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Anant Paradkar - One of the best experts on this subject based on the ideXlab platform.

  • study on mechanism for amorphous drug stabilization using Gelucire 50 13
    Chemical & Pharmaceutical Bulletin, 2009
    Co-Authors: Shamkant Laxman Shimpi, Kakasaheb R Mahadik, Anant Paradkar
    Abstract:

    Methods of preparation and application of amorphous form are well established but it is equally important to note that devitrification of amorphous drugs has limited their applications. Present study was performed to investigate mechanism for amorphous drug stabilization using Gelucire in comparison with polyvinylpyrrolidone (PVP). Etoricoxib and celecoxib were taken as model drugs for this study, as etoricoxib has only proton accepting site for hydrogen bonding in comparison with celecoxib, which has both proton accepting and donating site. Solid dispersion of celecoxib with polyvinylpyrrolidone and Gelucire was prepared by spray drying and melt-granulation technique respectively. X-ray powder diffractometry and differential scanning calorimetry were used to study the physical state of the drug. Dissolution studies were performed to differentiate dissolution performance. Stability study samples were evaluated for physical state of the drug and dissolution performance. An IR study in correlation with molecular modeling was carried out to study the mechanism for stabilization. Dissolution of melt-granulation of amorphous celecoxib was improved significantly as compared to amorphous celecoxib and Celecoxib-PVP solid dispersion. Melt-granulation with lipid seemed to be more dominant than amorphization of drug for improving dissolution. Stability data revealed that PVP was significantly advantageous for amorphous form stabilization whereas Gelucire failed in case of Celecoxib. In contrast to this, our previous study revealed the stabilization ability of Gelucire for amorphous etoricoxib. Molecular modeling and IR studies revealed that H-bonding was predominant mechanism for stabilization. Out of two proposed mechanism for amorphous drug stabilization by lipids, H-bonding ability is more dominant than immobilization of molecule in lipid matrix.

  • cefuroxime axetil solid dispersion with polyglycolized glycerides for improved stability and bioavailability
    Journal of Pharmacy and Pharmacology, 2009
    Co-Authors: Ravindra S Dhumal, Shailesh V Biradar, Suyog Aher, Anant Paradkar
    Abstract:

    Objectives Cefuroxime axetil (CA), a poorly soluble, broad spectrum cephalosporin ester prodrug, is hydrolysed by intestinal esterase prior to absorption, leading to poor and variable bioavailability. The objective was therefore to formulate a stable amorphous solid dispersion of the drug with enhanced solubility and stability against enzymatic degradation. Methods Spray drying was used to obtain a solid dispersion of CA with Gelucire 50/13 and Aerosil 200 (SDCAGA), and a solid dispersion of CA with polyvinyl pyrrolidone (SDCAP); amorphous CA (ACA) was obtained by spray drying CA alone. The formulations were characterized by differential scanning calorimetry, X-ray powder diffraction, scanning electron microscopy and Fourier transform infrared spectroscopy studies, and compared for solubility, dissolution and bioavailability in rats. Key findings SDCAP and SDCAGA showed improved solubility and dissolution profiles owing to amorphization and formation of solid dispersions with hydrophilic carriers. The improved stability of amorphous CA in solid dispersions compared to ACA alone was attributed to hydrogen bonding interactions involving the amide of CA with the carbonyl of polyvinyl pyrrolidone in SDCAP, whereas in SDCAGA the interactions were at multiple sites involving the amide and carbonyl of CA with the carbonyl and hydroxyl of Gelucire 50/13. However, SDCAGA showed superior bioavailability compared to SDCAP, ACA and CA. Conclusions Improvement in physical stability of solid dispersions was attributed to hydrogen bonding, while improvement in bioavailability of SDCAGA compared to SDCAP, in spite of comparable solubility and dissolution profile, may be attributed to Gelucire, which utilizes intestinal esterase for lipolysis, protecting the prodrug from enzymatic degradation to its non-absorbable base form.

