The Experts below are selected from a list of 13113 Experts worldwide ranked by ideXlab platform
Huiyuan Zheng - One of the best experts on this subject based on the ideXlab platform.
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Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and Gastrointestinal Regulation.
Histochemistry and cell biology, 2005Co-Authors: Hans-rudolf Berthoud, Laurel M. Patterson, Gregory M. Sutton, Christopher D. Morrison, Huiyuan ZhengAbstract:Orexin-expressing neurons in the lateral hypothalamus with their wide projections throughout the brain are important for the Regulation of sleep and wakefulness, ingestive behavior, and the coordination of these behaviors in the environmental context. To further identify downstream effector targets of the orexin system, we examined in detail orexin-A innervation of the caudal raphe nuclei in the medulla, known to harbor sympathetic preganglionic motor neurons involved in thermal, cardiovascular, and Gastrointestinal Regulation. All three components of the caudal raphe nuclei, raphe pallidus, raphe obscurus, and parapyramidal nucleus, are innervated by orexin-A-immunoreactive fibers. Using confocal microscopy, we demonstrate close anatomical appositions between varicose orexin-A immunoreactive axon profiles and sympathetic premotor neurons identified with either a transneuronal retrograde pseudorabies virus tracer injected into the interscapular brown fat pads, or with in situ hybridization of pro-TRH mRNA. Furthermore, orexin-A injected into the fourth ventricle induced c-Fos expression in the raphe pallidus and parapyramidal nucleus. These findings suggest that orexin neurons in the hypothalamus can modulate brown fat thermogenesis, cardiovascular, and Gastrointestinal functions by acting directly on neurons in the caudal raphe nuclei, and support the idea that orexin’s simultaneous stimulation of food intake and sympathetic activity might have evolved as a mechanism to stay alert while foraging.
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Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and Gastrointestinal Regulation
Histochemistry and Cell Biology, 2005Co-Authors: Hans-rudolf Berthoud, Laurel M. Patterson, Gregory M. Sutton, Christopher Morrison, Huiyuan ZhengAbstract:Orexin-expressing neurons in the lateral hypothalamus with their wide projections throughout the brain are important for the Regulation of sleep and wakefulness, ingestive behavior, and the coordination of these behaviors in the environmental context. To further identify downstream effector targets of the orexin system, we examined in detail orexin-A innervation of the caudal raphé nuclei in the medulla, known to harbor sympathetic preganglionic motor neurons involved in thermal, cardiovascular, and Gastrointestinal Regulation. All three components of the caudal raphé nuclei, raphé pallidus, raphé obscurus, and parapyramidal nucleus, are innervated by orexin-A-immunoreactive fibers. Using confocal microscopy, we demonstrate close anatomical appositions between varicose orexin-A immunoreactive axon profiles and sympathetic premotor neurons identified with either a transneuronal retrograde pseudorabies virus tracer injected into the interscapular brown fat pads, or with in situ hybridization of pro-TRH mRNA. Furthermore, orexin-A injected into the fourth ventricle induced c-Fos expression in the raphé pallidus and parapyramidal nucleus. These findings suggest that orexin neurons in the hypothalamus can modulate brown fat thermogenesis, cardiovascular, and Gastrointestinal functions by acting directly on neurons in the caudal raphé nuclei, and support the idea that orexin’s simultaneous stimulation of food intake and sympathetic activity might have evolved as a mechanism to stay alert while foraging.
Hans-rudolf Berthoud - One of the best experts on this subject based on the ideXlab platform.
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Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and Gastrointestinal Regulation.
