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Tzuming Pan - One of the best experts on this subject based on the ideXlab platform.

  • beneficial preventive effects of Gastric mucosal Lesion for soy skim milk fermented by lactic acid bacteria
    Journal of Agricultural and Food Chemistry, 2009
    Co-Authors: Chinfeng Liu, Shenshih Chiang, Kuochuan Tseng, Tzuming Pan
    Abstract:

    In this study, Lactobacillus paracasei subsp. paracasei NTU101 and Lactobacillus plantarum NTU 102 were used as starter to ferment soy−skim milk, and the optimal mixing ratio was evaluated. The influence of lactic acid bacteria (LAB)-fermented soy−skim milk on mucosal integrity in a Gastric mucosal Lesion rat model was also investigated. After 24 h, cell densities of L. paracasei subsp. paracasei NTU 101 and L. plantarum NTU 102 fermented in 75% soy milk and 25% milk (optimal condition) were 1.2 × 109 and 2.5 × 109 CFU/mL. After 180 days at 4 °C, the cell densities of the freeze-dried powders of the fermented soy−skim milks were 1 × 109 CFU/g; slight variations in pH and acidity were observed. Pylorus ligation with acidified ethanol treatment was used as the Gastric Lesion animal model. LAB-fermented soy−skim milk reduced the Gastric Lesion index and the lipid peroxides (LPO) of Gastric mucosa and serum. Administration of the fermented soy−skim milk enhanced superoxide dismutase (SOD) activity and prostag...

Elfriede Marianne Bacchi - One of the best experts on this subject based on the ideXlab platform.

  • antiulcerogenic effect and acute toxicity of a hydroethanolic extract from the cashew anacardium occidentale l leaves
    Journal of Ethnopharmacology, 2007
    Co-Authors: Nzi Andre Konan, Elfriede Marianne Bacchi
    Abstract:

    Abstract The antiulcerogenic effect of a hydroethanolic extract of Anacardium occidentale L. leaves was investigated. The extract inhibited Gastric Lesions induced by HCl/ethanol in female rats. A dose–response effect study showed that the ED50 was 150 mg/kg b.w. Extract doses higher than 100 mg/kg b.w. were more effective than 30 mg/kg of lansoprazol in inhibiting Gastric Lesions. A methanolic fraction (257.12 mg/kg) which reduced Gastric Lesion at 88.20% is likely to contain the active principle of the antiulcer effect. No signs of acute toxicity were observed when mice were treated with extract dose up to 2000 mg/kg b.w. A chemical analysis of the extract allowed the identification of phenolic compounds as the major components. Glycosylated quercetin, amentoflavone derivate and a tetramer of proanthocyanidin were identified by liquid chromatography coupled to mass spectrometry. The level of total phenolics in the extract was evaluated at 35.5% and flavonoid content was 2.58%.

  • antiulcerogenic effect and acute toxicity of a hydroethanolic extract from the cashew anacardium occidentale l leaves
    Journal of Ethnopharmacology, 2007
    Co-Authors: Nzi Andre Konan, Elfriede Marianne Bacchi
    Abstract:

    Abstract The antiulcerogenic effect of a hydroethanolic extract of Anacardium occidentale L. leaves was investigated. The extract inhibited Gastric Lesions induced by HCl/ethanol in female rats. A dose–response effect study showed that the ED50 was 150 mg/kg b.w. Extract doses higher than 100 mg/kg b.w. were more effective than 30 mg/kg of lansoprazol in inhibiting Gastric Lesions. A methanolic fraction (257.12 mg/kg) which reduced Gastric Lesion at 88.20% is likely to contain the active principle of the antiulcer effect. No signs of acute toxicity were observed when mice were treated with extract dose up to 2000 mg/kg b.w. A chemical analysis of the extract allowed the identification of phenolic compounds as the major components. Glycosylated quercetin, amentoflavone derivate and a tetramer of proanthocyanidin were identified by liquid chromatography coupled to mass spectrometry. The level of total phenolics in the extract was evaluated at 35.5% and flavonoid content was 2.58%.

Chinfeng Liu - One of the best experts on this subject based on the ideXlab platform.

