Gastrointestinal Tuberculosis

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Nina M Clark - One of the best experts on this subject based on the ideXlab platform.

  • Gastrointestinal Tuberculosis in renal transplant recipients case report and review of the literature
    Transplant Infectious Disease, 2011
    Co-Authors: O Jarrett, Shellee A Grim, Enrico Benedetti, Nina M Clark
    Abstract:

    O. Jarrett, S.A. Grim, E. Benedetti, N.M. Clark. Gastrointestinal Tuberculosis in renal transplant recipients: case report and review of the literature Transpl Infect Dis 2011: 13: 52–57. All rights reserved Abstract: Mycobacterium Tuberculosis is an important opportunistic pathogen following renal transplantation and is often associated with adverse outcomes. Gastrointestinal Tuberculosis (GITB) is an infrequent manifestation of TB but a potentially lethal one. We present a case of a renal allograft recipient with GITB 18 months after transplant and review other published cases to identify the typical presenting symptoms, risk factors, and natural history. Treatment of GITB is also discussed.

O Jarrett - One of the best experts on this subject based on the ideXlab platform.

  • Gastrointestinal Tuberculosis in renal transplant recipients case report and review of the literature
    Transplant Infectious Disease, 2011
    Co-Authors: O Jarrett, Shellee A Grim, Enrico Benedetti, Nina M Clark
    Abstract:

    O. Jarrett, S.A. Grim, E. Benedetti, N.M. Clark. Gastrointestinal Tuberculosis in renal transplant recipients: case report and review of the literature Transpl Infect Dis 2011: 13: 52–57. All rights reserved Abstract: Mycobacterium Tuberculosis is an important opportunistic pathogen following renal transplantation and is often associated with adverse outcomes. Gastrointestinal Tuberculosis (GITB) is an infrequent manifestation of TB but a potentially lethal one. We present a case of a renal allograft recipient with GITB 18 months after transplant and review other published cases to identify the typical presenting symptoms, risk factors, and natural history. Treatment of GITB is also discussed.

Sophia Saram - One of the best experts on this subject based on the ideXlab platform.

  • Clinicopathological profile of Gastrointestinal Tuberculosis: a multinational ID-IRI study
    European Journal of Clinical Microbiology & Infectious Diseases, 2020
    Co-Authors: Alpaslan Tanoglu, Hakan Erdem, Jon S. Friedland, Fahad M. Almajid, Ayse Batirel, Sholpan Kulzhanova, Maiya Konkayeva, Zauresh Smagulova, Filiz Pehlivanoglu, Sophia Saram
    Abstract:

    Data are relatively scarce on gastro-intestinal Tuberculosis (GITB). Most studies are old and from single centers, or did not include immunosuppressed patients. Thus, we aimed to determine the clinical, radiological, and laboratory profiles of GITB. We included adults with proven GITB treated between 2000 and 2018. Patients were enrolled from 21 referral centers in 8 countries (Belgium, Egypt, France, Italy, Kazakhstan, Saudi Arabia, UK, and Turkey). One hundred four patients were included. Terminal ileum ( n  = 46, 44.2%), small intestines except terminal ileum ( n  = 36, 34.6%), colon ( n  = 29, 27.8%), stomach ( n  = 6, 5.7%), and perianal (one patient) were the sites of GITB. One-third of all patients were immunosuppressed. Sixteen patients had diabetes, 8 had chronic renal failure, 5 were HIV positive, 4 had liver cirrhosis, and 3 had malignancies. Intestinal biopsy samples were cultured in 75 cases (78.1%) and TB was isolated in 65 patients (86.6%). PCR were performed to 37 (35.6%) biopsy samples and of these, 35 (94.6%) were positive. Ascites samples were cultured in 19 patients and M. Tuberculosis was isolated in 11 (57.9%). Upper Gastrointestinal endoscopy was performed to 40 patients (38.5%) and colonoscopy in 74 (71.1%). Surgical interventions were frequently the source of diagnostic samples (25 laparoscopy/20 laparotomy, n  = 45, 43.3%). Patients were treated with standard and second-line anti-TB medications. Ultimately, 4 (3.8%) patients died and 2 (1.9%) cases relapsed. There was a high incidence of underlying immunosuppression in GITB patients. A high degree of clinical suspicion is necessary to initiate appropriate and timely diagnostic procedures; many patients are first diagnosed at surgery.

  • Gastrointestinal and peritoneal Tuberculosis
    2019
    Co-Authors: Sophia Saram, Jon S. Friedland
    Abstract:

    Abdominal Tuberculosis may affect the Gastrointestinal tract, the peritoneum, intra-abdominal lymph nodes and the solid abdominal viscera. This chapter focuses on Tuberculosis involving the Gastrointestinal tract and peritoneum both of which are almost certainly underdiagnosed with the resulting loss of treatment opportunities. The epidemiology and pathogenesis are reviewed here before the common clinical presentations of this form of Tuberculosis are described. A discussion of the role of biochemical, radiological, histological, microbiological and immunological investigations in the investigation of patients is followed by a brief summary of medical and surgical management issues specific to Gastrointestinal Tuberculosis. The chapter ends with some suggestions for present research priorities.

Enrico Benedetti - One of the best experts on this subject based on the ideXlab platform.

  • Gastrointestinal Tuberculosis in renal transplant recipients case report and review of the literature
    Transplant Infectious Disease, 2011
    Co-Authors: O Jarrett, Shellee A Grim, Enrico Benedetti, Nina M Clark
    Abstract:

    O. Jarrett, S.A. Grim, E. Benedetti, N.M. Clark. Gastrointestinal Tuberculosis in renal transplant recipients: case report and review of the literature Transpl Infect Dis 2011: 13: 52–57. All rights reserved Abstract: Mycobacterium Tuberculosis is an important opportunistic pathogen following renal transplantation and is often associated with adverse outcomes. Gastrointestinal Tuberculosis (GITB) is an infrequent manifestation of TB but a potentially lethal one. We present a case of a renal allograft recipient with GITB 18 months after transplant and review other published cases to identify the typical presenting symptoms, risk factors, and natural history. Treatment of GITB is also discussed.

Shellee A Grim - One of the best experts on this subject based on the ideXlab platform.

  • Gastrointestinal Tuberculosis in renal transplant recipients case report and review of the literature
    Transplant Infectious Disease, 2011
    Co-Authors: O Jarrett, Shellee A Grim, Enrico Benedetti, Nina M Clark
    Abstract:

    O. Jarrett, S.A. Grim, E. Benedetti, N.M. Clark. Gastrointestinal Tuberculosis in renal transplant recipients: case report and review of the literature Transpl Infect Dis 2011: 13: 52–57. All rights reserved Abstract: Mycobacterium Tuberculosis is an important opportunistic pathogen following renal transplantation and is often associated with adverse outcomes. Gastrointestinal Tuberculosis (GITB) is an infrequent manifestation of TB but a potentially lethal one. We present a case of a renal allograft recipient with GITB 18 months after transplant and review other published cases to identify the typical presenting symptoms, risk factors, and natural history. Treatment of GITB is also discussed.