The Experts below are selected from a list of 1272 Experts worldwide ranked by ideXlab platform
Chen Siyang - One of the best experts on this subject based on the ideXlab platform.
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hopf bifurcation for General Hematopoiesis model with continuous and discrete time delay and numerical analysis
Computer Engineering and Applications, 2010Co-Authors: Chen SiyangAbstract:The stability and Hopf bifurcation for a General Hematopoiesis model with continuous and discrete delays of interference are investigated.Sufficient conditions of absolute stability are obtained by using the theory of characteristic value.Furthermoret,he conditions of the existence of Hopf bifurcation and the stability of model are given.Finallyt,he feasibility of the main results is shown by the numerical simulations.
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the hopf bifurcation periodic solution of a General Hematopoiesis model with time delay and interference
Journal of Yunnan Normal University, 2010Co-Authors: Chen SiyangAbstract:The stability and approximate expression of Hopf bifurcation periodic solution arediscussed for a class of General Hematopoiesis model with time delay and interference.First of all,The necessary and sufficient conditions of the existence and uniquity of the positive equlibria by applying functional derivative is obtained;After that,the form of approximate periodic solution is derived by the orthogonal method;In the end,the achievability of the results is verified by examples.The fitted curves are achieved by Matlab when assign the different parmaters to the model.
Ghen Siyang - One of the best experts on this subject based on the ideXlab platform.
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hopf bifurcation of a General Hematopoiesis model
Journal of Yunnan Normal University, 2009Co-Authors: Ghen SiyangAbstract:The Hopf bifurcation periodic solution in a General Hematopoiesis model with decrete delays and disturbs are discussed.The necessary and sufficient conditions of the existence and uniquity of the positive equlibria by applying functional derivative is obtained,bifurcation values for the existence of bifurcation periodic solution are derived and the form of the approximate periodic solution is obtained by using the solvability andition.Some specific examples are given and the solution diagrame appears by Matlab.The influence to period,swing,positive equilibrium of period solution are discussed.When parameters in the process of diversification.
Xiao Wang - One of the best experts on this subject based on the ideXlab platform.
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dynamics for a class of General Hematopoiesis model with periodic coefficients
Applied Mathematics and Computation, 2007Co-Authors: Xiao WangAbstract:Abstract Sufficient conditions are obtained for the existence and global attractivity of a unique positive periodic solution x ˜ ( t ) of (∗) x ′ ( t ) = - a ( t ) x ( t ) + b ( t ) 1 + x n ( t - τ ( t ) ) , t > 0 , where n > 1, a and b are continuous positive periodic function. Also, some sufficient conditions are established for oscillation of all positive solutions of (∗) about x ˜ ( t ) . For the proof of existence and uniqueness of x ˜ ( t ) , the method used here is better than contraction mapping principle.
Scott A Armstrong - One of the best experts on this subject based on the ideXlab platform.
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histone acetyltransferase activity of mof is required for adult but not early fetal Hematopoiesis in mice
Blood, 2017Co-Authors: Daria G Valerio, Meghan E Eisold, Carolien M Woolthuis, Tej K Pandita, Scott A ArmstrongAbstract:K(lysine) acetyltransferase 8 (KAT8, also known as MOF) mediates the acetylation of histone H4 at lysine 16 (H4K16ac) and is crucial for murine embryogenesis. Lysine acetyltransferases have been shown to regulate various stages of normal Hematopoiesis. However, the function of MOF in hematopoietic stem cell (HSC) development has not yet been elucidated. We set out to study the role of MOF in General Hematopoiesis by using a Vav1-cre-induced conditional murine Mof knockout system and found that MOF is critical for hematopoietic cell maintenance and HSC engraftment capacity in adult Hematopoiesis. Rescue experiments with a MOF histone acetyltransferase domain mutant illustrated the requirement for MOF acetyltransferase activity in the clonogenic capacity of HSCs and progenitors. In stark contrast, fetal steady-state Hematopoiesis at embryonic day (E) 14.5 was not affected by homozygous Mof deletion despite dramatic loss of global H4K16ac. Hematopoietic defects start manifesting in late gestation at E17.5. The discovery that MOF and its H4K16ac activity are required for adult but not early and midgestational Hematopoiesis supports the notion that multiple chromatin regulators may be crucial for Hematopoiesis at varying stages of development. MOF is therefore a developmental-stage-specific chromatin regulator found to be essential for adult but not early fetal Hematopoiesis.
Daria G Valerio - One of the best experts on this subject based on the ideXlab platform.
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histone acetyltransferase activity of mof is required for adult but not early fetal Hematopoiesis in mice
Blood, 2017Co-Authors: Daria G Valerio, Meghan E Eisold, Carolien M Woolthuis, Tej K Pandita, Scott A ArmstrongAbstract:K(lysine) acetyltransferase 8 (KAT8, also known as MOF) mediates the acetylation of histone H4 at lysine 16 (H4K16ac) and is crucial for murine embryogenesis. Lysine acetyltransferases have been shown to regulate various stages of normal Hematopoiesis. However, the function of MOF in hematopoietic stem cell (HSC) development has not yet been elucidated. We set out to study the role of MOF in General Hematopoiesis by using a Vav1-cre-induced conditional murine Mof knockout system and found that MOF is critical for hematopoietic cell maintenance and HSC engraftment capacity in adult Hematopoiesis. Rescue experiments with a MOF histone acetyltransferase domain mutant illustrated the requirement for MOF acetyltransferase activity in the clonogenic capacity of HSCs and progenitors. In stark contrast, fetal steady-state Hematopoiesis at embryonic day (E) 14.5 was not affected by homozygous Mof deletion despite dramatic loss of global H4K16ac. Hematopoietic defects start manifesting in late gestation at E17.5. The discovery that MOF and its H4K16ac activity are required for adult but not early and midgestational Hematopoiesis supports the notion that multiple chromatin regulators may be crucial for Hematopoiesis at varying stages of development. MOF is therefore a developmental-stage-specific chromatin regulator found to be essential for adult but not early fetal Hematopoiesis.