The Experts below are selected from a list of 44244 Experts worldwide ranked by ideXlab platform
John E. Pandolfino - One of the best experts on this subject based on the ideXlab platform.
-
Practical Manual of Gastroesophageal Reflux Disease: Vela/Practical Manual of Gastroesophageal Reflux Disease - Practical Manual of Gastroesophageal Reflux Disease
2013Co-Authors: Marcelo F. Vela, Joel E. Richter, John E. PandolfinoAbstract:Practical manual of Gastroesophageal Reflux Disease / , Practical manual of Gastroesophageal Reflux Disease / , کتابخانه دیجیتال جندی شاپور اهواز
-
The Diagnosis of Gastroesophageal Reflux Disease
The American journal of medicine, 2010Co-Authors: Brian E. Lacy, Joel E. Richter, John E. Pandolfino, Kirsten Weiser, Jocelyn D. Chertoff, Ronnie Fass, Richard I. Rothstein, Chad Spangler, Michael F VaeziAbstract:BACKGROUND: Gastroesophageal Reflux Disease is a highly prevalent condition that imposes a significant economic impact on the US health care system. The utility of commonly used tests for the diagnosis of Gastroesophageal Reflux Disease has not been adequately reviewed. METHODS: A comprehensive review of the literature was undertaken to provide an evidence-based approach to the diagnosis of Gastroesophageal Reflux Disease. EMBASE (1980-December 2008), OVID MEDLINE, and PubMed, (1966-December 2008) were searched using “Gastroesophageal Reflux” and “adults” with other terms, including medications, diagnostic tests, symptoms, and epidemiologic terms. Studies were limited to human trials, English language, and full articles. RESULTS: Heartburn is a reasonably sensitive symptom for the diagnosis of Gastroesophageal Reflux Disease, although it does not reliably predict esophagitis. Standardized questionnaires have limited specificity, whereas the double-contrast barium swallow has a low sensitivity to diagnose Gastroesophageal Reflux. The role of esophageal manometry is limited to accurate placement of a pH-measuring device. pH testing has reasonable sensitivity and specificity for the diagnosis of Gastroesophageal Reflux Disease. The sensitivity of upper endoscopy to diagnose Gastroesophageal Reflux is lower than that of pH tests. CONCLUSION: The diagnosis of Gastroesophageal Reflux Disease remains difficult. In the absence of alarm symptoms, empiric treatment with acid suppression is warranted. pH testing provides valuable information in many patients, although the clinical utility of newer tests needs to be determined. Endoscopy should not be the first test used to diagnose Gastroesophageal Reflux.
Ameneh Mashayekh - One of the best experts on this subject based on the ideXlab platform.
-
Epidemiology of Gastroesophageal Reflux Disease in Tehran, Iran.
Journal of gastroenterology and hepatology, 2007Co-Authors: Mohammad J Ehsani, Iradj Maleki, Fatemeh Mohammadzadeh, Ameneh MashayekhAbstract:Background and Aim: Epidemiological studies have indicated an increase in the preva- lence of Gastroesophageal Reflux Disease in Western countries; however, there is a lack of information about its prevalence in Iran. The aim of this study was to measure gastroesoph- ageal Reflux Disease prevalence in a representative sample of the Tehran population in 1999. Methods: In a cross-sectional study, 700 people, with a male : female ratio of 1:1, were selected by stratified randomization based on the probability of 20% prevalence of gastro- esophageal Reflux Disease and 3% error. They were divided equally into seven age groups. Heartburn and acid regurgitation were considered as the most common symptoms of Gastroesophageal Reflux Disease. The severity and frequency of heartburn and the role of personal habits in the appearance of this symptom were determined. The prevalence of Gastroesophageal Reflux Disease in samples was measured, and its actual prevalence in society was estimated. Results: Of 700 people, 350 were male and 350 were female. The major symptoms of Gastroesophageal Reflux Disease were observed in 278 (39.7%) people. The prevalence of Gastroesophageal Reflux Disease of smokers was twice that of non-smokers. Conclusions: Gastroesophageal Reflux Disease is a serious and unresolved problem in Western countries, and its increasing prevalence correlates with an increasing prevalence of adenocarcinoma of distal esophagus. The prevalence of Gastroesophageal Reflux Disease appears to be increasing in Iran also; therefore, it is recommended that major attention be paid to this Disease.