  • stabilization and improved in vivo performance of amorphous etoricoxib using Gelucire 50 13
    Pharmaceutical Research, 2005
    Co-Authors: Shamkant Laxman Shimpi, Bhaskar Chauhan, K R Mahadik, Anant Paradkar
    Abstract:

    Amorphous drugs have gained importance because of their advantageous biopharmaceutical properties; however, their stabilization remains a challenge. The purpose of this work was to stabilize the amorphous form of etoricoxib (ET) by using a low excipient/drug ratio to improve drug dissolution and thus bioavailability. The effect of Gelucire and polyvinylpyrrolidone (PVP) on stabilization and bioavailability of amorphous etoricoxib (AET) was studied. X-ray powder diffractometry, differential scanning calorimetry, and scanning electron microscopy were used to study the physical state of the drug. Dissolution studies were performed for melt granules of AET with Gelucire 50/13 (MG-AET) and solid dispersion with PVP (SDP) to differentiate dissolution performance. A stability study on samples was conducted for 3 months to evaluate the physical state of the drug and its dissolution in the formulation. The in vivo performance of the optimized and stable formulation of ET was evaluated in rat. Dissolution of MG-AET was significantly improved as compared to AET and SDP. Both factors, amorphization of drug and melt granulation with lipid, seemed to be important for improving dissolution. Stability data revealed that MG-AET was significantly advantageous for AET stabilization, whereas PVP was not. The amount of Gelucire required for the stabilization of one part of AET was 0.5 part (by weight), whereas even 1.5 part (by weight) of PVP failed to elicit the same result. The superior in vivo performance of MG-AET has been attributed to the altered physiochemical properties of AET and the presence of lipid in the system. Gelucire can stabilize AET and improve its biopharmaceutical performance at a low excipient/drug ratio and may provide a better alternative to conventional stabilizers such as PVP.

  • preparation and evaluation of floating risedronate sodium Gelucire 43 01 formulations
    Drug Development and Industrial Pharmacy, 2005
    Co-Authors: Bhaskar Chauhan, Shyam Shimpi, Kakasaheb R Mahadik, Anant Paradkar
    Abstract:

    Single and multi-unit floating matrices of risedronate sodium were prepared using Gelucire® 43/01 by melt solidification and melt granulation technique, respectively. The controlled release floating matrices were evaluated for in vitro and in vivo floating ability and in vitro drug release. Effect of aging on Gelucire® 43/01 was evaluated by hot stage microscopy (HSM), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), in vitro floating ability, and in vitro drug release. Multi-unit system obtained has shown initial burst release, which was suppressed in single unit system. Both single- as well as multi-unit systems showed increase in rate of drug release on aging due to changes in the properties of the Gelucire® 43/01. Multi-unit matrices obtained by melt granulation were relatively easier for scale up and advantageous if the initial burst release does not cause any significant clinical adversity.

  • preparation and evaluation of diltiazem hydrochloride Gelucire 43 01 floating granules prepared by melt granulation
    Aaps Pharmscitech, 2004
    Co-Authors: Shyam Shimpi, Bhaskar Chauhan, Kakasaheb R Mahadik, Anant Paradkar
    Abstract:

    The basic objective of this study was to explore the application of Gelucire 43/01 for the design of multi-unit floating systems of a highly water-soluble drug diltiazem HCl. Diltiazem HCl-Gelucire 43/01 granules were prepared by melt granulation technique. The granules were evaluated for in vitro and in vivo floating ability, surface topography, and in vitro drug release. Aging effect on storage was vvaluated using scanning electron microscopy, hot stage polarizing microscopy (HSPM), differential scanning calorimetry (DSC), and in vitro drug release. Granules were retained in stomach at least for 6 hours. Approximately 65% to 80% drug was released over 6 hours with initial fast release from the surface. Surface topography, HSPM, DSC study of the aged samples showed phase transformation of Gelucire. The phase transformation also caused significant increase in drug release. In conclusion, hydrophobic lipid, Gelucire 43/01, can be considered as an effective carrier for design of a multi-unit floating drug delivery system of highly water-soluble drugs such as diltiazem HCl.

Bhaskar Chauhan - One of the best experts on this subject based on the ideXlab platform.

