II concentrations, and H pylori infection were determined in 110 Japanese subjects in both the 1970s and 1990s. Results —Basal Acid output as well as maximal Acid output have greatly increased over the past 20 years, not only in individuals with H pylori infection but also in those without infection. Furthermore, subjects with H pylori infection tended to show decreased Gastric Acid secretion in comparison with those without infection, particularly in geriatric subjects. There was a positive correlation between Gastric Acid secretion and serum pepsinogen I concentrations. Conclusions —In Japan, both basal and stimulated Gastric Acid secretion have increased over the past 20 years; some unknown factors other than the decrease in H pylori infection may play an important role in this phenomenon.