Joel E. Richter - One of the best experts on this subject based on the ideXlab platform.
-
Practical Manual of Gastroesophageal Reflux Disease: Vela/Practical Manual of Gastroesophageal Reflux Disease - Practical Manual of Gastroesophageal Reflux Disease
2013Co-Authors: Marcelo F. Vela, Joel E. Richter, John E. PandolfinoAbstract:Practical manual of Gastroesophageal Reflux Disease / , Practical manual of Gastroesophageal Reflux Disease / , کتابخانه دیجیتال جندی شاپور اهواز
-
The Diagnosis of Gastroesophageal Reflux Disease
The American journal of medicine, 2010Co-Authors: Brian E. Lacy, Joel E. Richter, John E. Pandolfino, Kirsten Weiser, Jocelyn D. Chertoff, Ronnie Fass, Richard I. Rothstein, Chad Spangler, Michael F VaeziAbstract:BACKGROUND: Gastroesophageal Reflux Disease is a highly prevalent condition that imposes a significant economic impact on the US health care system. The utility of commonly used tests for the diagnosis of Gastroesophageal Reflux Disease has not been adequately reviewed. METHODS: A comprehensive review of the literature was undertaken to provide an evidence-based approach to the diagnosis of Gastroesophageal Reflux Disease. EMBASE (1980-December 2008), OVID MEDLINE, and PubMed, (1966-December 2008) were searched using “Gastroesophageal Reflux” and “adults” with other terms, including medications, diagnostic tests, symptoms, and epidemiologic terms. Studies were limited to human trials, English language, and full articles. RESULTS: Heartburn is a reasonably sensitive symptom for the diagnosis of Gastroesophageal Reflux Disease, although it does not reliably predict esophagitis. Standardized questionnaires have limited specificity, whereas the double-contrast barium swallow has a low sensitivity to diagnose Gastroesophageal Reflux. The role of esophageal manometry is limited to accurate placement of a pH-measuring device. pH testing has reasonable sensitivity and specificity for the diagnosis of Gastroesophageal Reflux Disease. The sensitivity of upper endoscopy to diagnose Gastroesophageal Reflux is lower than that of pH tests. CONCLUSION: The diagnosis of Gastroesophageal Reflux Disease remains difficult. In the absence of alarm symptoms, empiric treatment with acid suppression is warranted. pH testing provides valuable information in many patients, although the clinical utility of newer tests needs to be determined. Endoscopy should not be the first test used to diagnose Gastroesophageal Reflux.
Michael F Vaezi - One of the best experts on this subject based on the ideXlab platform.
-
Gastroesophageal Reflux Disease: A Gastroenterologist's Perspective
Perspectives on Voice and Voice Disorders, 2011Co-Authors: Michael F VaeziAbstract:Gastroesophageal Reflux Disease (GERD) is a commonly diagnosed condition often associated with the typical symptoms of heartburn and regurgitation, although it may present with atypical symptoms su...