  • stabilization and improved in vivo performance of amorphous etoricoxib using Gelucire 50 13
    Pharmaceutical Research, 2005
    Co-Authors: Shamkant Laxman Shimpi, Bhaskar Chauhan, K R Mahadik, Anant Paradkar
    Abstract:

    Amorphous drugs have gained importance because of their advantageous biopharmaceutical properties; however, their stabilization remains a challenge. The purpose of this work was to stabilize the amorphous form of etoricoxib (ET) by using a low excipient/drug ratio to improve drug dissolution and thus bioavailability. The effect of Gelucire and polyvinylpyrrolidone (PVP) on stabilization and bioavailability of amorphous etoricoxib (AET) was studied. X-ray powder diffractometry, differential scanning calorimetry, and scanning electron microscopy were used to study the physical state of the drug. Dissolution studies were performed for melt granules of AET with Gelucire 50/13 (MG-AET) and solid dispersion with PVP (SDP) to differentiate dissolution performance. A stability study on samples was conducted for 3 months to evaluate the physical state of the drug and its dissolution in the formulation. The in vivo performance of the optimized and stable formulation of ET was evaluated in rat. Dissolution of MG-AET was significantly improved as compared to AET and SDP. Both factors, amorphization of drug and melt granulation with lipid, seemed to be important for improving dissolution. Stability data revealed that MG-AET was significantly advantageous for AET stabilization, whereas PVP was not. The amount of Gelucire required for the stabilization of one part of AET was 0.5 part (by weight), whereas even 1.5 part (by weight) of PVP failed to elicit the same result. The superior in vivo performance of MG-AET has been attributed to the altered physiochemical properties of AET and the presence of lipid in the system. Gelucire can stabilize AET and improve its biopharmaceutical performance at a low excipient/drug ratio and may provide a better alternative to conventional stabilizers such as PVP.

  • preparation and evaluation of floating risedronate sodium Gelucire 43 01 formulations
    Drug Development and Industrial Pharmacy, 2005
    Co-Authors: Bhaskar Chauhan, Shyam Shimpi, Kakasaheb R Mahadik, Anant Paradkar
    Abstract:

    Single and multi-unit floating matrices of risedronate sodium were prepared using Gelucire® 43/01 by melt solidification and melt granulation technique, respectively. The controlled release floating matrices were evaluated for in vitro and in vivo floating ability and in vitro drug release. Effect of aging on Gelucire® 43/01 was evaluated by hot stage microscopy (HSM), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), in vitro floating ability, and in vitro drug release. Multi-unit system obtained has shown initial burst release, which was suppressed in single unit system. Both single- as well as multi-unit systems showed increase in rate of drug release on aging due to changes in the properties of the Gelucire® 43/01. Multi-unit matrices obtained by melt granulation were relatively easier for scale up and advantageous if the initial burst release does not cause any significant clinical adversity.

  • preparation and evaluation of diltiazem hydrochloride Gelucire 43 01 floating granules prepared by melt granulation
    Aaps Pharmscitech, 2004
    Co-Authors: Shyam Shimpi, Bhaskar Chauhan, Kakasaheb R Mahadik, Anant Paradkar
    Abstract:

    The basic objective of this study was to explore the application of Gelucire 43/01 for the design of multi-unit floating systems of a highly water-soluble drug diltiazem HCl. Diltiazem HCl-Gelucire 43/01 granules were prepared by melt granulation technique. The granules were evaluated for in vitro and in vivo floating ability, surface topography, and in vitro drug release. Aging effect on storage was vvaluated using scanning electron microscopy, hot stage polarizing microscopy (HSPM), differential scanning calorimetry (DSC), and in vitro drug release. Granules were retained in stomach at least for 6 hours. Approximately 65% to 80% drug was released over 6 hours with initial fast release from the surface. Surface topography, HSPM, DSC study of the aged samples showed phase transformation of Gelucire. The phase transformation also caused significant increase in drug release. In conclusion, hydrophobic lipid, Gelucire 43/01, can be considered as an effective carrier for design of a multi-unit floating drug delivery system of highly water-soluble drugs such as diltiazem HCl.

  • preparation and evaluation of diltiazem hydrochloride Gelucire 43 01 floating granules prepared by melt granulation
    Aaps Pharmscitech, 2004
    Co-Authors: Shyam Shimpi, Bhaskar Chauhan, Kakasaheb R Mahadik, Anant Paradkar
    Abstract:

    The basic objective of this study was to explore the application of Gelucire 43/01 for the design of multi-unit floating systems of a highly water-soluble drug diltiazem HCl. Diltiazem HCl-Gelucire 43/01 granules were prepared by melt granulation technique. The granules were evaluated for in vitro and in vivo floating ability, surface topography, and in vitro drug release. Aging effect on storage was evaluated using scanning electron microscopy, hot stage polarizing microscopy (HSPM), differential scanning calorimetry (DSC), and in vitro drug release. Granules were retained in stomach at least for 6 hours. Approximately 65% to 80% drug was released over 6 hours with initial fast release from the surface. Surface topography, HSPM, DSC study of the aged samples showed phase transformation of Gelucire. The phase transformation also caused significant increase in drug release. In conclusion, hydrophobic lipid, Gelucire 43/01, can be considered as an effective carrier for design of a multi-unit floating drug delivery system of highly water-soluble drugs such as diltiazem HCl.