  • beneficial preventive effects of Gastric mucosal Lesion for soy skim milk fermented by lactic acid bacteria
    Journal of Agricultural and Food Chemistry, 2009
    Co-Authors: Chinfeng Liu, Shenshih Chiang, Kuochuan Tseng, Tzuming Pan
    Abstract:

    In this study, Lactobacillus paracasei subsp. paracasei NTU101 and Lactobacillus plantarum NTU 102 were used as starter to ferment soy−skim milk, and the optimal mixing ratio was evaluated. The influence of lactic acid bacteria (LAB)-fermented soy−skim milk on mucosal integrity in a Gastric mucosal Lesion rat model was also investigated. After 24 h, cell densities of L. paracasei subsp. paracasei NTU 101 and L. plantarum NTU 102 fermented in 75% soy milk and 25% milk (optimal condition) were 1.2 × 109 and 2.5 × 109 CFU/mL. After 180 days at 4 °C, the cell densities of the freeze-dried powders of the fermented soy−skim milks were 1 × 109 CFU/g; slight variations in pH and acidity were observed. Pylorus ligation with acidified ethanol treatment was used as the Gastric Lesion animal model. LAB-fermented soy−skim milk reduced the Gastric Lesion index and the lipid peroxides (LPO) of Gastric mucosa and serum. Administration of the fermented soy−skim milk enhanced superoxide dismutase (SOD) activity and prostag...

Shanmugam Muruganandan - One of the best experts on this subject based on the ideXlab platform.

  • evaluation of anti inflammatory activity of pongamia pinnata leaves in rats
    Journal of Ethnopharmacology, 2001
    Co-Authors: K K Srinivasan, Shanmugam Muruganandan, S K Tandan, J Lal, Sadanandavalli Retnaswami Chandra, Ravi V Prakash
    Abstract:

    Abstract In the present study, the anti-inflammatory activity of 70% ethanolic extract of Pongamia pinnata leaves (PLE) in acute, subacute and chronic models of inflammation was assessed in rats. Per os (p.o.) administration of PLE (300, 1000 mg/kg) exhibited significant anti-inflammatory activity in acute (carrageenin, histamine, 5-hydroxytryptamine and prostaglandin E 2 -induced hind paw edema), subcute (kaolin-carrageenin and formaldehyde-induced hind paw edema) and chronic (cotton pellet granuloma) models of inflammation. PLE did not show any sign of toxicity and mortality up to a dose level of 10.125 g/kg, p.o. in mice. Both acute as well as chronic administration of PLE (100, 300 and 1000 mg/kg, p.o.) did not produce any Gastric Lesion in rats. These results indicate that PLE possesses significant anti-inflammatory activity without ulcerogenic activity suggesting its potential as an anti-inflammatory agent for use in the treatment of various inflammatory diseases.

  • anti inflammatory activity of syzygium cumini bark
    Fitoterapia, 2001
    Co-Authors: Shanmugam Muruganandan, Krishnapura Srinivasan, S Chandra, S K Tandan, J Lal, V Raviprakash
    Abstract:

    The ethanolic extract of the bark of Syzygium cumini was investigated for its anti-inflammatory activity in animal models. The extract did not show any sign of toxicity up to a dose of 10.125 g/kg, p.o. in mice. Significant anti-inflammatory activity was observed in carrageenin (acute), kaolin-carrageenin (subacute), formaldehyde (subacute)-induced paw oedema and cotton pellet granuloma (chronic) tests in rats. The extract did not induce any Gastric Lesion in both acute and chronic ulcerogenic tests in rats. Thus, the present study demonstrated that S. cumini bark extract has a potent anti-inflammatory action against different phases of inflammation without any side effect on Gastric mucosa.

V Raviprakash - One of the best experts on this subject based on the ideXlab platform.

  • anti inflammatory activity of syzygium cumini bark
    Fitoterapia, 2001
    Co-Authors: Shanmugam Muruganandan, Krishnapura Srinivasan, S Chandra, S K Tandan, J Lal, V Raviprakash
    Abstract:

    The ethanolic extract of the bark of Syzygium cumini was investigated for its anti-inflammatory activity in animal models. The extract did not show any sign of toxicity up to a dose of 10.125 g/kg, p.o. in mice. Significant anti-inflammatory activity was observed in carrageenin (acute), kaolin-carrageenin (subacute), formaldehyde (subacute)-induced paw oedema and cotton pellet granuloma (chronic) tests in rats. The extract did not induce any Gastric Lesion in both acute and chronic ulcerogenic tests in rats. Thus, the present study demonstrated that S. cumini bark extract has a potent anti-inflammatory action against different phases of inflammation without any side effect on Gastric mucosa.