The Experts below are selected from a list of 231 Experts worldwide ranked by ideXlab platform
Hong W Zhang - One of the best experts on this subject based on the ideXlab platform.
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melatonin attenuates noise stress induced Gastrointestinal Motility Disorder and gastric stress ulcer role of Gastrointestinal hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal Motility Disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal hormones.
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melatonin attenuates noise stress induced Gastrointestinal Motility Disorder and gastric stress ulcer role of Gastrointestinal hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal Motility Disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal hormones.
Paul E. Hyman - One of the best experts on this subject based on the ideXlab platform.
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Chronic Intestinal Pseudoobstruction Associated with Fetal Alcohol Syndrome
Digestive Diseases and Sciences, 1997Co-Authors: E. Vasiliauskas, D. A. Piccoli, A F Flores, C. Di Lorenzo, Paul E. HymanAbstract:Alcohol acts as a teratogen in the fetus, resulting in prenatal or postnatal growth failure, characteristic facial dysmorphic features, and central nervous system dysfunction. The toxic effects of alcohol on the developing brain are well recognized, but Gastrointestinal neuropathy has not been described in fetal alcohol syndrome (FAS). Five children with FAS presented in infancy with signs and symptoms suggestive of chronic intestinal pseudoobstruction. They were not able to sustain adequate caloric intake by mouth, and all required prolonged special methods of alimentation. We performed antroduodenal manometry in these children to determine whether their symptoms were associated with a Gastrointestinal Motility Disorder. All patients had abnormally propagating phase III-like episodes during fasting (retrograde in four, simultaneous in two). Persistent clusters of stationary contractions were a prominent feature in two patients. In utero neurotoxicity of alcohol may not be limited to the central nervous system, but may also cause an enteric neuropathy presenting in infancy as chronic intestinal pseudoobstruction.
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Antroduodenal manometry in children with no upper Gastrointestinal symptoms.
Scandinavian Journal of Gastroenterology, 1997Co-Authors: A. Hoon, C. Di Lorenzo, Paul E. HymanAbstract:Background: The interpretation of antroduodenal manometry in children with Gastrointestinal Motility Disorder has been limited by a paucity of data from normal children. The purpose of this study was to define antroduodenal manometry findings in children with no upper Gastrointestinal symptoms. Methods: We reviewed 260 consecutive antroduodenal manometries and selected 18 studies from subjects aged 2–12 years with no symptoms referable to a Gastrointestinal Motility Disorder involving the stomach and/or the small bowel. Results: During fasting, phase 3 of the migrating motor complex (MMC) was present in 14 of 18 children, and it was induced by erythromycin in 4 who failed to have a spontaneous phase 3. Phase 3 propagation velocity increased significantly with age. The cycle length between MMCs showed no age-dependent variation. Phase 3 occupied 3%; phase 1,10%; and phase 2, 87% of the fasting recording time. Conclusions: Antroduodenal manometry findings in children with no upper Gastrointestinal symptoms ...
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Gastrointestinal Motility IN NEONATAL AND PEDIATRIC PRACTICE
Gastroenterology clinics of North America, 1996Co-Authors: Carlo Di Lorenzo, Paul E. HymanAbstract:Caring for children with Gastrointestinal Motility Disorders requires an understanding of age-related changes in Gastrointestinal function and in the clinical expression of disease. Successful evaluation of the child with a Gastrointestinal Motility Disorder necessitates an approach that takes into account not only the child's symptoms, but also the stage of development. This article reviews the ontogeny of Gastrointestinal Motility; the techniques available for the study of Gastrointestinal Motility in children; and the presentation, pathophysiology, and treatment of pediatric functional bowel diseases. Differences in children compared to adults in performing and analyzing Motility testing and in evaluating Motility Disorders are emphasized. A more complete understanding of pediatric Motility Disorders may provide important insights in approaching functional bowel diseases in adults.
Lei Zhang - One of the best experts on this subject based on the ideXlab platform.
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melatonin attenuates noise stress induced Gastrointestinal Motility Disorder and gastric stress ulcer role of Gastrointestinal hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal Motility Disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal hormones.
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melatonin attenuates noise stress induced Gastrointestinal Motility Disorder and gastric stress ulcer role of Gastrointestinal hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal Motility Disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal hormones.
Hu Q Zhang - One of the best experts on this subject based on the ideXlab platform.
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melatonin attenuates noise stress induced Gastrointestinal Motility Disorder and gastric stress ulcer role of Gastrointestinal hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal Motility Disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal hormones.
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melatonin attenuates noise stress induced Gastrointestinal Motility Disorder and gastric stress ulcer role of Gastrointestinal hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal Motility Disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal hormones.
Hai F Zhang - One of the best experts on this subject based on the ideXlab platform.
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melatonin attenuates noise stress induced Gastrointestinal Motility Disorder and gastric stress ulcer role of Gastrointestinal hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal Motility Disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal hormones.
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melatonin attenuates noise stress induced Gastrointestinal Motility Disorder and gastric stress ulcer role of Gastrointestinal hormones and oxidative stress in rats
Journal of Neurogastroenterology and Motility, 2015Co-Authors: Lei Zhang, Ji T Gong, Hu Q Zhang, Quan H Song, Guang H Xu, Xiao D Tang, Hai F Zhang, Hong W ZhangAbstract:BACKGROUND/AIMS: There are increasing evidences for Gastrointestinal Motility Disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD and gastric stress ulcer induced by noise stress and potential mechanism. METHODS: Noise stress was induced on rats, and melatonin (15 mg/kg) was administered to rats by intraperitoneal injection. Differences were assessed in gastric residual rate (GRR), small intestine propulsion rate (SPR), Guth injury score, cortisol, Gastrointestinal hormones (calcitonin-gene-related peptide and motilin) and oxidative stress markers (superoxide dismutase and malondialde hyde) in blood plasma as well as gastric mucosa homogenate with or without melatonin. The pathological examination of gastric mucosa was also performed. RESULTS: The GRR and SPR were improved by noise stress compared with control (P < 0.05). The pathological examination and Guth injury score revealed gastric stress ulcer. Moreover, the levels of cortisol, motilin and malondialdehyde in blood plasma and ma-londialdehyde in gastric mucosa homogenate were increased by noise stress (P < 0.05). CGRP and superoxide dismutase activ-ity in both of blood plasma and gastric mucosa homogenate were significantly decreased (P< 0.05). Furthermore, melatonin reversed changes in GRR, SPR, pathological examination, Guth injury score, cortisol, motilin, CGRP, superoxide dismutase activity and malondialdehyde (P < 0.05). CONCLUSIONS: Melatonin is effective in reversing the GIMD and gastric stress ulcer induced by noise stress. The underlying mechanism may be involved in oxidative stress and Gastrointestinal hormones.
