The Experts below are selected from a list of 100569 Experts worldwide ranked by ideXlab platform
Masaaki Ogai - One of the best experts on this subject based on the ideXlab platform.
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early sirolimus Gel Treatment may diminish angiofibromas and prevent angiofibroma recurrence in children with tuberous sclerosis complex
Frontiers in Medicine, 2020Co-Authors: Tohru Okanishi, Ayataka Fujimoto, Hideo Enoki, Masaaki OgaiAbstract:Introduction: Tuberous sclerosis complex (TSC) is a multisystem neurocutaneous disorder. Angiofibromas (AF), fibrous plaques, and hypopigmented macules are the major skin findings in TSC. Topical sirolimus reduces the volume and redness of AF and other skin findings. However, the efficacy of early intervention and long-term Treatment remains to be clarified. We investigated the efficacy of sirolimus Gel for AF in children with TSC. Methods: We recruited nine children (five boys; four girls) with TSC and AF. We used 0.2% sirolimus Gel over 6 months. We reviewed each patient's medical records and photographs for clinical information and data related to improvements in skin lesions. We evaluated the size of AF, fibrous plaques, and color changes in AF and hypopigmented macules. Results: Age at the initiation of Treatment ranged from 3.5 to 11.0 years. The follow-up period ranged from 6 to 36 months (≥24 months in 3 children). Patients presented with papular AF (9), miliary AF (8), AF redness (9), fibrous plaques (5), and hypopigmented macules (2). After 6 months of Treatment, improvement of AF size and redness was seen in all nine patients. Patients treated for ≥24 months showed significant decrease in AF size that persisted until the final follow-up. Gradual improvement in fibrous plaques was observed, and marked reduction in size was achieved by 4-18 months. Conclusion: Early sirolimus Gel intervention is effective for the Treatment of AF and fibrous plaques in children with TSC. Early intervention with sirolimus Gel may maintain the skin at near-normal levels in patients with TSC.
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sirolimus Gel Treatment vs placebo for facial angiofibromas in patients with tuberous sclerosis complex a randomized clinical trial
JAMA Dermatology, 2018Co-Authors: Mari Watayakaneda, Masaaki Ogai, Yuuki Ohno, Yasuyuki Fujita, Hiroo Yokozeki, Hironori Niizeki, Kazuyoshi Fukai, Hiroshi Nagai, Yuichi Yoshida, Izumi HamadaAbstract:Importance Most patients with tuberous sclerosis complex (TSC), an autosomal-dominant disorder that is caused by the constitutive activation of mammalian target of rapamycin, experience disfigurement caused by skin lesions involving facial angiofibromas. Many have been left untreated because of a lack of therapeutic options that are less invasive than surgery or laser Treatment. Objective To confirm the efficacy and safety of sirolimus Gel, 0.2%, for Treatment of patients with angiofibromas and/or skin lesions. Design, Setting, and Patients Multicenter, randomized clinical trial at 9 centers in Japan from December 2015 to October 2016 including 62 children and adults with TSC. Interventions Patients who developed angiofibromas were randomly assigned, in a 1:1 ratio, to receive sirolimus Gel, 0.2%, or placebo, each applied topically twice daily for 12 weeks. Main Outcomes and Measures The primary end point was composite improvement in the size and color of angiofibromas in photographs at week 12 of Treatment. It was assessed by an independent review committee comprising 3 blinded dermatologists who categorized patient results into the following 6 categories: “markedly improved,” “improved,” “slightly improved,” “unchanged,” “slightly aggravated,” and “aggravated.” Results Sixty-two patients (27 pediatric and 35 adult; 34 [55%] female; mean [SD] age, 22.5 [11.9] years) were enrolled and randomly assigned to receive sirolimus Gel, 0.2% (30 patients), or placebo (32 patients). The response rates of angiofibromas at weeks 4, 8, and 12 of Treatment were 0 each in the placebo group in contrast to 20% (95% CI, 8%-39%;P = .01), 43% (95% CI, 26%-63%;P Conclusions and Relevance Sirolimus Gel, 0.2%, demonstrated a significant clinical benefit for patients with TSC involving angiofibromas, thus providing a promising therapeutic modality. Trial Registration ClinicalTrials.gov Identifier:NCT02635789
Shizhong Cui - One of the best experts on this subject based on the ideXlab platform.