Vincent Jannin - One of the best experts on this subject based on the ideXlab platform.

  • in vitro gastrointestinal lipolysis of four formulations of piroxicam and cinnarizine with the self emulsifying excipients labrasol and Gelucire 44 14
    Pharmaceutical Research, 2009
    Co-Authors: Sylvie Fernandez, Nicolas Ritter, Bruno Mahler, Frederic Demarne, Frederic Carriere, Stephanie Chevrier, Vincent Jannin
    Abstract:

    Purpose Labrasol® and Gelucire® 44/14 are defined admixtures of acylglycerols and PEG esters which are substrates for digestive lipases.

  • lipolysis of the semi solid self emulsifying excipient Gelucire 44 14 by digestive lipases
    Biochimica et Biophysica Acta, 2008
    Co-Authors: Sylvie Fernandez, Jeandavid Rodier, Nicolas Ritter, Bruno Mahler, Frederic Demarne, Frederic Carriere, Vincent Jannin
    Abstract:

    Abstract Gelucire® 44/14 is a semi-solid self-emulsifying excipient used for the oral delivery of poorly water-soluble drugs. It is composed of C8-C18 acylglycerols and PEG-32 esters, all of which are potential substrates for digestive lipases. Here we studied the lipolysis of Gelucire® 44/14 by porcine pancreatic extracts, human pancreatic juice and several purified digestive lipases. Human pancreatic lipase (HPL), the main lipase involved in the digestion of triacylglycerols, did not show any significant activity on Gelucire® 44/14 or on either of its individual compounds, C8-C18 acylglycerols and PEG-32 esters. Other pancreatic lipases such as human pancreatic lipase-related protein 2 (HPLRP2) showed low activity on Gelucire® 44/14 although the highest activity of HPLRP2 was that observed on the C8-C18 acylglycerol fraction, which accounts for 20% (w/w) of Gelucire® 44/14. In addition, HPLRP2 showed low activities on the PEG-32 esters, whether these were tested individually or mixed together. Carboxyl ester hydrolase (CEH) showed high activity on Gelucire® 44/14, and the highest activities of CEH were those recorded on the total PEG-32 ester fraction and on each individual PEG-32 ester, except for PEG-32 monostearate. The highest activity of all the enzymes tested was that of dog gastric lipase (DGL) on Gelucire® 44/14, although DGL showed low activity on the PEG-32 ester fraction and on each individual PEG-32 ester. We compared the lipolysis of Gelucire® 44/14 with that of Labrasol®, another self-emulsifying excipient, which is liquid at room temperature. Human pancreatic juice showed similar rates of activity on both Gelucire® 44/14 and Labrasol®. This finding means that these excipients are hydrolyzed in vivo during pancreatic digestion, mainly by CEH in the case of Gelucire® 44/14 and by both HPLRP2 and CEH in that of Labrasol®, whereas HPL showed very low activities on each of these two excipients. This is the first time the effects of PEG and acyl chain length on the lipolytic activity of digestive lipases on PEG esters have been investigated.

  • interest of multifunctional lipid excipients case of Gelucire 44 14
    Drug Development and Industrial Pharmacy, 2005
    Co-Authors: Odile Chambin, Vincent Jannin
    Abstract:

    This paper focuses on the interest of a multifunctional lipid excipient from the lauroyl macrogolglycerides, i.e., Gelucire® 44/14. This compound, characterized by a drop point of 44°C and a HLB (Hydrophilic Lipophilic Balance) of 14, is made of a specific mixture, leading to particular properties. Gelucire® 44/14 forms a fine emulsion in contact with aqueous fluids, inducing a pseudo-solubilization of poorly water-soluble active substances and thus increasing their bioavailability. It could be used either as a binder for immediate release pellets by melt granulation or as a self-emulsifying drug delivery system by capsule molding or as a powder obtained by cryogenic grinding. These different methods and their interests are then discussed.