Histochemistry and cell biology, 2005Co-Authors: Hans-rudolf Berthoud, Laurel M. Patterson, Gregory M. Sutton, Christopher D. Morrison, Huiyuan ZhengAbstract:Orexin-expressing neurons in the lateral hypothalamus with their wide projections throughout the brain are important for the Regulation of sleep and wakefulness, ingestive behavior, and the coordination of these behaviors in the environmental context. To further identify downstream effector targets of the orexin system, we examined in detail orexin-A innervation of the caudal raphe nuclei in the medulla, known to harbor sympathetic preganglionic motor neurons involved in thermal, cardiovascular, and Gastrointestinal Regulation. All three components of the caudal raphe nuclei, raphe pallidus, raphe obscurus, and parapyramidal nucleus, are innervated by orexin-A-immunoreactive fibers. Using confocal microscopy, we demonstrate close anatomical appositions between varicose orexin-A immunoreactive axon profiles and sympathetic premotor neurons identified with either a transneuronal retrograde pseudorabies virus tracer injected into the interscapular brown fat pads, or with in situ hybridization of pro-TRH mRNA. Furthermore, orexin-A injected into the fourth ventricle induced c-Fos expression in the raphe pallidus and parapyramidal nucleus. These findings suggest that orexin neurons in the hypothalamus can modulate brown fat thermogenesis, cardiovascular, and Gastrointestinal functions by acting directly on neurons in the caudal raphe nuclei, and support the idea that orexin’s simultaneous stimulation of food intake and sympathetic activity might have evolved as a mechanism to stay alert while foraging.
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Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and Gastrointestinal Regulation
Histochemistry and Cell Biology, 2005Co-Authors: Hans-rudolf Berthoud, Laurel M. Patterson, Gregory M. Sutton, Christopher Morrison, Huiyuan ZhengAbstract:Orexin-expressing neurons in the lateral hypothalamus with their wide projections throughout the brain are important for the Regulation of sleep and wakefulness, ingestive behavior, and the coordination of these behaviors in the environmental context. To further identify downstream effector targets of the orexin system, we examined in detail orexin-A innervation of the caudal raphé nuclei in the medulla, known to harbor sympathetic preganglionic motor neurons involved in thermal, cardiovascular, and Gastrointestinal Regulation. All three components of the caudal raphé nuclei, raphé pallidus, raphé obscurus, and parapyramidal nucleus, are innervated by orexin-A-immunoreactive fibers. Using confocal microscopy, we demonstrate close anatomical appositions between varicose orexin-A immunoreactive axon profiles and sympathetic premotor neurons identified with either a transneuronal retrograde pseudorabies virus tracer injected into the interscapular brown fat pads, or with in situ hybridization of pro-TRH mRNA. Furthermore, orexin-A injected into the fourth ventricle induced c-Fos expression in the raphé pallidus and parapyramidal nucleus. These findings suggest that orexin neurons in the hypothalamus can modulate brown fat thermogenesis, cardiovascular, and Gastrointestinal functions by acting directly on neurons in the caudal raphé nuclei, and support the idea that orexin’s simultaneous stimulation of food intake and sympathetic activity might have evolved as a mechanism to stay alert while foraging.
Tony K.t. Lam - One of the best experts on this subject based on the ideXlab platform.
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The metabolic role of vagal afferent innervation
Nature Reviews Gastroenterology & Hepatology, 2018Co-Authors: T.m. Zaved Waise, Helen J. Dranse, Tony K.t. LamAbstract:Metabolic homeostasis is orchestrated partly in response to nutrient-dependent vagal afferent signals transmitted from the gut to the central nervous system. This Review highlights our understanding of the vagal afferent system and its role in Regulation of appetite and glucose homeostasis. The Regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic Regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the Regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in Gastrointestinal Regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity. Vagal afferent nerve terminals innervate layers of the Gastrointestinal wall to sense nutrient-related hormonal and/or mechanical signals and trigger neuronal transmission to the central nervous system to affect metabolic homeostasis. Nutrient-dependent hormonal and mechanical stimulation in the stomach and the intestine regulate feeding through the vagal afferent network. Nutrient-dependent hormonal stimulation in the intestine regulates glucose homeostasis through the vagal afferent network. Manipulating gut nutrient-dependent and vagal-dependent afferent firing represents a potential novel therapeutic strategy for obesity and diabetes.
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The metabolic role of vagal afferent innervation.
Nature reviews. Gastroenterology & hepatology, 2018Co-Authors: T.m. Zaved Waise, Helen J. Dranse, Tony K.t. LamAbstract:The Regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic Regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the Regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in Gastrointestinal Regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity.
T.m. Zaved Waise - One of the best experts on this subject based on the ideXlab platform.