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An investigation on sol–Gel Treatment to aramid yarn to increase inter-yarn friction
Applied Surface Science, 2014Co-Authors: Yanyan Chu, Xiaogang Chen, Qing Wang, Shizhong CuiAbstract:Inter-yarn friction helps to increase energy absorption in ballistic fabrics. This paper reports on the results of sol–Gel Treatment on aramid yarns to increase the inter-yarn friction. Two types of TiO2/ZnO hydrosols (submicro-sized and nano-sized) prepared using hydrolysis and peptization methods were used to treat aramid yarns with and without curing. SEM was used to characterize the change in morphology. FTIR and EDX analyses were applied to identify the coating substance. The inter-yarn friction was tested using Capstan method. Images from SEM showed that the surface of the yarn treated with TiO2/ZnO submicro-sized hydrosol was covered with lump-like coating whilst in the case of TiO2/ZnO nano-sized sol Treatment, the coating on the fibres was more film-like. The substance in the coating was confirmed as titanium dioxide and zinc oxide by FTIR and EDX analyses. The test results for coefficient of friction revealed that the coefficient of friction between the yarns treated by submicro-sized hydrosol was 54% higher than the non-treated, and the nano-sized hydrosol was associated to a 10% increase. However, the curing process had little effect on the coefficient of friction between yarns. The study also showed that the tensile properties of the treated yarns and the weight add-on were not significantly affected.
Kun Sang Lee - One of the best experts on this subject based on the ideXlab platform.
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Assessment on synergic potential of hybrid Gel Treatment with low salinity waterflood
Geosystem Engineering, 2015Co-Authors: Ji Ho Lee, Kun Sang LeeAbstract:With Gel Treatment, application of low salinity waterflood recovers significant amount oil from mixed- or oil-wet and severely heterogeneous reservoirs due to wettability alteration. In order to assess the performance of hybrid Gel Treatment with low salinity waterflood, numerical simulations has been performed for various injection schemes including low salinity polymer flood and hybrid Gel Treatment with low salinity waterflood. While injectivity in polymer process is significantly reduced by injection of low salinity water, that of Gel Treatment process is not highly influenced. In addition, optimization algorithm maximizing net present value (NPV) is applied to injection scheme under consideration of injectivity to clarify the assessment of potential of hybrid Gel Treatment with low salinity waterflood comparing with low salinity polymer flood. Restricted constraint condition of injection makes hybrid Gel Treatment with low salinity waterflood to become efficient recovery method with respect to not on...
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Influence of Temperature on Gel Treatment under Various Reservoir Wettability Conditions
All Days, 2014Co-Authors: Guang Xi Shen, Ji Ho Lee, Kun Sang LeeAbstract:Heterogeneous reservoirs which especially characterize high permeability contrast bring about excessive water production. To avoid disproportionate water production, permeability reduction techniques are proposed and Gel Treatment is well-known as effective one of them. Previous studies have revealed the Gelation of various Gel types is sensitive to temperatures. Also, wettability of reservoir determines different performance. To date, most of former researches are carried out only concerning relationships between wettability and Gel Treatment or between temperature and Gel Treatment, mainly by experiments. To overcome these limitations, the assessment of non-isothermal Gel Treatment requires a model as a function of temperature under consideration of wettability of reservoir. Using a reservoir simulator including the model for wettability, extensive numerical studies have been performed to investigate the effect of temperature on the water-oil ratio and cumulative oil recovery. Analyzed target is the layered reservoir which has severe permeability contrast in vertical direction and low vertical communication with an injector under Gel Treatment followed by water flood. Results from a number of scenarios of different temperatures of reservoir and injection fluid clearly prove the temperature dependency of performance. The model can be used as quantitative tool to evaluate the comparative studies of Gel Treatment with respect to temperature dependency under different wettability of reservoir. The significant improvement is observed in both water-wet and oil-wet reservoirs as temperature elevates. However, improvement of performance of Gel Treatment according to temperature in oil-wet reservoir shows different results comparing with that in water-wet reservoir. As reservoir temperature increases, water-oil ratio in water-wet reservoir decreases more rapidly than that in oil-wet reservoir. Increases in oil recovery of oil-wet reservoirs are obtained while slight decreases in water-wet reservoirs. In terms of injection fluid temperature, the higher injection temperature, the more improvement in water-oil ratio is noticed for water-wet reservoir than oil-wet reservoir.