Nadia Passerini - One of the best experts on this subject based on the ideXlab platform.

  • development and in vitro evaluation of mucoadhesive gelatin films for the vaginal delivery of econazole
    International Journal of Pharmaceutics, 2020
    Co-Authors: Luisa Stella Dolci, Nadia Passerini, Beatrice Albertini, Maria Di Filippo, Francesca Bonvicini, Silvia Panzavolta
    Abstract:

    Abstract Several strategies have been explored to obtain effective econazole nitrate (ECN) concentrations at the site of application for a prolonged time. In this paper, different gelatin-based film formulations for vaginal application were investigated, containing ECN (10% w/w with respect to gelatin) as pure drug or as drug-solid dispersions (SD). For the production of SD, different polymers were evaluated: polyvinylpyrrolidone (PVP), Soluplus® (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) and Gelucire® 50/13 (mixture of mono-, di- and triglycerides of fatty acids, esters of PEG 1500 and free PEG). Gelucire®-SD showed the best solubility enhancement, increasing 9.2 times the ECN solubility in pH 4.5 solution respect to pure drug; DSC and XRD analysis confirmed the crystalline form of the drug. XRD results evidenced that all gelatin-based films, containing either the drug or the SD, underwent the topotactic transformation of ECN into crystalline econazole (EC), owing to a strong interaction between the drug and the gelatin. Films containing Gelucire®-based SD displayed lower brittleness and rigidity with respect to the other samples; moreover they demonstrated good structural integrity after 24 h of incubation in the acidic solution (swelling degree of about 350%). Then, Gelucire®-SD based films were compared with the corresponding formulations cross-linked by genipin (2% w/w). The addition of genipin did not interfere with the drug-gelatin interaction. Gelucire®-SD based films showed similar release profiles to neat gelatin films, enhancing the drug release in the first 5 h and controlling the EC release over time, avoiding the use of a crosslinking additive. Finally, gelatin films containing Gelucire® solid dispersion displayed good adhesiveness and anti-Candida activity. Overall, results support the potential use of this film formulation as noncytotoxic EC delivery system for the treatment of vaginal candidiasis.

  • different bcs class ii drug Gelucire solid dispersions prepared by spray congealing evaluation of solid state properties and in vitro performances
    Pharmaceutics, 2020
    Co-Authors: Serena Bertoni, Beatrice Albertini, Nadia Passerini
    Abstract:

    Delivery of poorly water soluble active pharmaceutical ingredients (APIs) by semi-crystalline solid dispersions prepared by spray congealing in form of microparticles (MPs) is an emerging method to increase their oral bioavailability. In this study, solid dispersions based on hydrophilic Gelucires® (Gelucire® 50/13 and Gelucire® 48/16 in different ratio) of three BCS class II model compounds (carbamazepine, CBZ, tolbutamide, TBM, and cinnarizine, CIN) having different physicochemical properties (logP, pKa, Tm) were produced by spray congealing process. The obtained MPs were investigated in terms of morphology, particles size, drug content, solid state properties, drug-carrier interactions, solubility, and dissolution performances. The solid-state characterization showed that the properties of the incorporated drug had a profound influence on the structure of the obtained solid dispersion: CBZ recrystallized in a different polymorphic form, TBM crystallinity was significantly reduced as a result of specific interactions with the carrier, while smaller crystals were observed in case of CIN. The in vitro tests suggested that the drug solubility was mainly influenced by carrier composition, while the drug dissolution behavior was affected by the API solid state in the MPs after the spray congealing process. Among the tested APIs, TBM-Gelucire dispersions showed the highest enhancement in drug dissolution as a result of the reduced drug crystallinity.

  • characterization of carbamazepine Gelucire 50 13 microparticles prepared by a spray congealing process using ultrasounds
    Journal of Pharmaceutical Sciences, 2002
    Co-Authors: Nadia Passerini, Beatrice Albertini, Beatrice Perissutti, Mariarosa Moneghini, Dario Voinovich, Cristina Cavallari, Lorenzo Rodriguez
    Abstract:

    In this work, the utilization of a spray-congealing technique using a new ultrasonic atomizer to prepare enhanced-release, solvent-free microspheres of carbamazepine (CBZ)–Gelucire 50/13 in different drug-to-polymer ratios was considered. Scanning electron microscopy analysis showed that it was possible to obtain spherically shaped and nonaggregated microparticles; the prevalent particle size was in the range 150–250 μm and the microspheres had a good encapsulation efficiency (> 90% in the prevalent size fraction). The in vitro dissolution tests displayed a significant increase of the CBZ dissolution rate from microspheres compared with pure drug and to drug–Gelucire 50/13 physical mixture. Differential scanning calorimetry, hot stage microscopy, X-ray powder diffractometry, and diffuse reflectance Fourier transform infrared spectroscopy demonstrated phase stability of the original polymorph of CBZ in all the systems; moreover, no interactions between the drug and Gelucire 50/13 were found. The results of this study suggested that the spray-congealing technique using the ultrasonic atomizer could be considered as a new and interesting method to enhance the dissolution rate of a poorly water-soluble drug as CBZ. © 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 91:699–707, 2002

Manoranjan Sahu - One of the best experts on this subject based on the ideXlab platform.

  • Gelucire: A versatile polymer for modified release drug delivery system
    Future Journal of Pharmaceutical Sciences, 2018
    Co-Authors: Kahnu Charan Panigrahi, Goutam Kumar Jena, Debashish Ghose, Jayashree Jena, Santosh Kumar Panda, Ch. Niranjan Patra, Manoranjan Sahu
    Abstract:

    Abstract Poly ethylene glycol (PEG) ester surfactants are synthesized by reacting polyethylene glycol with fatty acid. The polyethylene glycol comprises the hydrophilic part of the surfactant and the fatty acid is the lipophilic part. By varying the molecular weight of the PEG and the fatty acid, surfactants covering wide range of hydrophilic lipophilic balance (HLB) values can be produced. Gelucire is the family of vehicle derived from mixtures of mono, di and triglycerides with PEG esters of fatty acids. These are available with range of properties depending on their HLB and melting point range (33–65 °C). They have a wide variety of application in oral and topical formulations. The applications of oral formulation include solubility and bioavailability enhancement, sustain drug release, taste masking and active pharmaceutical ingredient (API) protection from oxygen, light and humidity. The applications of topical formulations include stabilization of creams, lotions and gels, thickener, superior penetration of drug through skin. Gelucire containing only PEG esters are generally used in the preparation of fast release formulations. Gelucire containing only glycerides or a mixture of glycerides and PEG esters are used in the preparation of sustained release formulations. Owing to their extreme hydrophobicity and low density, are considered as appropriate carriers for designing sustained release drug delivery systems. In this review manuscript, applications of various grades of Gelucire are compiled in the form of tables and discussed critically. A current literature on patents on Gelucire based formulations was also discussed.

  • Gelucire: A versatile polymer for modified release drug delivery system
    Elsevier, 2018
    Co-Authors: Kahnu Charan Panigrahi, Goutam Kumar Jena, Debashish Ghose, Jayashree Jena, Santosh Kumar Panda, Ch. Niranjan Patra, Manoranjan Sahu
    Abstract:

    Poly ethylene glycol (PEG) ester surfactants are synthesized by reacting polyethylene glycol with fatty acid. The polyethylene glycol comprises the hydrophilic part of the surfactant and the fatty acid is the lipophilic part. By varying the molecular weight of the PEG and the fatty acid, surfactants covering wide range of hydrophilic lipophilic balance (HLB) values can be produced. Gelucire is the family of vehicle derived from mixtures of mono, di and triglycerides with PEG esters of fatty acids. These are available with range of properties depending on their HLB and melting point range (33–65 °C). They have a wide variety of application in oral and topical formulations. The applications of oral formulation include solubility and bioavailability enhancement, sustain drug release, taste masking and active pharmaceutical ingredient (API) protection from oxygen, light and humidity. The applications of topical formulations include stabilization of creams, lotions and gels, thickener, superior penetration of drug through skin. Gelucire containing only PEG esters are generally used in the preparation of fast release formulations. Gelucire containing only glycerides or a mixture of glycerides and PEG esters are used in the preparation of sustained release formulations. Owing to their extreme hydrophobicity and low density, are considered as appropriate carriers for designing sustained release drug delivery systems. In this review manuscript, applications of various grades of Gelucire are compiled in the form of tables and discussed critically. A current literature on patents on Gelucire based formulations was also discussed. Keywords: Polyethyleneglycol esters, Glycerides, Mixture of glycerides, Hydrophilic lipophilic balanc