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The metabolic role of vagal afferent innervation
Nature Reviews Gastroenterology & Hepatology, 2018Co-Authors: T.m. Zaved Waise, Helen J. Dranse, Tony K.t. LamAbstract:Metabolic homeostasis is orchestrated partly in response to nutrient-dependent vagal afferent signals transmitted from the gut to the central nervous system. This Review highlights our understanding of the vagal afferent system and its role in Regulation of appetite and glucose homeostasis. The Regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic Regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the Regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in Gastrointestinal Regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity. Vagal afferent nerve terminals innervate layers of the Gastrointestinal wall to sense nutrient-related hormonal and/or mechanical signals and trigger neuronal transmission to the central nervous system to affect metabolic homeostasis. Nutrient-dependent hormonal and mechanical stimulation in the stomach and the intestine regulate feeding through the vagal afferent network. Nutrient-dependent hormonal stimulation in the intestine regulates glucose homeostasis through the vagal afferent network. Manipulating gut nutrient-dependent and vagal-dependent afferent firing represents a potential novel therapeutic strategy for obesity and diabetes.
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The metabolic role of vagal afferent innervation.
Nature reviews. Gastroenterology & hepatology, 2018Co-Authors: T.m. Zaved Waise, Helen J. Dranse, Tony K.t. LamAbstract:The Regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic Regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the Regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in Gastrointestinal Regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity.
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The metabolic role of vagal afferent innervation.
Nature Reviews Gastroenterology & Hepatology, 2018Co-Authors: T.m. Zaved Waise, Helen J. DranseAbstract:The Regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic Regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the Regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in Gastrointestinal Regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity. Metabolic homeostasis is orchestrated partly in response to nutrient-dependent vagal afferent signals transmitted from the gut to the central nervous system. This Review highlights our understanding of the vagal afferent system and its role in Regulation of appetite and glucose homeostasis.
Helen J. Dranse - One of the best experts on this subject based on the ideXlab platform.
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The metabolic role of vagal afferent innervation
Nature Reviews Gastroenterology & Hepatology, 2018Co-Authors: T.m. Zaved Waise, Helen J. Dranse, Tony K.t. LamAbstract:Metabolic homeostasis is orchestrated partly in response to nutrient-dependent vagal afferent signals transmitted from the gut to the central nervous system. This Review highlights our understanding of the vagal afferent system and its role in Regulation of appetite and glucose homeostasis. The Regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic Regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the Regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in Gastrointestinal Regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity. Vagal afferent nerve terminals innervate layers of the Gastrointestinal wall to sense nutrient-related hormonal and/or mechanical signals and trigger neuronal transmission to the central nervous system to affect metabolic homeostasis. Nutrient-dependent hormonal and mechanical stimulation in the stomach and the intestine regulate feeding through the vagal afferent network. Nutrient-dependent hormonal stimulation in the intestine regulates glucose homeostasis through the vagal afferent network. Manipulating gut nutrient-dependent and vagal-dependent afferent firing represents a potential novel therapeutic strategy for obesity and diabetes.
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The metabolic role of vagal afferent innervation.
Nature reviews. Gastroenterology & hepatology, 2018Co-Authors: T.m. Zaved Waise, Helen J. Dranse, Tony K.t. LamAbstract:The Regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic Regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the Regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in Gastrointestinal Regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity.
-
The metabolic role of vagal afferent innervation.
Nature Reviews Gastroenterology & Hepatology, 2018Co-Authors: T.m. Zaved Waise, Helen J. DranseAbstract:The Regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic Regulation is disrupted in obesity and diabetes. Metabolic homeostasis is orchestrated partly in response to nutrient and vagal-dependent gut-initiated functions. Specifically, the sensory and motor fibres of the vagus nerve transmit intestinal signals to the central nervous system and exert biological and physiological responses. In the past decade, the understanding of the Regulation of vagal afferent signals and of the associated metabolic effect on whole-body energy and glucose balance has progressed. This Review highlights the contributions made to the understanding of the vagal afferent system and examines the integrative role of the vagal afferent in Gastrointestinal Regulation of appetite and glucose homeostasis. Investigating the integrative and metabolic role of vagal afferent signalling represents a potential strategy to discover novel therapeutic targets to restore energy and glucose balance in diabetes and obesity. Metabolic homeostasis is orchestrated partly in response to nutrient-dependent vagal afferent signals transmitted from the gut to the central nervous system. This Review highlights our understanding of the vagal afferent system and its role in Regulation of appetite and glucose homeostasis.