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Application of Horizontal Wells to Reduce Water Production during Gel Treatment
Advanced Materials Research, 2013Co-Authors: Guang Xi Shen, Ji Ho Lee, Kun Sang LeeAbstract:It is well known that Gel Treatment has outstanding potential to delay water breakthrough and reduce water production. However, it causes the decrease of oil production by permeability reduction, even though it is not as much as reduction of water production. For this reason, to improve oil production with substantial reduction of water production, performances of Gel Treatments through the combination of horizontal and/or vertical wells were assessed and compared. An extensive numerical simulation was executed for four different well configurations under Gel Treatment associated with waterflood to accomplish the purpose of this study. Performances were compared according to cumulative oil recovery and water-oil ratio at the production well for different systems. Though all of well configurations considered in this study effectively decreased the water production compared with waterflood, applications of horizontal wells led to much higher oil recovery than vertical well because of improved sweep efficiency. Based on these results, the potential of horizontal wells was examined through different scenarios in combinations of injection and production wells. Furthermore, various well lengths of injectors or producers were assessed for horizontal wells. Because cross-flow between layers dominates performance of Gel Treatment, effects of vertical permeability were also investigated in application of Gel Treatment with horizontal well. Longer wells and higher cross-flow results in better performance. This study represents that effectiveness of horizontal wells for Gel Treatment even for reservoirs having dominant cross-flow.
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Performance of Silicate Gel and Polymer/Cr(III) Gel Treatments in High Temperature Reservoirs
Applied Mechanics and Materials, 2013Co-Authors: Guang Xi Shen, Ji Ho Lee, Kun Sang LeeAbstract:Gel Treatment is increasingly used as permeability modifiers in reducing high water production. To analyze the influences of reservoir temperature on the performance of Gel Treatment, extensive numerical simulation study is undertaken to model the behavior of high temperature reservoirs. Polyacrylamide (PAM)/Cr3+ Gel Treatment and silicate Gel method are compared with waterflooding through water-oil ratio and cumulative oil recovery. The results demonstrate that, for the case of common temperature, PAM/Cr3+ Gel Treatment results in highly decreased water-oil ratio compared with water flooding. PAM/Cr3+ Gel have shown poor performance in high temperature reservoirs. However, silicate Gel is still effective in high temperature reservoirs.
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Performance of Gel Treatments in Reservoirs with Multiscale Heterogeneity
Journal of Chemistry, 2013Co-Authors: Ji Ho Lee, Kun Sang LeeAbstract:Spatially correlated permeability fields are usually generated by single-scale correlation. To overcome the limitations of single-scale permeability fields in describing real situation, permeability fields should be generated by multiscale correlation. Multiscale heterogeneity results in the existence of various permeability magnitudes and spatial distributions of permeability. Gel Treatment is applied on the heterogeneous permeability fields realized by multiscale correlation. Performance of Gel Treatment has been shown to depend on permeability distribution and permeability values, which are determined by correlation length, variance, and number of scales. Generally, spatially-correlated permeability fields generated with longer correlation length, higher variance, and multiscale lead to higher improvement in the performance of Gel Treatment. In addition, longer application of preflush as waterflooding results in larger reduction of water-oil ratio when the Gel Treatment is applied to heterogeneous permeability fields after preflush.