-
The Diagnosis of Gastroesophageal Reflux Disease
The American journal of medicine, 2010Co-Authors: Brian E. Lacy, Joel E. Richter, John E. Pandolfino, Kirsten Weiser, Jocelyn D. Chertoff, Ronnie Fass, Richard I. Rothstein, Chad Spangler, Michael F VaeziAbstract:BACKGROUND: Gastroesophageal Reflux Disease is a highly prevalent condition that imposes a significant economic impact on the US health care system. The utility of commonly used tests for the diagnosis of Gastroesophageal Reflux Disease has not been adequately reviewed. METHODS: A comprehensive review of the literature was undertaken to provide an evidence-based approach to the diagnosis of Gastroesophageal Reflux Disease. EMBASE (1980-December 2008), OVID MEDLINE, and PubMed, (1966-December 2008) were searched using “Gastroesophageal Reflux” and “adults” with other terms, including medications, diagnostic tests, symptoms, and epidemiologic terms. Studies were limited to human trials, English language, and full articles. RESULTS: Heartburn is a reasonably sensitive symptom for the diagnosis of Gastroesophageal Reflux Disease, although it does not reliably predict esophagitis. Standardized questionnaires have limited specificity, whereas the double-contrast barium swallow has a low sensitivity to diagnose Gastroesophageal Reflux. The role of esophageal manometry is limited to accurate placement of a pH-measuring device. pH testing has reasonable sensitivity and specificity for the diagnosis of Gastroesophageal Reflux Disease. The sensitivity of upper endoscopy to diagnose Gastroesophageal Reflux is lower than that of pH tests. CONCLUSION: The diagnosis of Gastroesophageal Reflux Disease remains difficult. In the absence of alarm symptoms, empiric treatment with acid suppression is warranted. pH testing provides valuable information in many patients, although the clinical utility of newer tests needs to be determined. Endoscopy should not be the first test used to diagnose Gastroesophageal Reflux.
-
Therapy Insight: Gastroesophageal Reflux Disease and laryngopharyngeal Reflux
Nature Clinical Practice Gastroenterology & Hepatology, 2005Co-Authors: Michael F VaeziAbstract:Gastroesophageal Reflux Disease is associated with laryngopharyngeal Reflux, but the cause and effect relationship between these two clinical entities is far from established. This Review considers studies of the pathogenesis of laryngopharyngeal Reflux, the value of diagnostic testing either on or off therapy, and treatment options and duration, that have increased our our understanding of this field. Gastroesophageal Reflux Disease has been increasingly associated with ear, nose and throat signs and symptoms; however, the cause and effect relationship between these two clinical entities is far from established. Many patients initially diagnosed with Gastroesophageal Reflux Disease as the cause of laryngeal signs do not respond either symptomatically or laryngoscopically to aggressive acid suppression, and do not have abnormal esophageal acid exposure as measured by pH monitoring. This has resulted in frustration on the part of both gastroenterologists and ear, nose and throat physicians, and confusion on the part of patients. This review discusses the reasons for this controversy and highlights data that attempt to clarify this complex area.
Timothy T. Nostrant - One of the best experts on this subject based on the ideXlab platform.
-
Atypical presentations of Gastroesophageal Reflux Disease.
American family physician, 2008Co-Authors: Joel J. Heidelbaugh, Arvin S. Gill, R. Van Harrison, Timothy T. NostrantAbstract:Gastroesophageal Reflux Disease typically manifests as heartburn and regurgitation, but it may also present with atypical or extraesophageal symptoms, including asthma, chronic cough, laryngitis, hoarseness, chronic sore throat, dental erosions, and noncardiac chest pain. Diagnosing atypical manifestations of Gastroesophageal Reflux Disease is often a challenge because heartburn and regurgitation may be absent, making it difficult to prove a cause-and-effect relationship. Upper endoscopy and 24-hour pH monitoring are insensitive and not useful for many patients as initial diagnostic modalities for evaluation of atypical symptoms. In patients with Gastroesophageal Reflux Disease who have atypical or extraesophageal symptoms, aggressive acid suppression using proton pump inhibitors twice daily before meals for three to four months is the standard treatment, although some studies have failed to show a significant benefit in symptomatic improvement. If these symptoms improve or resolve, patients may step down to a minimal dose of antisecretory therapy over the following three to six months. Surgical intervention via Nissen fundoplication is an option for patients who are unresponsive to aggressive antisecretory therapy. However, long-term studies have shown that some patients still require antisecretory therapy and are more likely to develop dysphagia, rectal flatulence, and the inability to belch or vomit.