Izumi Hamada - One of the best experts on this subject based on the ideXlab platform.
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sirolimus Gel Treatment vs placebo for facial angiofibromas in patients with tuberous sclerosis complex a randomized clinical trial
JAMA Dermatology, 2018Co-Authors: Mari Watayakaneda, Masaaki Ogai, Yuuki Ohno, Yasuyuki Fujita, Hiroo Yokozeki, Hironori Niizeki, Kazuyoshi Fukai, Hiroshi Nagai, Yuichi Yoshida, Izumi HamadaAbstract:Importance Most patients with tuberous sclerosis complex (TSC), an autosomal-dominant disorder that is caused by the constitutive activation of mammalian target of rapamycin, experience disfigurement caused by skin lesions involving facial angiofibromas. Many have been left untreated because of a lack of therapeutic options that are less invasive than surgery or laser Treatment. Objective To confirm the efficacy and safety of sirolimus Gel, 0.2%, for Treatment of patients with angiofibromas and/or skin lesions. Design, Setting, and Patients Multicenter, randomized clinical trial at 9 centers in Japan from December 2015 to October 2016 including 62 children and adults with TSC. Interventions Patients who developed angiofibromas were randomly assigned, in a 1:1 ratio, to receive sirolimus Gel, 0.2%, or placebo, each applied topically twice daily for 12 weeks. Main Outcomes and Measures The primary end point was composite improvement in the size and color of angiofibromas in photographs at week 12 of Treatment. It was assessed by an independent review committee comprising 3 blinded dermatologists who categorized patient results into the following 6 categories: “markedly improved,” “improved,” “slightly improved,” “unchanged,” “slightly aggravated,” and “aggravated.” Results Sixty-two patients (27 pediatric and 35 adult; 34 [55%] female; mean [SD] age, 22.5 [11.9] years) were enrolled and randomly assigned to receive sirolimus Gel, 0.2% (30 patients), or placebo (32 patients). The response rates of angiofibromas at weeks 4, 8, and 12 of Treatment were 0 each in the placebo group in contrast to 20% (95% CI, 8%-39%;P = .01), 43% (95% CI, 26%-63%;P Conclusions and Relevance Sirolimus Gel, 0.2%, demonstrated a significant clinical benefit for patients with TSC involving angiofibromas, thus providing a promising therapeutic modality. Trial Registration ClinicalTrials.gov Identifier:NCT02635789
Yanyan Chu - One of the best experts on this subject based on the ideXlab platform.
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An investigation on sol–Gel Treatment to aramid yarn to increase inter-yarn friction
Applied Surface Science, 2014Co-Authors: Yanyan Chu, Xiaogang Chen, Qing Wang, Shizhong CuiAbstract:Inter-yarn friction helps to increase energy absorption in ballistic fabrics. This paper reports on the results of sol–Gel Treatment on aramid yarns to increase the inter-yarn friction. Two types of TiO2/ZnO hydrosols (submicro-sized and nano-sized) prepared using hydrolysis and peptization methods were used to treat aramid yarns with and without curing. SEM was used to characterize the change in morphology. FTIR and EDX analyses were applied to identify the coating substance. The inter-yarn friction was tested using Capstan method. Images from SEM showed that the surface of the yarn treated with TiO2/ZnO submicro-sized hydrosol was covered with lump-like coating whilst in the case of TiO2/ZnO nano-sized sol Treatment, the coating on the fibres was more film-like. The substance in the coating was confirmed as titanium dioxide and zinc oxide by FTIR and EDX analyses. The test results for coefficient of friction revealed that the coefficient of friction between the yarns treated by submicro-sized hydrosol was 54% higher than the non-treated, and the nano-sized hydrosol was associated to a 10% increase. However, the curing process had little effect on the coefficient of friction between yarns. The study also showed that the tensile properties of the treated yarns and the weight add-on were not significantly affected.
